AutismKB 2.0

Annotation Detail for INPP5F


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Basic Information Top
Gene Symbol:INPP5F ( FLJ13081,KIAA0966,MGC131851,MGC59773,MSTPO47,SAC2,hSAC2 )
Gene Full Name: inositol polyphosphate-5-phosphatase F
Band: 10q26.11
Quick LinksEntrez ID:22876; OMIM: 609389; Uniprot ID:SAC2_HUMAN; ENSEMBL ID: ENSG00000198825; HGNC ID: 17054
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-6358superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism
PWY-6363D-myo-inositol (1,4,5)-trisphosphate degradation
PWY-63683-phosphoinositide degradation
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of INPP5F mRNAaffects expression 17562736
C068073 Am 580 Am 580 results in increased expression of INPP5F mRNAincreases expression 16982809
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of INPP5F mRNAaffects binding|decreases expression|increases activity 19710929
C089730 rosiglitazone rosiglitazone results in increased expression of INPP5F mRNAincreases expression 16982809
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of INPP5F mRNAdecreases expression 19465110
D013752 Tetracycline Tetracycline results in increased expression of INPP5F mRNAincreases expression 16917069
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3115322242 14514962 11752688
MESH:D055371 Acute Lung Injury pirinixic acid 3.4718653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.4916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.4916835633
MESH:D000544 Alzheimer Disease rosiglitazone 2.9019621015
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2511748828
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.8719483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.8712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.3115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9515746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6720435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.403084413
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5216120746 18670907 18850075
MESH:D002386 Cataract Acetaminophen 8.2410977129
MESH:D002386 Cataract Am 580 8.2417460283
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4516835633
MESH:D002779 Cholestasis pirinixic acid 3.0519176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2112621046 15340226 16354765 8697196 15668235
MESH:D003092 Colitis Am 580 5.3817035595
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3417141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 10048152 15322242
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5518249437
MESH:D003920 Diabetes Mellitus rosiglitazone 4.5917446233
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 4.7012642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.7017107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.6918071297 11743745 11287661 2444490 10915739 17562736 11834606 19370779 16781746 16393943 16227642 14550746 19085960 12153990 17522070 18713872 11421492 17906064 15968718 11529661 12958197 19164858 12705907 19420014 16177239 16485898 16081117 10663392 16109766 12540782 14986274 12392966 11461765 15619225 19416960 19923254 19739265 12594235 14725611 10774834 11739529
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.6920420201
MESH:D056486 Drug-Induced Liver Injury Tetracycline 6.6917522070
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9911462148
MESH:D004487 Edema pirinixic acid 13.4312083418
MESH:D004487 Edema rosiglitazone 13.4312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 13.4312711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.4215322242 18230668 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.339294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2411564622
MESH:D005234 Fatty Liver pirinixic acid 15.2820131406 19236843
MESH:D005234 Fatty Liver rosiglitazone 15.2819196556
MESH:D005234 Fatty Liver Tetracycline 15.2816917069 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8711858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3620067830
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.1210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4711294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.7120558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6611000095
MESH:D006529 Hepatomegaly pirinixic acid 9.6918467677 16221962 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.6915340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.578697196 16959395 15340226 16354765 18606429
MESH:D006930 Hyperalgesia Acetaminophen 8.7416870215
MESH:D006930 Hyperalgesia rosiglitazone 8.7412083418
MESH:D006943 Hyperglycemia pirinixic acid 3.4920558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0018670907 18850075
MESH:D007249 Inflammation rosiglitazone 5.6612083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.6612200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 8.1516306350
MESH:D007333 Insulin Resistance rosiglitazone 8.1516306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6616580747
MESH:D007674 Kidney Diseases Acetaminophen 2.3612587719 15629191
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.6515474484
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 3.6515980055 17347453
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.6512878042
MESH:D008107 Liver Diseases Acetaminophen 1.6919460945 19784758 19014921 16611625 12969438 16610002 12587719 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5417185352 16871587
MESH:D008113 Liver Neoplasms pirinixic acid 4.5816377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.5816984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2812151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 3.5816827153
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.6417261469
MESH:D009135 Muscular Diseases pirinixic acid 3.9216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2519151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2712213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1916411023
MESH:D009369 Neoplasms pirinixic acid 2.0817405874
MESH:D009395 Nephritis, Interstitial Tetracycline 5.309884423
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5914600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D009765 Obesity pirinixic acid 1.8720558911
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.7712520081
MESH:D010391 Pemphigoid, Bullous Tetracycline 5.9511026799
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.9418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.6511118676 11222880 11896295 11399792
MESH:D017096 Prion Diseases Tetracycline 5.8810903871
MESH:D015427 Reperfusion Injury pirinixic acid 2.5219058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2218990726
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1716192470
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.4212697716
MESH:D014581 Urticaria Acetaminophen 3.3310982225
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.1212125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.7715886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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