AutismKB 2.0

Annotation Detail for ANKRD6


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Basic Information Top
Gene Symbol:ANKRD6 ( - )
Gene Full Name: ankyrin repeat domain 6
Band: 6q15
Quick LinksEntrez ID:22881; OMIM: 610583; Uniprot ID:ANKR6_HUMAN; ENSEMBL ID: ENSG00000135299; HGNC ID: 17280
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene 1,4-bis(2-(3,5-dichloropyridyloxy))benzene affects the expression of ANKRD6 mRNAaffects expression 18281256
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ANKRD6 mRNAdecreases expression 20064835
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of ANKRD6 mRNAincreases expression 15336504
C009131 pyrimidin-2-one beta-ribofuranoside pyrimidin-2-one beta-ribofuranoside results in decreased expression of ANKRD6 mRNAdecreases expression 19194470
D014635 Valproic Acid Valproic Acid results in increased expression of ANKRD6 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 4.028875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.3019490988
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0520127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.846695378
MESH:D000550 Amblyopia Valproic Acid 5.8517688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.8617497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.5619183758
MESH:D001321 Autistic Disorder Valproic Acid 1.9819232924 17688650 20603192 17157402 15238991 17507914 18775368 18316065 18177632 18985861 19460635 18558336 18396377 16609825 18940202
MESH:D001714 Bipolar Disorder Valproic Acid 3.2320046352 17594078
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.618888407
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0020146248 17474063
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1320419170
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.8120734317
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.908888407 17688650 16575769
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 2.2519641884 1733752
MESH:D004421 Dystonia Valproic Acid 4.451851702
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.6417275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.533922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0920417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.917562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.787750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.603659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0716530937
MESH:D005234 Fatty Liver Valproic Acid 3.6719224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.5016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.5718558336 8888407
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8220471113
MESH:D006529 Hepatomegaly 1,4-bis(2-(3,5-dichloropyridyloxy))benzene 5.2416109766
MESH:D006849 Hydrocephalus Valproic Acid 5.4117688650
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1917596541 16294345
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 2.1421137059 20195826
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.8717228818
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5718816296 20869020 18569708 20064080 20464547 17053015 18520028 6695378 20135361
MESH:D008545 Melanoma pyrimidin-2-one beta-ribofuranoside 3.7816505122
MESH:D008881 Migraine Disorders Valproic Acid 3.4418803445 18765137
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4616381670
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.408888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.3317596541
MESH:D009369 Neoplasms Benzo(a)pyrene 2.3111141357
MESH:D009436 Neural Tube Defects Valproic Acid 3.348888407 16359493
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.3720603192
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9117292933
MESH:D019310 Pseudolymphoma Valproic Acid 5.1511422049 12752131
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.5819155313
MESH:D012559 Schizophrenia Valproic Acid 2.1019110320 15737665
MESH:D012640 Seizures Valproic Acid 2.9615475178 14763951 17978042 1511512 16876388 11738929 3137016 11044598
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 6.1910029692 19755658
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 6.198532709
MESH:D016135 Spinal Dysraphism Valproic Acid 4.0619490988
MESH:D013226 Status Epilepticus Valproic Acid 5.1512833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D014178 Translocation, Genetic Valproic Acid 5.8517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 5.063119515
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2917053015
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.138888407
No data
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Syndromic Genes

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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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