Annotation Detail for DIS3
Basic Information Top
| Gene Symbol: | DIS3 ( DKFZp667L1817,EXOSC11,FLJ10484,KIAA1008,MGC33035,RP11-342J4.3,RRP44,bA555G22.1,dis3p ) |
|---|---|
| Gene Full Name: | DIS3 mitotic control homolog (S. cerevisiae) |
| Band: | 13q21.33 |
| Quick Links | Entrez ID:22894; OMIM: 607533; Uniprot ID:RRP44_HUMAN; ENSEMBL ID: ENSG00000083520; HGNC ID: 20604 |
| Relate to Another Database: | SFARIGene; denovo-db |
| No data |
| Pathway ID | Pathway Name |
|---|---|
| hsa03018 | RNA degradation |
| Pathway ID | Pathway Name |
|---|---|
| Metabolism of RNA |
| No data |
| No data |
| Pathway ID | Pathway Name |
|---|---|
| 500856 | mRNA Decay by 3' to 5' Exoribonuclease |
Related Diseases/Disorders| Chemical ID | Chemical Name | Interaction | Interaction Action | Publication |
|---|---|---|---|---|
| D000082 | Acetaminophen | Acetaminophen affects the expression of DIS3 mRNA | affects expression | 17562736 |
| D008942 | Mitoxantrone | DIS3 protein affects the susceptibility to Mitoxantrone | affects response to substance | 16217747 |
| Disease ID | Disease Name | Direct Evidence | Inference Chemical Name | Inference Score | Publication |
|---|---|---|---|---|---|
| MESH:D000799 | Angioedema | Acetaminophen | 4.91 | 10982225 | |
| MESH:D001321 | Autistic Disorder | Acetaminophen | 1.39 | 18445737 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Acetaminophen | 1.41 | 3084413 | |
| MESH:D002386 | Cataract | Acetaminophen | 2.83 | 10977129 | |
| MESH:D056486 | Drug-Induced Liver Injury | Acetaminophen | 1.68 | 10663392 19164858 18713872 15619225 17906064 19923254 12153990 2444490 16109766 14550746 19085960 11739529 11287661 11743745 15968718 19420014 16393943 11529661 16781746 12540782 14725611 12594235 16485898 10774834 12958197 17522070 11461765 16177239 11834606 18071297 14986274 16081117 19370779 19739265 10915739 16227642 11421492 17562736 19416960 12392966 12705907 | |
| MESH:D056487 | Drug-Induced Liver Injury, Chronic | Acetaminophen | 5.17 | 19426721 | |
| MESH:D005756 | Gastritis | Acetaminophen | 4.74 | 16983495 | |
| MESH:D006331 | Heart Diseases | Mitoxantrone | 4.48 | 16019553 | |
| MESH:D006930 | Hyperalgesia | Acetaminophen | 3.11 | 16870215 | |
| MESH:D007674 | Kidney Diseases | Acetaminophen | 2.44 | 15629191 12587719 | |
| MESH:D015451 | Leukemia, Lymphocytic, Chronic, B-Cell | Mitoxantrone | 3.95 | 18172266 | |
| MESH:D008107 | Liver Diseases | Acetaminophen | 1.71 | 19014921 11587558 12969438 16611625 19460945 12587719 19784758 16610002 | |
| MESH:D017114 | Liver Failure, Acute | Acetaminophen | 3.74 | 16871587 17185352 | |
| MESH:D008546 | Melanoma, Experimental | Acetaminophen | 4.33 | 19513568 | |
| MESH:D009369 | Neoplasms | Mitoxantrone | 3.61 | 16640825 | |
| MESH:D019636 | Neurodegenerative Diseases | Acetaminophen | 3.31 | 18514411 | |
| MESH:D010146 | Pain | Acetaminophen | 2.82 | 16870215 | |
| MESH:D014581 | Urticaria | Acetaminophen | 3.58 | 10982225 |
| Pathway ID | Pathway Name |
|---|---|
| REACT:21257 | Metabolism of RNA |
| KEGG:03018 | RNA degradation |