AutismKB 2.0

Annotation Detail for DENND3


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Basic Information Top
Gene Symbol:DENND3 ( KIAA0870 )
Gene Full Name: DENN/MADD domain containing 3
Band: 8q24.3
Quick LinksEntrez ID:22898; OMIM: NA; Uniprot ID:DEND3_HUMAN; ENSEMBL ID: ENSG00000105339; HGNC ID: 29134
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of DENND3 mRNAaffects expression 17562736
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of DENND3 mRNAdecreases expression 15336504
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of DENND3 mRNAaffects binding|decreases expression|increases activity 19710929
D014212 Tretinoin Tretinoin results in increased expression of DENND3 mRNAincreases expression 16054129
C025643 vinclozolin vinclozolin affects the expression of DENND3 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.5218653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.0216434500
MESH:D000505 Alopecia Tretinoin 3.9015955085
MESH:D000799 Angioedema Acetaminophen 4.4510982225
MESH:D001008 Anxiety Disorders vinclozolin 3.9319015723
MESH:D001169 Arthritis, Experimental Tretinoin 3.2816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3316292516
MESH:D001249 Asthma Tretinoin 2.4316456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001471 Barrett Esophagus Tretinoin 4.8416935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 10.2419483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 10.2416206674 16197459
MESH:D001943 Breast Neoplasms Tretinoin 2.2316873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 5.1316813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.7716168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.003084413
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.001917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3716051514 16096774
MESH:D002386 Cataract Acetaminophen 7.8510977129
MESH:D002386 Cataract Tretinoin 7.8517460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.1316129372
MESH:D002779 Cholestasis pirinixic acid 3.0819176532
MESH:D002822 Choriocarcinoma Tretinoin 5.7716461808
MESH:D002972 Cleft Palate Tretinoin 2.799407595
MESH:D003092 Colitis Tretinoin 4.1917035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.838800419 14991402 16925845 9142499 10589399 9211117 17551590 9125849 9664655 9224671
MESH:D003456 Cryptorchidism vinclozolin 4.7814966744
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5618249437
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6614986274 14550746 17522070 12540782 10774834 17906064 18071297 19739265 11461765 10915739 11421492 11287661 12392966 11529661 14725611 15619225 16227642 12594235 12705907 19164858 16177239 19370779 16781746 19420014 16081117 16485898 11834606 18713872 12958197 11739529 15968718 11743745 19416960 16393943 19085960 19923254 16109766 2444490 12153990 17562736 10663392
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.7119426721
MESH:D004487 Edema pirinixic acid 2.8512083418
MESH:D004489 Edema, Cardiac Tretinoin 5.0818230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.3216569247
MESH:D005124 Eye Abnormalities Tretinoin 3.849664655 16938888
MESH:D005234 Fatty Liver pirinixic acid 3.1420131406 19236843
MESH:D005355 Fibrosis Tretinoin 3.9917994277
MESH:D005756 Gastritis Acetaminophen 4.2916983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.4716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.9116417039
MESH:D005909 Glioblastoma Tretinoin 3.2217312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.4116096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.7716084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.059664655 14991402
MESH:D006333 Heart Failure pirinixic acid 2.7320558911
MESH:D006529 Hepatomegaly pirinixic acid 3.4818467677 19772884 19176532 16221962
MESH:D006930 Hyperalgesia Acetaminophen 8.6016870215
MESH:D006930 Hyperalgesia Tretinoin 8.6016870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 5.0516778211
MESH:D006943 Hyperglycemia pirinixic acid 3.5320558911
MESH:D007248 Infertility, Male vinclozolin 3.2616467254
MESH:D007333 Insulin Resistance pirinixic acid 2.8516306350
MESH:D007410 Intestinal Diseases Tretinoin 4.2517994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.2717551590 15992940
MESH:D007674 Kidney Diseases Acetaminophen 2.3812587719 15629191
MESH:D007938 Leukemia Tretinoin 2.9217143497
MESH:D007951 Leukemia, Myeloid Tretinoin 4.0716482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1219850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3717107899 19075265 17294898 12679006 16140955 17506722 17217047 16788101 19642359 19225113 19035177 15748426 16823087 16331271 17712046 16935935 17339181 16766008 17649720 17301526 17361223 19029980 9834237 17368321 16891316
MESH:D007984 Leydig Cell Tumor vinclozolin 5.2716417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.559224671
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4315474484
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.4318397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 1.6916610002 12969438 12587719 19460945 11587558 19014921 16611625 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5817185352 16871587
MESH:D008113 Liver Neoplasms pirinixic acid 1.9220007298 16377806 15890375
MESH:D008527 Medulloblastoma Tretinoin 2.9017453147
MESH:D008545 Melanoma Tretinoin 1.9816752155
MESH:D008546 Melanoma, Experimental Acetaminophen 4.0519513568
MESH:D008591 Meningomyelocele Tretinoin 4.9116940565
MESH:D009135 Muscular Diseases pirinixic acid 3.9916239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2617596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.2619151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2216411023
MESH:D009369 Neoplasms pirinixic acid 5.4217405874
MESH:D009369 Neoplasms Tretinoin 5.4216594593 16946489
MESH:D009421 Nervous System Malformations Tretinoin 4.229125849
MESH:D009436 Neural Tube Defects Tretinoin 3.279142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1818514411
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4316936753
MESH:D010146 Pain Acetaminophen 7.6116870215
MESH:D010146 Pain Tretinoin 7.6116870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5615976015
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.4419015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 5.4718220299
MESH:D011472 Prostatitis vinclozolin 5.4718629315
MESH:D011507 Proteinuria Tretinoin 4.0116636307
MESH:D011625 Pterygium Tretinoin 5.3316723453
MESH:D015427 Reperfusion Injury pirinixic acid 2.5319058328
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.5016283617 16116481
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 6.288532709
MESH:D012878 Skin Neoplasms Tretinoin 6.2816467112
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013964 Thyroid Neoplasms Tretinoin 3.2916026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 4.1416051514
MESH:D014376 Tuberculosis Tretinoin 3.4316040207
MESH:D014581 Urticaria Acetaminophen 3.3810982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 4.0216129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.2216752155
MESH:D014820 Vitiligo Tretinoin 4.5016761959
MESH:D009396 Wilms Tumor Tretinoin 4.2916287080
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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