AutismKB 2.0

Annotation Detail for ARSG


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Basic Information Top
Gene Symbol:ARSG ( KIAA1001 )
Gene Full Name: arylsulfatase G
Band: 17q24.2
Quick LinksEntrez ID:22901; OMIM: 610008; Uniprot ID:ARSG_HUMAN; ENSEMBL ID: ENSG00000141337; HGNC ID: 24102
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D004041 Dietary Fats Dietary Fats results in increased expression of ARSG mRNAincreases expression 18457598
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of ARSG mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of ARSG mRNAdecreases expression 19482888
19270015
C006253 pirinixic acid pirinixic acid results in increased expression of ARSG mRNAincreases expression 17426115
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ARSG mRNAincreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 10.486195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 10.4811752688 14514962 15322242
MESH:D055371 Acute Lung Injury pirinixic acid 3.5818653653
MESH:D018248 Adenoma, Liver Cell Phenobarbital 21.3517620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 21.3516434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 21.3516835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.3411748828
MESH:D001161 Arteriosclerosis Dietary Fats 4.4515238619
MESH:D001778 Blood Coagulation Disorders pirinixic acid 10.2219483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 10.2212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.5115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 3.0015746008
MESH:D001943 Breast Neoplasms Dietary Fats 1.9520435547
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9520435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.1216835633
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 1.9520935162 20007298 17173139 6705139 1701930
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5616120746 18850075 18670907
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.814080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.5316835633
MESH:D002779 Cholestasis pirinixic acid 3.1219176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2412621046 8697196 16354765 15668235 15340226
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.4314669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2710048152 20055451 15322242
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5718249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7417107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.6220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0511462148
MESH:D050171 Dyslipidemias Dietary Fats 3.7318367378
MESH:D004421 Dystonia Phenobarbital 4.471851702
MESH:D004487 Edema pirinixic acid 7.9712083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.9711000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.6215322242 18230668 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.4210568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.673659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.593922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.0620417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.916401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.817750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.653659116
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.3111564622
MESH:D005234 Fatty Liver Dietary Fats 9.1519551842 17967931 18296743 19004024
MESH:D005234 Fatty Liver pirinixic acid 9.1520131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 4.0211858732
MESH:D005355 Fibrosis Dietary Fats 10.5618296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 10.5620067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.3210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.5111294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.7620558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.7611000095
MESH:D006529 Hepatomegaly Phenobarbital 17.9216109766
MESH:D006529 Hepatomegaly pirinixic acid 17.9218467677 19176532 16221962 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 17.9215340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.7716354765 15340226 16959395 18606429 8697196
MESH:D006937 Hypercholesterolemia Dietary Fats 4.0221332399
MESH:D006943 Hyperglycemia pirinixic acid 3.5820558911
MESH:D006949 Hyperlipidemias Dietary Fats 4.0821332399
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0218850075 18670907
MESH:D007249 Inflammation Dietary Fats 5.5220412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.5212878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 8.0611836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 8.0616306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.7616580747
MESH:D008103 Liver Cirrhosis Dietary Fats 7.3018296743
MESH:D008103 Liver Cirrhosis Phenobarbital 7.3021047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.2315474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.2312878042
MESH:D008107 Liver Diseases Phenobarbital 2.2419363144
MESH:D008113 Liver Neoplasms Phenobarbital 8.0721047994 15975961 19482888 19073162 8742319 19812893
MESH:D008113 Liver Neoplasms pirinixic acid 8.0715890375 16377806 20007298
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 8.0716984957
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 6.561399818 2563599 17172636 18308698 6150874
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.5612151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D009135 Muscular Diseases pirinixic acid 4.0716239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2719151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3412213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2516411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 5.1117484760
MESH:D009369 Neoplasms pirinixic acid 2.1117405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.7214600291
MESH:D009765 Obesity Dietary Fats 4.6920518802 20132043 11836018 18457598 18674790 16723640 21332399 19632207 17217161
MESH:D009765 Obesity pirinixic acid 4.6920558911
MESH:D010018 Osteomalacia Phenobarbital 5.0017016548
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.6016965848
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.9712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.0718163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.992563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.8211399792 11896295 11222880 11118676
MESH:D019310 Pseudolymphoma Phenobarbital 5.2212752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.5519058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.3518990726
MESH:D012640 Seizures Phenobarbital 2.953137016 16876388 11442880 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 5.456407741
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.2016192470
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.6212697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.361399818
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.3212125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.9715886252
MESH:D015430 Weight Gain Dietary Fats 4.1116723640
Pathway ID Pathway Name
KEGG:04142 Lysosome
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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