AutismKB 2.0

Annotation Detail for RUFY3


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Basic Information Top
Gene Symbol:RUFY3 ( KIAA0871,RIPX,SINGAR1 )
Gene Full Name: RUN and FYVE domain containing 3
Band: 4q13.3
Quick LinksEntrez ID:22902; OMIM: 611194; Uniprot ID:RUFY3_HUMAN; ENSEMBL ID: ENSG00000018189; HGNC ID: 30285
Relate to Another Database: SFARIGene; denovo-db
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of RUFY3 mRNAdecreases expression 19933214
D000082 Acetaminophen Acetaminophen affects the expression of RUFY3 mRNAaffects expression 17562736
D001151 Arsenic Arsenic results in decreased expression of RUFY3 mRNAdecreases expression 16835338
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of RUFY3 mRNAdecreases expression 17484886
D016572 Cyclosporine Cyclosporine results in increased expression of RUFY3 mRNAincreases expression 20106945
D012643 Selenium Selenium results in decreased expression of RUFY3 mRNAdecreases expression 19244175
C004648 testosterone enanthate testosterone enanthate affects the expression of RUFY3 mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of RUFY3 mRNAdecreases expression 19933214
D014810 Vitamin E Vitamin E results in decreased expression of RUFY3 mRNAdecreases expression 19244175
C528002 Weichang'an Weichang'an results in decreased expression of RUFY3 mRNAdecreases expression 18205257
18161298
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0814514962 15322242 11752688
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6116835633
MESH:D018246 Adrenocortical Adenoma Arsenic 5.4817306315
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D020261 Arsenic Poisoning marker/mechanism 16835338
MESH:D020261 Arsenic Poisoning Arsenic 2.9118414634 16835338 12569548 16251483
MESH:D050197 Atherosclerosis Arsenic 3.3419371607 12928151
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6920435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 10.6615700767 16227642 16192424 15673190 16097048 18705752 16124888 15721981 16011737 10355542 16050911 3786805
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 10.6616050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.6817687452 15504454
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.723084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 4.7217306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.7218788625
MESH:D002294 Carcinoma, Squamous Cell Arsenic 2.7315504454 18922899 17687452
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.2418640142
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4518670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Arsenic 3.5615738583 17938729 19152805
MESH:D002340 Carotid Artery Diseases Arsenic 4.4616973168 18022660
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6412371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis Cyclosporine 3.0419486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1615668235 16354765 15340226 12621046 8697196
MESH:D003092 Colitis Selenium 3.9917936198
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5210048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.5219769572
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.3315619225 12153990 19923254 18713872 12594235 14550746 19164858 10663392 14986274 12540782 11834606 11743745 15968718 19416960 17906064 16393943 11287661 14725611 16177239 11739529 19085960 19370779 2444490 17562736 19420014 16485898 10915739 19739265 12705907 12392966 16081117 11461765 16227642 11529661 12958197 16781746 11421492 17522070 18071297 16109766 10774834
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 9.333786805 4309450 15968718 10915739 11566570 7440962 3732212 15027814 6623471 21278145 9327722 7179309 19336974 16227642 15998439 17522070 7120509 6884620 16177239 10092053 2869522 19085960
MESH:D056486 Drug-Induced Liver Injury Selenium 9.3315131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.3320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:C538011 Eales disease Vitamin E 4.979068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1715322242 16714409 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.189294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.2915959796 61145 16045604 19224547 17595544 12631006 16239168 12795759
MESH:D005234 Fatty Liver Cyclosporine 8.2919224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005355 Fibrosis Carbon Tetrachloride 16.0218705752
MESH:D005355 Fibrosis Cyclosporine 16.0212639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 16.0220067830
MESH:D005534 Foot Diseases Arsenic 5.826392382
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.8511294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 6.8516080930
MESH:D006333 Heart Failure Selenium 3.1717162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7919900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1115340226 16120746 12621046
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7516863852 16490937
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 6.0117440010
MESH:D019584 Hot Flashes Vitamin E 4.2414716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.318697196 18606429 16354765 16959395 15340226
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7716899240
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.6217050553
MESH:D006973 Hypertension Arsenic 8.929931084 16076760 11953799
MESH:D006973 Hypertension Cyclosporine 8.9210903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.9218850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3015338365
MESH:D006987 Hypesthesia Arsenic 5.8216093927
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9312878042 12200463
MESH:D007251 Influenza, Human Selenium 11.8616624496
MESH:D007251 Influenza, Human Vitamin E 11.8616624496
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007642 Keratosis Arsenic 5.2312749816 16930632
MESH:D007674 Kidney Diseases Acetaminophen 10.5515629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 10.5518776723 8314463 10903974
MESH:D007674 Kidney Diseases Vitamin E 10.5512488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.0616518626
MESH:D007680 Kidney Neoplasms Cyclosporine 2.8812371664
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.6617339181
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8916239168 11408273 16221502 11903743 17334410 17157831 17174718 16943688 21278145
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5618395095 18156304 17900296 14620537 15893842 17761835 12586293 17631135 18472332 18251166 10355542 16248980 12741479 15818738 17922224 14512876 15959796 12445418 17721639 12632512 18279442 12898905 18054572 18376398 20821823 17823541 12958196 12632514 12649538 15925388 11481614 17708605 15650968 15673190 18205269 18418968 16136751 17698563 17481882 12389079 15931870 12546737 18472094 12667390 17976157 18006644 16097048 15338365 14716833 18395914 15052691 12445421 17869086 17640975 16033810 15730626 16011737 17525996 18420326 13678700 15057751 17714472 18705752 14716496 16116963 16192424 14748882 17805973 18317297 18210741 18429990 16015684 17944888 18412020 18277467 18187930 17565644 17766677 15123356 15370692 15362042 12666154 14724832 15876570 18339082 17557913 12609069 16027843 15996030 18481824 16638106 18166357 18263696
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5612878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.5616169303
MESH:D008107 Liver Diseases Acetaminophen 6.7619014921 19784758 16610002 16611625 12587719 12969438 19460945 11587558
MESH:D008107 Liver Diseases Arsenic 6.7611134558
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.7616246199 16964402 15720792 17285989 15830285
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3815123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.9516871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.9516899240 14706259
MESH:D008113 Liver Neoplasms Arsenic 7.7916368122
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.7919294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.7916984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.1015583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.1012151625
MESH:D008171 Lung Diseases Vitamin E 3.2916863852
MESH:D008175 Lung Neoplasms Arsenic 3.5417976673 19168569 17306315
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5411884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 3.5411062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8615318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008654 Mesothelioma Selenium 2.8515107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D017202 Myocardial Ischemia Arsenic 9.4715371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.4712213967
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4419348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4114600291
MESH:D009436 Neural Tube Defects Arsenic 3.5616620997
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D020078 Neurogenic Inflammation Arsenic 4.5617056641
MESH:D010051 Ovarian Neoplasms Arsenic 2.7917306315
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.3816093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.2315371236 6392382 16905509
MESH:D010954 Plasmacytoma Selenium 5.1515087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3712371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4311896295 11118676 11399792 11222880
MESH:D011471 Prostatic Neoplasms Arsenic 3.3816140617
MESH:D011471 Prostatic Neoplasms Vitamin E 3.3815084515
MESH:D011507 Proteinuria Arsenic 4.1921343184
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012871 Skin Diseases marker/mechanism 16835338
MESH:D012871 Skin Diseases Arsenic 5.1719834688 16759981 17453740 17050553 6392382 18709164 15952646 17548696 16353154 16702368 17938729
MESH:D012871 Skin Diseases Vitamin E 5.1718709164
MESH:D012878 Skin Neoplasms Arsenic 5.9517029826 19538983 17976673 15504454 16251483 17050553
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.9516192470
MESH:D013274 Stomach Neoplasms Weichang'an 4.2217498489
MESH:D020521 Stroke Vitamin E 3.6616517955
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D001749 Urinary Bladder Neoplasms Arsenic 2.8719322015 17306315 11144890 15987713 17976673 19429237 18640142
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D014652 Vascular Diseases Arsenic 4.9717056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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