AutismKB 2.0

Annotation Detail for KLRK1


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Basic Information Top
Gene Symbol:KLRK1 ( CD314,D12S2489E,FLJ17759,FLJ75772,KLR,NKG2-D,NKG2D )
Gene Full Name: killer cell lectin-like receptor subfamily K, member 1
Band: 12p13.2
Quick LinksEntrez ID:22914; OMIM: 611817; Uniprot ID:NKG2D_HUMAN; ENSEMBL ID: ENSG00000213809; HGNC ID: 18788
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04650Natural killer cell mediated cytotoxicity
hsa05144Malaria
Pathway IDPathway Name
Signaling in Immune system
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of KLRK1 mRNAaffects expression 16483693
D001151 Arsenic Arsenic affects the expression of KLRK1 mRNAaffects expression 18414638
C006632 arsenic trioxide KLRK1 protein results in increased susceptibility to arsenic trioxideincreases response to substance 18463537
D000431 Ethanol Ethanol results in decreased expression of KLRK1 proteindecreases expression 18166357
D005419 Flavonoids Flavonoids results in decreased expression of KLRK1 mRNAdecreases expression 18035473
D009020 Morphine Morphine results in decreased expression of KLRK1 mRNAdecreases expression 20144693
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of KLRK1 mRNAaffects binding|increases activity|increases expression 19710929
D011070 Poly I-C Poly I-C results in increased expression of KLRK1 mRNAincreases expression 16472598
D011070 Poly I-C Poly I-C results in increased expression of KLRK1 proteinincreases expression 16472598
C025299 polyphenols polyphenols results in decreased expression of KLRK1 mRNAdecreases expression 16293270
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in decreased expression of KLRK1 mRNAaffects cotreatment|decreases expression 19059307
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in decreased expression of KLRK1 mRNAaffects cotreatment|decreases expression 19059307
D004786 Toxic Actions Toxic Actions results in decreased expression of KLRK1 proteindecreases expression 18468695
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.7214745880
MESH:D000014 Abnormalities, Drug-Induced Ethanol 4.0718926900 17676605
MESH:D000138 Acidosis Ammonium Chloride 10.9918287403
MESH:D000138 Acidosis Ethanol 10.9911192467
MESH:D055371 Acute Lung Injury pirinixic acid 3.2318653653
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3111798837 19825857
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.6316434500
MESH:D018246 Adrenocortical Adenoma Arsenic 5.3917306315
MESH:D000419 Albuminuria Raloxifene 4.7217451421 17308373
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.4915451040 15451039
MESH:D000544 Alzheimer Disease Raloxifene 2.5615800139
MESH:D000853 Anophthalmos Ethanol 4.9615513904
MESH:D001008 Anxiety Disorders Ethanol 4.0911141031
MESH:D020261 Arsenic Poisoning Arsenic 2.8912569548 16835338 16251483 18414634
MESH:D050197 Atherosclerosis Arsenic 3.3112928151 19371607
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.3716206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.3719483382
MESH:D001930 Brain Injuries Raloxifene 4.6116580743
MESH:D002545 Brain Ischemia Morphine 5.3019211983
MESH:D001943 Breast Neoplasms Raloxifene 2.3017049068 15572757 15775269 15758505 17952589 16912660 17440819 17893378 16837676 17595753 17242785 17261762
MESH:D001943 Breast Neoplasms Tamoxifen 2.3021138602 17893378 19410462 18815881 19288272 19189212 20390343 16202921 17440819 19084267 20005174 19487384 19244106 20544844 18984771 17049068 16873071 19221464 19066611 19011961 20135344 18351453 16818667 11161223 19103187 19115204 19200415 15565566 21152245 18629630 17261762 18855134 17242785 19155303 19289846 19189210 20859285 15668708 16273361 19142967 18821012 20065188 18997820 19059307 18425577
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.4511589617
MESH:D002056 Burns Ethanol 4.7916374292
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.6515504454 17687452
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.6419066611
MESH:D006528 Carcinoma, Hepatocellular Arsenic 6.7617306315 16507464
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 6.7611135700 14691202 15553829 16217749 15073043
MESH:D006528 Carcinoma, Hepatocellular Ethanol 6.7618788625 15763234 15289165
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.7616924424
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.0519014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.2212490120
MESH:D002294 Carcinoma, Squamous Cell Arsenic 2.7215504454 18922899 17687452
MESH:D002295 Carcinoma, Transitional Cell Arsenic 16.5418640142
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 16.5417572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 16.5417572228
MESH:D006332 Cardiomegaly Ethanol 3.4919332462
MESH:D002318 Cardiovascular Diseases Arsenic 7.8117938729 15738583 19152805
MESH:D002318 Cardiovascular Diseases Raloxifene 7.8115775269
MESH:D002340 Carotid Artery Diseases Arsenic 4.4118022660 16973168
MESH:D002779 Cholestasis pirinixic acid 2.9119176532
MESH:D002971 Cleft Lip Ethanol 3.6415513904
MESH:D002972 Cleft Palate Ethanol 3.2115513904
MESH:D003072 Cognition Disorders Raloxifene 4.7615800139
MESH:D003110 Colonic Neoplasms polyphenols 2.6916293270
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.3112609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.8910525206
MESH:D019465 Craniofacial Abnormalities Ethanol 2.8919302082 10194807 15451039 11873399 15451040 11198716 15513904
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.2115213294
MESH:D003711 Demyelinating Diseases Tamoxifen 4.5019031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.2617474826
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D003928 Diabetic Nephropathies Raloxifene 9.3615920148 17451421 17308373
MESH:D003928 Diabetic Nephropathies Tamoxifen 9.3619279558
MESH:D003967 Diarrhea Morphine 4.642540324
MESH:D056486 Drug-Induced Liver Injury Ethanol 4.4711566570
MESH:D056486 Drug-Induced Liver Injury polyphenols 4.4719370779
MESH:D004487 Edema pirinixic acid 7.2512083418
MESH:D004487 Edema Raloxifene 7.2515860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 9.6715845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.6719031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1119155303 17893378 16202921 20544844
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.8012903497
MESH:D004938 Esophageal Neoplasms Ethanol 4.8016704527
MESH:D005234 Fatty Liver arsenic trioxide 25.9215073043
MESH:D005234 Fatty Liver Ethanol 25.9218620774 16409862 19236843
MESH:D005234 Fatty Liver pirinixic acid 25.9219236843 20131406
MESH:D005234 Fatty Liver Raloxifene 25.9217473493
MESH:D005234 Fatty Liver Tamoxifen 25.9214986274 19224547
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.8417920746
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3016709447
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.4516946407 10194807 15451040 15513904
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.6814745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.3419069698
MESH:D005534 Foot Diseases Arsenic 5.736392382
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.3916904648
MESH:D005756 Gastritis Ethanol 4.8715046732
MESH:D006331 Heart Diseases Raloxifene 3.6111110106
MESH:D006333 Heart Failure pirinixic acid 2.6020558911
MESH:D006529 Hepatomegaly pirinixic acid 3.1318467677 16221962 19772884 19176532
MESH:D006930 Hyperalgesia Ethanol 3.8018783367
MESH:D006943 Hyperglycemia pirinixic acid 3.2920558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.5617050553
MESH:D006973 Hypertension Arsenic 5.7116076760 11953799 9931084
MESH:D006973 Hypertension Raloxifene 5.7117577099 15787275
MESH:D006987 Hypesthesia Arsenic 5.7316093927
MESH:D007249 Inflammation Flavonoids 8.7917296493
MESH:D007249 Inflammation polyphenols 8.7916366677
MESH:D007249 Inflammation Tamoxifen 8.7919457130
MESH:D007333 Insulin Resistance pirinixic acid 2.7016306350
MESH:D007569 Jaw Abnormalities Ethanol 4.5215513904
MESH:D007642 Keratosis Arsenic 5.1412749816 16930632
MESH:D007680 Kidney Neoplasms Tamoxifen 3.1318625569
MESH:D007859 Learning Disorders Ethanol 4.3515451040
MESH:D007889 Leiomyoma Raloxifene 4.6116973256
MESH:D007938 Leukemia arsenic trioxide 2.8815070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.9017077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.4616972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5114633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.8719077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1516467208 20471514 17050201 16968895 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 8.0117339181
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 8.0117107899 17217047 12712474 16330433 12679006 15622746 17712046 15336539 19075265 16112521 9834237 11161223 16891316 16331271 19035177 15748426 19642359 12018890 15213294 17869043 16823087 19225113 17649720 16966277 11468182
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.4816882451
MESH:D017880 Limb Deformities, Congenital Ethanol 3.8917676605
MESH:D008064 Lipidoses Tamoxifen 3.2317567588 15342952
MESH:D008103 Liver Cirrhosis Ethanol 3.4315289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 5.2518295389
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 5.1518166357
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 5.1515474484
MESH:D008106 Liver Cirrhosis, Experimental Poly I-C 5.1518166357
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 5.1518564211
MESH:D008107 Liver Diseases Arsenic 4.5811134558
MESH:D008107 Liver Diseases polyphenols 4.5816698588
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.7917347304 17207112
MESH:D008113 Liver Neoplasms Arsenic 11.0416368122
MESH:D008113 Liver Neoplasms arsenic trioxide 11.0414682389
MESH:D008113 Liver Neoplasms pirinixic acid 11.0420007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tamoxifen 11.0416684651
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 2.8020377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4315213294
MESH:D008175 Lung Neoplasms Arsenic 3.5719168569 17306315 17976673
MESH:D008175 Lung Neoplasms arsenic trioxide 3.5719825857 11798837
MESH:D008175 Lung Neoplasms Tamoxifen 3.5718625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.9119428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.6911731420 19196722 14580682 16827153 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 4.7219453300
MESH:D008545 Melanoma marker/mechanism 17295095
MESH:D008545 Melanoma Tamoxifen 1.8919393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.3415990972
MESH:D008569 Memory Disorders Ethanol 4.3118411066 15451040
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.7315863610
MESH:D009101 Multiple Myeloma arsenic trioxide 7.6711468182 19417148 14977855 15949261 19549372
MESH:D009101 Multiple Myeloma Raloxifene 7.6716497877
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.8518349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2016105982 16882451
MESH:D009203 Myocardial Infarction pirinixic acid 2.1819151258
MESH:D017202 Myocardial Ischemia Arsenic 4.0715371236
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0316411023
MESH:D009232 Myxoma Raloxifene 5.7316343187
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.0916624393
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5819393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5519410462
MESH:D009369 Neoplasms pirinixic acid 1.9917405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.1719200415 19189210 19196722
MESH:D009436 Neural Tube Defects Arsenic 7.6816620997
MESH:D009436 Neural Tube Defects arsenic trioxide 7.6810525206
MESH:D020078 Neurogenic Inflammation Arsenic 4.4917056641
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D010024 Osteoporosis Raloxifene 3.4617882678 19059307 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.3417823083 15579764 17893378 15758505
MESH:D010051 Ovarian Neoplasms Arsenic 5.1217306315
MESH:D010051 Ovarian Neoplasms arsenic trioxide 5.1216624393 19769630 12452020
MESH:D010146 Pain Morphine 4.2816273134 6776300 20225289 15275824 15215642 18699797
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.5915580305
MESH:D010190 Pancreatic Neoplasms Ethanol 5.5912384795
MESH:D010235 Paraganglioma arsenic trioxide 4.2819927285
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.3016093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.1415371236 6392382 16905509
MESH:D011471 Prostatic Neoplasms Arsenic 2.0916140617
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.0919131511
MESH:D011471 Prostatic Neoplasms Raloxifene 2.0916220300 15731164 16536755
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0915067354
MESH:D011507 Proteinuria Arsenic 4.1221343184
MESH:D011693 Purpura Raloxifene 5.7315770314
MESH:D015427 Reperfusion Injury Morphine 7.0519211983
MESH:D015427 Reperfusion Injury pirinixic acid 7.0519058328
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.0916646077
MESH:D012640 Seizures Ethanol 3.249754883
MESH:D012871 Skin Diseases Arsenic 2.7719834688 6392382 17548696 16759981 17938729 16353154 17050553 16702368 17453740 18709164 15952646
MESH:D012878 Skin Neoplasms Arsenic 3.0517029826 17050553 17976673 19538983 15504454 16251483
MESH:D013088 Spermatocele Tamoxifen 4.4716709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.1919457130
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.6717007042
MESH:D013274 Stomach Neoplasms Ethanol 2.6718456281
MESH:D013276 Stomach Ulcer Ethanol 3.649211565 11906479 9562338 16755016 17189318 17918041
MESH:D020521 Stroke Raloxifene 3.9116837676
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.369754883
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.4317997062
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.1719014326
MESH:D013978 Tibial Fractures Raloxifene 5.3819048282
MESH:D016171 Torsades de Pointes arsenic trioxide 4.1115213294
MESH:D001749 Urinary Bladder Neoplasms Arsenic 12.3117976673 15987713 11144890 17306315 19322015 18640142 19429237
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 12.3112845720 20435036 12973940 11780464
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 12.3117572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 12.3116712894 8653321 17572228
MESH:D014652 Vascular Diseases Arsenic 4.8917056641
MESH:D054556 Venous Thromboembolism Raloxifene 5.3816837676
MESH:D014846 Vulvar Neoplasms Raloxifene 5.7316343187
Pathway ID Pathway Name
KEGG:05144 Malaria
KEGG:04650 Natural killer cell mediated cytotoxicity
REACT:6900 Signaling in Immune system
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA128394594
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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