AutismKB 2.0

Annotation Detail for SEPHS2


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Basic Information Top
Gene Symbol:SEPHS2 ( SPS2 )
Gene Full Name: selenophosphate synthetase 2
Band: 16p11.2
Quick LinksEntrez ID:22928; OMIM: 606218; Uniprot ID:SPS2_HUMAN; ENSEMBL ID: ENSG00000179918,ENSG00000246275; HGNC ID: 19686
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-6281selenocysteine biosynthesis II (archaea and eukaryotes)
Pathway IDPathway Name
hsa00450Selenoamino acid metabolism
hsa01100Metabolic pathways
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No data
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of SEPHS2 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of SEPHS2 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of SEPHS2 mRNAaffects expression 17562736
D000965 Antimony Antimony results in decreased expression of SEPHS2 mRNAdecreases expression 17547211
D000966 Antimony Potassium Tartrate Antimony Potassium Tartrate results in decreased expression of SEPHS2 mRNAdecreases expression 17547211
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of SEPHS2 mRNAincreases expression 20713471
D003907 Dexamethasone Dexamethasone results in increased expression of SEPHS2 mRNAincreases expression 19576170
D003907 Dexamethasone Metformin inhibits the reaction [Dexamethasone results in increased expression of SEPHS2 mRNA]decreases reaction|increases expression 19576170
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of SEPHS2 mRNAdecreases expression 17108234
D005472 Fluorouracil SEPHS2 protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased expression of SEPHS2 mRNAdecreases expression 19136613
D008687 Metformin Metformin inhibits the reaction [Dexamethasone results in increased expression of SEPHS2 mRNA]decreases reaction|increases expression 19576170
C022838 nickel chloride nickel chloride results in decreased expression of SEPHS2 mRNAdecreases expression 17547211
D010634 Phenobarbital Phenobarbital results in decreased expression of SEPHS2 mRNAdecreases expression 19270015
D019800 Phenol Phenol results in decreased expression of SEPHS2 mRNAdecreases expression 17547211
C059514 resveratrol resveratrol results in increased expression of SEPHS2 mRNAincreases expression 17261084
D012643 Selenium Selenium affects the expression of SEPHS2 mRNAaffects expression 19106321
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SEPHS2 mRNAincreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.276195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.2711752688 14514962 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9417505938
MESH:D058186 Acute Kidney Injury resveratrol 3.8316538975
MESH:D055371 Acute Lung Injury Lipopolysaccharides 4.0111850527 18653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.0220127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.0214692618
MESH:D000230 Adenocarcinoma Fluorouracil 7.0217638652
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 11.123712494
MESH:D000236 Adenoma Benzo(a)pyrene 11.126695378
MESH:D000236 Adenoma resveratrol 11.1215688382
MESH:D018248 Adenoma, Liver Cell Phenobarbital 10.0517620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.0516835633
MESH:D000544 Alzheimer Disease resveratrol 2.5616162502 16183991
MESH:D000740 Anemia Fluorouracil 8.6215504547 16511603 17963324
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.6211748828
MESH:D000799 Angioedema Acetaminophen 3.8410982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0619183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4511256880
MESH:D001169 Arthritis, Experimental Dexamethasone 12.2617659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 12.2615885639
MESH:D001169 Arthritis, Experimental resveratrol 12.2617115116
MESH:D050197 Atherosclerosis resveratrol 3.2616873680 17967414
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.021440618 11289319
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.0212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7515746008
MESH:D001859 Bone Neoplasms Phenol 5.1910556009
MESH:D001913 Bowen's Disease Phenol 5.7519293009
MESH:D002545 Brain Ischemia resveratrol 4.2717600658
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9517474063 20146248
MESH:D001943 Breast Neoplasms Fluorouracil 1.9518608205 15136595 19217205 18357371 16595493 16557594 16110121
MESH:D001943 Breast Neoplasms resveratrol 1.9517651959 16393696 17534123
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9520435547
MESH:D001991 Bronchitis Antimony 6.138768112
MESH:D002276 Carcinoid Tumor Fluorouracil 4.6716051944
MESH:D002277 Carcinoma Fluorouracil 8.1317121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.1316835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 11.3616705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 11.367296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.363084413
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 11.3617971768 17088986 17045692 16799960 16332177 18930000
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 11.3620007298 1701930 20935162 17173139 6705139
MESH:D006528 Carcinoma, Hepatocellular resveratrol 11.3616227395 19321006
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.5816675471
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.467296757
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.4618695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.5520419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 7.5516280240 17066447 18986760 16757204
MESH:D002294 Carcinoma, Squamous Cell resveratrol 7.5516227395
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3518670907 18850075 16120746
MESH:D002311 Cardiomyopathy, Dilated Antimony 3.9110334427
MESH:D002318 Cardiovascular Diseases resveratrol 3.4615458977
MESH:D002386 Cataract Acetaminophen 2.5710977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.747505956
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.244080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1416835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 7.8119486331 9022650
MESH:D002779 Cholestasis Ethinyl Estradiol 7.8116105132 17333356 16919318 17110522 15861022 11677210 17681005
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0915340226 8697196 15668235 16354765 12621046
MESH:D003092 Colitis resveratrol 9.6116474422
MESH:D003092 Colitis Selenium 9.6117936198
MESH:D003110 Colonic Neoplasms Dexamethasone 5.9115824018
MESH:D003110 Colonic Neoplasms Fluorouracil 5.9117169374 16510598 17172411 15001691 17016597 17725105 18772588 17287894 17018589 16340194
MESH:D003110 Colonic Neoplasms resveratrol 5.9116338953
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.6718949393 18383874 15289873 17695437 14970324 16391804 18288408 17454858 17255274 18509181 17016601 18448328 17094418 16524972 17594712 18802399 16282729 15148649 16303861 20501625 17401013 16331619
MESH:D015179 Colorectal Neoplasms resveratrol 2.6716550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0417141729 14669216
MESH:D003327 Coronary Disease resveratrol 3.7416507316
MESH:D019465 Craniofacial Abnormalities Dexamethasone 2.6117728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.6110048152 15322242 20055451
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.0018551238
MESH:D007644 Darier Disease Fluorouracil 4.7816733453
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 7.0014531868 12868966 18759878 11906362 2524372 8156756 8970840 11298694
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 7.0012438553
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.472952479 3621924
MESH:D003920 Diabetes Mellitus Metformin 5.3017446233
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.7516873680
MESH:D003924 Diabetes Mellitus, Type 2 Metformin 4.8521186350
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.8517107852
MESH:D003925 Diabetic Angiopathies Metformin 6.0016385087
MESH:D003928 Diabetic Nephropathies resveratrol 3.9416286809
MESH:D003967 Diarrhea Dexamethasone 3.687237001
MESH:D004283 Dog Diseases Antimony 5.6512019027
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 11.9418551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 11.949653073 6679447 16192314 9328219 11289319 7440962 9022650 18692083 6482804 18648102 1440618 8291058 18289764
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 11.9411461765 16109766 19164858 14725611 19416960 11834606 18713872 16081117 11529661 17562736 12594235 19923254 10774834 12958197 12540782 12705907 11739529 16177239 14550746 16781746 19739265 19370779 10663392 17522070 18071297 15968718 19420014 2444490 10915739 19085960 12153990 14986274 12392966 11421492 15619225 16393943 11287661 16485898 17906064 16227642 11743745
MESH:D056486 Drug-Induced Liver Injury Selenium 11.9415131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.9420420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1019426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7411462148
MESH:D004421 Dystonia Phenobarbital 3.991851702
MESH:D004485 Eczema Dexamethasone 4.4412438553
MESH:D004487 Edema Dexamethasone 11.4519703484
MESH:D004487 Edema resveratrol 11.458985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 11.4512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9015322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.0712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 9.0717872969
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.009294722 10568697
MESH:D019446 Endotoxemia Lipopolysaccharides 4.3915328337 17637181 15821434
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.8317923197
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.093659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.873922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.8820417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.526401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.247750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.013659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.203581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.2016530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 7.2016337965 16785472 15173087 16481741 17638652
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0011564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 2.8015345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4411858732
MESH:D005334 Fever Lipopolysaccharides 3.9911852909 9205823
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.026705139
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.9320067830
MESH:D005756 Gastritis Acetaminophen 3.6816983495
MESH:D005910 Glioma Fluorouracil 2.8616145905
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.027505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5910696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.3715162350 18337622 15102660
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.4120471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.4110048152 11294989
MESH:D006333 Heart Failure Selenium 3.0617162251
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.3616366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3211000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.506705139
MESH:D006529 Hepatomegaly Phenobarbital 8.4016109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.4015340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 3.067520565
MESH:D006561 Herpes Simplex resveratrol 4.1716876885
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.058697196 15340226 16959395 16354765 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.6816870215
MESH:D017588 Hyperandrogenism Metformin 5.9915356085 17062894
MESH:D006937 Hypercholesterolemia resveratrol 3.9917188708
MESH:D006949 Hyperlipidemias resveratrol 4.0116873680
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.9215034207
MESH:D006973 Hypertension Dexamethasone 5.2317042910
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2318850075 18670907
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.2817488730
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8016945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.6317600658
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4412013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4717937319
MESH:D007249 Inflammation Dexamethasone 11.9311099482 8960868
MESH:D007249 Inflammation Lipopolysaccharides 11.939205823 17963957 12878042 17255318 17237260
MESH:D007249 Inflammation resveratrol 11.9316366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.9312878042 12200463
MESH:D007251 Influenza, Human resveratrol 11.0816624496
MESH:D007251 Influenza, Human Selenium 11.0816624496
MESH:D007333 Insulin Resistance Metformin 4.8117062894
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.6117255318
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.029022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3216580747
MESH:D055623 Keratosis, Actinic Phenol 6.4419293009
MESH:D007674 Kidney Diseases Acetaminophen 2.1915629191 12587719
MESH:D007676 Kidney Failure, Chronic Selenium 3.8716518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 12.3416705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 12.346582329
MESH:D007680 Kidney Neoplasms Fluorouracil 12.3416985049
MESH:D007896 Leishmaniasis Antimony 4.7915220340 10953559 21182181 21063981 12019027
MESH:D016773 Leishmaniasis, Cutaneous Antimony 4.6519141829 11475954 8889330
MESH:D007897 Leishmaniasis, Mucocutaneous Antimony 5.487854095 9643325 11370249 10651420 10881086
MESH:D007898 Leishmaniasis, Visceral Antimony 8.681899875 11105143 20495762 7875148 8142506 7854095 7554475
MESH:D007898 Leishmaniasis, Visceral Antimony Potassium Tartrate 8.6812707265
MESH:D015473 Leukemia, Promyelocytic, Acute Antimony Potassium Tartrate 8.229834237
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 8.2216087638
MESH:D007970 Leukopenia Lipopolysaccharides 4.6915821434
MESH:D008103 Liver Cirrhosis Phenobarbital 2.8821047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.1815034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 3.5716718785
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 3.5712878042
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5712878042
MESH:D008107 Liver Diseases Acetaminophen 3.9119460945 11587558 12969438 19784758 16611625 16610002 12587719 19014921
MESH:D008107 Liver Diseases Phenobarbital 3.9119363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2217185352 16871587
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.1720195826 21137059
MESH:D008113 Liver Neoplasms Fluorouracil 14.1717045692 15113037 16603448 18383874
MESH:D008113 Liver Neoplasms Phenobarbital 14.178742319 15975961 19812893 21047994 19073162 19482888
MESH:D008113 Liver Neoplasms resveratrol 14.1719073162 19812893 20405173 19321006
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.1716984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 9.72598648 1399818 3712494 6587162
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 9.7217172636 18308698 2563599 6150874 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.7212151625
MESH:D055370 Lung Injury Lipopolysaccharides 3.9921114838
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.8420464547 20135361 17053015 18569708 6695378 18520028 20064080 18816296 20869020
MESH:D008175 Lung Neoplasms Dexamethasone 4.8411195469 15824018
MESH:D008175 Lung Neoplasms Fluorouracil 4.8415246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.8419555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.7815086387
MESH:D016393 Lymphoma, B-Cell resveratrol 4.2817088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.8514749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.2415688416
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 6.1811606380 8985016
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.1815318939
MESH:D008545 Melanoma resveratrol 2.3617992120
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5519513568
MESH:D008654 Mesothelioma Selenium 2.7815107826
MESH:D008659 Metabolic Diseases resveratrol 4.3617112576
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.4716381670
MESH:D009062 Mouth Neoplasms Fluorouracil 8.4716757204 18986760
MESH:D009101 Multiple Myeloma Dexamethasone 7.5216118317 15744524 15867202
MESH:D009101 Multiple Myeloma resveratrol 7.5216490592 17935668 17164350 14749477 17049120 16267019
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.8617962980
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.539809623
MESH:D009203 Myocardial Infarction resveratrol 3.0216456233 16317513 17188708 16525036 17125593 17015251
MESH:D017202 Myocardial Ischemia resveratrol 8.9517015251 17125593
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.9512213967
MESH:D009205 Myocarditis resveratrol 4.7517322642
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.4717484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.8518551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.463581430
MESH:D009369 Neoplasms Benzo(a)pyrene 5.0311141357
MESH:D009369 Neoplasms Fluorouracil 5.0318239605 16928823 18600527
MESH:D009374 Neoplasms, Experimental resveratrol 3.998985016
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2014600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.906679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.2918514411
MESH:D019636 Neurodegenerative Diseases resveratrol 8.2917652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.3817929310
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.4216436463
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.8216049721 12819281
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 8.824026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.023988306
MESH:D010018 Osteomalacia Phenobarbital 4.3617016548
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.2417513867
MESH:D010146 Pain Acetaminophen 7.0016870215
MESH:D010146 Pain Phenol 7.0017610455
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.3319003803 16929163 15113037 16500647
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.3316965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6711578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.477296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2512520081
MESH:D010392 Pemphigus Phenol 6.4417163923 16522979
MESH:D010409 Penile Diseases Antimony 5.719643325
MESH:D010493 Pericarditis Antimony 6.1020465667
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.476228378
MESH:D010864 Pilonidal Sinus Phenol 6.4415622588 19655223
MESH:D010954 Plasmacytoma Selenium 4.8915087411
MESH:D011014 Pneumonia Lipopolysaccharides 4.5511605937 12224865
MESH:D011041 Poisoning Phenol 4.708825745
MESH:D011085 Polycystic Ovary Syndrome Metformin 5.5215356085 17062894
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5418163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.602563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.5321297632
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 9.5616679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.5611222880 11896295 11399792 11118676
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.6217292933
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.6219082440 18626508
MESH:D011471 Prostatic Neoplasms resveratrol 2.6215767336 17636462 17804756 17675339 17718901 16731767
MESH:D011537 Pruritus Ethinyl Estradiol 3.3016919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 4.5012752131
MESH:D012004 Rectal Neoplasms Fluorouracil 3.9918286688 18722050 15538739 16160472
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.5816325855
MESH:D015427 Reperfusion Injury resveratrol 3.2616314181 15827377 17520802 17058453 16317513
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 4.0011700416 18379247
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.7210835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8218990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.363692021
MESH:D012640 Seizures 2,4-dinitrotoluene 5.8818551238
MESH:D012640 Seizures Phenobarbital 5.883137016 11442880 4039156 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.816407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.3919755658 10029692
MESH:D012878 Skin Neoplasms resveratrol 9.3915837718 8985016
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.3916192470
MESH:D013088 Spermatocele Ethinyl Estradiol 12.0616709447
MESH:D013088 Spermatocele Phenol 12.0618646496
MESH:D013272 Stomach Diseases Dexamethasone 4.3115472012
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.412093021 20155912
MESH:D013274 Stomach Neoplasms Fluorouracil 2.4119015929 19084572 17522103 15786421 16951190 17498489 16424979 18567086 18396642 17172411
MESH:D013276 Stomach Ulcer Dexamethasone 3.4715138204
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.4616321402
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.1515821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9012697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.096582329 6587162 1399818 3712494 7505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.091399818
MESH:D014062 Tongue Neoplasms Fluorouracil 9.9216280240
MESH:D014062 Tongue Neoplasms resveratrol 9.9216227395
MESH:D014277 Trigeminal Neuralgia Phenol 6.4410223447 16527771
MESH:D014352 Trypanosomiasis Antimony 5.9315220340
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.2216049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.228074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.2217053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.3110091137
MESH:D014581 Urticaria Acetaminophen 2.9610982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 9.5516803524
MESH:D002583 Uterine Cervical Neoplasms resveratrol 9.5517473185
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 9.4414692618
MESH:D014594 Uterine Neoplasms resveratrol 9.4417044934
MESH:D014605 Uveitis Dexamethasone 4.821336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5214671159 15869587
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.2917488730
MESH:D014860 Warts Phenol 6.1019122958
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2515886252
Pathway ID Pathway Name
KEGG:01100 Metabolic pathways
KEGG:00450 Selenocompound metabolism
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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