AutismKB 2.0

Annotation Detail for PTGR1


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Basic Information Top
Gene Symbol:PTGR1 ( FLJ99229,LTB4DH,MGC34943,PGR1,ZADH3 )
Gene Full Name: prostaglandin reductase 1
Band: 9q31.3
Quick LinksEntrez ID:22949; OMIM: 601274; Uniprot ID:PTGR1_HUMAN; ENSEMBL ID: ENSG00000106853; HGNC ID: 18429
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C057461 1-pentene-3-one [PTGR1 protein co-treated with NADP] affects the reduction of 1-pentene-3-oneaffects cotreatment|affects reduction 11524419
C412886 2,4-nonadienal [PTGR1 protein co-treated with NADP] affects the reduction of 2,4-nonadienalaffects cotreatment|affects reduction 11524419
C012796 2-butenal [PTGR1 protein co-treated with NADP] affects the reduction of 2-butenalaffects cotreatment|affects reduction 11524419
C476489 (2E)-decenal [PTGR1 protein co-treated with NADP] affects the reduction of (2E)-decenalaffects cotreatment|affects reduction 11524419
C051750 2-hexenal [PTGR1 protein co-treated with NADP] affects the reduction of 2-hexenalaffects cotreatment|affects reduction 11524419
C013166 2-nonenal [PTGR1 protein co-treated with NADP] affects the reduction of 2-nonenalaffects cotreatment|affects reduction 11524419
C057348 2-octenal [PTGR1 protein co-treated with NADP] affects the reduction of 2-octenalaffects cotreatment|affects reduction 11524419
C064599 2-pentenal [PTGR1 protein co-treated with NADP] affects the reduction of 2-pentenalaffects cotreatment|affects reduction 11524419
C018855 2-tert-butylhydroquinone 2-tert-butylhydroquinone results in increased expression of PTGR1 mRNAincreases expression 16014739
C057920 3-buten-2-one [PTGR1 protein co-treated with NADP] affects the reduction of 3-buten-2-oneaffects cotreatment|affects reduction 11524419
C045934 4-hydroxy-2-hexenal [PTGR1 protein co-treated with NADP] affects the reduction of 4-hydroxy-2-hexenalaffects cotreatment|affects reduction 11524419
C027576 4-hydroxy-2-nonenal [PTGR1 protein co-treated with NADP] affects the reduction of 4-hydroxy-2-nonenalaffects cotreatment|affects reduction 11524419
C027576 4-hydroxy-2-nonenal PTGR1 protein results in decreased susceptibility to 4-hydroxy-2-nonenaldecreases response to substance 11524419
D000171 Acrolein [PTGR1 protein co-treated with NADP] affects the reduction of Acroleinaffects cotreatment|affects reduction 11524419
C000188 alachlor alachlor results in increased expression of PTGR1 mRNAincreases expression 12419858
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PTGR1 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of PTGR1 mRNAincreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PTGR1 mRNAdecreases expression 20018196
C025383 benzylideneacetone [PTGR1 protein co-treated with NADP] affects the reduction of benzylideneacetoneaffects cotreatment|affects reduction 11524419
C002791 bismuth tripotassium dicitrate bismuth tripotassium dicitrate results in decreased expression of PTGR1 mRNAdecreases expression 15912405
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of PTGR1 mRNAincreases expression 14729362
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of PTGR1 mRNAaffects expression 17484886
D002599 Chalcone [PTGR1 protein co-treated with NADP] affects the reduction of Chalconeaffects cotreatment|affects reduction 11524419
C012843 cinnamic aldehyde [PTGR1 protein co-treated with NADP] affects the reduction of cinnamic aldehydeaffects cotreatment|affects reduction 11524419
D009249 NADP [PTGR1 protein co-treated with NADP] affects the reduction of 1-pentene-3-oneaffects cotreatment|affects reduction 11524419
D009249 NADP [PTGR1 protein co-treated with NADP] affects the reduction of 2,4-nonadienalaffects cotreatment|affects reduction 11524419
D009249 NADP [PTGR1 protein co-treated with NADP] affects the reduction of 2-butenalaffects cotreatment|affects reduction 11524419
D009249 NADP [PTGR1 protein co-treated with NADP] affects the reduction of (2E)-decenalaffects cotreatment|affects reduction 11524419
D009249 NADP [PTGR1 protein co-treated with NADP] affects the reduction of 2-hexenalaffects cotreatment|affects reduction 11524419
D009249 NADP [PTGR1 protein co-treated with NADP] affects the reduction of 2-nonenalaffects cotreatment|affects reduction 11524419
D009249 NADP [PTGR1 protein co-treated with NADP] affects the reduction of 2-octenalaffects cotreatment|affects reduction 11524419
D009249 NADP [PTGR1 protein co-treated with NADP] affects the reduction of 2-pentenalaffects cotreatment|affects reduction 11524419
D009249 NADP [PTGR1 protein co-treated with NADP] affects the reduction of 3-buten-2-oneaffects cotreatment|affects reduction 11524419
D009249 NADP [PTGR1 protein co-treated with NADP] affects the reduction of 4-hydroxy-2-hexenalaffects cotreatment|affects reduction 11524419
D009249 NADP [PTGR1 protein co-treated with NADP] affects the reduction of 4-hydroxy-2-nonenalaffects cotreatment|affects reduction 11524419
D009249 NADP [PTGR1 protein co-treated with NADP] affects the reduction of Acroleinaffects cotreatment|affects reduction 11524419
D009249 NADP [PTGR1 protein co-treated with NADP] affects the reduction of benzylideneacetoneaffects cotreatment|affects reduction 11524419
D009249 NADP [PTGR1 protein co-treated with NADP] affects the reduction of Chalconeaffects cotreatment|affects reduction 11524419
D009249 NADP [PTGR1 protein co-treated with NADP] affects the reduction of cinnamic aldehydeaffects cotreatment|affects reduction 11524419
C030123 coumarin coumarin results in increased expression of PTGR1 mRNAincreases expression 18480146
C061481 dibenzoylmethane [sulforafan co-treated with dibenzoylmethane] results in increased expression of PTGR1 mRNAaffects cotreatment|increases expression 17942926
D004041 Dietary Fats Dietary Fats results in decreased expression of PTGR1 mRNAdecreases expression 18042831
D004052 Diethylnitrosamine [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of PTGR1 mRNAaffects cotreatment|increases expression 16158176
D015073 2-Acetylaminofluorene [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of PTGR1 mRNAaffects cotreatment|increases expression 16158176
D005472 Fluorouracil Fluorouracil results in increased expression of PTGR1 proteinincreases expression 15585135
C071834 glycidamide glycidamide results in increased expression of PTGR1 mRNAincreases expression 17822822
D007975 Leukotriene B4 Indomethacin binds to and affects the folding of and results in decreased activity of [Leukotriene B4 binds to [PTGR1 protein binds to PTGR2 protein]]affects binding|affects folding|decreases activity 16916844
D007975 Leukotriene B4 Leukotriene B4 binds to [PTGR1 protein binds to PTGR2 protein]affects binding 16916844
D006861 Hydrogen Peroxide Hydrogen Peroxide results in increased expression of PTGR1 mRNAincreases expression 14729362
D007052 Ibuprofen Ibuprofen results in increased expression of PTGR1 mRNAincreases expression 16827938
D007213 Indomethacin Indomethacin binds to and affects the folding of and results in decreased activity of [Leukotriene B4 binds to [PTGR1 protein binds to PTGR2 protein]]affects binding|affects folding|decreases activity 16916844
C041786 palm oil palm oil results in decreased expression of PTGR1 mRNAdecreases expression 18042831
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PTGR1 mRNAaffects binding|increases activity|increases expression 19710929
D011374 Progesterone Progesterone results in decreased activity of PTGR1 proteindecreases activity 11524419
D011794 Quercetin Quercetin affects the expression of PTGR1 mRNAaffects expression 18178720
D011794 Quercetin Quercetin results in decreased activity of PTGR1 proteindecreases activity 11524419
D012643 Selenium Selenium affects the expression of PTGR1 proteinaffects expression 19351701
C016766 sulforafan [sulforafan co-treated with dibenzoylmethane] results in increased expression of PTGR1 mRNAaffects cotreatment|increases expression 17942926
D014635 Valproic Acid Valproic Acid results in increased expression of PTGR1 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.058875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.5319490988
MESH:D000138 Acidosis Ammonium Chloride 3.1218287403
MESH:D058186 Acute Kidney Injury Ibuprofen 4.066375363
MESH:D055371 Acute Lung Injury Acrolein 7.9421297076 20525806
MESH:D055371 Acute Lung Injury pirinixic acid 7.9418653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 9.1720464547 20127859
MESH:D000230 Adenocarcinoma Fluorouracil 9.1717638652
MESH:D000230 Adenocarcinoma Ibuprofen 9.1710697514
MESH:D000230 Adenocarcinoma Indomethacin 9.1716537180
MESH:D000236 Adenoma 2-Acetylaminofluorene 13.8410737359
MESH:D000236 Adenoma Benzo(a)pyrene 13.846695378
MESH:D000236 Adenoma Diethylnitrosamine 13.846695378 10737359
MESH:D000236 Adenoma Indomethacin 13.8411497255
MESH:D002759 Adenoma, Bile Duct 2-Acetylaminofluorene 5.566705139
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 8.6219052882 16434500 17620307 18056438 19061943 17162532
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.6216434500
MESH:D011125 Adenomatous Polyposis Coli dibenzoylmethane 14.5217942926
MESH:D011125 Adenomatous Polyposis Coli Leukotriene B4 14.5217942926
MESH:D011125 Adenomatous Polyposis Coli sulforafan 14.5217942926
MESH:D000382 Agricultural Workers' Diseases alachlor 4.2214769641 11874814
MESH:D016301 Alveolar Bone Loss Indomethacin 4.9217225004
MESH:D000544 Alzheimer Disease 2-butenal 8.6416538519
MESH:D000544 Alzheimer Disease Acrolein 8.6417570602 14715435 15207723
MESH:D000544 Alzheimer Disease Ibuprofen 8.6418351690
MESH:D000544 Alzheimer Disease Indomethacin 8.6415579461 17627676
MESH:D000550 Amblyopia Valproic Acid 4.7817688650
MESH:D000690 Amyotrophic Lateral Sclerosis 2-butenal 7.9417319283
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 7.9410965797
MESH:D000707 Anaphylaxis Ibuprofen 4.819532969
MESH:D000740 Anemia Fluorouracil 3.3316511603 17963324 15504547
MESH:D000743 Anemia, Hemolytic Quercetin 3.8417084956
MESH:D001008 Anxiety Disorders Valproic Acid 3.2217497229
MESH:D001014 Aortic Aneurysm Indomethacin 4.4310231640
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 10.2719183758
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 10.2710388637
MESH:D001161 Arteriosclerosis Acrolein 9.0415014928
MESH:D001161 Arteriosclerosis Dietary Fats 9.0415238619
MESH:D018771 Arthralgia Indomethacin 4.722160914
MESH:D001168 Arthritis Leukotriene B4 5.7211006272
MESH:D001172 Arthritis, Rheumatoid Indomethacin 2.7111248219
MESH:D001249 Asthma Leukotriene B4 3.9311006272 19667530
MESH:D001250 Asthma, Exercise-Induced Leukotriene B4 5.4719667531
MESH:D001260 Ataxia Telangiectasia Quercetin 4.5315336622
MESH:D050197 Atherosclerosis Acrolein 3.7116037261 17363696 16126721
MESH:D001321 Autistic Disorder Valproic Acid 2.0615238991 19232924 20603192 18396377 17507914 19460635 18316065 18775368 18985861 17157402 18558336 17688650 18177632 16609825 18940202
MESH:D001327 Autoimmune Diseases Quercetin 9.8319761891
MESH:D001327 Autoimmune Diseases sulforafan 9.8319761891
MESH:D001477 Bartter Syndrome Indomethacin 4.5510684365
MESH:D001714 Bipolar Disorder Valproic Acid 2.8417594078 20046352
MESH:D001778 Blood Coagulation Disorders pirinixic acid 2.7519483382
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.118888407
MESH:D001929 Brain Edema Indomethacin 4.5711481608
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.8917868700
MESH:D001930 Brain Injuries Progesterone 3.8315665606 15380490 15845082
MESH:D002545 Brain Ischemia Ibuprofen 9.1115837124
MESH:D002545 Brain Ischemia Indomethacin 9.1112524144
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.4217474063 20146248
MESH:D001943 Breast Neoplasms Dietary Fats 3.4220435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 3.4217474063
MESH:D001943 Breast Neoplasms Fluorouracil 3.4219217205 15136595 18608205 18357371 16595493 16110121 16557594
MESH:D001943 Breast Neoplasms Indomethacin 3.4217401462
MESH:D001943 Breast Neoplasms Progesterone 3.4215562024 16175315 17614352
MESH:D001943 Breast Neoplasms Quercetin 3.4218628248
MESH:D016535 Bronchial Hyperreactivity Leukotriene B4 4.7612654629 12794006
MESH:D002056 Burns Indomethacin 4.2710459503
MESH:D002100 Cachexia Ibuprofen 11.1915141370
MESH:D002100 Cachexia Indomethacin 11.1915141370 16537180 11239499 15625704
MESH:D002105 Cadmium Poisoning Quercetin 5.0916962696
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.3518705752 10355542 16227642 16124888 15721981 16050911 15700767 16097048 15673190 16192424 3786805 16011737
MESH:D002276 Carcinoid Tumor Fluorouracil 4.2216051944
MESH:D002277 Carcinoma Fluorouracil 3.2217121937
MESH:D006528 Carcinoma, Hepatocellular 2-Acetylaminofluorene 10.266705139 3581430 17761372 3084413 10737359
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 10.2618788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 10.2617978847 16328049 21159647 19107877 16830150 17761372 16540662 19052882 11831363 20727157 18665156 17162532 20935162 20512989 19822196 19208518 10737359 3084413 20007298 16569478 17428255 17055752 18971187 18393292 17173139 16502159 16698587 19919837 20432363 18494052 18056438 20101231 3581430 18210153 19394651 10672840 19335982 16878318 18506893 19383236 20084675 16935385 19701751 20214788 20524982 20514400 17138121 18978308 19519916 18788625 19171122 19539802 16779866 16288022 16807293 16681979 18785209 19418558 18691550
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 10.2617045692 17971768 17088986 16332177 18930000 16799960
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 10.2616391822
MESH:D006528 Carcinoma, Hepatocellular Quercetin 10.2619519916 12508355
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.2811053908
MESH:D018276 Carcinoma, Medullary Indomethacin 4.9118791128 14736730 11352223
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.5217234771
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.0118695887
MESH:D002292 Carcinoma, Renal Cell Indomethacin 6.0117341418
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 6.7320419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 6.7316757204 16280240 17066447 18986760
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 6.7315482327 12636206
MESH:D006332 Cardiomegaly Quercetin 3.0719794523
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 3.2116936243
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 9.6320889678
MESH:D002471 Cell Transformation, Neoplastic cinnamic aldehyde 9.638243401
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 9.632727394 17174075 7505956 21159647
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.5420734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.3119052882
MESH:D002764 Cholecystitis Indomethacin 4.7211181007
MESH:D002779 Cholestasis pirinixic acid 2.5019176532
MESH:D003092 Colitis Selenium 3.3517936198
MESH:D003110 Colonic Neoplasms cinnamic aldehyde 7.5716343908 17510524
MESH:D003110 Colonic Neoplasms Fluorouracil 7.5717172411 15001691 18772588 17725105 17018589 16510598 17287894 17169374 16340194 17016597
MESH:D003110 Colonic Neoplasms Indomethacin 7.5715936596 15963497 15625704 15637740 15786552 11260862
MESH:D003110 Colonic Neoplasms Quercetin 7.5719056647 19440933 11134977 17148506 17191121 15741050 16640504
MESH:D015179 Colorectal Neoplasms Acrolein 4.4517597105
MESH:D015179 Colorectal Neoplasms Fluorouracil 4.4516524972 14970324 16282729 17255274 17454858 16331619 20501625 17094418 17695437 17594712 18802399 18949393 18448328 18288408 18509181 16391804 16303861 15148649 18383874 15289873 17016601 17401013
MESH:D015179 Colorectal Neoplasms Indomethacin 4.4512606626 11197048 17054584 18059344
MESH:D015179 Colorectal Neoplasms Quercetin 4.4518095365 18852136
MESH:D018352 Coronavirus Infections Indomethacin 5.2717302372
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.878888407 17688650 16575769
MESH:D003556 Cystitis Acrolein 4.9412161096
MESH:D007644 Darier Disease Fluorouracil 4.3516733453
MESH:D017449 Dermatitis, Allergic Contact alachlor 6.588428444
MESH:D017449 Dermatitis, Allergic Contact cinnamic aldehyde 6.5811042091
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2118249437
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.3719496084
MESH:D003924 Diabetes Mellitus, Type 2 coumarin 4.3619647726
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.3620387270
MESH:D003929 Diabetic Neuropathies Progesterone 4.0617187935
MESH:D003967 Diarrhea Indomethacin 3.397907874 7237001
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 7.762869522 6623471 10092053 7440962 17522070 3732212 6884620 16177239 4309450 11566570 15027814 16227642 7179309 7120509 21278145 3786805 9327722 19336974 15968718 15998439 10915739 19085960
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 7.7619107877
MESH:D056486 Drug-Induced Liver Injury Selenium 7.7615131321
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 7.761733752 19641884
MESH:D004374 Ductus Arteriosus, Patent Ibuprofen 11.7618446180 18450898 16133044
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 11.7618043480 18446180 16133044 17190690 12774134 16326151
MESH:D004381 Duodenal Ulcer Indomethacin 3.7217329845 11991626 11535926 11595431 17151854 17202747 17351913 17045617 11595415 10671773 16699067
MESH:D050171 Dyslipidemias Dietary Fats 3.1318367378
MESH:D004421 Dystonia Valproic Acid 3.641851702
MESH:D004487 Edema Indomethacin 5.678985016 16100529 10653021 7907874 8273558 19703484 7990266
MESH:D004487 Edema pirinixic acid 5.6712083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.3617692515
MESH:D004715 Endometriosis Ibuprofen 13.3015652904
MESH:D004715 Endometriosis Indomethacin 13.3015652904
MESH:D004715 Endometriosis Progesterone 13.3016134523
MESH:D019446 Endotoxemia Ibuprofen 9.3911545620
MESH:D019446 Endotoxemia Indomethacin 9.3918509659
MESH:D004751 Enteritis Indomethacin 4.3010567023 16328016 17763956
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 4.5517980183
MESH:D004802 Eosinophilia Indomethacin 3.6311298111
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.7217275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 3.473922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.7020417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.226254150 7562514 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 3.867750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.623659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.6616302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 9.3120426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 9.3116530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 9.3115173087 16785472 17638652 16481741 16337965
MESH:D004938 Esophageal Neoplasms Indomethacin 9.3111005569
MESH:D005234 Fatty Liver Carbon Tetrachloride 20.4716239168 12631006 16045604 15959796 17595544 61145 12795759 19224547
MESH:D005234 Fatty Liver Dietary Fats 20.4717967931 18296743 19004024 19551842
MESH:D005234 Fatty Liver Diethylnitrosamine 20.4721071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 20.4719236843 20131406
MESH:D005234 Fatty Liver Valproic Acid 20.4714986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 4.4316575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.718888407 18558336
MESH:D005334 Fever Ibuprofen 8.2916997862
MESH:D005334 Fever Indomethacin 8.2910431976 11852909 17627676
MESH:D005354 Fibrosarcoma Indomethacin 4.4510962813
MESH:D005355 Fibrosis Carbon Tetrachloride 17.6818705752
MESH:D005355 Fibrosis Dietary Fats 17.6818296743
MESH:D005355 Fibrosis Indomethacin 17.6817994277
MESH:D005355 Fibrosis Quercetin 17.6819474275
MESH:D005499 Folliculitis Indomethacin 4.7211298111
MESH:D005756 Gastritis Indomethacin 4.3015046732
MESH:D005909 Glioblastoma Indomethacin 6.4812870263
MESH:D005909 Glioblastoma Quercetin 6.4819804834
MESH:D005910 Glioma Fluorouracil 8.8916145905
MESH:D005910 Glioma Indomethacin 8.8918371953 16487511
MESH:D005910 Glioma Quercetin 8.8917643826
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 3.9311849393
MESH:D006073 Gout Indomethacin 4.9111248219
MESH:D006258 Head and Neck Neoplasms Fluorouracil 6.9915162350 18337622 15102660
MESH:D006258 Head and Neck Neoplasms Indomethacin 6.9915482327
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.4120471113
MESH:D006333 Heart Failure pirinixic acid 6.0220558911
MESH:D006333 Heart Failure Selenium 6.0217162251
MESH:D006390 Hemangioendothelioma 2-Acetylaminofluorene 4.866705139
MESH:D006394 Hemangiosarcoma 2-Acetylaminofluorene 4.016705139
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.1715633222
MESH:D006505 Hepatitis Carbon Tetrachloride 3.1819110552 19900420
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.2615135802
MESH:D006529 Hepatomegaly pirinixic acid 2.5716221962 19176532 18467677 19772884
MESH:D006849 Hydrocephalus Valproic Acid 4.4217688650
MESH:D006930 Hyperalgesia Indomethacin 3.4312727271
MESH:D034321 Hyperamylasemia Indomethacin 5.2717883296
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.0916899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.2021332399
MESH:D006940 Hyperemia Indomethacin 4.5612524144
MESH:D006943 Hyperglycemia pirinixic acid 7.9720558911
MESH:D006943 Hyperglycemia Quercetin 7.9711834736 18262572
MESH:D006949 Hyperlipidemias Dietary Fats 7.9921332399
MESH:D006949 Hyperlipidemias Indomethacin 7.9917546600
MESH:D006973 Hypertension Quercetin 2.6818356687
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.6615338365
MESH:D006984 Hypertrophy Ibuprofen 4.5816672835
MESH:D007077 Ileal Diseases Indomethacin 4.5718306037 10574470
MESH:D007079 Ileitis Indomethacin 4.9110647630 10651667 16133968
MESH:D007235 Infant, Premature, Diseases Ibuprofen 12.6916133044
MESH:D007235 Infant, Premature, Diseases Indomethacin 12.6916133044
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 3.9715869954
MESH:D007248 Infertility, Male alachlor 3.8516466525 17049205 12948887
MESH:D007249 Inflammation Dietary Fats 13.3120412841
MESH:D007249 Inflammation Diethylnitrosamine 13.3118785209
MESH:D007249 Inflammation Ibuprofen 13.313291741
MESH:D007249 Inflammation Indomethacin 13.3112568917 7812673 3291741
MESH:D007249 Inflammation Progesterone 13.3115869954
MESH:D015212 Inflammatory Bowel Diseases Leukotriene B4 4.2811006272
MESH:D007251 Influenza, Human Quercetin 9.5616624496
MESH:D007251 Influenza, Human Selenium 9.5616624496
MESH:D007333 Insulin Resistance Dietary Fats 6.2618457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 6.2616306350
MESH:D007410 Intestinal Diseases Indomethacin 3.9018236018 11855677 17994277 11686837 15610444 15831440 10210152 17329856 11713966
MESH:D019586 Intracranial Hypertension Indomethacin 4.9215241188
MESH:D007579 Jejunal Diseases Indomethacin 4.5718306037 10574470 16133968
MESH:D007627 Keloid Quercetin 4.5217086741
MESH:D007674 Kidney Diseases Acrolein 8.8512488133
MESH:D007674 Kidney Diseases Indomethacin 8.8517190690
MESH:D007674 Kidney Diseases Quercetin 8.8516962696
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 8.7116518626
MESH:D007676 Kidney Failure, Chronic Selenium 8.7116518626
MESH:D007680 Kidney Neoplasms Fluorouracil 2.9616985049
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.5511703811 12228301 10320625
MESH:D007938 Leukemia alachlor 6.1414769641
MESH:D007938 Leukemia Quercetin 6.1417468513
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 3.6016572323 15631656 10785260
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 3.7718360721
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.7717596541 16294345
MESH:D007964 Leukocytosis Indomethacin 4.9216537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.2717980183
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.2711479899
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 9.5317157831 11903743 17174718 16943688 16221502 11408273 17334410 21278145 16239168
MESH:D008103 Liver Cirrhosis Dietary Fats 9.5318296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 9.5318522880 19638242 18407596 20032147 18665156
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 4.4612898905 17922224 18006644 17640975 17698563 12445421 18279442 16097048 15730626 18481824 12632514 18472332 18395914 18166357 17557913 15876570 16015684 20821823 15818738 18263696 12445418 18418968 17721639 18420326 15123356 11481614 16027843 16136751 17761835 16638106 18205269 12649538 17823541 17976157 14512876 18395095 18429990 17525996 17708605 15893842 15925388 15931870 15673190 12586293 18210741 12667390 18054572 12609069 12389079 18277467 17714472 14716833 14716496 18156304 16248980 14724832 18339082 14748882 18412020 15996030 18376398 12632512 18251166 15959796 12741479 16192424 15362042 12958196 17805973 17631135 15338365 17869086 12666154 17565644 14620537 16033810 10355542 18187930 12546737 13678700 15370692 16011737 16116963 18705752 15057751 15650968 18317297 17766677 15052691 17944888 17481882 17900296 18472094
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 4.4618194892
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.4615474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 4.4612741479
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.6415830285 17285989 16246199 16964402 15720792
MESH:D008107 Liver Diseases Diethylnitrosamine 3.6417034775
MESH:D017093 Liver Failure Carbon Tetrachloride 3.7315123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.3116899240 14706259
MESH:D008113 Liver Neoplasms 2-Acetylaminofluorene 19.0510672840 11376686 14678523 18001218 16273603 10737359
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 19.0520195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 19.0519294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 19.0521047994 20434301 19996281 19850985 19073162 18648771 2862719 15885732 20137499 18754104 19551842 20452335 19256749 19812893 19638242 20101389 19690152 18644402 19833225 19255062 9163691 19254457 12112319 18977376 19426721 21167192 19090486 15175105 20583210 19294768 21278145 20501860 16942905 10737359 20492335 21071580 2422723 20405173 12771043 19642983 18978307 19499222 20118626 19427195
MESH:D008113 Liver Neoplasms Fluorouracil 19.0517045692 15113037 16603448 18383874
MESH:D008113 Liver Neoplasms pirinixic acid 19.0520007298 15890375 16377806
MESH:D008113 Liver Neoplasms Quercetin 19.0518980244
MESH:D008114 Liver Neoplasms, Experimental 2-Acetylaminofluorene 11.861399818 534488 6150874
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 11.8615583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 11.8618079962 17174075 19539802 2563599 18775883 3124819 21159647 19126423 18308698 19519916 18544905 18093689 17854601 18164116 16842330 18282651 16267830 9362446 19009564 17942915 18253720 19004024
MESH:D008114 Liver Neoplasms, Experimental Quercetin 11.8619519916
MESH:D008171 Lung Diseases Acrolein 3.9111504702
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 3.8117228818
MESH:D008175 Lung Neoplasms 2-Acetylaminofluorene 7.6911376686
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 7.6918520028 20064080 20464547 20869020 18816296 6695378 17053015 20135361 18569708
MESH:D008175 Lung Neoplasms Diethylnitrosamine 7.6920970405 20512841 21163286 6695378
MESH:D008175 Lung Neoplasms Fluorouracil 7.6915246190
MESH:D008175 Lung Neoplasms Indomethacin 7.6911053908 11497255 16537180
MESH:D008175 Lung Neoplasms Quercetin 7.6916280456
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.3515086387
MESH:D008325 Mammary Neoplasms, Experimental Ibuprofen 8.4610697514
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 8.4611408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Selenium 8.4615318939
MESH:D008546 Melanoma, Experimental Acrolein 4.7810803710
MESH:D008654 Mesothelioma Selenium 2.6015107826
MESH:D008881 Migraine Disorders Indomethacin 6.6611903285
MESH:D008881 Migraine Disorders Valproic Acid 6.6618765137 18803445
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 12.4516381670
MESH:D009062 Mouth Neoplasms Fluorouracil 12.4516757204 18986760
MESH:D009062 Mouth Neoplasms Indomethacin 12.4512636206
MESH:D009101 Multiple Myeloma alachlor 3.9714769641
MESH:D009135 Muscular Diseases pirinixic acid 3.0816239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.638888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 2.8917596541
MESH:D009203 Myocardial Infarction pirinixic acid 5.0619151258
MESH:D009203 Myocardial Infarction Quercetin 5.0619595682
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.3116411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 7.3119207477
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.323581430 9029167
MESH:D009362 Neoplasm Metastasis Indomethacin 5.3216537180 11239499 11053908
MESH:D009369 Neoplasms 2-butenal 20.4810626223
MESH:D009369 Neoplasms 2-hexenal 20.4810626223
MESH:D009369 Neoplasms Acrolein 20.4817329238
MESH:D009369 Neoplasms Benzo(a)pyrene 20.4811141357
MESH:D009369 Neoplasms Fluorouracil 20.4818600527 18239605 16928823
MESH:D009369 Neoplasms pirinixic acid 20.4817405874
MESH:D009369 Neoplasms Quercetin 20.4815185748
MESH:D009374 Neoplasms, Experimental Indomethacin 3.7115625704 10663608
MESH:D009393 Nephritis Acrolein 5.8412653641
MESH:D009395 Nephritis, Interstitial Ibuprofen 4.546375363
MESH:D009410 Nerve Degeneration Ibuprofen 4.0510961664
MESH:D009436 Neural Tube Defects Valproic Acid 2.8416359493 8888407
MESH:D019636 Neurodegenerative Diseases Acrolein 12.2111342003
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 12.2120387270
MESH:D019636 Neurodegenerative Diseases Indomethacin 12.2112349958
MESH:D020078 Neurogenic Inflammation Quercetin 3.9517929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.6620387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.1316436463
MESH:D009503 Neutropenia Leukotriene B4 4.938305713
MESH:D009669 Nose Neoplasms alachlor 4.3811127290 16178123 16698726 14563481 15580706
MESH:D009765 Obesity Dietary Fats 4.0118674790 11836018 19632207 20518802 16723640 17217161 18457598 20132043 21332399
MESH:D009765 Obesity pirinixic acid 4.0120558911
MESH:D007752 Obstetric Labor, Premature Indomethacin 4.726374098
MESH:D010003 Osteoarthritis Ibuprofen 7.137009135
MESH:D010003 Osteoarthritis Indomethacin 7.137009135
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 3.8119495926
MESH:D010051 Ovarian Neoplasms Progesterone 4.5416525653 17393432
MESH:D010051 Ovarian Neoplasms Quercetin 4.5419005980
MESH:D010146 Pain Ibuprofen 6.183291741
MESH:D010146 Pain Indomethacin 6.1817627676 3291741 13679232 17440234
MESH:D010149 Pain, Postoperative Ibuprofen 9.9816678543
MESH:D010149 Pain, Postoperative Indomethacin 9.9818702446 12538197
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 10.9416540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 10.9416500647 16929163 19003803 15113037
MESH:D010190 Pancreatic Neoplasms Ibuprofen 10.9412384795
MESH:D010190 Pancreatic Neoplasms Quercetin 10.9416965848
MESH:D010195 Pancreatitis Indomethacin 3.5215028970 17883296
MESH:D010212 Papilloma Hydrogen Peroxide 3.6612065085
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.2716537180
MESH:D010300 Parkinson Disease Acrolein 3.4217690948
MESH:D020734 Parkinsonian Disorders Indomethacin 3.7412349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.2711903285
MESH:D010437 Peptic Ulcer Indomethacin 4.7111148446
MESH:D010518 Periodontitis Indomethacin 4.4617225004
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 11.9611550810
MESH:D010787 Photosensitivity Disorders Acrolein 11.9611550810
MESH:D010954 Plasmacytoma Selenium 4.4415087411
MESH:D011230 Precancerous Conditions Diethylnitrosamine 7.992563599
MESH:D011230 Precancerous Conditions Quercetin 7.9919056647
MESH:D047928 Premature Birth Indomethacin 4.6917000239
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 3.3920603192
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.2417292933
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.2418626508 19082440
MESH:D011471 Prostatic Neoplasms Ibuprofen 2.2417409433
MESH:D011471 Prostatic Neoplasms Quercetin 2.2414715546 17292933
MESH:D011507 Proteinuria Ibuprofen 8.366375363
MESH:D011507 Proteinuria Indomethacin 8.3611849393
MESH:D019310 Pseudolymphoma Valproic Acid 4.0912752131 11422049
MESH:D011565 Psoriasis Leukotriene B4 4.1611006272
MESH:D012004 Rectal Neoplasms Fluorouracil 3.6415538739 16160472 18722050 18286688
MESH:D051437 Renal Insufficiency Acrolein 4.5812732208
MESH:D015427 Reperfusion Injury pirinixic acid 2.1619058328
MESH:D012135 Respiratory Sounds alachlor 4.5211874814
MESH:D012208 Rhabdomyosarcoma Valproic Acid 3.7719155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.6918045962
MESH:D012554 Schistosomiasis japonica Quercetin 5.0916862918
MESH:D012559 Schizophrenia Valproic Acid 2.0119110320 15737665
MESH:D012640 Seizures Valproic Acid 2.451511512 17978042 11044598 15475178 14763951 11738929 3137016 16876388
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 8.2419755658 10029692
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 8.2412065085
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 8.248532709
MESH:D013119 Spinal Cord Injuries Progesterone 3.8416503802 15862959
MESH:D016135 Spinal Dysraphism Valproic Acid 3.4419490988
MESH:D013226 Status Epilepticus Valproic Acid 4.0912833885
MESH:D013272 Stomach Diseases Indomethacin 3.9818545984 17160473 16184426 16113693 10215738 17207306 10192188 15472012 10486359 15038085 16280098 17638125 18209964
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.3020155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.3018456281
MESH:D013274 Stomach Neoplasms Fluorouracil 4.3016424979 19015929 16951190 18396642 18567086 17522103 15786421 17498489 19084572 17172411
MESH:D013274 Stomach Neoplasms Indomethacin 4.3015609394
MESH:D013276 Stomach Ulcer Indomethacin 3.2010878458 18237397 16755016 18543354 17895592 10750652 17918041 11729361 17657623 11145282 10423059 11595415 18193104 18726076 15138204 17654042 15104355 18087811 16397915 16252198 11906479 16169175 16934674 14567935 11595431 18181030 16631530 12467913 18431645 16150113 17977527 12787963 17627676 15255614 1323529 18209962 12077510 18299717 12498302 11523592 17135157 12500499
MESH:D020521 Stroke Acrolein 4.2116269634
MESH:D013964 Thyroid Neoplasms alachlor 10.268812207
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 10.267505956
MESH:D013964 Thyroid Neoplasms Indomethacin 10.2618791128 14736730 11352223
MESH:D014062 Tongue Neoplasms Fluorouracil 3.6116280240
MESH:D014178 Translocation, Genetic Valproic Acid 4.7817262798
MESH:D014456 Ulcer Indomethacin 4.4510574470 17380554
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.083119515
MESH:D001749 Urinary Bladder Neoplasms 2-Acetylaminofluorene 7.3615289314 1399818 15867355
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 7.3617053015
MESH:D001749 Urinary Bladder Neoplasms Quercetin 7.3616720314
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.218888407
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 3.5016803524
MESH:D020301 Vasospasm, Intracranial Ibuprofen 4.7519057314
MESH:D014689 Venous Insufficiency coumarin 5.3212708602
MESH:D014839 Vomiting Indomethacin 4.3011897121
MESH:D015430 Weight Gain Dietary Fats 3.3716723640
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB03461 - 2'-Monophosphoadenosine 5'-Diphosphoribose
DB04066 - Para-Coumaric Acid Anti-Infective Agents;Antioxidants;Free Radical Scavengers;Contraceptive Agents, Male
DB07177 - (5E,13E)-11-HYDROXY-9,15-DIOXOPROSTA-5,13-DIEN-1-OIC ACID
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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