AutismKB 2.0

Annotation Detail for TRIM32


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Basic Information Top
Gene Symbol:TRIM32 ( BBS11,HT2A,LGMD2H,TATIP )
Gene Full Name: tripartite motif-containing 32
Band: 9q33.1
Quick LinksEntrez ID:22954; OMIM: 602290; Uniprot ID:TRI32_HUMAN; ENSEMBL ID: ENSG00000119401; HGNC ID: 16380
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04120Ubiquitin mediated proteolysis
No data
No data
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Other genetic disorders
H00418Bardet-Biedl syndrome
Genetic disorders
No data
No data
No data
Desease Name
Bardet-Biedl syndrome 11
Muscular dystrophy, limb-girdle, type 2H
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of TRIM32 mRNAaffects expression 21346803
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of TRIM32 mRNAaffects cotreatment|affects expression 17602206
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of TRIM32 mRNAaffects cotreatment|affects expression 17602206
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of TRIM32 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TRIM32 mRNAaffects cotreatment|increases expression 17942748
C029938 nickel sulfate nickel sulfate results in decreased expression of TRIM32 mRNAdecreases expression 16780908
D010634 Phenobarbital Phenobarbital results in increased expression of TRIM32 mRNAincreases expression 19270015
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TRIM32 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 9.656195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.6511752688 14514962 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3817505938
MESH:D055371 Acute Lung Injury nickel sulfate 4.6112718980 16100012 11954676 19131640
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8614692618
MESH:D000236 Adenoma Diethylnitrosamine 2.996695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 19.8017620307 19052882 18056438 19061943 17162532 16434500
MESH:D018248 Adenoma, Liver Cell Phenobarbital 19.8017620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 19.8016835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2111748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8215885639
MESH:D020788 Bardet-Biedl Syndrome marker/mechanism
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9417474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9420435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.7916705839
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.7918971187 3084413 16878318 20007298 18691550 19701751 16830150 20524982 18056438 21159647 16502159 16807293 10672840 19052882 16681979 18785209 19107877 17428255 20101231 20935162 20514400 18210153 17761372 19519916 17162532 18393292 18978308 11831363 16698587 19822196 16540662 3581430 17978847 20084675 17138121 16779866 19539802 19335982 16328049 19394651 18494052 10737359 18506893 19383236 17055752 18665156 20432363 20512989 19919837 20214788 19418558 16288022 16569478 18788625 17173139 20727157 19171122 19208518 16935385
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.7920935162 17173139 20007298 1701930 6705139
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5018850075 18670907 16120746
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 3.0421159647 2727394 7505956 17174075
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.614080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 10.1719052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 10.1716835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0717110522 17333356 15861022 11677210 16105132 17681005 16919318
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2015340226 12621046 16354765 8697196 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 10048152 20055451
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.3718551238
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 4.0216823706 11298694 16780908
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.4120387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.4117107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.5818551238 21346803
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.5819107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.5820420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9611462148
MESH:D004421 Dystonia Phenobarbital 4.311851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.3515322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.5212538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.299294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.473659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.313922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.0120417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.796401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.617750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.413659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.5616302075
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2111564622
MESH:D005234 Fatty Liver Diethylnitrosamine 8.6520387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.6515345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3120067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4611294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006529 Hepatomegaly Phenobarbital 9.6616109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.6616120746 12621046 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.498697196 15340226 16959395 18606429 16354765
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9918670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1716945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6617937319
MESH:D007249 Inflammation Diethylnitrosamine 5.3318785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.3312878042 12200463
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6216580747
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.2116705839
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 7.1019638242 18522880 20032147 18665156 18407596
MESH:D008103 Liver Cirrhosis Phenobarbital 7.1021047994
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008107 Liver Diseases Diethylnitrosamine 4.3017034775
MESH:D008107 Liver Diseases Phenobarbital 4.3019363144
MESH:D008113 Liver Neoplasms Clofibric Acid 11.4717602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 11.4720583210 19426721 19996281 20492335 12771043 21047994 20137499 19073162 20434301 10737359 19812893 19256749 18648771 16942905 2422723 19427195 21167192 18754104 20501860 18644402 20101389 20405173 19850985 19833225 15885732 9163691 19551842 15175105 19255062 19294768 2862719 21071580 21278145 12112319 18977376 18978307 19090486 19499222 20118626 19690152 20452335 19638242 19254457 19642983
MESH:D008113 Liver Neoplasms Phenobarbital 11.4719482888 8742319 15975961 19812893 21047994 19073162
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.4716984957
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.7618093689 18544905 18164116 18308698 17942915 9362446 3124819 21159647 19126423 16842330 18253720 18775883 17174075 18079962 17854601 19009564 18282651 16267830 19519916 19004024 19539802 2563599
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 10.7617172636 1399818 18308698 2563599 6150874
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.7612151625
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.3220970405 6695378 20512841 21163286
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3219555203 11884234
OMIM:254110 MUSCULAR DYSTROPHY, LIMB-GIRDLE, TYPE 2H marker/mechanism
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2412213967
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.8717484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.2518551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.663581430 9029167
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5414600291
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.5720387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.5620387270
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.6912819281 16049721
MESH:D010018 Osteomalacia Phenobarbital 4.7617016548
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.5416540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.5416965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9911578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.932563599
MESH:D011230 Precancerous Conditions Phenobarbital 9.932563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5911222880 11118676 11399792 11896295
MESH:D011537 Pruritus Ethinyl Estradiol 3.7115861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 4.9412752131
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012640 Seizures 2,4-dinitrotoluene 6.5318551238
MESH:D012640 Seizures Phenobarbital 6.534039156 3137016 11442880 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 5.226407741
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1516192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3816709447
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.897505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.891399818
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.3716049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.7110091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6314692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8214671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
Pathway ID Pathway Name
KEGG:04120 Ubiquitin mediated proteolysis
Pharmacogenomics Knowledge Base Top
Drug Bank Top

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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