AutismKB 2.0

Annotation Detail for TPX2


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Basic Information Top
Gene Symbol:TPX2 ( C20orf1,C20orf2,DIL-2,DIL2,FLS353,GD:C20orf1,HCA519,HCTP4,REPP86,p100 )
Gene Full Name: TPX2, microtubule-associated, homolog (Xenopus laevis)
Band: 20q11.21
Quick LinksEntrez ID:22974; OMIM: 605917; Uniprot ID:TPX2_HUMAN; ENSEMBL ID: ENSG00000088325; HGNC ID: 1249
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200087PLK1 signaling events
200166Aurora A signaling
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C063002 2,3-dimethoxy-1,4-naphthoquinone 2,3-dimethoxy-1,4-naphthoquinone results in increased expression of TPX2 mRNAincreases expression 19031421
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of TPX2 proteinaffects expression 20106945
C015001 arsenite arsenite results in decreased expression of TPX2 mRNAdecreases expression 18929588
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TPX2 mRNAdecreases expression 19150397
20382639
C053541 bicalutamide bicalutamide results in decreased expression of TPX2 mRNAdecreases expression 15638997
C006780 bisphenol A bisphenol A results in decreased expression of TPX2 mRNAdecreases expression 17706920
C006780 bisphenol A LHB protein affects the reaction [bisphenol A results in decreased expression of TPX2 mRNA]affects reaction|decreases expression 17706920
D002104 Cadmium Cadmium results in increased expression of TPX2 mRNAincreases expression 19031421
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of TPX2 mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in decreased expression of TPX2 mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of TPX2 mRNAdecreases expression 18042831
C051890 irinotecan irinotecan metabolite results in decreased expression of TPX2 mRNAdecreases expression 15956246
C051890 irinotecan irinotecan results in decreased expression of TPX2 mRNAdecreases expression 15956246
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of TPX2 mRNAincreases expression 20713471
D015741 Metribolone Metribolone results in increased expression of TPX2 mRNAincreases expression 17010196
C080955 N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased expression of TPX2 mRNAdecreases expression 11494140
D009532 Nickel Nickel results in increased expression of TPX2 mRNAincreases expression 19031421
C041786 palm oil palm oil results in decreased expression of TPX2 mRNAdecreases expression 18042831
C487081 PXD101 PXD101 results in decreased expression of TPX2 mRNAdecreases expression 19606018
C017947 sodium arsenite sodium arsenite results in decreased expression of TPX2 mRNAdecreases expression 17998272
D013750 Tetrachloroethylene Tetrachloroethylene results in increased expression of TPX2 mRNAincreases expression 19031421
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased expression of TPX2 mRNAincreases expression 19031421
C496197 trans-10,cis-12-conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid results in decreased expression of TPX2 mRNAdecreases expression 17951470
D014212 Tretinoin Tretinoin results in decreased expression of TPX2 mRNAdecreases expression 16249480
C012589 trichostatin A trichostatin A results in decreased expression of TPX2 mRNAdecreases expression 19606018
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury Nickel 4.4416166738
MESH:D000236 Adenoma Methylcholanthrene 3.416695378 10545420
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.5515276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.7517306315 16712894
MESH:D000505 Alopecia Tretinoin 3.4915955085
MESH:D001161 Arteriosclerosis Dietary Fats 3.7415238619
MESH:D001169 Arthritis, Experimental Tretinoin 2.9816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2316292516
MESH:D001249 Asthma Tretinoin 2.3016456186
MESH:D050197 Atherosclerosis Cadmium 6.8115687053
MESH:D050197 Atherosclerosis Methylcholanthrene 6.8111922910
MESH:D001471 Barrett Esophagus Tretinoin 4.2516935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.4716206674 16197459
MESH:D001862 Bone Resorption bisphenol A 3.7211985600
MESH:D001943 Breast Neoplasms bisphenol A 2.9117123778
MESH:D001943 Breast Neoplasms Dietary Fats 2.9120435547
MESH:D001943 Breast Neoplasms Methylcholanthrene 2.9117474063
MESH:D001943 Breast Neoplasms Nickel 2.9115986119
MESH:D001943 Breast Neoplasms Tetrachloroethylene 2.9115986119
MESH:D001943 Breast Neoplasms Tretinoin 2.9116873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.4416813970
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.6316050911 15673190 16192424 15721981 3786805 16097048 10355542 18705752 16011737 16124888 16227642 15700767
MESH:D002277 Carcinoma Methylcholanthrene 3.8510545420
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.0116168501
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.3912619106 12907637 21507988
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.3918788625
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 6.3916507464 17306315 15276417
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.391917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.8417123778
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 7.3718572023
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 7.3718922899
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.3716051514 16096774
MESH:D002386 Cataract Tretinoin 3.0117460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 20.0120889678
MESH:D002471 Cell Transformation, Neoplastic Cadmium 20.0117332340
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 20.0112371664
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 20.0116192471
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 20.0120056578 19524636
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.4416129372
MESH:D002779 Cholestasis Cyclosporine 2.8019486331
MESH:D002822 Choriocarcinoma Tretinoin 5.0116461808
MESH:D002972 Cleft Palate Tretinoin 2.619407595
MESH:D003092 Colitis Tretinoin 3.5517035595
MESH:D003110 Colonic Neoplasms arsenite 4.0015037631
MESH:D003110 Colonic Neoplasms irinotecan 4.0017287894 17725105
MESH:D015179 Colorectal Neoplasms irinotecan 2.3616391804 18259882 18509181 16303861 15273666 17159606 17454858
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.8117551590 8800419 14991402 9211117 10589399 9224671 9664655 16925845 9125849 9142499
MESH:D017449 Dermatitis, Allergic Contact Nickel 3.8019470301 17100760 17244072
MESH:D003877 Dermatitis, Contact Nickel 4.492952479
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 2.0017522070 6623471 7179309 7440962 16177239 15998439 15968718 3732212 15027814 7120509 10092053 19336974 19085960 11566570 6884620 16227642 4309450 3786805 10915739 21278145 9327722 2869522
MESH:D050171 Dyslipidemias Dietary Fats 3.3418367378
MESH:D004487 Edema Tetradecanoylphorbol Acetate 3.489599246 11698051 8273558 8113982 16716910 7812673 15177302
MESH:D004489 Edema, Cardiac Tretinoin 4.3218230668
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 5.4919294695
MESH:D016889 Endometrial Neoplasms Tretinoin 3.0116569247
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.0420426865
MESH:D005124 Eye Abnormalities Tretinoin 3.4616938888 9664655
MESH:D005234 Fatty Liver arsenite 17.6618296743
MESH:D005234 Fatty Liver Carbon Tetrachloride 17.6617595544 15959796 16239168 16045604 12631006 12795759 61145 19224547
MESH:D005234 Fatty Liver Cyclosporine 17.6619224547
MESH:D005234 Fatty Liver Dietary Fats 17.6618296743 17967931 19004024 19551842
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.7910962813 14633661
MESH:D005355 Fibrosis arsenite 26.1518296743
MESH:D005355 Fibrosis Carbon Tetrachloride 26.1518705752
MESH:D005355 Fibrosis Cyclosporine 26.1512168785 12639820
MESH:D005355 Fibrosis Dietary Fats 26.1518296743
MESH:D005355 Fibrosis Tretinoin 26.1517994277
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.5316452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.078708960
MESH:D005909 Glioblastoma Tretinoin 7.0917312396
MESH:D005909 Glioblastoma trichostatin A 7.0918801729
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.0816096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.0116084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.829664655 14991402
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2715720958
MESH:D006505 Hepatitis Carbon Tetrachloride 3.4519900420 19110552
MESH:D015658 HIV Infections Nickel 3.7417263646
MESH:D006689 Hodgkin Disease sodium arsenite 3.0312676792
MESH:D006930 Hyperalgesia Tretinoin 3.0916870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3816899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.4521332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.4216778211
MESH:D006949 Hyperlipidemias Dietary Fats 3.4721332399
MESH:D006973 Hypertension Cyclosporine 2.0410903974
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9415338365
MESH:D007248 Infertility, Male sodium arsenite 2.8915346721 12646999
MESH:D007249 Inflammation Dietary Fats 8.1320412841
MESH:D007249 Inflammation Nickel 8.1316166738
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 8.1315177302 7562506 7812673 8273558 11698051
MESH:D007333 Insulin Resistance bisphenol A 7.1616393666
MESH:D007333 Insulin Resistance Dietary Fats 7.1611836018 18457598
MESH:D007410 Intestinal Diseases Tretinoin 3.6217994277
MESH:D007569 Jaw Abnormalities Tretinoin 3.7615992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2915604871
MESH:D007674 Kidney Diseases Cadmium 9.6816226777 16962696 16322080
MESH:D007674 Kidney Diseases Cyclosporine 9.6810903974 18776723 8314463
MESH:D007674 Kidney Diseases sodium arsenite 9.6820008137
MESH:D007680 Kidney Neoplasms Cyclosporine 2.6112371664
MESH:D007938 Leukemia Tretinoin 2.7017143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.5616932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 4.0717596541 19850784 16294345
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 4.0718206229
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.0519225113 16891316 17506722 17649720 17301526 16331271 16823087 17339181 19029980 19075265 17294898 9834237 12679006 17217047 16935935 19035177 16788101 17107899 17368321 16766008 17712046 17361223 16140955 15748426 19642359
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.209224671
MESH:D008103 Liver Cirrhosis arsenite 10.6218296743
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.6216221502 17157831 16239168 11903743 11408273 16943688 17334410 21278145 17174718
MESH:D008103 Liver Cirrhosis Dietary Fats 10.6218296743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.4415959796 17557913 16015684 18251166 18481824 18429990 14716833 18412020 18263696 15730626 17766677 12898905 15931870 17761835 12389079 12632514 15893842 15338365 11481614 15123356 17721639 12741479 15052691 18339082 14620537 18210741 14724832 18395914 10355542 12586293 12445418 15996030 12667390 17714472 15057751 18376398 16116963 15673190 18279442 12546737 18205269 17805973 16136751 16248980 18418968 15818738 12649538 15362042 12666154 16027843 15925388 17708605 13678700 16033810 17481882 14716496 17869086 15650968 18472332 18472094 17525996 12445421 17640975 14748882 17922224 12958196 15876570 18006644 16011737 17900296 18166357 18277467 18187930 17976157 17565644 18395095 12609069 17823541 18156304 14512876 16638106 20821823 16097048 18420326 17698563 18317297 15370692 18054572 17631135 17944888 16192424 12632512 18705752
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.4416248980 18397230
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.5316246199 16964402 15830285 15720792 17285989
MESH:D008107 Liver Diseases Tetrachloroethylene 4.5317267091
MESH:D017093 Liver Failure Carbon Tetrachloride 4.0115123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.5616899240 14706259
MESH:D008113 Liver Neoplasms Aflatoxin B1 7.1618177683 15890375 2125692 9163691
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.1619294768
MESH:D008113 Liver Neoplasms sodium arsenite 7.1615276417 16712894
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 13.488603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 13.4812014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 13.481399818 598648
MESH:D008114 Liver Neoplasms, Experimental Tetrachloroethylene 13.487955063
MESH:D008171 Lung Diseases sodium arsenite 3.0719095001
MESH:D008175 Lung Neoplasms Aflatoxin B1 6.4314755239
MESH:D008175 Lung Neoplasms arsenite 6.4316809336
MESH:D008175 Lung Neoplasms Methylcholanthrene 6.4317909032 9230183 16337739 20970405 6695378 15390079 21163286 16271038 20512841 1399818 10545420 7750092 11893704
MESH:D008175 Lung Neoplasms sodium arsenite 6.4317306315 15276417 16712894 17077188 19931552
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 6.4311807781
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 3.268985016
MESH:D008527 Medulloblastoma Tretinoin 2.7317453147
MESH:D008545 Melanoma N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 7.1816487513
MESH:D008545 Melanoma sodium arsenite 7.1819082730 16487513
MESH:D008545 Melanoma Tretinoin 7.1816752155
MESH:D008545 Melanoma trichostatin A 7.1816505122
MESH:D008591 Meningomyelocele Tretinoin 4.2716940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6416801185
MESH:D052016 Mucositis irinotecan 4.8617159606
MESH:D009101 Multiple Myeloma trichostatin A 3.7618172295
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.9917596541
MESH:D009362 Neoplasm Metastasis irinotecan 3.1118259882
MESH:D009369 Neoplasms sodium arsenite 8.0811559025
MESH:D009369 Neoplasms Tetrachloroethylene 8.0811911487
MESH:D009369 Neoplasms Tretinoin 8.0816946489 16594593
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.5220056578
MESH:D009389 Neovascularization, Pathologic arsenite 4.2615738583
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1519348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 9.3011399458 16427766
MESH:D009421 Nervous System Malformations Tretinoin 9.309125849
MESH:D009436 Neural Tube Defects sodium arsenite 6.9812854658
MESH:D009436 Neural Tube Defects Tretinoin 6.989142499
MESH:D009447 Neuroblastoma irinotecan 3.408761367
MESH:D017599 Neuroectodermal Tumors irinotecan 4.588761367
MESH:D009765 Obesity Dietary Fats 2.2517217161 18674790 11836018 20132043 20518802 21332399 18457598 16723640 19632207
MESH:D010049 Ovarian Diseases bisphenol A 4.8411985600
MESH:D010051 Ovarian Neoplasms sodium arsenite 7.7215276417 17306315
MESH:D010051 Ovarian Neoplasms Tretinoin 7.7216936753
MESH:D010051 Ovarian Neoplasms trichostatin A 7.7219331143
MESH:D010146 Pain Tretinoin 2.7816870215
MESH:D010190 Pancreatic Neoplasms N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 12.0311504793
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 12.0315976015
MESH:D010190 Pancreatic Neoplasms Tretinoin 12.0315976015
MESH:D010190 Pancreatic Neoplasms trichostatin A 12.0319294695
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 4.1418922899 12065085 8330346 18404319
MESH:D016491 Peripheral Vascular Diseases Cadmium 5.2315687053
MESH:D011230 Precancerous Conditions Cyclosporine 3.0912371664
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 3.8010548101
MESH:D055728 Primary Myelofibrosis trichostatin A 5.1017616702
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.0720887781
MESH:D011471 Prostatic Neoplasms bicalutamide 1.9218487222 17914592 19240160 15638997 19011039
MESH:D011471 Prostatic Neoplasms bisphenol A 1.9216740699
MESH:D011471 Prostatic Neoplasms Cadmium 1.9217075824
MESH:D011471 Prostatic Neoplasms sodium arsenite 1.9216039940
MESH:D011471 Prostatic Neoplasms trichostatin A 1.9219789329 18798265
MESH:D011507 Proteinuria Tretinoin 3.4616636307
MESH:D011565 Psoriasis Cyclosporine 2.1816882103
MESH:D011625 Pterygium Tretinoin 4.6416723453
MESH:D011629 Puberty, Precocious bisphenol A 4.6310548101
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.9616283617 16116481
MESH:D012878 Skin Neoplasms sodium arsenite 9.1919524636 18572023
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 9.198330346 12065085 8985016 11807781 18404319
MESH:D012878 Skin Neoplasms Tretinoin 9.1916467112
MESH:D016135 Spinal Dysraphism sodium arsenite 3.6812854658
MESH:D013274 Stomach Neoplasms irinotecan 2.6015723263
MESH:D013274 Stomach Neoplasms Tretinoin 2.6017261132
MESH:D019966 Substance-Related Disorders bisphenol A 3.8316045194 16684133
MESH:D013964 Thyroid Neoplasms Tretinoin 2.9116026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.6516051514
MESH:D014376 Tuberculosis Tretinoin 3.1316040207
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 2.4517306315 16712894 16452187 11723127
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 8.9611813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 8.9616129372
MESH:D014591 Uterine Diseases bisphenol A 4.8614652134
MESH:D014604 Uveal Neoplasms Tretinoin 4.4616752155
MESH:D014605 Uveitis Cyclosporine 3.831336536
MESH:D014652 Vascular Diseases sodium arsenite 4.2717056641
MESH:D014820 Vitiligo Tretinoin 3.9116761959
MESH:D015430 Weight Gain Dietary Fats 3.6116723640
MESH:D009396 Wilms Tumor Tretinoin 3.8416287080
MESH:D014985 Xerophthalmia Cyclosporine 4.2917120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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