AutismKB 2.0

Annotation Detail for PDCD11


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Basic Information Top
Gene Symbol:PDCD11 ( ALG-4,ALG4,KIAA0185,NFBP,RRP5 )
Gene Full Name: programmed cell death 11
Band: 10q24.33
Quick LinksEntrez ID:22984; OMIM: 612333; Uniprot ID:RRP5_HUMAN; ENSEMBL ID: ENSG00000148843; HGNC ID: 13408
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PDCD11 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PDCD11 mRNAaffects expression 21346803
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of PDCD11 mRNAaffects expression 21346803
C014949 acetylhydrazine acetylhydrazine results in decreased expression of PDCD11 mRNAdecreases expression 15282401
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PDCD11 mRNAaffects cotreatment|affects expression 17602206
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PDCD11 mRNAaffects cotreatment|affects expression 17602206
D004317 Doxorubicin Doxorubicin results in decreased expression of PDCD11 mRNAdecreases expression 16243910
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 4.347525203
MESH:D000230 Adenocarcinoma Doxorubicin 2.6217418594
MESH:D000236 Adenoma Diethylnitrosamine 2.996695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.3018056438 19052882 16434500 17162532 19061943 17620307
MESH:D000419 Albuminuria Doxorubicin 4.8721441931
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 5.1414601052
MESH:D001932 Brain Neoplasms Doxorubicin 4.0717150277
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2817474063
MESH:D001943 Breast Neoplasms Doxorubicin 2.2817369602 16935488 11325840 15136595 16595493 15634643 15993339 18628466 17983394 16322301 18382427 19526202 18234424 15939500 15692762 16096432 15994142 15567936 16826403 16264153 16115903 18695136 15668708 17426702
MESH:D002276 Carcinoid Tumor Doxorubicin 5.2516051944
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.8916705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.8916705839
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.8919171122 18971187 16569478 19519916 17138121 20007298 19052882 16878318 19539802 20432363 18393292 19335982 17978847 19107877 16288022 19418558 17428255 18056438 17173139 18494052 19919837 16698587 20514400 16502159 16807293 20101231 19701751 18978308 10672840 18691550 17761372 19822196 16935385 20084675 19208518 19394651 20214788 16830150 20935162 18665156 18210153 20727157 18785209 10737359 17055752 20512989 3084413 21159647 18506893 17162532 20524982 16328049 18788625 16779866 16681979 19383236 3581430 11831363 16540662
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 6.8918059187 16023760 17876044 16234567
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.271485588 16201981
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 2.706189445
MESH:D009202 Cardiomyopathies Doxorubicin 3.7017382496 16278810 15505089 16952015 15792986 16455267 16364871 17308081 16731534 17924179 18627295 17928571 15811867 17974986 17131338 17007740 17329180 16242529 17519947 16612575 15476868 16269455 16651473 17351982 16109756
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 3.0216243910 17334414
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 3.7814694615
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.316135515
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 7.317505956 17174075 21159647 2727394
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.9319052882
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.1418259882 18802399
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 4.4115095906
MESH:D003490 Cyanosis 2,4-dinitrotoluene 12.1218551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 12.1218551238
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2420387270
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.8021346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.8018551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 12.8021346803
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 12.8019107877
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 12.8017416283
MESH:D004362 Drug Toxicity Doxorubicin 3.8718602426
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.6217359293
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.6018037988
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.5616302075
MESH:D005234 Fatty Liver Diethylnitrosamine 3.4620387270 21071580
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.9819069698
MESH:D005909 Glioblastoma Doxorubicin 3.5217150277
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.7015692506
MESH:D006331 Heart Diseases Doxorubicin 3.6716495754 12587719 18006777 16330681 17875725 17888722 16879835 16144979 14766674 16244371 16244372 18674790 16707910
MESH:D006333 Heart Failure Doxorubicin 3.5017481944
MESH:D006394 Hemangiosarcoma Doxorubicin 4.1815692506
MESH:D006689 Hodgkin Disease Doxorubicin 3.6515147373 18501091 17606976
MESH:D007249 Inflammation Diethylnitrosamine 2.5018785209
MESH:D007674 Kidney Diseases Doxorubicin 3.2015369732 15699352 16775033
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.4416707910
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 8.1516705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.1516705839
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.6016085563
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9619638242 20032147 18522880 18665156 18407596
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 2.1516595196 16439617
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1517034775
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 8.047678174
MESH:D008113 Liver Neoplasms Clofibric Acid 8.0417602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 8.0420501860 21278145 19427195 19426721 19255062 20452335 19642983 20101389 19073162 19690152 20405173 12112319 21071580 19812893 18978307 12771043 19850985 20137499 19551842 15175105 2862719 18648771 20434301 19499222 21167192 19254457 20492335 9163691 19090486 19256749 2422723 19638242 20583210 18754104 16942905 18644402 15885732 19833225 10737359 21047994 20118626 18977376 19294768 19996281
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.862876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.8617854601 18079962 17942915 3124819 19539802 18775883 16267830 18544905 19009564 18093689 16842330 18282651 19004024 21159647 9362446 2563599 18253720 19126423 17174075 19519916 18308698 18164116
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 10.8616842330 17085340
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.6520512841 20970405 6695378 21163286
MESH:D008175 Lung Neoplasms Doxorubicin 2.6517418594 6189445
MESH:D008223 Lymphoma Doxorubicin 3.6516098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 4.0217654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.9315621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 3.1915458769
MESH:D008545 Melanoma Doxorubicin 2.3216827129
MESH:D008654 Mesothelioma Doxorubicin 3.1517638057
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.7815792986
MESH:D052016 Mucositis Doxorubicin 5.1917415656
MESH:D009203 Myocardial Infarction Doxorubicin 3.0415857846 19429709
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.7018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.707678174 18551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 6.199029167 3581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 6.1918259882
MESH:D009401 Nephrosis Doxorubicin 5.1316899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 4.2515640375 16889571
MESH:D009447 Neuroblastoma Doxorubicin 3.3915555623
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.5720387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.5620387270
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 16.7512819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 16.7516049721
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 16.7514694615
MESH:D012516 Osteosarcoma Doxorubicin 4.3415930896
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.5016540662
MESH:D003557 Phyllodes Tumor Doxorubicin 5.6017983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.6017638057
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.802563599
MESH:D011471 Prostatic Neoplasms Doxorubicin 3.5115897917 16868541 16888761 15749863 18437689 16729912
MESH:D051437 Renal Insufficiency Doxorubicin 4.5817922066
MESH:D012509 Sarcoma Doxorubicin 4.2518313854 16767912 17710206 17203757 15625365 15675481
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.5714601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 5.1917846226
MESH:D012640 Seizures 2,4-dinitrotoluene 6.4718551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.4718551238
MESH:D012878 Skin Neoplasms Doxorubicin 3.0615692506
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.9316767912 15625365 17203757
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 8.007505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 8.0016010429 17909728
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.8916049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.8916049721
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 8.8917653716
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.3510091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.3510091137
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.5817678736 16364871 17334414 17638931
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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