AutismKB 2.0

Annotation Detail for SORCS3


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Basic Information Top
Gene Symbol:SORCS3 ( SORCS )
Gene Full Name: sortilin-related VPS10 domain containing receptor 3
Band: 10q25.1
Quick LinksEntrez ID:22986; OMIM: 606285; Uniprot ID:SORC3_HUMAN; ENSEMBL ID: ENSG00000156395; HGNC ID: 16699
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of SORCS3 mRNAincreases expression 18648102
C018021 cobaltous chloride cobaltous chloride results in increased expression of SORCS3 mRNAincreases expression 20105288
C002802 tungsten carbide tungsten carbide affects the expression of SORCS3 mRNAaffects expression 20105288
C025643 vinclozolin vinclozolin affects the expression of SORCS3 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.963712494
MESH:D001008 Anxiety Disorders vinclozolin 3.9719015723
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.7411289319 1440618
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 1.783581430 7296757
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.837296757
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 3.027505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.449022650 19486331
MESH:D003456 Cryptorchidism vinclozolin 4.8514966744
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 9.192524372 18759878 11906362 8970840 14531868 11298694 8156756 12868966
MESH:D017449 Dermatitis, Allergic Contact cobaltous chloride 9.1915059100 16823706 11298694
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.953621924 2952479
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 2.0418289764 1440618 18648102 6679447 18692083 7440962 8291058 9022650 16192314 9653073 11289319 6482804 9328219
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.183581430
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.746705139
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.5716973722
MESH:D005832 Genital Diseases, Male vinclozolin 6.0216417039
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.507505956
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 4.026705139
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.5015034207
MESH:D007248 Infertility, Male vinclozolin 3.2916467254
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.748074119 9022650
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.316582329
MESH:D007984 Leydig Cell Tumor vinclozolin 5.3616417039
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.4215034207 9327722
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.75598648 6587162 1399818 3712494
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.593581430
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.156679447
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.816482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.743988306
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 4.047296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 5.196228378
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.5318042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.5718220299
MESH:D011472 Prostatitis vinclozolin 5.5718629315
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.673692021
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.197505956 6582329 3712494 6587162 1399818
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.408074119
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134949387
    • No data
    Releated disease ID Related disease Name
    PA443319Alzheimer Disease
    No data
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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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