AutismKB 2.0

Annotation Detail for AZI1


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Basic Information Top
Gene Symbol:AZI1 ( AZ1,Cep131,ZA1 )
Gene Full Name: 5-azacytidine induced 1
Band: 17q25.3
Quick LinksEntrez ID:22994; OMIM: 613479; Uniprot ID:AZI1_HUMAN; ENSEMBL ID: ENSG00000141577; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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No data
Pathway IDPathway Name
Cell Cycle, Mitotic
No data
No data
Pathway IDPathway Name
500383Loss of proteins required for interphase microtubule organization from the centrosome
500384Loss of Nlp from mitotic centrosomes
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of AZI1 mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of AZI1 mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of AZI1 mRNAdecreases expression 20504355
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of AZI1 mRNAincreases expression 17942748
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of AZI1 mRNAaffects binding|decreases expression|increases activity 19710929
D014028 Tobacco Smoke Pollution Tobacco Smoke Pollution results in decreased expression of AZI1 mRNAdecreases expression 18087596
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.4617505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.4718653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.3920127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3914692618
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Tobacco Smoke Pollution 6.0515814487
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 7.153712494
MESH:D000236 Adenoma Benzo(a)pyrene 7.156695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.9416434500
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4919183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8415885639
MESH:D001172 Arthritis, Rheumatoid Tobacco Smoke Pollution 3.2419898480
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.5411289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4719483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0020146248 17474063
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 2.933581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.933084413
MESH:D002289 Carcinoma, Non-Small-Cell Lung Tobacco Smoke Pollution 3.5111212258
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.807296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 5.1520419170
MESH:D002294 Carcinoma, Squamous Cell Tobacco Smoke Pollution 5.1511212258
MESH:D002386 Cataract Acetaminophen 2.7510977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.967505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 14.7419486331 9022650
MESH:D002779 Cholestasis Ethinyl Estradiol 14.7417110522 16105132 15861022 17681005 17333356 16919318 11677210
MESH:D002779 Cholestasis pirinixic acid 14.7419176532
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.2118759878 11298694 14531868 8970840 2524372 11906362 12868966 8156756
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5518249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.843621924 2952479
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 3.961440618 9328219 8291058 9653073 6679447 18648102 7440962 11289319 9022650 18289764 16192314 18692083 6482804
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9614725611 2444490 17522070 19370779 16781746 19923254 11421492 11739529 12958197 10774834 12705907 16109766 19416960 16485898 14986274 19085960 11461765 15619225 19739265 16393943 11834606 16177239 16227642 19164858 12540782 16081117 11287661 12594235 10915739 11743745 18713872 12392966 18071297 17562736 10663392 15968718 14550746 19420014 17906064 12153990 11529661
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D004487 Edema pirinixic acid 2.8012083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.5712538720
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.583581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5816530937
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.6515345470
MESH:D005234 Fatty Liver pirinixic acid 8.6519236843 20131406
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.546705139
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.397505956
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8020471113
MESH:D006333 Heart Failure pirinixic acid 2.7120558911
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.896705139
MESH:D006529 Hepatomegaly pirinixic acid 3.4119176532 18467677 19772884 16221962
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D006943 Hyperglycemia pirinixic acid 3.4920558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.3615034207
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2316569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6817937319
MESH:D007249 Inflammation Tobacco Smoke Pollution 3.4818590791
MESH:D007333 Insulin Resistance pirinixic acid 2.8216306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.548074119 9022650
MESH:D007674 Kidney Diseases Acetaminophen 2.3612587719 15629191
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.236582329
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3815034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 1.6919014921 11587558 19460945 16611625 12969438 12587719 16610002 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5417185352 16871587
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.7020195826 21137059
MESH:D008113 Liver Neoplasms pirinixic acid 4.7016377806 15890375 20007298
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.71598648 6587162 1399818 3712494
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.8020064080 20464547 20869020 17053015 20135361 18520028 18569708 18816296 6695378
MESH:D008175 Lung Neoplasms Tobacco Smoke Pollution 2.8012111688 3440675 16288123 11091918
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 9.6116381670
MESH:D009062 Mouth Neoplasms Tobacco Smoke Pollution 9.6115006635
MESH:D009135 Muscular Diseases pirinixic acid 3.9216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2519151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1916411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.573581430
MESH:D009369 Neoplasms Benzo(a)pyrene 5.2811141357
MESH:D009369 Neoplasms pirinixic acid 5.2817405874
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.106679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D009765 Obesity pirinixic acid 1.8720558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.726482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.543988306
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0411578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.907296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.996228378
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9217292933
MESH:D011537 Pruritus Ethinyl Estradiol 3.7716919318 15861022
MESH:D015427 Reperfusion Injury pirinixic acid 2.5219058328
MESH:D012135 Respiratory Sounds Tobacco Smoke Pollution 5.0418410779
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.613692021
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 6.4510029692 19755658
MESH:D012878 Skin Neoplasms Tobacco Smoke Pollution 6.4518590791
MESH:D013088 Spermatocele Ethinyl Estradiol 4.4616709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4415669648
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.127505956 6582329 6587162 3712494 1399818
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 9.028074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 9.0217053015
MESH:D001749 Urinary Bladder Neoplasms Tobacco Smoke Pollution 9.0212846360
MESH:D014581 Urticaria Acetaminophen 3.3310982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6814692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8714671159 15869587
Pathway ID Pathway Name
REACT:152 Cell Cycle, Mitotic
Pharmacogenomics Knowledge Base Top
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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