AutismKB 2.0

Annotation Detail for TTC39A


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Basic Information Top
Gene Symbol:TTC39A ( C1orf34,DEME-6,KIAA0452 )
Gene Full Name: tetratricopeptide repeat domain 39A
Band: 1p32.3
Quick LinksEntrez ID:22996; OMIM: NA; Uniprot ID:TT39A_HUMAN; ENSEMBL ID: ENSG00000085831; HGNC ID: 18657
Relate to Another Database: SFARIGene; denovo-db
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of TTC39A mRNAaffects expression 17562736
C030123 coumarin coumarin results in increased expression of TTC39A mRNAincreases expression 18480146
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of TTC39A mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of TTC39A mRNAincreases expression 19482888
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TTC39A mRNAaffects binding|decreases expression|increases activity 19710929
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 4.076195326
MESH:D055371 Acute Lung Injury pirinixic acid 3.5818653653
MESH:D018248 Adenoma, Liver Cell Phenobarbital 12.3217620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 12.3216434500
MESH:D000799 Angioedema Acetaminophen 4.5710982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.5719483382
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.023084413
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 3.0220007298 17173139 6705139 1701930 20935162
MESH:D002386 Cataract Acetaminophen 2.7910977129
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.814080065
MESH:D002779 Cholestasis pirinixic acid 3.1219176532
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5718249437
MESH:D003924 Diabetes Mellitus, Type 2 coumarin 3.2719647726
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6716177239 14550746 11421492 14725611 12958197 16393943 17522070 17562736 19085960 19370779 19164858 10663392 15968718 12705907 16081117 15619225 19923254 10915739 16109766 11743745 12594235 18071297 14986274 11461765 2444490 19416960 16227642 12392966 11834606 18713872 10774834 12540782 11529661 12153990 17906064 16781746 11287661 16485898 19420014 19739265 11739529
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.8219426721
MESH:D004421 Dystonia Phenobarbital 4.471851702
MESH:D004487 Edema pirinixic acid 2.9012083418
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.673659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.5911558140 3922381
MESH:D004827 Epilepsy Phenobarbital 3.0620417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.916401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.817750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.653659116
MESH:D005234 Fatty Liver pirinixic acid 3.1919236843 20131406
MESH:D005756 Gastritis Acetaminophen 4.4016983495
MESH:D006333 Heart Failure pirinixic acid 2.7620558911
MESH:D006529 Hepatomegaly Phenobarbital 10.4116109766
MESH:D006529 Hepatomegaly pirinixic acid 10.4119176532 19772884 16221962 18467677
MESH:D006930 Hyperalgesia Acetaminophen 3.0216870215
MESH:D006943 Hyperglycemia pirinixic acid 3.5820558911
MESH:D007333 Insulin Resistance pirinixic acid 2.8716306350
MESH:D007674 Kidney Diseases Acetaminophen 2.4012587719 15629191
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0821047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 4.2019014921 16611625 11587558 12969438 16610002 19460945 19784758 12587719
MESH:D008107 Liver Diseases Phenobarbital 4.2019363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.6316871587 17185352
MESH:D008113 Liver Neoplasms Phenobarbital 4.8719812893 15975961 8742319 19482888 21047994 19073162
MESH:D008113 Liver Neoplasms pirinixic acid 4.8720007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 2.922563599 17172636 1399818 18308698 6150874
MESH:D008546 Melanoma, Experimental Acetaminophen 4.1319513568
MESH:D009135 Muscular Diseases pirinixic acid 4.0716239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2719151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2516411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 5.1117484760
MESH:D009369 Neoplasms pirinixic acid 2.1117405874
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2118514411
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D010018 Osteomalacia Phenobarbital 5.0017016548
MESH:D010146 Pain Acetaminophen 2.7316870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.6016965848
MESH:D011230 Precancerous Conditions Phenobarbital 3.992563599
MESH:D019310 Pseudolymphoma Phenobarbital 5.2212752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.5519058328
MESH:D012640 Seizures Phenobarbital 2.954039156 3137016 16876388 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 5.456407741
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.361399818
MESH:D014581 Urticaria Acetaminophen 3.4410982225
MESH:D014689 Venous Insufficiency coumarin 6.5012708602
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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