AutismKB 2.0

Annotation Detail for LIMCH1


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Basic Information Top
Gene Symbol:LIMCH1 ( DKFZp434I0312,DKFZp686A01247,DKFZp686B2470,DKFZp686G18243,DKFZp686G2094,DKFZp781C1754,DKFZp781I1455,LIMCH1A,LMO7B,MGC72127 )
Gene Full Name: LIM and calponin homology domains 1
Band: 4p13
Quick LinksEntrez ID:22998; OMIM: NA; Uniprot ID:LIMC1_HUMAN; ENSEMBL ID: ENSG00000064042; HGNC ID: 29191
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of LIMCH1 mRNAincreases expression 16788091
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of LIMCH1 mRNAdecreases expression 19150397
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of LIMCH1 mRNAincreases expression 15336504
D002945 Cisplatin LIMCH1 protein affects the susceptibility to Cisplatinaffects response to substance 16217747
D002117 Calcitriol Calcitriol results in decreased expression of LIMCH1 mRNAdecreases expression 16002434
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of LIMCH1 mRNAaffects cotreatment|increases expression 19619570
D004958 Estradiol Estradiol results in increased expression of LIMCH1 mRNAincreases expression 19619570
D005047 Etoposide LIMCH1 protein affects the susceptibility to Etoposideaffects response to substance 16217747
D016685 Mitomycin LIMCH1 protein affects the susceptibility to Mitomycinaffects response to substance 16217747
D012643 Selenium [Selenium co-treated with Vitamin E] results in decreased expression of LIMCH1 mRNAaffects cotreatment|decreases expression 19244175
D012643 Selenium Selenium results in decreased expression of LIMCH1 mRNAdecreases expression 19244175
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of LIMCH1 mRNAaffects cotreatment|increases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of LIMCH1 mRNAincreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of LIMCH1 mRNAincreases expression 19465110
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in decreased expression of LIMCH1 mRNAaffects cotreatment|decreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0414514962 15322242 11752688
MESH:D058186 Acute Kidney Injury Cisplatin 4.1015814532 12690470 17670903
MESH:D000230 Adenocarcinoma Cisplatin 4.6711798837 17638652
MESH:D000230 Adenocarcinoma Estradiol 4.6711473722
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5716835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 12.9714601052
MESH:D019046 Bone Marrow Neoplasms Etoposide 12.9714601052
MESH:D001943 Breast Neoplasms Calcitriol 2.3911237771
MESH:D001943 Breast Neoplasms Cisplatin 2.3919526202 18382427
MESH:D001943 Breast Neoplasms Estradiol 2.3917289903 16675129 12948864 19861407 14630087 17261762 18497071 17018787
MESH:D001943 Breast Neoplasms Etoposide 2.3916322251
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3920435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.6616111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1116050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 3.2617982673
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.2616924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.0816685392 12023789
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 5.0911237771
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 5.0917066447 18337622 6189445
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4418850075 18670907 16120746
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.9620889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.9618566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1516354765 8697196 12621046 15340226 15668235
MESH:D003092 Colitis Selenium 3.9517936198
MESH:D015179 Colorectal Neoplasms Cisplatin 2.3315273666
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5210048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.5219769572
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.5419279558
MESH:D056486 Drug-Induced Liver Injury Selenium 3.8915131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8920420201
MESH:D004362 Drug Toxicity Cisplatin 8.5212649298 19839026 12231392 15033597
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.5211462148
MESH:C538011 Eales disease Vitamin E 4.929068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1215322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.0915138306
MESH:D016889 Endometrial Neoplasms Estradiol 3.0711473722 19148513 18566989
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1510568697 9294722
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.7420426865
MESH:D004938 Esophageal Neoplasms Cisplatin 4.7415464296 16785472 15173087 16481741 17638652
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.1220067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006258 Head and Neck Neoplasms Cisplatin 3.8015464296 15102660
MESH:D034381 Hearing Loss Cisplatin 4.4219898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.5415464296
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.8010048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 6.8016080930
MESH:D006333 Heart Failure Selenium 3.1517162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0715340226 16120746 12621046
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7416490937 16863852
MESH:D006558 Herpes Genitalis Estradiol 5.2515709030
MESH:D006561 Herpes Simplex Etoposide 4.7610809021
MESH:D006689 Hodgkin Disease Cisplatin 8.2216170182 16200630
MESH:D006689 Hodgkin Disease Etoposide 8.2215147373 18180244 16135485 17606976 16200630
MESH:D019584 Hot Flashes Estradiol 10.7917088409
MESH:D019584 Hot Flashes Vitamin E 10.7914716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2616959395 8697196 16354765 15340226 18606429
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9518850075 18670907
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9212878042 12200463
MESH:D007251 Influenza, Human Selenium 11.7016624496
MESH:D007251 Influenza, Human Vitamin E 11.7016624496
MESH:D007333 Insulin Resistance Estradiol 3.0516627594 16393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.3615464296
MESH:D007674 Kidney Diseases Cisplatin 10.6319839026 12649298 15190930 18289764 12231392
MESH:D007674 Kidney Diseases Estradiol 10.6315618244
MESH:D007674 Kidney Diseases Vitamin E 10.6312488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.0216518626
MESH:D007680 Kidney Neoplasms Estradiol 3.0915610895
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 5.0111231351
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.5314716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5312878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.5316169303
MESH:D008113 Liver Neoplasms Mitomycin 4.9415113037
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.9416984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.1912151625
MESH:D008171 Lung Diseases Vitamin E 3.2716863852
MESH:D008175 Lung Neoplasms Cisplatin 3.5411798837 17225452 6189445
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5419555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 3.5411062179
MESH:D008223 Lymphoma Etoposide 4.0212556972 12854902
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.3117203775 11807958 11408345 16891317
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.3115318939
MESH:D020149 Manganese Poisoning Estradiol 4.7019453300
MESH:D008545 Melanoma Cisplatin 2.4912374674 15577323 18176117 18505091 17023156 16248763 12393984 16432458 11135225 17761969 18332650 16809738 12883367
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.9715990972
MESH:D008654 Mesothelioma Cisplatin 6.5217638057
MESH:D008654 Mesothelioma Selenium 6.5215107826
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3916810080
MESH:D009369 Neoplasms Cisplatin 3.0016773208
MESH:D009389 Neovascularization, Pathologic Estradiol 3.9317289903
MESH:D009395 Nephritis, Interstitial Cisplatin 4.7115464296
MESH:D009421 Nervous System Malformations Estradiol 10.0116427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.0114600291
MESH:D009447 Neuroblastoma Cisplatin 3.518761367
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.898761367
MESH:D010051 Ovarian Neoplasms Cisplatin 5.1319769630 17225452 6897625 15464296
MESH:D010051 Ovarian Neoplasms Estradiol 5.1319401270
MESH:D010190 Pancreatic Neoplasms Cisplatin 9.1919003803
MESH:D010190 Pancreatic Neoplasms Etoposide 9.1919003803
MESH:D010190 Pancreatic Neoplasms Mitomycin 9.1915113037
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.4715464296
MESH:D010954 Plasmacytoma Selenium 5.1115087411
MESH:D010997 Pleural Neoplasms Cisplatin 5.5617638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3811222880 11896295 11399792 11118676
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.9715572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0220887781
MESH:D011471 Prostatic Neoplasms Calcitriol 2.1015754350 12479363 16289102 16644109 18247401
MESH:D011471 Prostatic Neoplasms Estradiol 2.1016740699
MESH:D011471 Prostatic Neoplasms Etoposide 2.1017172428
MESH:D011471 Prostatic Neoplasms Vitamin E 2.1015084515
MESH:D051437 Renal Insufficiency Cisplatin 4.5815464296
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012512 Sarcoma, Ewing's Cisplatin 11.1714601052
MESH:D012512 Sarcoma, Ewing's Etoposide 11.1714601052
MESH:D012871 Skin Diseases Vitamin E 2.4718709164
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 5.798532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7916192470
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.5615464296
MESH:D013274 Stomach Neoplasms Cisplatin 2.3315958060 17522103 18396642
MESH:D020521 Stroke Vitamin E 3.6316517955
MESH:D013736 Testicular Neoplasms Cisplatin 4.7815464296 17225452
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D013978 Tibial Fractures Estradiol 4.9019048282
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 2.9917225452 12973940 15464296
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 4.3416803524
MESH:D014625 Vaginal Neoplasms Cisplatin 4.7815577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D014839 Vomiting Cisplatin 4.9311897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
No data
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Syndromic Genes

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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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