AutismKB 2.0

Annotation Detail for RIMS1


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Basic Information Top
Gene Symbol:RIMS1 ( CORD7,KIAA0340,MGC167823,MGC176677,RAB3IP2,RIM,RIM1 )
Gene Full Name: regulating synaptic membrane exocytosis 1
Band: 6q13
Quick LinksEntrez ID:22999; OMIM: 606629; Uniprot ID:RIMS1_HUMAN; ENSEMBL ID: ENSG00000079841; HGNC ID: 17282
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Synaptic Transmission
Pathway IDPathway Name
200160Effects of Botulinum toxin
Pathway IDPathway Name
P05734Synaptic vesicle trafficking
Pathway IDPathway Name
500153Acetylcholine Neurotransmitter Release Cycle
500147Neurotransmitter Release Cycle
500148Norepinephrine Neurotransmitter Release Cycle
500149Serotonin Neurotransmitter Release Cycle
500151Dopamine Neurotransmitter Release Cycle
500150Glutamate Neurotransmitter Release Cycle
Related Diseases/Disorders Top
No data
No data
Desease Name
NEUROLOGICAL
Cognitive performance
Desease Name
Cognitive test performance
Desease Name
Cone-rod dystrophy 7
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of RIMS1 mRNAaffects expression 16483693
D002713 Chlorine [Ozone co-treated with Chlorine] results in increased expression of RIMS1 mRNAaffects cotreatment|increases expression 18636392
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of RIMS1 mRNAdecreases expression 15834898
D005419 Flavonoids Flavonoids results in decreased expression of RIMS1 mRNAdecreases expression 18035473
D006220 Haloperidol Haloperidol results in decreased expression of RIMS1 mRNAdecreases expression 15860345
D007657 Ketone Bodies Ketone Bodies results in decreased expression of RIMS1 mRNAdecreases expression 16807920
D010126 Ozone [Ozone co-treated with Chlorine] results in increased expression of RIMS1 mRNAaffects cotreatment|increases expression 18636392
C025643 vinclozolin vinclozolin affects the expression of RIMS1 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.9018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3217505938
MESH:D055371 Acute Lung Injury Chlorine 4.5820601635
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8614692618
MESH:D000544 Alzheimer Disease Ozone 2.4815513908
MESH:D001008 Anxiety Disorders vinclozolin 3.8319015723
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8015885639
MESH:D001172 Arthritis, Rheumatoid Ozone 2.6015570426
MESH:D001249 Asthma Ozone 2.7016373670 17854713
MESH:D001321 Autistic Disorder Haloperidol 2.7218080171 19368416
MESH:D016535 Bronchial Hyperreactivity Ozone 3.8717626835 18417511 14754758 15516495 16777450 19059883 18315731
MESH:D002100 Cachexia Ozone 5.0816183385
MESH:D002375 Catalepsy Haloperidol 5.2515215559 1977408
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0516105132 11677210 17681005 17333356 16919318 17110522 15861022
OMIM:603649 CONE-ROD DYSTROPHY 7 marker/mechanism
MESH:D003456 Cryptorchidism vinclozolin 4.6214966744
MESH:D016757 Death, Sudden, Cardiac Haloperidol 5.1020210726
MESH:D003704 Dementia Haloperidol 4.8211575062
MESH:D004417 Dyspnea Chlorine 5.0020016425
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.4712538720
MESH:D005234 Fatty Liver Ethinyl Estradiol 3.0515345470
MESH:D005739 Gas Poisoning Chlorine 5.3920016425
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.2716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.6816417039
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1216945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.1717937319
MESH:D007248 Infertility, Male vinclozolin 7.1716467254
MESH:D007249 Inflammation Flavonoids 2.7517296493
MESH:D007984 Leydig Cell Tumor vinclozolin 5.0716417039
MESH:D008171 Lung Diseases Ozone 3.5319066396 8266340
MESH:D055370 Lung Injury Ozone 4.1520417186
MESH:D008175 Lung Neoplasms Ozone 2.108597069 7614698
MESH:D001523 Mental Disorders Haloperidol 4.3416856516
MESH:D008679 Metaplasia Ozone 5.4810496685
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9511578682
MESH:D010538 Peritonitis Ozone 4.4416369182
MESH:D011014 Pneumonia Ozone 4.7318929643 18007984 18381685
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.2318042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.2718220299
MESH:D011472 Prostatitis vinclozolin 5.2718629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.6516919318 15861022
MESH:D011595 Psychomotor Agitation Haloperidol 5.2611575062
MESH:D011618 Psychotic Disorders Haloperidol 4.4211575062
MESH:D012120 Respiration Disorders Chlorine 5.5918579056
MESH:D012559 Schizophrenia Haloperidol 2.8319369910 18513383 20107430 1830565
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3216709447
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.9920210726
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3715669648
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5814692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7815869587 14671159
Pathway ID Pathway Name
REACT:13685 Synaptic Transmission
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA38220
    • No data
    No data
    Releated drug ID Related drug Name
    PA451898vitamin c
    PA10090l-glutamine
    PA450197l-leucine
    PA448976choline
    PA449396dopamine
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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