Annotation Detail for WDFY3
Basic Information
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| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| C023514 |
2,6-dinitrotoluene |
2,6-dinitrotoluene results in decreased expression of WDFY3 mRNA | decreases expression | 20406850
|
| C023514 |
2,6-dinitrotoluene |
2,6-dinitrotoluene affects the expression of WDFY3 mRNA | affects expression | 21346803
|
| D000082 |
Acetaminophen |
Acetaminophen affects the expression of WDFY3 mRNA | affects expression | 17562736
|
| D000082 |
Acetaminophen |
MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of WDFY3 mRNA] | affects reaction|increases expression | 18700144
|
| D001564 |
Benzo(a)pyrene |
Benzo(a)pyrene results in decreased expression of WDFY3 mRNA | decreases expression | 20106945
20064835
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D000230 |
Adenocarcinoma |
|
Benzo(a)pyrene |
2.06 | 20464547 20127859 |
| MESH:D000236 |
Adenoma |
|
Benzo(a)pyrene |
2.88 | 6695378 |
| MESH:D000799 |
Angioedema |
|
Acetaminophen |
4.71 | 10982225 |
| MESH:D017544 |
Aortic Aneurysm, Abdominal |
|
Benzo(a)pyrene |
4.73 | 19183758 |
| MESH:D001321 |
Autistic Disorder |
|
Acetaminophen |
1.39 | 18445737 |
| MESH:D001943 |
Breast Neoplasms |
|
Benzo(a)pyrene |
1.99 | 20146248 17474063 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
2,6-dinitrotoluene |
2.97 | 16705839 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
Acetaminophen |
2.97 | 3084413 |
| MESH:D002294 |
Carcinoma, Squamous Cell |
|
Benzo(a)pyrene |
2.14 | 20419170 |
| MESH:D002386 |
Cataract |
|
Acetaminophen |
2.81 | 10977129 |
| MESH:D002471 |
Cell Transformation, Neoplastic |
|
2,6-dinitrotoluene |
3.06 | 6135515 |
| MESH:D003490 |
Cyanosis |
|
2,6-dinitrotoluene |
4.67 | 18551238 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
2,6-dinitrotoluene |
4.05 | 21346803 18551238 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
Acetaminophen |
4.05 | 12392966 10663392 11834606 12705907 16109766 19739265 11421492 16781746 19370779 10915739 12540782 11287661 19420014 14725611 12594235 18071297 16485898 19416960 18713872 12153990 19164858 11461765 11529661 17906064 15968718 16393943 12958197 17522070 14550746 10774834 17562736 15619225 16227642 16177239 16081117 19085960 14986274 11743745 11739529 19923254 2444490 |
| MESH:D056487 |
Drug-Induced Liver Injury, Chronic |
|
Acetaminophen |
4.96 | 19426721 |
| MESH:D004938 |
Esophageal Neoplasms |
|
Benzo(a)pyrene |
2.09 | 16530937 |
| MESH:D005756 |
Gastritis |
|
Acetaminophen |
4.54 | 16983495 |
| MESH:D006330 |
Heart Defects, Congenital |
|
Benzo(a)pyrene |
2.85 | 20471113 |
| MESH:D006930 |
Hyperalgesia |
|
Acetaminophen |
3.06 | 16870215 |
| MESH:D007674 |
Kidney Diseases |
|
Acetaminophen |
2.42 | 15629191 12587719 |
| MESH:D007680 |
Kidney Neoplasms |
|
2,6-dinitrotoluene |
3.36 | 16705839 |
| MESH:D008107 |
Liver Diseases |
|
Acetaminophen |
1.71 | 19784758 19014921 11587558 16610002 12587719 12969438 19460945 16611625 |
| MESH:D017114 |
Liver Failure, Acute |
|
Acetaminophen |
3.68 | 16871587 17185352 |
| MESH:D008113 |
Liver Neoplasms |
|
2,6-dinitrotoluene |
4.93 | 7678174 |
| MESH:D008113 |
Liver Neoplasms |
|
Benzo(a)pyrene |
4.93 | 20195826 21137059 |
| MESH:D008114 |
Liver Neoplasms, Experimental |
|
2,6-dinitrotoluene |
2.79 | 2876784 6135515 2876786 |
| MESH:D008175 |
Lung Neoplasms |
|
Benzo(a)pyrene |
1.57 | 20064080 18520028 20869020 18816296 18569708 6695378 20135361 20464547 17053015 |
| MESH:D008546 |
Melanoma, Experimental |
|
Acetaminophen |
4.22 | 19513568 |
| MESH:D009062 |
Mouth Neoplasms |
|
Benzo(a)pyrene |
3.53 | 16381670 |
| MESH:D009336 |
Necrosis |
|
2,6-dinitrotoluene |
4.60 | 18551238 7678174 |
| MESH:D009369 |
Neoplasms |
|
Benzo(a)pyrene |
2.35 | 11141357 |
| MESH:D019636 |
Neurodegenerative Diseases |
|
Acetaminophen |
3.26 | 18514411 |
| MESH:D009784 |
Occupational Diseases |
|
2,6-dinitrotoluene |
3.88 | 16049721 |
| MESH:D010146 |
Pain |
|
Acetaminophen |
2.77 | 16870215 |
| MESH:D011471 |
Prostatic Neoplasms |
|
Benzo(a)pyrene |
2.90 | 17292933 |
| MESH:D012640 |
Seizures |
|
2,6-dinitrotoluene |
2.82 | 18551238 |
| MESH:D012878 |
Skin Neoplasms |
|
Benzo(a)pyrene |
2.54 | 10029692 19755658 |
| MESH:D013274 |
Stomach Neoplasms |
|
Benzo(a)pyrene |
1.56 | 2093021 20155912 |
| MESH:D001749 |
Urinary Bladder Neoplasms |
|
2,6-dinitrotoluene |
5.44 | 16049721 |
| MESH:D001749 |
Urinary Bladder Neoplasms |
|
Benzo(a)pyrene |
5.44 | 17053015 |
| MESH:D014571 |
Urologic Neoplasms |
|
2,6-dinitrotoluene |
5.06 | 10091137 |
| MESH:D014581 |
Urticaria |
|
Acetaminophen |
3.50 | 10982225 |
Related Pathway Information