Annotation Detail for SPEN
Basic Information
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| Gene Symbol: | SPEN ( HIAA0929,KIAA0929,MINT,RBM15C,SHARP ) |
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| Gene Full Name: | spen homolog, transcriptional regulator (Drosophila) |
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| Band: | 1p36.21-p36.13 |
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| Quick Links | Entrez ID:23013; OMIM: 613484; Uniprot ID:MINT_HUMAN; ENSEMBL ID: ENSG00000065526; HGNC ID: 17575 |
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| Relate to Another Database: |
SFARIGene;
denovo-db |
| Pathway ID | Pathway Name |
|---|
| 200013 | Notch signaling pathway |
| 200196 | Notch-mediated HES/HEY network |
| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| D015123 |
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SPEN mRNA | decreases expression | 20382639
20018196
19150397
|
| D010269 |
Paraquat |
Paraquat results in decreased expression of SPEN mRNA | decreases expression | 15458575
|
| C006253 |
pirinixic acid |
[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of SPEN mRNA | affects binding|increases activity|increases expression | 19710929
|
| D012643 |
Selenium |
[Selenium co-treated with Vitamin E] results in decreased expression of SPEN mRNA | affects cotreatment|decreases expression | 19244175
|
| D012643 |
Selenium |
Selenium results in decreased expression of SPEN mRNA | decreases expression | 19244175
|
| C004648 |
testosterone enanthate |
testosterone enanthate results in increased expression of SPEN mRNA | increases expression | 17440010
|
| D014810 |
Vitamin E |
[Selenium co-treated with Vitamin E] results in decreased expression of SPEN mRNA | affects cotreatment|decreases expression | 19244175
|
| D014810 |
Vitamin E |
Vitamin E results in decreased expression of SPEN mRNA | decreases expression | 19244175
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D055371 |
Acute Lung Injury |
|
pirinixic acid |
3.47 | 18653653 |
| MESH:D018248 |
Adenoma, Liver Cell |
|
pirinixic acid |
3.94 | 16434500 |
| MESH:D000382 |
Agricultural Workers' Diseases |
|
Paraquat |
4.22 | 11874814 |
| MESH:D001778 |
Blood Coagulation Disorders |
|
pirinixic acid |
3.47 | 19483382 |
| MESH:D002252 |
Carbon Tetrachloride Poisoning |
|
Vitamin E |
4.35 | 16050911 |
| MESH:D002471 |
Cell Transformation, Neoplastic |
|
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
2.93 | 20889678 |
| MESH:D002779 |
Cholestasis |
|
pirinixic acid |
3.05 | 19176532 |
| MESH:D003092 |
Colitis |
|
Selenium |
4.20 | 17936198 |
| MESH:D019465 |
Craniofacial Abnormalities |
|
Vitamin E |
1.92 | 19769572 |
| MESH:D003876 |
Dermatitis, Atopic |
|
pirinixic acid |
2.55 | 18249437 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
Selenium |
2.24 | 15131321 |
| MESH:C538011 |
Eales disease |
|
Vitamin E |
5.22 | 9068938 |
| MESH:D004487 |
Edema |
|
pirinixic acid |
2.80 | 12083418 |
| MESH:D004938 |
Esophageal Neoplasms |
|
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
2.13 | 20426865 |
| MESH:D005234 |
Fatty Liver |
|
pirinixic acid |
3.09 | 20131406 19236843 |
| MESH:D005911 |
Gliosis |
|
Paraquat |
5.68 | 11124998 |
| MESH:D006330 |
Heart Defects, Congenital |
|
Vitamin E |
3.13 | 16080930 |
| MESH:D006333 |
Heart Failure |
|
pirinixic acid |
7.55 | 20558911 |
| MESH:D006333 |
Heart Failure |
|
Selenium |
7.55 | 17162251 |
| MESH:D006529 |
Hepatomegaly |
|
pirinixic acid |
3.41 | 18467677 19176532 16221962 19772884 |
| MESH:D006548 |
Hernia, Diaphragmatic |
|
Vitamin E |
2.79 | 16863852 16490937 |
| MESH:D019247 |
HIV Wasting Syndrome |
|
testosterone enanthate |
6.27 | 17440010 |
| MESH:D019584 |
Hot Flashes |
|
Vitamin E |
4.49 | 14716179 |
| MESH:D006943 |
Hyperglycemia |
|
pirinixic acid |
3.49 | 20558911 |
| MESH:D007248 |
Infertility, Male |
|
Paraquat |
3.45 | 4850670 |
| MESH:D007251 |
Influenza, Human |
|
Selenium |
12.76 | 16624496 |
| MESH:D007251 |
Influenza, Human |
|
Vitamin E |
12.76 | 16624496 |
| MESH:D007333 |
Insulin Resistance |
|
pirinixic acid |
2.82 | 16306350 |
| MESH:D007674 |
Kidney Diseases |
|
Vitamin E |
2.96 | 12488133 |
| MESH:D007676 |
Kidney Failure, Chronic |
|
Selenium |
4.21 | 16518626 |
| MESH:D008106 |
Liver Cirrhosis, Experimental |
|
pirinixic acid |
2.45 | 15474484 |
| MESH:D008106 |
Liver Cirrhosis, Experimental |
|
Vitamin E |
2.45 | 16169303 |
| MESH:D008113 |
Liver Neoplasms |
|
pirinixic acid |
1.91 | 15890375 16377806 20007298 |
| MESH:D008171 |
Lung Diseases |
|
Vitamin E |
3.37 | 16863852 |
| MESH:D008175 |
Lung Neoplasms |
|
Vitamin E |
1.90 | 11062179 |
| MESH:D008325 |
Mammary Neoplasms, Experimental |
|
Selenium |
2.95 | 15318939 |
| MESH:D008654 |
Mesothelioma |
|
Selenium |
2.89 | 15107826 |
| MESH:D009135 |
Muscular Diseases |
|
pirinixic acid |
3.92 | 16239165 |
| MESH:D009203 |
Myocardial Infarction |
|
pirinixic acid |
2.25 | 19151258 |
| MESH:D015428 |
Myocardial Reperfusion Injury |
|
pirinixic acid |
3.19 | 16411023 |
| MESH:D009369 |
Neoplasms |
|
pirinixic acid |
2.08 | 17405874 |
| MESH:D009410 |
Nerve Degeneration |
|
Paraquat |
3.96 | 16893418 |
| MESH:D009765 |
Obesity |
|
pirinixic acid |
1.87 | 20558911 |
| MESH:D010300 |
Parkinson Disease |
|
Paraquat |
2.91 | 11445065 11181820 15451049 16140633 16510128 11124998 12911755 15824117 |
| MESH:D010302 |
Parkinson Disease, Secondary |
|
Paraquat |
4.85 | 16190885 |
| MESH:D010954 |
Plasmacytoma |
|
Selenium |
5.41 | 15087411 |
| MESH:D011014 |
Pneumonia |
|
Paraquat |
4.91 | 12504350 |
| MESH:D011471 |
Prostatic Neoplasms |
|
Vitamin E |
3.25 | 15084515 |
| MESH:D011658 |
Pulmonary Fibrosis |
|
Paraquat |
3.01 | 17997886 16324872 |
| MESH:D015427 |
Reperfusion Injury |
|
pirinixic acid |
2.52 | 19058328 |
| MESH:D012128 |
Respiratory Distress Syndrome, Adult |
|
Paraquat |
4.26 | 11700416 |
| MESH:D012135 |
Respiratory Sounds |
|
Paraquat |
4.47 | 11874814 |
| MESH:D012162 |
Retinal Degeneration |
|
Paraquat |
4.10 | 16458197 |
| MESH:D012871 |
Skin Diseases |
|
Vitamin E |
2.50 | 18709164 |
| MESH:D020521 |
Stroke |
|
Vitamin E |
3.77 | 16517955 |
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