AutismKB 2.0

Annotation Detail for GOLGA8A


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Basic Information Top
Gene Symbol:GOLGA8A ( GM88 )
Gene Full Name: golgin A8 family, member A
Band: 15q14
Quick LinksEntrez ID:23015; OMIM: NA; Uniprot ID:GOG8A_HUMAN; ENSEMBL ID: ENSG00000175265; HGNC ID: 31972
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of GOLGA8A proteinaffects expression 20106945
C068073 Am 580 Am 580 results in decreased expression of GOLGA8A mRNAdecreases expression 16982809
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of GOLGA8A mRNAdecreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of GOLGA8A mRNAincreases expression 20018196
D002945 Cisplatin GOLGA8A protein affects the susceptibility to Cisplatinaffects response to substance 16217747
D004958 Estradiol Estradiol results in increased expression of GOLGA8A mRNAincreases expression 20106945
D005472 Fluorouracil GOLGA8A mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with irinotecan]affects cotreatment|increases response to substance 17327601
D002955 Leucovorin GOLGA8A mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with irinotecan]affects cotreatment|increases response to substance 17327601
C051890 irinotecan GOLGA8A mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with irinotecan]affects cotreatment|increases response to substance 17327601
C089730 rosiglitazone rosiglitazone results in decreased expression of GOLGA8A mRNAdecreases expression 16982809
D012643 Selenium [Selenium co-treated with Vitamin E] results in increased expression of GOLGA8A mRNAaffects cotreatment|increases expression 19244175
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of GOLGA8A mRNAdecreases expression 20106945
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in increased expression of GOLGA8A mRNAaffects cotreatment|increases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9615322242 14514962 11752688
MESH:D058186 Acute Kidney Injury Cisplatin 4.0417670903 15814532 12690470
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 10.3720464547 20127859
MESH:D000230 Adenocarcinoma Cisplatin 10.3711798837 17638652
MESH:D000230 Adenocarcinoma Estradiol 10.3711473722
MESH:D000230 Adenocarcinoma Fluorouracil 10.3717638652
MESH:D000236 Adenoma Benzo(a)pyrene 2.706695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4916835633
MESH:D000544 Alzheimer Disease rosiglitazone 2.8719621015
MESH:D000740 Anemia Fluorouracil 8.9417963324 15504547 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.9411748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1819183758
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 5.0214601052
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.3620146248 17474063
MESH:D001943 Breast Neoplasms Cisplatin 2.3619526202 18382427
MESH:D001943 Breast Neoplasms Estradiol 2.3612948864 16675129 17289903 17261762 17018787 14630087 19861407 18497071
MESH:D001943 Breast Neoplasms Fluorouracil 2.3618608205 16110121 18357371 15136595 16595493 19217205 16557594
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3620435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5816111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.0316050911
MESH:D002276 Carcinoid Tumor Fluorouracil 4.8016051944
MESH:D002277 Carcinoma Fluorouracil 8.4017121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.4016835633
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.7212907637 21507988 12619106
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 6.7217982673
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.7216924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 6.7217045692 16799960 16332177 18930000 17971768 17088986
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.0612023789 16685392
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0518695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.7320419170
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 7.7317066447 18337622 6189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 7.7316757204 16280240 18986760 17066447
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4118850075 18670907 16120746
MESH:D002386 Cataract Am 580 4.3917460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.8320889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.8318566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2316835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1315340226 12621046 8697196 16354765 15668235
MESH:D003092 Colitis Am 580 10.3117035595
MESH:D003092 Colitis Selenium 10.3117936198
MESH:D003110 Colonic Neoplasms Fluorouracil 4.0116340194 16510598 18772588 15001691 17287894 17725105 17172411 17018589 17016597 17169374
MESH:D003110 Colonic Neoplasms irinotecan 4.0117725105 17287894
MESH:D015179 Colorectal Neoplasms Cisplatin 4.9715273666
MESH:D015179 Colorectal Neoplasms Fluorouracil 4.9714970324 16282729 17255274 15148649 15289873 17594712 18448328 18383874 18288408 16524972 18949393 18802399 17016601 16303861 17094418 17695437 16391804 17401013 20501625 16331619 18509181 17454858
MESH:D015179 Colorectal Neoplasms irinotecan 4.9717454858 16391804 15273666 18259882 16303861 17159606 18509181
MESH:D015179 Colorectal Neoplasms Leucovorin 4.9717594712 16303861 17255274 20501625 17454858 17401013
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1314669216 17141729
MESH:D019465 Craniofacial Abnormalities Leucovorin 4.0416925845
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 4.0410048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin E 4.0419769572
MESH:D007644 Darier Disease Fluorouracil 4.9116733453
MESH:D003920 Diabetes Mellitus rosiglitazone 4.3717446233
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 4.5612642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.5617107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.4819279558
MESH:D056486 Drug-Induced Liver Injury Selenium 3.8415131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8420420201
MESH:D004362 Drug Toxicity Cisplatin 8.3812649298 12231392 15033597 19839026
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.3811462148
MESH:C538011 Eales disease Vitamin E 4.849068938
MESH:D004487 Edema rosiglitazone 7.2412083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.2412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0415322242 18230668 16714409
MESH:D016889 Endometrial Neoplasms Estradiol 3.0311473722 18566989 19148513
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1010568697 9294722
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.5920426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 10.5916530937
MESH:D004938 Esophageal Neoplasms Cisplatin 10.5916481741 15173087 17638652 15464296 16785472
MESH:D004938 Esophageal Neoplasms Fluorouracil 10.5916337965 16785472 15173087 16481741 17638652
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver rosiglitazone 4.0119196556
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.0520067830
MESH:D005910 Glioma Fluorouracil 2.9016145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006258 Head and Neck Neoplasms Cisplatin 8.1715464296 15102660
MESH:D006258 Head and Neck Neoplasms Fluorouracil 8.1715162350 18337622 15102660
MESH:D034381 Hearing Loss Cisplatin 4.3719898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.4915464296
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 11.3420471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.3411294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 11.3416080930
MESH:D006333 Heart Failure Selenium 3.1217162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0015340226 16120746 12621046
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7316490937 16863852
MESH:D006558 Herpes Genitalis Estradiol 5.1715709030
MESH:D006689 Hodgkin Disease Cisplatin 3.6616200630 16170182
MESH:D019584 Hot Flashes Estradiol 10.5017088409
MESH:D019584 Hot Flashes Vitamin E 10.5014716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1816959395 18606429 16354765 8697196 15340226
MESH:D006930 Hyperalgesia rosiglitazone 3.9812083418
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9318670907 18850075
MESH:D007249 Inflammation rosiglitazone 5.3012083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.3012878042 12200463
MESH:D007251 Influenza, Human Selenium 11.4116624496
MESH:D007251 Influenza, Human Vitamin E 11.4116624496
MESH:D007333 Insulin Resistance Estradiol 7.8016627594 16393666
MESH:D007333 Insulin Resistance rosiglitazone 7.8016306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4216580747
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.2715464296
MESH:D007674 Kidney Diseases Cisplatin 10.4412231392 12649298 15190930 19839026 18289764
MESH:D007674 Kidney Diseases Estradiol 10.4415618244
MESH:D007674 Kidney Diseases Vitamin E 10.4412488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.9716518626
MESH:D007680 Kidney Neoplasms Estradiol 7.7115610895
MESH:D007680 Kidney Neoplasms Fluorouracil 7.7116985049
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.9311231351
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 5.0514716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 5.0515980055 17347453
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.0512878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 5.0516169303
MESH:D008113 Liver Neoplasms Aflatoxin B1 10.949163691 15890375 2125692 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 10.9421137059 20195826
MESH:D008113 Liver Neoplasms Fluorouracil 10.9415113037 16603448 17045692 18383874
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.9416984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 5.978603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.9712151625
MESH:D008171 Lung Diseases Vitamin E 3.2316863852
MESH:D008175 Lung Neoplasms Aflatoxin B1 8.6814755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 8.6818569708 6695378 18816296 20869020 20464547 20135361 20064080 18520028 17053015
MESH:D008175 Lung Neoplasms Cisplatin 8.686189445 17225452 11798837
MESH:D008175 Lung Neoplasms Fluorouracil 8.6815246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.6811884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 8.6811062179
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.9115086387
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 10.3617203775 11807958 11408345 16891317
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 10.3616827153
MESH:D008325 Mammary Neoplasms, Experimental Selenium 10.3615318939
MESH:D020149 Manganese Poisoning Estradiol 4.6219453300
MESH:D008545 Melanoma Cisplatin 2.4812374674 16248763 18332650 15577323 18176117 17761969 12393984 17023156 11135225 16809738 12883367 18505091 16432458
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.8915990972
MESH:D008654 Mesothelioma Cisplatin 6.4617638057
MESH:D008654 Mesothelioma Selenium 6.4615107826
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.4417261469
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.7416381670
MESH:D009062 Mouth Neoplasms Fluorouracil 8.7416757204 18986760
MESH:D052016 Mucositis irinotecan 5.1217159606
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3416810080
MESH:D009362 Neoplasm Metastasis irinotecan 3.2018259882
MESH:D009369 Neoplasms Benzo(a)pyrene 8.5811141357
MESH:D009369 Neoplasms Cisplatin 8.5816773208
MESH:D009369 Neoplasms Fluorouracil 8.5818239605 18600527 16928823
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8517289903
MESH:D009395 Nephritis, Interstitial Cisplatin 4.6315464296
MESH:D009421 Nervous System Malformations Estradiol 9.7816427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.7814600291
MESH:D009447 Neuroblastoma Cisplatin 7.358761367
MESH:D009447 Neuroblastoma irinotecan 7.358761367
MESH:D017599 Neuroectodermal Tumors Cisplatin 11.868761367
MESH:D017599 Neuroectodermal Tumors irinotecan 11.868761367
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.4916436463
MESH:D010051 Ovarian Neoplasms Cisplatin 5.0819769630 15464296 17225452 6897625
MESH:D010051 Ovarian Neoplasms Estradiol 5.0819401270
MESH:D010190 Pancreatic Neoplasms Cisplatin 5.6219003803
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.6216929163 16500647 19003803 15113037
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.4015464296
MESH:D010954 Plasmacytoma Selenium 5.0215087411
MESH:D010997 Pleural Neoplasms Cisplatin 5.4817638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3111399792 11896295 11222880 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9720887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0517292933
MESH:D011471 Prostatic Neoplasms Estradiol 2.0516740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.0519082440 18626508
MESH:D011471 Prostatic Neoplasms Vitamin E 2.0515084515
MESH:D012004 Rectal Neoplasms Fluorouracil 4.0815538739 16160472 18722050 18286688
MESH:D051437 Renal Insufficiency Cisplatin 4.5115464296
MESH:D015427 Reperfusion Injury Leucovorin 4.6217295595
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.5214601052
MESH:D012871 Skin Diseases Vitamin E 2.4618709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.5919755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.5916192470
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.4815464296
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.8320155912 2093021
MESH:D013274 Stomach Neoplasms Cisplatin 4.8315958060 17522103 18396642
MESH:D013274 Stomach Neoplasms Fluorouracil 4.8318567086 19084572 18396642 16951190 15786421 17172411 17522103 19015929 16424979 17498489
MESH:D013274 Stomach Neoplasms irinotecan 4.8315723263
MESH:D020521 Stroke Vitamin E 3.5816517955
MESH:D013736 Testicular Neoplasms Cisplatin 4.7215464296 17225452
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D013978 Tibial Fractures Estradiol 4.8219048282
MESH:D014062 Tongue Neoplasms Fluorouracil 4.0616280240
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.3117053015
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 5.3117225452 12973940 15464296
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 9.9016803524
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 9.9016803524
MESH:D014625 Vaginal Neoplasms Cisplatin 4.7115577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D014839 Vomiting Cisplatin 4.8511897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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