AutismKB 2.0

Annotation Detail for USP33


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:USP33 ( KIAA1097,MGC16868,VDU1 )
Gene Full Name: ubiquitin specific peptidase 33
Band: 1p31.1
Quick LinksEntrez ID:23032; OMIM: NA; Uniprot ID:UBP33_HUMAN; ENSEMBL ID: ENSG00000077254; HGNC ID: 20059
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of USP33 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of USP33 mRNAaffects expression 21346803
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of USP33 mRNAdecreases expression 19150397
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of USP33 mRNAaffects cotreatment|increases expression 17183730
D012643 Selenium [Selenium co-treated with Vitamin E] results in decreased expression of USP33 mRNAaffects cotreatment|decreases expression 19244175
D012643 Selenium Selenium results in decreased expression of USP33 mRNAdecreases expression 19244175
C004648 testosterone enanthate testosterone enanthate affects the expression of USP33 mRNAaffects expression 17440010
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of USP33 mRNAaffects cotreatment|increases expression 17183730
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in decreased expression of USP33 mRNAaffects cotreatment|decreases expression 19244175
D014810 Vitamin E Vitamin E results in decreased expression of USP33 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.828875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1719490988
MESH:D000550 Amblyopia Valproic Acid 5.6117688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.7617497229
MESH:D001321 Autistic Disorder Valproic Acid 1.9919460635 17157402 19232924 17507914 18940202 18316065 17688650 15238991 18177632 20603192 18558336 18775368 16609825 18985861 18396377
MESH:D001714 Bipolar Disorder Valproic Acid 3.1820046352 17594078
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.548888407
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.2416050911
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 3.0516705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 3.0516705839
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.186135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.1820889678
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7820734317
MESH:D003092 Colitis Selenium 4.0917936198
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.7717688650 16575769 8888407
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.7719769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.9418551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.9418551238
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.5121346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.5118551238 21346803
MESH:D056486 Drug-Induced Liver Injury Selenium 9.5115131321
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 9.511733752 19641884
MESH:D004421 Dystonia Valproic Acid 4.311851702
MESH:C538011 Eales disease Vitamin E 5.089068938
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.4617275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.2916628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0420417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.806426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.607750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.403659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1220426865
MESH:D005234 Fatty Liver Valproic Acid 3.5414986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 5.2616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.418888407 18558336
MESH:D006330 Heart Defects, Congenital Vitamin E 3.1016080930
MESH:D006333 Heart Failure Selenium 3.2117162251
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7716863852 16490937
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 6.1217440010
MESH:D019584 Hot Flashes Vitamin E 4.3514716179
MESH:D006849 Hydrocephalus Valproic Acid 5.2017688650
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.9316612254
MESH:D007251 Influenza, Human Selenium 12.2516624496
MESH:D007251 Influenza, Human Vitamin E 12.2516624496
MESH:D007674 Kidney Diseases Vitamin E 2.9312488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.1316518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 8.0416705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.0416705839
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1817596541 16294345
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 1.9016169303
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 2.227678174
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.686135515 2876784 2876786
MESH:D008171 Lung Diseases Vitamin E 3.3316863852
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.6417228818
MESH:D008175 Lung Neoplasms Vitamin E 1.9011062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9015318939
MESH:D008654 Mesothelioma Selenium 2.8715107826
MESH:D008881 Migraine Disorders Valproic Acid 3.3618765137 18803445
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.278888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2817596541
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.5018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.5018551238 7678174
MESH:D009436 Neural Tube Defects Valproic Acid 3.2716359493 8888407
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.6612819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.6616049721
MESH:D010954 Plasmacytoma Selenium 5.2715087411
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.1720603192
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2615084515
MESH:D019310 Pseudolymphoma Valproic Acid 4.9212752131 11422049
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.4419155313
MESH:D012559 Schizophrenia Valproic Acid 2.0915737665 19110320
MESH:D012640 Seizures 2,4-dinitrotoluene 10.7518551238
MESH:D012640 Seizures 2,6-dinitrotoluene 10.7518551238
MESH:D012640 Seizures Valproic Acid 10.7511738929 16876388 3137016 11044598 14763951 15475178 17978042 1511512
MESH:D012871 Skin Diseases Vitamin E 2.4918709164
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9619490988
MESH:D013226 Status Epilepticus Valproic Acid 4.9212833885
MESH:D020521 Stroke Vitamin E 3.7116517955
MESH:D014178 Translocation, Genetic Valproic Acid 5.6117262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.863119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.2816049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.2816049721
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.958888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.1410091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.1410091137
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved