AutismKB 2.0

Annotation Detail for MYT1L


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Basic Information Top
Gene Symbol:MYT1L ( NZF1 )
Gene Full Name: myelin transcription factor 1-like
Band: 2p25.3
Quick LinksEntrez ID:23040; OMIM: 613084; Uniprot ID:MYT1L_HUMAN; ENSEMBL ID: ENSG00000186487; HGNC ID: 7623
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
ADHD
PSYCH
attention-deficit hyperactivity disorder
Desease Name
Attention deficit hyperactivity disorder
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in decreased expression of MYT1L mRNAdecreases expression 20406850
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of MYT1L mRNAincreases expression 18648102
C006632 arsenic trioxide arsenic trioxide results in decreased expression of MYT1L mRNAdecreases expression 20458559
C002791 bismuth tripotassium dicitrate bismuth tripotassium dicitrate results in decreased expression of MYT1L mRNAdecreases expression 15912405
D008345 Manganese Manganese results in increased expression of MYT1L mRNAincreases expression 17175027
C025340 manganese chloride manganese chloride results in increased expression of MYT1L mRNAincreases expression 17175027
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in decreased expression of MYT1L mRNAaffects cotreatment|decreases expression 19059307
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in decreased expression of MYT1L mRNAaffects cotreatment|decreases expression 19059307
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of MYT1L mRNAdecreases expression 19465110
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of MYT1L mRNAincreases expression 16922920
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.8714745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1315322242 11752688 14514962
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3319825857 11798837
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.863712494
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6616835633
MESH:D000419 Albuminuria Raloxifene 4.8317308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.5815800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D000756 Anemia, Sideroblastic Manganese 11.7316910769
MESH:D000756 Anemia, Sideroblastic manganese chloride 11.7316910769
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.3411289319 1440618
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.6616206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.6612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D001930 Brain Injuries Raloxifene 4.7316580743
MESH:D001943 Breast Neoplasms Raloxifene 1.8817893378 16837676 16912660 15775269 17440819 17242785 15572757 17049068 15758505 17952589 17261762 17595753
MESH:D001943 Breast Neoplasms Tamoxifen 1.8818425577 19142967 17261762 18629630 19059307 18855134 19288272 17893378 21138602 18815881 19084267 19115204 17440819 19066611 15668708 18351453 17049068 20065188 18984771 19244106 16873071 15565566 19410462 16818667 20859285 19011961 19200415 18997820 19103187 19155303 20005174 20135344 16273361 19189210 19487384 20544844 20390343 16202921 19289846 11161223 17242785 19189212 21152245 19221464 18821012
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8820435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5511589617
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.7619066611
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.8016705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.803581430 7296757
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 6.8016217749 15073043 14691202 15553829 11135700
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.8016924424
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.1919014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.767296757
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3112490120
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 10.1517572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 10.1517572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4718850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Raloxifene 3.5815775269
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.126135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.127505956
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.3019486331 9022650
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1816354765 15340226 8697196 15668235 12621046
MESH:D003072 Cognition Disorders Raloxifene 4.8815800139
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2414669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 4.4212609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.5210525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5220055451 15322242 10048152
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.2818551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.3215213294
MESH:D003711 Demyelinating Diseases Tamoxifen 4.6219031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.3417474826
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.0612868966 8970840 18759878 11906362 8156756 11298694 14531868 2524372
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.713621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D003928 Diabetic Nephropathies Raloxifene 9.6515920148 17308373 17451421
MESH:D003928 Diabetic Nephropathies Tamoxifen 9.6519279558
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.4718551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.4716192314 1440618 18289764 18692083 7440962 9653073 6679447 9022650 9328219 6482804 11289319 18648102 8291058
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.4720420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D004487 Edema Raloxifene 7.5415860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.5412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2215322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 10.0515845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.0519031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1717893378 16202921 20544844 19155303
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.219294722 10568697
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.623581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.6212903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver arsenic trioxide 14.4515073043
MESH:D005234 Fatty Liver Raloxifene 14.4517473493
MESH:D005234 Fatty Liver Tamoxifen 14.4514986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3516709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.346705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.8114745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.4719069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2120067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5016904648
MESH:D005909 Glioblastoma Manganese 4.0417043766
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.267505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4311294989 10048152
MESH:D006331 Heart Diseases Raloxifene 3.6711110106
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.756705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1516120746 15340226 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.368697196 16959395 16354765 18606429 15340226
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2015034207
MESH:D006973 Hypertension Raloxifene 5.4517577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.4518670907 18850075
MESH:D007249 Inflammation Tamoxifen 5.2119457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.2112200463 12878042
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.348074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.4316705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 13.436582329
MESH:D007680 Kidney Neoplasms Tamoxifen 13.4318625569
MESH:D007889 Leiomyoma Raloxifene 4.7216973256
MESH:D007938 Leukemia arsenic trioxide 2.9215070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0012560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5916972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5814633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.9719077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1616968895 20471514 16467208 19850784 17050201
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3419642359 15748426 12712474 15622746 17107899 17869043 11468182 16891316 16112521 16966277 17217047 19225113 17712046 19075265 17649720 11161223 9834237 15213294 19035177 15336539 16823087 16330433 16331271 12679006 12018890
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5916882451
MESH:D008064 Lipidoses Tamoxifen 3.3015342952 17567588
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.319327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.3318564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3312878042
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 11.267678174
MESH:D008113 Liver Neoplasms arsenic trioxide 11.2614682389
MESH:D008113 Liver Neoplasms Tamoxifen 11.2616684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.2616984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 15.132876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 15.133712494 6587162 598648 1399818
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 15.1320377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 15.1312151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5115213294
MESH:D008175 Lung Neoplasms arsenic trioxide 3.4911798837 19825857
MESH:D008175 Lung Neoplasms Tamoxifen 3.4918625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4919555203 11884234
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.0419428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7411731420 16827153 14580682 19196722 19196723
MESH:D020149 Manganese Poisoning Manganese 14.1119453300 16551646 16568477
MESH:D020149 Manganese Poisoning Tamoxifen 14.1119453300
MESH:D008545 Melanoma Tamoxifen 1.9019393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.4715990972
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.8715863610
MESH:D009069 Movement Disorders Manganese 5.2316551646
MESH:D009101 Multiple Myeloma arsenic trioxide 7.8914977855 11468182 15949261 19417148 19549372
MESH:D009101 Multiple Myeloma Raloxifene 7.8916497877
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.9918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2516105982 16882451
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D009232 Myxoma Raloxifene 5.8716343187
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.157678174 18551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2016624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.933581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.9319393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5719410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.3219189210 19196722 19200415
MESH:D009410 Nerve Degeneration Manganese 4.4316551646
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4514600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.686679447
MESH:D009436 Neural Tube Defects arsenic trioxide 7.6810525206
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.5416049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.544026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.343988306
MESH:D010024 Osteoporosis Raloxifene 3.5117882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.4517823083 17893378 15579764 15758505
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4616624393 19769630 12452020
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.5815580305
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.747296757
MESH:D010235 Paraganglioma arsenic trioxide 4.3819927285
MESH:D010300 Parkinson Disease Manganese 3.4311181820
MESH:D020734 Parkinsonian Disorders Manganese 4.6616140633
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.796228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4811896295 11399792 11118676 11222880
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.5819131511
MESH:D011471 Prostatic Neoplasms Raloxifene 2.5815731164 16220300 16536755
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.5815067354
MESH:D011693 Purpura Raloxifene 5.8715770314
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.523692021
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2016646077
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6718551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1316192470
MESH:D013088 Spermatocele Tamoxifen 4.6116709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.3219457130
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D020521 Stroke Raloxifene 3.9816837676
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.686582329 1399818 7505956 6587162 3712494
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.6819014326
MESH:D013978 Tibial Fractures Raloxifene 5.5319048282
MESH:D016171 Torsades de Pointes arsenic trioxide 4.2415213294
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 16.5716049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 16.578074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 16.5711780464 12845720 12973940 20435036
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 16.5717572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 16.5716712894 17572228 8653321
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.6010091137
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.5316837676
MESH:D014846 Vulvar Neoplasms Raloxifene 5.8716343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA31427
    • No data
    Releated disease ID Related disease Name
    PA447216Schizophrenia
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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