AutismKB 2.0

Annotation Detail for TNIK


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Basic Information Top
Gene Symbol:TNIK ( - )
Gene Full Name: TRAF2 and NCK interacting kinase
Band: 3q26.2-q26.31
Quick LinksEntrez ID:23043; OMIM: 610005; Uniprot ID:TNIK_HUMAN; ENSEMBL ID: ENSG00000154310; HGNC ID: 30765
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200086TNF receptor signaling pathway
200106Regulation of Wnt-mediated beta catenin signaling and target gene transcription
No data
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Related Diseases/Disorders Top
No data
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Desease Name
PSYCH
Brain imaging in schizophrenia (interaction)
Desease Name
Brain imaging in schizophrenia (interaction)
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of TNIK mRNAincreases expression 19933214
D000082 Acetaminophen Acetaminophen affects the expression of TNIK mRNAaffects expression 17562736
C014949 acetylhydrazine acetylhydrazine results in decreased expression of TNIK mRNAdecreases expression 15282401
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of TNIK proteinaffects expression 20106945
D001151 Arsenic Arsenic results in decreased expression of TNIK mRNAdecreases expression 16835338
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of TNIK mRNAdecreases expression 20064835
20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TNIK mRNAdecreases expression 20382639
D003024 Clozapine Clozapine results in decreased expression of TNIK mRNAdecreases expression 14647396
D004041 Dietary Fats Dietary Fats results in increased expression of TNIK mRNAincreases expression 18503570
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of TNIK mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of TNIK mRNAincreases expression 19619570
D006220 Haloperidol Haloperidol results in decreased expression of TNIK mRNAdecreases expression 14647396
D007657 Ketone Bodies Ketone Bodies results in increased expression of TNIK mRNAincreases expression 16807920
C030110 oxaliplatin oxaliplatin results in increased expression of TNIK mRNAincreases expression 16510598
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in increased expression of TNIK mRNAaffects cotreatment|increases expression 19059307
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in increased expression of TNIK mRNAaffects cotreatment|increases expression 19059307
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of TNIK mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of TNIK mRNAdecreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TNIK mRNAincreases expression 19933214
D014635 Valproic Acid Valproic Acid results in increased expression of TNIK mRNAincreases expression 19101580
C025643 vinclozolin vinclozolin affects the expression of TNIK mRNAaffects expression 19015723
D014810 Vitamin E Vitamin E results in decreased expression of TNIK mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.4914745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.1111752688 14514962 15322242
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 8.118875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.8619490988
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.2320464547 20127859
MESH:D000230 Adenocarcinoma Estradiol 4.2311473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.616695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.3216835633
MESH:D018246 Adrenocortical Adenoma Arsenic 5.1617306315
MESH:D000380 Agranulocytosis Clozapine 4.9916160616 12649775 14617031
MESH:D000419 Albuminuria Raloxifene 4.5317308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.5315800139
MESH:D000550 Amblyopia Valproic Acid 5.1817688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8911748828
MESH:D000799 Angioedema Acetaminophen 3.7910982225
MESH:D001008 Anxiety Disorders Valproic Acid 8.6717497229
MESH:D001008 Anxiety Disorders vinclozolin 8.6719015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0119183758
MESH:D020261 Arsenic Poisoning marker/mechanism 16835338
MESH:D020261 Arsenic Poisoning Arsenic 2.8518414634 16835338 12569548 16251483
MESH:D001161 Arteriosclerosis Dietary Fats 3.8215238619
MESH:D050197 Atherosclerosis Arsenic 3.2112928151 19371607
MESH:D001321 Autistic Disorder Acetaminophen 2.1918445737
MESH:D001321 Autistic Disorder Haloperidol 2.1918080171 19368416
MESH:D001321 Autistic Disorder Valproic Acid 2.1919232924 15238991 16609825 17157402 19460635 17688650 18396377 18558336 18940202 18316065 18177632 20603192 18775368 18985861 17507914
MESH:D001714 Bipolar Disorder Valproic Acid 3.0420046352 17594078
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.9812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.8815746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.888888407
MESH:D001930 Brain Injuries Raloxifene 4.4116580743
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.9217474063 20146248
MESH:D001943 Breast Neoplasms Dietary Fats 2.9220435547
MESH:D001943 Breast Neoplasms Estradiol 2.9217261762 19861407 17289903 18497071 14630087 17018787 16675129 12948864
MESH:D001943 Breast Neoplasms Raloxifene 2.9217952589 17595753 17261762 16912660 17049068 17242785 17893378 15775269 15572757 17440819 15758505 16837676
MESH:D001943 Breast Neoplasms Tamoxifen 2.9215565566 17893378 16873071 20065188 19487384 18815881 19189210 18629630 20390343 18351453 19410462 15668708 17440819 19244106 21138602 18984771 19200415 19289846 19115204 19066611 19189212 19059307 20544844 19221464 19288272 18855134 17049068 18821012 19103187 17242785 20859285 19155303 21152245 19011961 17261762 19084267 11161223 16202921 16273361 20135344 20005174 18997820 19142967 16818667 18425577
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.9220435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4016111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.8716050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7416835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.5515504454 17687452
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.4419066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.763084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 8.7612907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular Arsenic 8.7617306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Estradiol 8.7616924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 8.7616924424
MESH:D002294 Carcinoma, Squamous Cell Arsenic 4.6515504454 18922899 17687452
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.6520419170
MESH:D002295 Carcinoma, Transitional Cell Arsenic 15.5818640142
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 15.5817572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 15.5817572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3318850075 16120746 18670907
MESH:D002318 Cardiovascular Diseases Arsenic 7.4015738583 17938729 19152805
MESH:D002318 Cardiovascular Diseases Raloxifene 7.4015775269
MESH:D002340 Carotid Artery Diseases Arsenic 4.2516973168 18022660
MESH:D002375 Catalepsy Haloperidol 4.8515215559 1977408
MESH:D002386 Cataract Acetaminophen 2.5410977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.4920889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.4918566989
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6820734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1016835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0816354765 12621046 8697196 15668235 15340226
MESH:D003072 Cognition Disorders Clozapine 11.4717123785
MESH:D003072 Cognition Disorders Raloxifene 11.4715800139
MESH:D003110 Colonic Neoplasms oxaliplatin 3.1616004971 16510598 16024531
MESH:D015179 Colorectal Neoplasms oxaliplatin 2.9417255274 18448328 17594712 17695437 17401013 18509181
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0017141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.7310048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.7317688650 8888407 16575769
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.7319769572
MESH:D003456 Cryptorchidism vinclozolin 4.2814966744
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.7820210726
MESH:D003704 Dementia Haloperidol 4.5211575062
MESH:D003711 Demyelinating Diseases Tamoxifen 4.3019031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.1017474826
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 4.4516402076
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.4517107852
MESH:D003928 Diabetic Nephropathies Estradiol 14.6919279558
MESH:D003928 Diabetic Nephropathies Raloxifene 14.6915920148 17451421 17308373
MESH:D003928 Diabetic Nephropathies Tamoxifen 14.6919279558
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.5015331141
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.0311739529 19416960 18071297 16109766 14550746 12594235 12540782 11461765 11529661 16177239 12153990 19420014 11287661 14986274 11743745 16485898 12705907 19085960 10663392 15968718 18713872 17562736 10915739 16227642 19164858 15619225 11421492 12958197 19923254 17522070 12392966 10774834 11834606 19739265 16393943 16081117 16781746 19370779 17906064 14725611 2444490
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.0320420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.0319641884 1733752
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0419426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7111462148
MESH:D050171 Dyslipidemias Clozapine 8.7016402076
MESH:D050171 Dyslipidemias Dietary Fats 8.7018367378
MESH:D004421 Dystonia Valproic Acid 3.991851702
MESH:C538011 Eales disease Vitamin E 4.659068938
MESH:D004487 Edema Raloxifene 6.6515860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.6511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8518230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 9.0315845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.0319031437
MESH:D016889 Endometrial Neoplasms Estradiol 7.2418566989 19148513 11473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.2419155303 20544844 16202921 17893378
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.9610568697 9294722
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.093659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 3.8616628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.9018234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.537562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.237750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.003659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.2920426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.2916530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9611564622
MESH:D005234 Fatty Liver Dietary Fats 18.3117967931 18296743 19004024 19551842
MESH:D005234 Fatty Liver Raloxifene 18.3117473493
MESH:D005234 Fatty Liver Tamoxifen 18.3119224547 14986274
MESH:D005234 Fatty Liver Valproic Acid 18.3114986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1916709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3911858732
MESH:D005315 Fetal Diseases Valproic Acid 4.8316575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.0718558336 8888407
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.4714745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.1219069698
MESH:D005355 Fibrosis Dietary Fats 8.4118296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.4120067830
MESH:D005534 Foot Diseases Arsenic 5.506392382
MESH:D005756 Gastritis Acetaminophen 3.6216983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.8716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.2416417039
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5410696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.9020471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.9010048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 10.9016080930
MESH:D006331 Heart Diseases Raloxifene 3.4911110106
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2711000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.8312621046 15340226 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6816863852 16490937
MESH:D006558 Herpes Genitalis Estradiol 4.9815709030
MESH:D019584 Hot Flashes Estradiol 9.8617088409
MESH:D019584 Hot Flashes Vitamin E 9.8614716179
MESH:D006849 Hydrocephalus Valproic Acid 4.8117688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9918606429 8697196 16354765 15340226 16959395
MESH:D006930 Hyperalgesia Acetaminophen 7.8616870215
MESH:D006930 Hyperalgesia oxaliplatin 7.8617418472
MESH:D006937 Hypercholesterolemia Dietary Fats 3.5321332399
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.3917050553
MESH:D006948 Hyperkinesis Clozapine 4.8516046005
MESH:D006949 Hyperlipidemias Dietary Fats 3.5521332399
MESH:D006973 Hypertension Arsenic 8.549931084 11953799 16076760
MESH:D006973 Hypertension Raloxifene 8.5415787275 17577099
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.5418850075 18670907
MESH:D006987 Hypesthesia Arsenic 5.5016093927
MESH:D007248 Infertility, Male vinclozolin 3.0016467254
MESH:D007249 Inflammation Dietary Fats 8.0720412841
MESH:D007249 Inflammation Tamoxifen 8.0719457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.0712200463 12878042
MESH:D007251 Influenza, Human Vitamin E 4.1616624496
MESH:D007333 Insulin Resistance Dietary Fats 7.2211836018 18457598
MESH:D007333 Insulin Resistance Estradiol 7.2216627594 16393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2716580747
MESH:D007642 Keratosis Arsenic 4.9312749816 16930632
MESH:D007674 Kidney Diseases Acetaminophen 9.8215629191 12587719
MESH:D007674 Kidney Diseases Estradiol 9.8215618244
MESH:D007674 Kidney Diseases Vitamin E 9.8212488133
MESH:D007680 Kidney Neoplasms Estradiol 7.2015610895
MESH:D007680 Kidney Neoplasms Tamoxifen 7.2018625569
MESH:D007889 Leiomyoma Raloxifene 4.4316973256
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1416294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.5117339181
MESH:D007984 Leydig Cell Tumor vinclozolin 4.6716417039
MESH:D008064 Lipidoses Clozapine 7.9217567588
MESH:D008064 Lipidoses Tamoxifen 7.9215342952 17567588
MESH:D008103 Liver Cirrhosis Dietary Fats 2.8418296743
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.8814659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 4.8818564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.8812878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 4.8816169303
MESH:D008107 Liver Diseases Acetaminophen 4.0111587558 19784758 16610002 12969438 12587719 19460945 19014921 16611625
MESH:D008107 Liver Diseases Arsenic 4.0111134558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.1816871587 17185352
MESH:D008113 Liver Neoplasms Aflatoxin B1 13.9818177683 15890375 2125692 9163691
MESH:D008113 Liver Neoplasms Arsenic 13.9816368122
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 13.9820195826 21137059
MESH:D008113 Liver Neoplasms Tamoxifen 13.9816684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.9816984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 5.678603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.6712151625
MESH:D008171 Lung Diseases Vitamin E 3.1316863852
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.2117228818
MESH:D008175 Lung Neoplasms Aflatoxin B1 8.4514755239
MESH:D008175 Lung Neoplasms Arsenic 8.4517976673 19168569 17306315
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 8.4520064080 17053015 18569708 20464547 20869020 18520028 20135361 18816296 6695378
MESH:D008175 Lung Neoplasms Tamoxifen 8.4518625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.4511884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 8.4511062179
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.7019428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.8317203775 16891317 11807958 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 5.8314580682 19196722 19196723 16827153 11731420
MESH:D020149 Manganese Poisoning Estradiol 12.4619453300
MESH:D020149 Manganese Poisoning Tamoxifen 12.4619453300
MESH:D008545 Melanoma Tamoxifen 1.8719393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.1215990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5019513568
MESH:D001523 Mental Disorders Clozapine 8.1616856516
MESH:D001523 Mental Disorders Haloperidol 8.1616856516
MESH:D024821 Metabolic Syndrome X Clozapine 4.3519142101
MESH:D008881 Migraine Disorders Valproic Acid 3.1418765137 18803445
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.5015863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1416381670
MESH:D009101 Multiple Myeloma Raloxifene 3.3916497877
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.968888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.1217596541
MESH:D017202 Myocardial Ischemia Arsenic 8.8215371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.8212213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.2316810080
MESH:D009232 Myxoma Raloxifene 5.5016343187
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5219393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4919410462
MESH:D009369 Neoplasms Benzo(a)pyrene 2.1411141357
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.9419200415 19189210 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.6717289903
MESH:D009421 Nervous System Malformations Estradiol 9.2511399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.2514600291
MESH:D009436 Neural Tube Defects Arsenic 7.3116620997
MESH:D009436 Neural Tube Defects Valproic Acid 7.3116359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8118514411
MESH:D020078 Neurogenic Inflammation Arsenic 4.3117056641
MESH:D009765 Obesity Clozapine 4.8219142110 18515891
MESH:D009765 Obesity Dietary Fats 4.8218674790 17217161 19632207 20132043 16723640 11836018 18457598 20518802 21332399
MESH:D010024 Osteoporosis Raloxifene 3.3515775268 19059307 17882678
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.1615758505 17823083 15579764 17893378
MESH:D010051 Ovarian Neoplasms Arsenic 4.8817306315
MESH:D010051 Ovarian Neoplasms Estradiol 4.8819401270
MESH:D010146 Pain Acetaminophen 2.3416870215
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1912520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.1116093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.936392382 16905509 15371236
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 15.8911399792 11118676 11896295 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 15.8920603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 15.8919015723 18042343 18220299
MESH:D011469 Prostatic Diseases vinclozolin 4.8718220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8220887781
MESH:D011471 Prostatic Neoplasms Arsenic 1.8816140617
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8817292933
MESH:D011471 Prostatic Neoplasms Estradiol 1.8816740699
MESH:D011471 Prostatic Neoplasms Raloxifene 1.8816536755 16220300 15731164
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8815067354
MESH:D011471 Prostatic Neoplasms Vitamin E 1.8815084515
MESH:D011472 Prostatitis vinclozolin 4.8718629315
MESH:D011507 Proteinuria Arsenic 3.9421343184
MESH:D019310 Pseudolymphoma Valproic Acid 4.4911422049 12752131
MESH:D011595 Psychomotor Agitation Haloperidol 4.8911575062
MESH:D011618 Psychotic Disorders Clozapine 9.0015331141
MESH:D011618 Psychotic Disorders Haloperidol 9.0011575062
MESH:D011693 Purpura Raloxifene 5.5015770314
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7718990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.1119155313
MESH:D012559 Schizophrenia Clozapine 5.6618806925 17667964 11763009 16141801 11151749 20168265 17123785 20521320 20521326 18855531 20107430 20452607 20580759 19369910 17726453
MESH:D012559 Schizophrenia Haloperidol 5.6619369910 1830565 18513383 20107430
MESH:D012559 Schizophrenia Valproic Acid 5.6619110320 15737665
MESH:D012640 Seizures Valproic Acid 2.6911044598 16876388 1511512 14763951 3137016 15475178 11738929 17978042
MESH:D012871 Skin Diseases marker/mechanism 16835338
MESH:D012871 Skin Diseases Arsenic 4.9816353154 6392382 18709164 17938729 19834688 16702368 15952646 17453740 16759981 17548696 17050553
MESH:D012871 Skin Diseases Vitamin E 4.9818709164
MESH:D012878 Skin Neoplasms Arsenic 9.2617029826 17976673 17050553 15504454 16251483 19538983
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.2619755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.2616192470
MESH:D013088 Spermatocele Tamoxifen 4.2416709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.9819457130
MESH:D016135 Spinal Dysraphism Valproic Acid 3.7319490988
MESH:D013226 Status Epilepticus Valproic Acid 4.4912833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D020521 Stroke Raloxifene 8.5316837676
MESH:D020521 Stroke Vitamin E 8.5316517955
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.6420210726
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8512697716
MESH:D013978 Tibial Fractures Estradiol 13.5319048282
MESH:D013978 Tibial Fractures Raloxifene 13.5319048282
MESH:D014178 Translocation, Genetic Valproic Acid 5.1817262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.463119515
MESH:D001749 Urinary Bladder Neoplasms Arsenic 11.7517306315 11144890 15987713 19322015 17976673 19429237 18640142
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 11.7517053015
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 11.7517572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 11.758653321 16712894 17572228
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.588888407
MESH:D014581 Urticaria Acetaminophen 2.9110982225
MESH:D014652 Vascular Diseases Arsenic 4.6717056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5412125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.1516837676
MESH:D014846 Vulvar Neoplasms Raloxifene 5.5016343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1915886252
MESH:D015430 Weight Gain Clozapine 9.6316402076 16141801 20107430 17502770 20521320 20564506
MESH:D015430 Weight Gain Dietary Fats 9.6316723640
MESH:D015431 Weight Loss Clozapine 5.0217933447
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134893180
    • No data
    Releated disease ID Related disease Name
    PA447216Schizophrenia
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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