AutismKB 2.0

Annotation Detail for KIF21B


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Basic Information Top
Gene Symbol:KIF21B ( FLJ16314 )
Gene Full Name: kinesin family member 21B
Band: 1q32.1
Quick LinksEntrez ID:23046; OMIM: 608322; Uniprot ID:KI21B_HUMAN; ENSEMBL ID: ENSG00000116852; HGNC ID: 29442
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
ulcerative colitis
IMMUNE
Desease Name
Ulcerative colitis
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C006632 arsenic trioxide arsenic trioxide results in increased expression of KIF21B mRNAincreases expression 15761015
D014635 Valproic Acid Valproic Acid results in increased expression of KIF21B mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 4.378875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.4819490988
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3719825857 11798837
MESH:D000550 Amblyopia Valproic Acid 6.3017688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.9817497229
MESH:D001321 Autistic Disorder Valproic Acid 1.9818775368 18316065 17157402 15238991 19460635 17507914 18940202 18985861 18396377 18558336 16609825 20603192 18177632 19232924 17688650
MESH:D001714 Bipolar Disorder Valproic Acid 3.2820046352 17594078
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 4.2216206674
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.698888407
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.9411589617
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 1.9911135700 14691202 15553829 16217749 15073043
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.9419014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.6312490120
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.8420734317
MESH:D003093 Colitis, Ulcerative marker/mechanism 20228799
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8720501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.8612609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.8110525206
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.818888407 17688650 16575769
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.7015213294
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 2.271733752 19641884
MESH:D004421 Dystonia Valproic Acid 4.661851702
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.9217275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.983922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.1420417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 4.066426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 5.067750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.953659116
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.4012903497
MESH:D005234 Fatty Liver arsenic trioxide 9.8015073043
MESH:D005234 Fatty Liver Valproic Acid 9.8019224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.9616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.818888407 18558336
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.9416904648
MESH:D006849 Hydrocephalus Valproic Acid 5.7517688650
MESH:D007938 Leukemia arsenic trioxide 3.0315070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.3517077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 5.1916972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.7914633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.3119077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 4.1316467208 16968895 19850784 20471514 17050201
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 4.1317596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.5116112521 12018890 19035177 19225113 19642359 17217047 9834237 16331271 17712046 17869043 16891316 15748426 15213294 11161223 17107899 16966277 19075265 16330433 11468182 17649720 12712474 15622746 16823087 12679006 15336539
MESH:D015458 Leukemia, T-Cell arsenic trioxide 5.0316882451
MESH:D008113 Liver Neoplasms arsenic trioxide 2.4814682389
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 3.0120377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.7315213294
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 5.3317228818
MESH:D008175 Lung Neoplasms arsenic trioxide 1.8711798837 19825857
MESH:D008881 Migraine Disorders Valproic Acid 3.5318803445 18765137
MESH:D009101 Multiple Myeloma arsenic trioxide 3.4411468182 15949261 19549372 19417148 14977855
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.588888407
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.7418349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 8.2316105982 16882451
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 8.2317596541
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.6316624393
MESH:D009436 Neural Tube Defects arsenic trioxide 8.3310525206
MESH:D009436 Neural Tube Defects Valproic Acid 8.3316359493 8888407
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.5212452020 19769630 16624393
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.6615580305
MESH:D010235 Paraganglioma arsenic trioxide 4.7719927285
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.7120603192
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2019131511
MESH:D019310 Pseudolymphoma Valproic Acid 5.6112752131 11422049
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.7819155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.6316646077
MESH:D012559 Schizophrenia Valproic Acid 2.1115737665 19110320
MESH:D012640 Seizures Valproic Acid 3.0511044598 15475178 14763951 16876388 3137016 11738929 1511512 17978042
MESH:D016135 Spinal Dysraphism Valproic Acid 4.1719490988
MESH:D013226 Status Epilepticus Valproic Acid 5.6112833885
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.4719014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.8515213294
MESH:D014178 Translocation, Genetic Valproic Acid 6.3017262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 5.413119515
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.6220435036 11780464 12973940 12845720
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.418888407
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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