AutismKB 2.0

Annotation Detail for FOXM1


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Basic Information Top
Gene Symbol:FOXM1 ( FKHL16,FOXM1B,HFH-11,HFH11,HNF-3,INS-1,MPHOSPH2,MPP-2,MPP2,PIG29,TGT3,TRIDENT )
Gene Full Name: forkhead box M1
Band: 12p13.33
Quick LinksEntrez ID:2305; OMIM: 602341; Uniprot ID:FOXM1_HUMAN; ENSEMBL ID: ENSG00000111206; HGNC ID: 3818
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200120FOXM1 transcription factor network
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene 1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of FOXM1 proteinincreases expression 15382178
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of FOXM1 mRNAaffects expression 21346803
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of FOXM1 proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of FOXM1 mRNAdecreases expression 20064835
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of FOXM1 mRNAincreases expression 20713471
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of FOXM1 mRNAdecreases expression 20382639
D002084 Butylated Hydroxytoluene Butylated Hydroxytoluene affects the localization of FOXM1 mRNAaffects localization 12867420
D002084 Butylated Hydroxytoluene Butylated Hydroxytoluene results in increased expression of FOXM1 mRNAincreases expression 11238010
12867420
D002084 Butylated Hydroxytoluene [Butylated Hydroxytoluene results in increased expression of FOXM1 mRNA] which results in increased expression of CCNA2 mRNAincreases expression 12867420
D002084 Butylated Hydroxytoluene [Butylated Hydroxytoluene results in increased expression of FOXM1 mRNA] which results in increased expression of CCNB1 mRNAincreases expression 12867420
D002084 Butylated Hydroxytoluene [Butylated Hydroxytoluene results in increased expression of FOXM1 mRNA] which results in increased expression of CCNE1 mRNAincreases expression 12867420
D002084 Butylated Hydroxytoluene [Butylated Hydroxytoluene results in increased expression of FOXM1 mRNA] which results in increased expression of CCNF mRNAincreases expression 12867420
D002084 Butylated Hydroxytoluene Butylated Hydroxytoluene results in increased expression of FOXM1 proteinincreases expression 11238010
D002084 Butylated Hydroxytoluene FOXM1 protein affects the susceptibility to Butylated Hydroxytolueneaffects response to substance 19672312
18345025
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of FOXM1 mRNAdecreases expression 12414654
15336504
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of FOXM1 mRNAincreases expression 17256749
D016572 Cyclosporine Cyclosporine results in decreased expression of FOXM1 mRNAdecreases expression 20106945
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of FOXM1 mRNAincreases expression 17854601
D004052 Diethylnitrosamine Diethylnitrosamine results in increased phosphorylation of FOXM1 proteinincreases phosphorylation 18393292
D004052 Diethylnitrosamine RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of FOXM1 mRNA]decreases reaction|increases expression 17854601
D004958 Estradiol ESR1 protein promotes the reaction [Estradiol results in increased expression of FOXM1 mRNA]increases expression|increases reaction 20208560
D004958 Estradiol ESR1 protein promotes the reaction [Estradiol results in increased expression of FOXM1 protein]increases expression|increases reaction 20208560
D004958 Estradiol Estradiol promotes the reaction [ESR1 protein binds to FOXM1 promoter]affects binding|increases reaction 20208560
D004958 Estradiol Estradiol promotes the reaction [[ESR1 protein binds to FOXM1 promoter] which results in increased expression of FOXM1 mRNA]affects binding|increases expression|increases reaction 20208560
D004958 Estradiol Estradiol results in increased expression of FOXM1 mRNAincreases expression 20208560
D004958 Estradiol Estradiol results in increased expression of FOXM1 proteinincreases expression 20208560
D004958 Estradiol FOXM1 protein results in increased susceptibility to Estradiolincreases response to substance 20208560
D004958 Estradiol Tamoxifen inhibits the reaction [Estradiol promotes the reaction [[ESR1 protein binds to FOXM1 promoter] which results in increased expression of FOXM1 mRNA]]affects binding|decreases reaction|increases expression|increases reaction 20208560
C070081 fulvestrant fulvestrant results in decreased expression of FOXM1 mRNAdecreases expression 20208560
C070081 fulvestrant fulvestrant results in decreased expression of FOXM1 proteindecreases expression 20208560
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased expression of FOXM1 mRNAdecreases expression 12414654
D008748 Methylcholanthrene FOXM1 protein affects the susceptibility to Methylcholanthreneaffects response to substance 19672312
18345025
C006253 pirinixic acid pirinixic acid results in decreased expression of FOXM1 mRNAdecreases expression 20059764
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in decreased expression of FOXM1 mRNA]decreases expression|increases reaction 20059764
C025462 sulindac sulfide sulindac sulfide results in decreased expression of FOXM1 mRNAdecreases expression 16184548
D013629 Tamoxifen ESR1 protein inhibits the reaction [Tamoxifen results in decreased expression of FOXM1 mRNA]decreases expression|decreases reaction 20208560
D013629 Tamoxifen ESR1 protein promotes the reaction [Tamoxifen results in decreased expression of FOXM1 protein]decreases expression|increases reaction 20208560
D013629 Tamoxifen FOXM1 protein affects the reaction [ESR1 protein results in increased susceptibility to Tamoxifen]affects reaction|increases response to substance 20208560
D013629 Tamoxifen FOXM1 protein results in decreased susceptibility to Tamoxifendecreases response to substance 20208560
D013629 Tamoxifen Tamoxifen inhibits the reaction [Estradiol promotes the reaction [[ESR1 protein binds to FOXM1 promoter] which results in increased expression of FOXM1 mRNA]]affects binding|decreases reaction|increases expression|increases reaction 20208560
D013629 Tamoxifen Tamoxifen promotes the reaction [HDAC1 protein binds to FOXM1 promoter]affects binding|increases reaction 20208560
D013629 Tamoxifen Tamoxifen promotes the reaction [HDAC2 protein binds to FOXM1 promoter]affects binding|increases reaction 20208560
D013629 Tamoxifen Tamoxifen results in decreased expression of FOXM1 mRNAdecreases expression 20208560
D013629 Tamoxifen Tamoxifen results in decreased expression of FOXM1 proteindecreases expression 20208560
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of FOXM1 mRNAdecreases expression 16714409
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of FOXM1 mRNAincreases expression 15667827
D014212 Tretinoin Tretinoin results in decreased expression of FOXM1 mRNAdecreases expression 18230668
D014520 Urethane FOXM1 protein affects the susceptibility to Urethaneaffects response to substance 19672312
D014520 Urethane Urethane results in increased expression of FOXM1 proteinincreases expression 16489016
D014810 Vitamin E Vitamin E results in decreased expression of FOXM1 mRNAdecreases expression 19244175
D024483 Vitamin K 3 Vitamin K 3 results in decreased expression of FOXM1 mRNAdecreases expression 12414654
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.4214745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7215322242 11752688 14514962
MESH:D055371 Acute Lung Injury pirinixic acid 2.9918653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.0120127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 7.0111473722
MESH:D000230 Adenocarcinoma Urethane 7.0118316556
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Urethane 5.5815814487
MESH:D000236 Adenoma Benzo(a)pyrene 15.436695378
MESH:D000236 Adenoma Diethylnitrosamine 15.436695378 10737359
MESH:D000236 Adenoma Methylcholanthrene 15.4310545420 6695378
MESH:D000236 Adenoma Urethane 15.4311497255 6695378 17093202 16926031 10530776 10822126 17195641
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 16.5217620307 18056438 19061943 17162532 19052882 16434500
MESH:D018248 Adenoma, Liver Cell pirinixic acid 16.5216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 16.5216835633
MESH:D000505 Alopecia Tretinoin 3.5115955085
MESH:D000544 Alzheimer Disease sulindac sulfide 3.0618759972
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8311748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9419183758
MESH:D001169 Arthritis, Experimental Tretinoin 3.0016412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2316292516
MESH:D001249 Asthma Tretinoin 2.3116456186
MESH:D050197 Atherosclerosis Methylcholanthrene 3.3811922910
MESH:D001284 Atrophy fulvestrant 4.7211514358
MESH:D001471 Barrett Esophagus Tretinoin 4.2716935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 14.5719483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.5712125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 14.5716206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6815746008
MESH:D001943 Breast Neoplasms marker/mechanism 20208560
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 4.6320146248 17474063
MESH:D001943 Breast Neoplasms Diethylnitrosamine 4.6317474063
MESH:D001943 Breast Neoplasms Estradiol 4.6312948864 16675129 17289903 19861407 17261762 18497071 14630087 17018787
MESH:D001943 Breast Neoplasms fulvestrant 4.6318984771
MESH:D001943 Breast Neoplasms Methylcholanthrene 4.6317474063
MESH:D001943 Breast Neoplasms Tamoxifen 4.6319200415 19155303 17261762 18997820 21152245 18351453 19103187 20135344 19244106 18821012 19288272 20065188 16273361 19066611 20005174 11161223 19487384 16202921 19410462 19011961 19289846 18629630 17440819 15668708 21138602 19084267 20390343 19189210 18984771 19142967 17049068 19189212 16873071 19115204 17242785 18855134 19059307 17893378 18425577 18815881 20859285 19221464 16818667 20544844 15565566
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.6320435547
MESH:D001943 Breast Neoplasms Tretinoin 4.6316166294 16873071 16443354
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.4616813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.3316111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 9.5016050911 15721981 16124888 15700767 10355542 15673190 16011737 16227642 3786805 16097048 18705752 16192424
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 9.5016050911
MESH:D002277 Carcinoma Methylcholanthrene 7.9910545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.9916835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.3819066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.0316168501
MESH:D006528 Carcinoma, Hepatocellular marker/mechanism 17173139
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 13.7716705839
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 13.7721507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 13.7718788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 13.7719394651 18788625 19335982 19208518 3581430 17761372 18978308 20432363 20101231 20214788 19519916 18691550 19107877 18494052 10737359 16681979 16807293 20727157 19383236 16328049 20935162 16935385 19418558 19919837 18971187 10672840 20512989 3084413 18665156 17055752 17428255 18210153 20524982 17162532 18785209 19701751 11831363 19052882 16830150 16569478 16540662 16502159 16698587 18506893 20084675 20514400 21159647 18393292 19539802 18056438 17138121 16878318 19822196 19171122 17173139 17978847 16288022 20007298 16779866
MESH:D006528 Carcinoma, Hepatocellular Estradiol 13.7716924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 13.7716924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 13.771917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung marker/mechanism 18345025 19672312
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfide 3.4012391285
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.4420419170
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.4416051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.5017572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3016120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 3.4216936243
MESH:D002386 Cataract Tretinoin 3.0217460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 20.1420889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 20.1412371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 20.1417174075 2727394 21159647 7505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 20.1418566989
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 20.1416192471
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.4616129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.9519052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.9516835633
MESH:D002779 Cholestasis Cyclosporine 7.4319486331
MESH:D002779 Cholestasis pirinixic acid 7.4319176532
MESH:D002822 Choriocarcinoma Tretinoin 5.0316461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 9.6112621046 8697196 16354765 15340226 15668235
MESH:D002972 Cleft Palate Tretinoin 9.619407595
MESH:D002972 Cleft Palate Urethane 9.6112810352
MESH:D003092 Colitis Tretinoin 3.5717035595
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9517141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.6810048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.689142499 17551590 16925845 10589399 9125849 14991402 8800419 9211117 9664655 9224671
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.6819769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.8818551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.2319031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3718249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.1120387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.1117107852
MESH:D003928 Diabetic Nephropathies Estradiol 8.4719279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.4719279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 8.6421346803 18551238
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 8.6415998439 15968718 10092053 16227642 19336974 7440962 6623471 21278145 3732212 9327722 6884620 2869522 7120509 4309450 11566570 19085960 16177239 17522070 3786805 7179309 15027814 10915739
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 8.6419107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.6420420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6611462148
MESH:C538011 Eales disease Vitamin E 4.579068938
MESH:D004487 Edema pirinixic acid 6.1412083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.1411000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.5115322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 11.5118230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 3.4119031437
MESH:D016889 Endometrial Neoplasms Estradiol 11.9319148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Tamoxifen 11.9319155303 20544844 17893378 16202921
MESH:D016889 Endometrial Neoplasms Tretinoin 11.9316569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.919294722 10568697
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9916302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.2420426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.2416530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.5111564622
MESH:D005124 Eye Abnormalities Tretinoin 8.5116938888 9664655
MESH:D005234 Fatty Liver Carbon Tetrachloride 23.3617595544 12631006 16239168 12795759 15959796 19224547 61145 16045604
MESH:D005234 Fatty Liver Cyclosporine 23.3619224547
MESH:D005234 Fatty Liver Diethylnitrosamine 23.3621071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 23.3619236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 23.3619224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1616709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3311858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.4014745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.0519069698
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.8114633661 10962813
MESH:D005355 Fibrosis Carbon Tetrachloride 20.0618705752
MESH:D005355 Fibrosis Cyclosporine 20.0612639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 20.0620067830
MESH:D005355 Fibrosis Tretinoin 20.0617994277
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.098708960
MESH:D005909 Glioblastoma Tretinoin 2.9217312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4710696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.1016096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.0316084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 15.4020471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 15.4010048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 15.4014991402 9664655
MESH:D006330 Heart Defects, Congenital Vitamin E 15.4016080930
MESH:D006331 Heart Diseases Urethane 4.1516046796
MESH:D006333 Heart Failure pirinixic acid 2.4620558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2915720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2111000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.4719900420 19110552
MESH:D006529 Hepatomegaly 1,4-bis(2-(3,5-dichloropyridyloxy))benzene 13.8016109766
MESH:D006529 Hepatomegaly pirinixic acid 13.8016221962 18467677 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.8015340226 16120746 12621046
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6616490937 16863852
MESH:D006558 Herpes Genitalis Estradiol 4.9015709030
MESH:D019584 Hot Flashes Estradiol 9.6217088409
MESH:D019584 Hot Flashes Vitamin E 9.6214716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9216354765 16959395 8697196 18606429 15340226
MESH:D006930 Hyperalgesia Tretinoin 3.1116870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.4016899240
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.4416778211
MESH:D006943 Hyperglycemia pirinixic acid 3.0720558911
MESH:D006967 Hypersensitivity Butylated Hydroxytoluene 4.3917604070
MESH:D006973 Hypertension Cyclosporine 4.7810903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.7818850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9615338365
MESH:D007248 Infertility, Male fulvestrant 3.6611514358
MESH:D007249 Inflammation Diethylnitrosamine 7.8718785209
MESH:D007249 Inflammation Tamoxifen 7.8719457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.8712200463 12878042
MESH:D007251 Influenza, Human Vitamin E 4.0916624496
MESH:D007333 Insulin Resistance Estradiol 6.9116627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 6.9116306350
MESH:D007410 Intestinal Diseases Tretinoin 3.6417994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.5316580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.5315992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3115604871
MESH:D007674 Kidney Diseases Cyclosporine 9.6218776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 9.6215618244
MESH:D007674 Kidney Diseases Vitamin E 9.6212488133
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 4.1516518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 16.8516705839
MESH:D007680 Kidney Neoplasms Cyclosporine 16.8512371664
MESH:D007680 Kidney Neoplasms Estradiol 16.8515610895
MESH:D007680 Kidney Neoplasms Tamoxifen 16.8518625569
MESH:D007938 Leukemia marker/mechanism 19436953
MESH:D007938 Leukemia Tretinoin 2.7117143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.5819285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0619850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.0712679006 17294898 16140955 19075265 19029980 17107899 17506722 16788101 17368321 17712046 17217047 16823087 16935935 19642359 19225113 17361223 16891316 17339181 16766008 16331271 17301526 15748426 17649720 19035177 9834237
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.219224671
MESH:D008064 Lipidoses Tamoxifen 3.0617567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.3711408273 17334410 11903743 17174718 16943688 21278145 16221502 17157831 16239168
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.3718522880 18407596 20032147 19638242 18665156
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 10.6815818738 12958196 12445418 17565644 17922224 18317297 18279442 15052691 17805973 17944888 16638106 17525996 18412020 17976157 17714472 12445421 10355542 17631135 14512876 16192424 12546737 12632512 16248980 15057751 17823541 18705752 14716496 16116963 12389079 18187930 13678700 18418968 15338365 16011737 18205269 15362042 12649538 15123356 16015684 12667390 18210741 16027843 15673190 17766677 15370692 18166357 18395914 18263696 12632514 18481824 15730626 15959796 17761835 17640975 15931870 12741479 17557913 18156304 15925388 12586293 17708605 15876570 12898905 15893842 14620537 18339082 18251166 15650968 18006644 18429990 12666154 15996030 18054572 14748882 17698563 18472332 18376398 16033810 17721639 20821823 17481882 14716833 18472094 11481614 16097048 16136751 18395095 12609069 17869086 17900296 18277467 14724832 18420326
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 10.6814716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 10.6815474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 10.6818564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 10.6812878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 10.6816248980 18397230
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 10.6816169303
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.9617285989 15720792 15830285 16964402 16246199
MESH:D008107 Liver Diseases Diethylnitrosamine 3.9617034775
MESH:D017093 Liver Failure Carbon Tetrachloride 4.0315123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.5716899240 14706259
MESH:D008113 Liver Neoplasms Aflatoxin B1 29.242125692 15890375 9163691 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 29.2421137059 20195826
MESH:D008113 Liver Neoplasms Butylated Hydroxytoluene 29.2418177683
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 29.2419294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 29.2420405173 19499222 18978307 19254457 2862719 18754104 10737359 21278145 20492335 15175105 19642983 19426721 21167192 20101389 19850985 19638242 19551842 19294768 19256749 19812893 21047994 20452335 9163691 18644402 19996281 18648771 19255062 20501860 20434301 18977376 20118626 15885732 21071580 12771043 19090486 19427195 2422723 19833225 20583210 20137499 19690152 12112319 16942905 19073162
MESH:D008113 Liver Neoplasms pirinixic acid 29.2416377806 15890375 20007298
MESH:D008113 Liver Neoplasms Tamoxifen 29.2416684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 29.2416984957
MESH:D008113 Liver Neoplasms Urethane 29.2417559639 17093202 16391232
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 17.798603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 17.7912014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 17.7918093689 18544905 19126423 19004024 17942915 18079962 18282651 18775883 16842330 19539802 9362446 19009564 18253720 16267830 17174075 18164116 17854601 18308698 3124819 2563599 19519916 21159647
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 17.79598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 17.7912151625
MESH:D008171 Lung Diseases Vitamin E 3.0916863852
MESH:D008175 Lung Neoplasms marker/mechanism 16489016
MESH:D008175 Lung Neoplasms Aflatoxin B1 15.1314755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 15.1318816296 20869020 18569708 20135361 20464547 20064080 18520028 6695378 17053015
MESH:D008175 Lung Neoplasms Butylated Hydroxytoluene 15.1318597497 16337739 19925653 19359593 11246140 11696405 15390079
MESH:D008175 Lung Neoplasms Diethylnitrosamine 15.1320970405 20512841 6695378 21163286
MESH:D008175 Lung Neoplasms Methylcholanthrene 15.1315390079 9230183 1399818 7750092 20970405 6695378 16337739 10545420 16271038 21163286 11893704 20512841 17909032
MESH:D008175 Lung Neoplasms Tamoxifen 15.1318625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 15.1319555203 11884234
MESH:D008175 Lung Neoplasms Urethane 15.1312765245 7750092 16289808 11074608 10822126 16337739 10997738 10779650 11544531 17195641 15166089 12117781 11992545 17093202 11807781 11497255 16204055 16391232 12466968 16788158 15902970 10530776 11893704 11246140 17255336 11062179 12957351 11323394 6695378 14587096 11552296 16007126 15136453 16926031 11307925
MESH:D008175 Lung Neoplasms Vitamin E 15.1311062179
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.6319428831
MESH:D008325 Mammary Neoplasms, Experimental Butylated Hydroxytoluene 9.601500032
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.6011408345 17203775 16891317 11807958
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 9.6014580682 19196723 11731420 16827153 19196722
MESH:D020149 Manganese Poisoning Estradiol 12.2219453300
MESH:D020149 Manganese Poisoning Tamoxifen 12.2219453300
MESH:D008527 Medulloblastoma Tretinoin 2.7317453147
MESH:D008545 Melanoma Tamoxifen 5.1119393235 12393984
MESH:D008545 Melanoma Tretinoin 5.1116752155
MESH:D008545 Melanoma Vitamin K 3 5.1119082730
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.0515990972
MESH:D008591 Meningomyelocele Tretinoin 4.2916940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6616801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0916381670
MESH:D009135 Muscular Diseases pirinixic acid 3.3816239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.0117596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.0919151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.9116810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.9116411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.7318551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.569029167 3581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.5619393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4719410462
MESH:D009369 Neoplasms Benzo(a)pyrene 11.3611141357
MESH:D009369 Neoplasms pirinixic acid 11.3617405874
MESH:D009369 Neoplasms Tretinoin 11.3616594593 16946489
MESH:D009369 Neoplasms Urethane 11.3615625555
MESH:D009374 Neoplasms, Experimental Urethane 4.5515582191
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.8719196722 19189210 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 3.6017289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1719348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 15.5916427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.5914600291
MESH:D009421 Nervous System Malformations Tretinoin 15.599125849
MESH:D009436 Neural Tube Defects Tretinoin 2.979142499
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.2320387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9920387270
MESH:D009765 Obesity pirinixic acid 1.7820558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.3112819281 16049721
MESH:D010051 Ovarian Neoplasms Estradiol 7.7719401270
MESH:D010051 Ovarian Neoplasms Tretinoin 7.7716936753
MESH:D010051 Ovarian Neoplasms Urethane 7.7716391232
MESH:D010146 Pain Tretinoin 2.8016870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.0916540662
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.0915976015
MESH:D010212 Papilloma Hydrogen Peroxide 3.9612065085
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1212520081
MESH:D010911 Pituitary Neoplasms Urethane 5.2816391232
MESH:D011014 Pneumonia Butylated Hydroxytoluene 5.0311893704
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4318163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.5712371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.572563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.0611118676 11896295 11222880 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.7620887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0717292933
MESH:D011471 Prostatic Neoplasms Estradiol 2.0716740699
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0715067354
MESH:D011471 Prostatic Neoplasms Vitamin E 2.0715084515
MESH:D011507 Proteinuria Tretinoin 3.4816636307
MESH:D011565 Psoriasis Cyclosporine 2.1816882103
MESH:D011625 Pterygium Tretinoin 4.6616723453
MESH:D015427 Reperfusion Injury pirinixic acid 2.3219058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7118990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.9816116481 16283617
MESH:D012640 Seizures 2,4-dinitrotoluene 2.4518551238
MESH:D012871 Skin Diseases Vitamin E 2.4118709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 21.7010029692 19755658
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 21.7012065085
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 21.708532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 21.7016192470
MESH:D012878 Skin Neoplasms Tretinoin 21.7016467112
MESH:D012878 Skin Neoplasms Urethane 21.7011807781
MESH:D013088 Spermatocele Tamoxifen 4.1616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.9119457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.2620155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.2618456281
MESH:D013274 Stomach Neoplasms Tretinoin 3.2617261132
MESH:D020521 Stroke Vitamin E 3.4116517955
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7712697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 6.847505956
MESH:D013964 Thyroid Neoplasms Tretinoin 6.8416026305 17045167
MESH:D013978 Tibial Fractures Estradiol 4.5619048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.6716051514
MESH:D014376 Tuberculosis Tretinoin 3.1516040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 7.9816049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 7.9817053015
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 7.9816712894 8653321 17572228
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.1810091137
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.5616129372
MESH:D014594 Uterine Neoplasms sulindac sulfide 4.5318645019
MESH:D014604 Uveal Neoplasms Tretinoin 4.4816752155
MESH:D014605 Uveitis Cyclosporine 3.851336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4712125929
MESH:D019043 Vascular Neoplasms Urethane 5.7810620525
MESH:D014820 Vitiligo Tretinoin 3.9316761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1215886252
MESH:D009396 Wilms Tumor Tretinoin 3.8516287080
MESH:D014985 Xerophthalmia Cyclosporine 4.3117120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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