AutismKB 2.0

Annotation Detail for ENDOD1


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Basic Information Top
Gene Symbol:ENDOD1 ( KIAA0830,MGC88092 )
Gene Full Name: endonuclease domain containing 1
Band: 11q21
Quick LinksEntrez ID:23052; OMIM: NA; Uniprot ID:ENDD1_HUMAN; ENSEMBL ID: ENSG00000149218; HGNC ID: 29129
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of ENDOD1 mRNAaffects expression 17562736
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of ENDOD1 mRNAaffects expression 17484886
D003907 Dexamethasone Dexamethasone results in decreased expression of ENDOD1 mRNAdecreases expression 12782123
D007529 Isoflavones Isoflavones results in decreased expression of ENDOD1 mRNAdecreases expression 17374662
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of ENDOD1 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of ENDOD1 mRNAincreases expression 19482888
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in decreased expression of ENDOD1 mRNAaffects cotreatment|decreases expression 19059307
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in decreased expression of ENDOD1 mRNAaffects cotreatment|decreases expression 19059307
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ENDOD1 mRNAincreases expression 19465110
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.9214745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 9.446195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.4411752688 15322242 14514962
MESH:D018248 Adenoma, Liver Cell Phenobarbital 11.2317620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.2316835633
MESH:D000419 Albuminuria Raloxifene 4.8817451421 17308373
MESH:D000505 Alopecia Isoflavones 4.9117569567
MESH:D000544 Alzheimer Disease Raloxifene 2.5815800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001169 Arthritis, Experimental Dexamethasone 3.6717659584
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D001930 Brain Injuries Raloxifene 4.7816580743
MESH:D001943 Breast Neoplasms Raloxifene 1.8815758505 16837676 16912660 17261762 17893378 17049068 15572757 17595753 15775269 17952589 17440819 17242785
MESH:D001943 Breast Neoplasms Tamoxifen 1.8817261762 15565566 20390343 19221464 19011961 19155303 19200415 18629630 21152245 16202921 19084267 15668708 17242785 19142967 19410462 18815881 19288272 17893378 18997820 19189210 17049068 20544844 18351453 11161223 19059307 19115204 18855134 19189212 21138602 20135344 19244106 16818667 16873071 18821012 19066611 16273361 19487384 20065188 19289846 20005174 20859285 18425577 19103187 17440819 18984771
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8820435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.0816050911 15721981 16011737 16227642 16097048 15700767 18705752 3786805 16124888 10355542 16192424 15673190
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.8119066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.823084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.8218788625
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 6.821701930 6705139 20007298 20935162 17173139
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.8216924424
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 10.2717572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 10.2717572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4918850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Isoflavones 8.3517689850
MESH:D002318 Cardiovascular Diseases Raloxifene 8.3515775269
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.564080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.198697196 15668235 15340226 12621046 16354765
MESH:D003072 Cognition Disorders Raloxifene 4.9215800139
MESH:D003110 Colonic Neoplasms Dexamethasone 2.5215824018
MESH:D015179 Colorectal Neoplasms Isoflavones 2.9017116718
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2717141729 14669216
MESH:D019465 Craniofacial Abnormalities Dexamethasone 2.6717728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.6710048152 15322242 20055451
MESH:D003711 Demyelinating Diseases Tamoxifen 4.6719031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.3817474826
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.7012438553
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D003928 Diabetic Nephropathies Raloxifene 9.7617451421 17308373 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 9.7619279558
MESH:D003967 Diarrhea Dexamethasone 3.977237001
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.4811421492 19085960 17522070 12594235 16081117 2444490 19416960 19923254 16227642 19370779 11461765 10774834 18071297 19420014 11834606 16177239 17906064 11739529 10915739 11743745 12705907 17562736 14986274 12540782 12958197 15619225 11287661 12153990 16109766 19164858 14550746 16485898 19739265 18713872 14725611 16393943 16781746 15968718 10663392 12392966 11529661
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.487179309 3732212 6623471 17522070 10092053 15968718 6884620 4309450 19336974 9327722 15998439 7120509 15027814 2869522 11566570 16227642 3786805 7440962 10915739 21278145 16177239 19085960
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.4820420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D004421 Dystonia Phenobarbital 4.261851702
MESH:D004485 Eczema Dexamethasone 4.7412438553
MESH:D004487 Edema Dexamethasone 13.0019703484
MESH:D004487 Edema Raloxifene 13.0015860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 13.0011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2816714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 10.2015845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.2019031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1920544844 19155303 17893378 16202921
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2510568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.413659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.253922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.0020417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.766401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.567750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.363659116
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 14.6615959796 12631006 12795759 16045604 19224547 16239168 17595544 61145
MESH:D005234 Fatty Liver Raloxifene 14.6617473493
MESH:D005234 Fatty Liver Tamoxifen 14.6619224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3716709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.8714745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.5219069698
MESH:D005355 Fibrosis Carbon Tetrachloride 9.6418705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.6420067830
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4410048152 11294989
MESH:D006331 Heart Diseases Raloxifene 3.6911110106
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.8819110552 19900420
MESH:D006529 Hepatomegaly Phenobarbital 9.4816109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.4816120746 15340226 12621046
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 3.147520565
MESH:D019584 Hot Flashes Isoflavones 5.3614716179 17290160
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4218606429 8697196 16354765 15340226 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8716899240
MESH:D006973 Hypertension Dexamethasone 9.1517042910
MESH:D006973 Hypertension Raloxifene 9.1517577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 9.1518670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3915338365
MESH:D007249 Inflammation Dexamethasone 9.008960868 11099482
MESH:D007249 Inflammation Tamoxifen 9.0019457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 9.0012200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D007674 Kidney Diseases Acetaminophen 2.3212587719 15629191
MESH:D007680 Kidney Neoplasms Tamoxifen 3.2418625569
MESH:D007889 Leiomyoma Raloxifene 4.7616973256
MESH:D008064 Lipidoses Tamoxifen 3.3217567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 7.0411408273 17157831 16943688 17334410 16239168 16221502 21278145 17174718 11903743
MESH:D008103 Liver Cirrhosis Phenobarbital 7.0421047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 5.1616015684 17525996 17714472 18481824 12389079 12586293 17922224 18705752 14716496 15362042 12445418 17640975 15673190 12445421 18210741 16011737 12546737 17976157 12898905 12609069 17869086 18395095 18412020 18166357 15730626 12741479 18251166 18420326 12632514 15876570 18472332 16116963 17481882 15123356 12666154 15893842 14512876 16027843 18006644 15959796 18472094 18263696 11481614 14716833 18277467 18156304 14748882 17721639 16248980 17944888 20821823 18429990 15931870 10355542 17823541 18279442 12649538 15996030 18054572 18205269 14620537 15052691 15925388 17565644 18395914 15057751 17698563 18317297 16136751 18339082 18376398 17900296 17805973 16097048 15650968 18418968 14724832 16033810 17557913 12667390 16638106 13678700 15338365 12632512 15370692 17631135 12958196 17761835 17766677 16192424 18187930 17708605 15818738
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 5.1616718785
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 5.1618564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.1612878042
MESH:D008107 Liver Diseases Acetaminophen 6.7919784758 11587558 12969438 12587719 19014921 16611625 19460945 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.7916246199 15720792 15830285 16964402 17285989
MESH:D008107 Liver Diseases Phenobarbital 6.7919363144
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4715123358
MESH:D017114 Liver Failure, Acute Acetaminophen 10.1817185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 10.1816899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 11.3519294768
MESH:D008113 Liver Neoplasms Phenobarbital 11.3515975961 21047994 19073162 8742319 19812893 19482888
MESH:D008113 Liver Neoplasms Tamoxifen 11.3516684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.3516984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.6312014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 10.631399818 6150874 2563599 17172636 18308698
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.6312151625
MESH:D008175 Lung Neoplasms Dexamethasone 3.5615824018 11195469
MESH:D008175 Lung Neoplasms Tamoxifen 3.5618625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5611884234 19555203
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.1019428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7611731420 19196722 14580682 16827153 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 4.9219453300
MESH:D008545 Melanoma Tamoxifen 1.9112393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.5215990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.9315863610
MESH:D009101 Multiple Myeloma Dexamethasone 8.1215867202 16118317 15744524
MESH:D009101 Multiple Myeloma Raloxifene 8.1216497877
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.669809623
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.8117484760
MESH:D009232 Myxoma Raloxifene 5.9316343187
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6319393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5819410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.3819189210 19196722 19200415
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4914600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D010018 Osteomalacia Phenobarbital 4.7017016548
MESH:D010024 Osteoporosis Isoflavones 8.1016562857
MESH:D010024 Osteoporosis Raloxifene 8.1015775268 17882678 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.4917823083 15579764 17893378 15758505
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5616965848
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.842563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.6621297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5311118676 11896295 11222880 11399792
MESH:D011471 Prostatic Neoplasms Isoflavones 2.7117571952 17374662 16365062 17219775
MESH:D011471 Prostatic Neoplasms Raloxifene 2.7116536755 16220300 15731164
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.7115067354
MESH:D019310 Pseudolymphoma Phenobarbital 4.8712752131
MESH:D011693 Purpura Raloxifene 5.9315770314
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 4.2811700416 18379247
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012640 Seizures Phenobarbital 2.843137016 16876388 4039156 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 5.166407741
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1416192470
MESH:D013088 Spermatocele Tamoxifen 4.6716709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.3819457130
MESH:D013272 Stomach Diseases Dexamethasone 4.6615472012
MESH:D013276 Stomach Ulcer Dexamethasone 3.7215138204
MESH:D020521 Stroke Raloxifene 4.0116837676
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.231399818
MESH:D013978 Tibial Fractures Raloxifene 5.5819048282
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 5.5017572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.5017572228 16712894 8653321
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D014605 Uveitis Dexamethasone 5.191336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.5816837676
MESH:D014846 Vulvar Neoplasms Raloxifene 5.9316343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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