AutismKB 2.0

Annotation Detail for NCOA6


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Basic Information Top
Gene Symbol:NCOA6 ( AIB3,ASC2,KIAA0181,NRC,PRIP,RAP250,TRBP )
Gene Full Name: nuclear receptor coactivator 6
Band: 20q11.22
Quick LinksEntrez ID:23054; OMIM: 605299; Uniprot ID:NCOA6_HUMAN; ENSEMBL ID: ENSG00000198646; HGNC ID: 15936
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Metabolism of lipids and lipoproteins
Pathway IDPathway Name
200038Coregulation of Androgen receptor activity
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene 1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [NCOA6 protein binds to and results in increased activity of NR1I3 protein]affects binding|increases activity|increases reaction 15764585
C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene 1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [NCOA6 protein binds to CYP2B6 gene]affects binding|increases reaction 15764585
C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene 1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [NCOA6 protein binds to CYP3A4 gene]affects binding|increases reaction 15764585
C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene androstan-3-ol inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [NCOA6 protein binds to CYP2B6 gene]]affects binding|decreases reaction|increases reaction 15764585
C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene NCOA6 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CYP1A2 mRNA]increases expression|increases reaction 15764585
C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene NCOA6 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CYP2B10 mRNA]increases expression|increases reaction 15764585
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of NCOA6 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of NCOA6 mRNAaffects expression 21346803
D000082 Acetaminophen NCOA6 protein promotes the reaction [NR1I3 protein results in increased susceptibility to Acetaminophen]increases reaction|increases response to substance 15764585
D000082 Acetaminophen Acetaminophen affects the expression of NCOA6 mRNAaffects expression 17562736
D000450 Aldosterone [Aldosterone binds to NR3C2 protein] which binds to NCOA6 protein alternative formaffects binding 15761029
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NCOA6 mRNAaffects expression 16483693
C000658 androstan-3-ol androstan-3-ol inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [NCOA6 protein binds to CYP2B6 gene]]affects binding|decreases reaction|increases reaction 15764585
C000658 androstan-3-ol androstan-3-ol inhibits the reaction [NCOA6 protein binds to and results in increased activity of NR1I3 protein]affects binding|decreases reaction|increases activity 15764585
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of NCOA6 mRNAdecreases expression 19150397
D015741 Metribolone Metribolone results in increased expression of NCOA6 mRNAincreases expression 17010196
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of NCOA6 mRNAaffects binding|increases activity|increases expression 19710929
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7216434500
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3219483382
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.6416705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.6416705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.643084413
MESH:D002318 Cardiovascular Diseases Aldosterone 4.8411230374
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.036135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.0320889678
MESH:D002779 Cholestasis pirinixic acid 2.9519176532
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.6318551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.6318551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.4421346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.4421346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.4419923254 10663392 2444490 16227642 12392966 19085960 14550746 15968718 16393943 11421492 11529661 16781746 17562736 11834606 16485898 17906064 16109766 17522070 12540782 11287661 12594235 14725611 19164858 14986274 11743745 18071297 11739529 12705907 19370779 19416960 19420014 12958197 10774834 19739265 15619225 16177239 16081117 10915739 18713872 12153990 11461765
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004487 Edema pirinixic acid 2.6512083418
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1120426865
MESH:D005234 Fatty Liver pirinixic acid 2.9319236843 20131406
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D006333 Heart Failure pirinixic acid 2.6320558911
MESH:D006529 Hepatomegaly 1,4-bis(2-(3,5-dichloropyridyloxy))benzene 9.6716109766
MESH:D006529 Hepatomegaly pirinixic acid 9.6718467677 19176532 19772884 16221962
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D007333 Insulin Resistance pirinixic acid 2.7416306350
MESH:D007674 Kidney Diseases Acetaminophen 2.2912587719 15629191
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.8516705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.8516705839
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3415474484
MESH:D008107 Liver Diseases Acetaminophen 1.6612587719 19784758 16611625 12969438 11587558 19014921 16610002 19460945
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4016871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.607678174
MESH:D008113 Liver Neoplasms pirinixic acid 4.6015890375 20007298 16377806
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.642876784 6135515 2876786
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0816411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.1518551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.1518551238 7678174
MESH:D009369 Neoplasms pirinixic acid 2.0217405874
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.4316049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.4316049721
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D012640 Seizures 2,4-dinitrotoluene 6.2518551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.2518551238
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.2116049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.2116049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.8010091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.8010091137
MESH:D014581 Urticaria Acetaminophen 3.1610982225
Pathway ID Pathway Name
REACT:22258 Metabolism of lipids and lipoproteins
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA31475
    • No data
    Releated disease ID Related disease Name
    PA443560Breast Neoplasms
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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