AutismKB 2.0

Annotation Detail for MYCBP2


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Basic Information Top
Gene Symbol:MYCBP2 ( DKFZp686M08244,FLJ10106,FLJ13826,FLJ21597,FLJ21646,KIAA0916,PAM )
Gene Full Name: MYC binding protein 2
Band: 13q22.3
Quick LinksEntrez ID:23077; OMIM: 610392; Uniprot ID:MYCB2_HUMAN; ENSEMBL ID: ENSG00000005810; HGNC ID: 23386
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000638 Amiodarone Amiodarone affects the expression of MYCBP2 mRNAaffects expression 19483382
C006632 arsenic trioxide arsenic trioxide results in increased expression of MYCBP2 mRNAincreases expression 20458559
D001553 Benzbromarone Benzbromarone affects the expression of MYCBP2 mRNAaffects expression 19483382
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of MYCBP2 mRNAdecreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MYCBP2 mRNAdecreases expression 19150397
D002994 Clofibrate Clofibrate affects the expression of MYCBP2 mRNAaffects expression 19483382
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of MYCBP2 mRNAincreases expression 17475347
D005001 Ethionine Ethionine affects the expression of MYCBP2 mRNAaffects expression 19483382
D005557 Formaldehyde Formaldehyde results in increased expression of MYCBP2 mRNAincreases expression 14756816
C106014 gedunin gedunin results in decreased expression of MYCBP2 mRNAdecreases expression 17010675
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of MYCBP2 mRNAaffects cotreatment|increases expression 17183730
D007657 Ketone Bodies Ketone Bodies results in increased expression of MYCBP2 mRNAincreases expression 16807920
D008942 Mitoxantrone MYCBP2 protein affects the susceptibility to Mitoxantroneaffects response to substance 16217747
D009853 Omeprazole Omeprazole affects the expression of MYCBP2 mRNAaffects expression 19483382
C006253 pirinixic acid pirinixic acid affects the expression of MYCBP2 mRNAaffects expression 19483382
D011441 Propylthiouracil Propylthiouracil affects the expression of MYCBP2 mRNAaffects expression 19483382
D018038 Sodium Selenite Sodium Selenite results in increased expression of MYCBP2 mRNAincreases expression 18175754
D013853 Thioacetamide Thioacetamide affects the expression of MYCBP2 mRNAaffects expression 19483382
C050414 tripterine tripterine results in decreased expression of MYCBP2 mRNAdecreases expression 17010675
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of MYCBP2 mRNAaffects cotreatment|increases expression 17183730
D015054 Zymosan Zymosan results in increased expression of MYCBP2 mRNAincreases expression 14756816
D015054 Zymosan Zymosan results in increased expression of MYCBP2 proteinincreases expression 14756816
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.388875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.8319490988
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.8417505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.0118653653
MESH:D000230 Adenocarcinoma arsenic trioxide 6.8619825857 11798837
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.8620127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.8614692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.596695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.3716434500
MESH:D000550 Amblyopia Valproic Acid 5.1317688650
MESH:D000740 Anemia Zymosan 4.4618664788
MESH:D001008 Anxiety Disorders Valproic Acid 3.4817497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9619183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.7018057881 18218290 20041841
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.3611256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.3715885639
MESH:D001169 Arthritis, Experimental Zymosan 7.3715142272 16872482 15188379 17659584 15944321
MESH:D001281 Atrial Fibrillation Amiodarone 3.8218651412 19698954
MESH:D001321 Autistic Disorder Valproic Acid 2.0118396377 18940202 17157402 16609825 19232924 18985861 17688650 20603192 19460635 18558336 18177632 18775368 17507914 18316065 15238991
MESH:D001714 Bipolar Disorder Valproic Acid 3.0217594078 20046352
MESH:D001778 Blood Coagulation Disorders Amiodarone 56.5019483382
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 56.5016206674
MESH:D001778 Blood Coagulation Disorders Benzbromarone 56.5019483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 56.5019483382
MESH:D001778 Blood Coagulation Disorders Ethionine 56.5019483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 56.5019483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 56.5019483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 56.5019483382
MESH:D001778 Blood Coagulation Disorders Thioacetamide 56.5019483382
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.338888407
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.7720146248 17474063
MESH:D001943 Breast Neoplasms Formaldehyde 2.7715986119
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.2211589617
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.7016217749 15073043 15553829 11135700 14691202
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 4.701701930
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 4.7017997003
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.7719014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.0212490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0220419170
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.8619225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.9818974383
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.6720889678
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 6.671399818
MESH:D002637 Chest Pain Omeprazole 5.0015447763
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6720734317
MESH:D018281 Cholangiocarcinoma Thioacetamide 4.1918291259
MESH:D002779 Cholestasis Ethinyl Estradiol 7.4716919318 17110522 17681005 15861022 16105132 11677210 17333356
MESH:D002779 Cholestasis pirinixic acid 7.4719176532
MESH:D019457 Chromosome Breakage Sodium Selenite 4.6415894690
MESH:D016770 Ciliophora Infections Formaldehyde 5.5412113305
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.0812609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.6710525206
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.678888407 16575769 17688650
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.9915213294
MESH:D017449 Dermatitis, Allergic Contact Formaldehyde 4.6115932584 12081698 15059100 16958921 14996049
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3818249437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.6816285004
MESH:D056486 Drug-Induced Liver Injury Amiodarone 8.7918218290 15265979
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 8.7915131321
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 8.7912963478
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 8.7919641884 1733752
MESH:D004381 Duodenal Ulcer Omeprazole 4.2215991576 21218061 17151854 16613094
MESH:D050171 Dyslipidemias Clofibrate 3.9916707586
MESH:D004421 Dystonia Valproic Acid 3.941851702
MESH:D004487 Edema pirinixic acid 6.8012083418
MESH:D004487 Edema Zymosan 6.807907874
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.0812538720
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.0417275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 3.813922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.8820417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.496426943 6254150 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.197750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.963659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.0420426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 7.0412903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.0416530937
MESH:D005141 Eyelid Diseases Formaldehyde 6.2714996049
MESH:D005218 Fat Necrosis Thioacetamide 5.6116456712
MESH:D005234 Fatty Liver Amiodarone 29.4114986274
MESH:D005234 Fatty Liver arsenic trioxide 29.4115073043
MESH:D005234 Fatty Liver Clofibrate 29.4119224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 29.4115345470
MESH:D005234 Fatty Liver pirinixic acid 29.4119236843 20131406
MESH:D005234 Fatty Liver Valproic Acid 29.4114986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 4.7816575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.028888407 18558336
MESH:D005393 Fish Diseases Formaldehyde 5.5012113305
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.1516904648
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.6020471113
MESH:D006331 Heart Diseases Mitoxantrone 4.0716019553
MESH:D006333 Heart Failure pirinixic acid 2.4720558911
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.4717276928 18665440 15929193
MESH:D006505 Hepatitis Thioacetamide 9.5316456712
MESH:D006505 Hepatitis Zymosan 9.5319110552
MESH:D006529 Hepatomegaly Amiodarone 8.2115265979
MESH:D006529 Hepatomegaly pirinixic acid 8.2119176532 16221962 19772884 18467677
MESH:D006849 Hydrocephalus Valproic Acid 4.7617688650
MESH:D006937 Hypercholesterolemia Amiodarone 3.779751232 8137927
MESH:D006943 Hyperglycemia pirinixic acid 3.0820558911
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.5216612254
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7016945680 16569931
MESH:D007037 Hypothyroidism Amiodarone 11.2518020914 17991464
MESH:D007037 Hypothyroidism Propylthiouracil 11.258137927 18031379
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3612013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4117937319
MESH:D007249 Inflammation Zymosan 3.4111289658 8014878
MESH:D007333 Insulin Resistance pirinixic acid 7.0716306350
MESH:D007333 Insulin Resistance Sodium Selenite 7.0714714311
MESH:D043183 Irritable Bowel Syndrome Zymosan 5.7317553498
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 4.0019248655
MESH:D007938 Leukemia arsenic trioxide 2.7815070760
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Mitoxantrone 3.7418172266
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.6912560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.2016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.3514633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.6619077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.8417050201 16968895 16467208 19850784 20471514
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.8417596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.1416891316 16966277 17712046 16331271 16112521 19225113 17649720 15748426 16823087 12018890 15622746 11161223 19075265 19642359 15213294 19035177 9834237 15336539 11468182 17217047 17107899 12679006 12712474 17869043 16330433
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.2416882451
MESH:D008064 Lipidoses Amiodarone 3.4317567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.5215474484
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 2.5215158331 10677585 18032466 15362042 18380797 18458672 15095483 15075984 17629604 12531686 18295389 11481614 15316131 12679928 17355460 18416461 16343077 18606216 15474484 18031379 15288472 15716488 11682029 18615449 18395095 16097051 18263696 12085344 17127702 15334695 15078482 14739098 11172339 12557150 16126171 12175628 17292413 12891558 16489207 15288473 17050028 16098781 16248980 15465738 16511523
MESH:D008107 Liver Diseases Thioacetamide 2.6815158337 16337175 18374380
MESH:D017114 Liver Failure, Acute Thioacetamide 4.2115633222 15313186 17276928 12479984
MESH:D008113 Liver Neoplasms arsenic trioxide 7.1514682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.1520195826 21137059
MESH:D008113 Liver Neoplasms pirinixic acid 7.1515890375 16377806 20007298
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 2.6720377131
MESH:D008133 Long QT Syndrome Amiodarone 7.9115350150 17391786 11989578
MESH:D008133 Long QT Syndrome arsenic trioxide 7.9115213294
MESH:D008171 Lung Diseases Amiodarone 3.3012587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 10.9118516814
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 10.9117228818
MESH:D008175 Lung Neoplasms arsenic trioxide 2.3819825857 11798837
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.3818520028 20464547 20064080 18816296 17053015 18569708 20869020 20135361 6695378
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 3.9514737004
MESH:D008881 Migraine Disorders Valproic Acid 3.1118765137 18803445
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1016381670
MESH:D009101 Multiple Myeloma arsenic trioxide 3.0319417148 11468182 15949261 19549372 14977855
MESH:D009102 Multiple Organ Failure Zymosan 5.1012130978 12879239 15241586 15213630 10479408 15259001 18160304 10890648 15834315 17724436
MESH:D009135 Muscular Diseases pirinixic acid 3.4016239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.928888407
MESH:D009181 Mycoses Amiodarone 4.8012754197 17974566
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.5718349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.2116105982 16882451
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.2117596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1019151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8616411023
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.8516624393
MESH:D009369 Neoplasms Benzo(a)pyrene 8.0111141357
MESH:D009369 Neoplasms Mitoxantrone 8.0116640825
MESH:D009369 Neoplasms pirinixic acid 8.0117405874
MESH:D009436 Neural Tube Defects arsenic trioxide 7.0910525206
MESH:D009436 Neural Tube Defects Valproic Acid 7.0916359493 8888407
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 4.839802331
MESH:D009669 Nose Neoplasms Formaldehyde 5.234038687
MESH:D009765 Obesity pirinixic acid 1.7920558911
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.3716624393 19769630 12452020
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.4915580305
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5811578682
MESH:D010235 Paraganglioma arsenic trioxide 4.0619927285
MESH:D010538 Peritonitis Zymosan 4.7718977430 19641140 18760300 18557954 11985352 19088179 17826846 17371808 14761945 15259001 15979727
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 3.7220603192
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.5919131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5917292933
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.5918760546
MESH:D011537 Pruritus Ethinyl Estradiol 3.2015861022 16919318
MESH:D019310 Pseudolymphoma Valproic Acid 4.4412752131 11422049
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.8112490602 11597910 12832656
MESH:D015427 Reperfusion Injury pirinixic acid 2.3319058328
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.0719155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.8516646077
MESH:D012559 Schizophrenia Valproic Acid 2.0519110320 15737665
MESH:D012595 Scleroderma, Systemic Formaldehyde 5.7614979077
MESH:D012640 Seizures Valproic Acid 2.661511512 17978042 14763951 11738929 11044598 15475178 16876388 3137016
MESH:D018805 Sepsis Zymosan 4.5611441115
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.9818724381
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.3210029692 19755658
MESH:D013088 Spermatocele Ethinyl Estradiol 3.8416709447
MESH:D016135 Spinal Dysraphism Valproic Acid 3.6919490988
MESH:D013226 Status Epilepticus Valproic Acid 4.4412833885
MESH:D013272 Stomach Diseases Omeprazole 4.5018545984
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.3417007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.342093021 20155912
MESH:D013276 Stomach Ulcer Amiodarone 7.2418087811
MESH:D013276 Stomach Ulcer Omeprazole 7.2417977527 18237397 16755016 10750652 11906479 15991576
MESH:D013610 Tachycardia Amiodarone 4.1811238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.0819225199
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0615669648
MESH:D013959 Thyroid Diseases Amiodarone 4.6519731979
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.1719014326
MESH:D013964 Thyroid Neoplasms Propylthiouracil 7.1715710170
MESH:D013971 Thyrotoxicosis Amiodarone 4.7519584973 18020914
MESH:D016171 Torsades de Pointes Amiodarone 9.9011989578 17467628
MESH:D016171 Torsades de Pointes arsenic trioxide 9.9015213294
MESH:D014178 Translocation, Genetic Valproic Acid 5.1317262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.413119515
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 4.9011780464 20435036 12973940 12845720
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 4.9017053015
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.538888407
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1914692618
MESH:D014605 Uveitis Zymosan 5.2911006244
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4415869587 14671159
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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