AutismKB 2.0

Annotation Detail for FOXO1


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Basic Information Top
Gene Symbol:FOXO1 ( FKH1,FKHR,FOXO1A )
Gene Full Name: forkhead box O1
Band: 13q14.11
Quick LinksEntrez ID:2308; OMIM: 136533; Uniprot ID:FOXO1_HUMAN; ENSEMBL ID: ENSG00000150907; HGNC ID: 3819
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04910Insulin signaling pathway
hsa05215Prostate cancer
hsa05200Pathways in cancer
Pathway IDPathway Name
Signalling by NGF
Regulation of beta-cell development
Pathway IDPathway Name
200002Regulation of nuclear SMAD2/3 signaling
200020Signaling events mediated by HDAC Class III
200124IL6-mediated signaling events
200083CXCR4-mediated signaling events
200066Angiopoietin receptor Tie2-mediated signaling
200091FoxO family signaling
200169Class I PI3K signaling events mediated by Akt
200102Regulation of Androgen receptor activity
Pathway IDPathway Name
P00048PI3 kinase pathway
Pathway IDPathway Name
500522Regulation of gene expression in beta cells
500523AKT-mediated inactivation of FOXO1A
Related Diseases/Disorders Top
Desease IDDesease Name
Cancers
H00037Alveolar rhabdomyosarcoma
Cancers of soft tissues and bone
Desease IDDesease Name
1775Muscular atrophy
1831Prostate cancer
1832Congenital abnormality
2051Leukemia
No data
Desease Name
Central corneal thickness
Desease Name
Rhabdomyosarcoma, alveolar
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of FOXO1 mRNAincreases expression 18648102
C065250 4-hydroxy-equilenin 4-hydroxy-equilenin results in increased expression of FOXO1 mRNAincreases expression 15135645
C046938 9,11-linoleic acid 9,11-linoleic acid affects the localization of FOXO1 proteinaffects localization 15992797
D000171 Acrolein Acrolein results in increased phosphorylation of FOXO1 proteinincreases phosphorylation 20525806
D000643 Ammonium Chloride Ammonium Chloride affects the expression of FOXO1 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene affects the activity of FOXO1 proteinaffects activity 20624995
C511635 bis(allixinato)oxovanadium(IV) [bis(allixinato)oxovanadium(IV) results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of FOXO1 proteinincreases activity|increases phosphorylation 17805585
C511635 bis(allixinato)oxovanadium(IV) bis(allixinato)oxovanadium(IV) results in increased phosphorylation of FOXO1 proteinincreases phosphorylation 17805585
C511635 bis(allixinato)oxovanadium(IV) [bis(allixinato)oxovanadium(IV) results in increased phosphorylation of FOXO1 protein] inhibits the reaction [[FOXO1 protein binds to G6PC promoter] which results in increased expression of G6PC mRNA]affects binding|decreases reaction|increases expression|increases phosphorylation 17805585
D003300 Copper Copper affects the localization of FOXO1 proteinaffects localization 16973122
D003300 Copper Copper results in increased phosphorylation of FOXO1 proteinincreases phosphorylation 16973122
D003300 Copper wortmannin inhibits the reaction [Copper affects the localization of FOXO1 protein]affects localization|decreases reaction 16973122
D003300 Copper wortmannin inhibits the reaction [Copper results in increased phosphorylation of FOXO1 protein]decreases reaction|increases phosphorylation 16973122
D019327 Copper Sulfate Copper Sulfate affects the localization of FOXO1 proteinaffects localization 16973122
D019327 Copper Sulfate Copper Sulfate results in increased phosphorylation of FOXO1 proteinincreases phosphorylation 16973122
D019327 Copper Sulfate wortmannin inhibits the reaction [Copper Sulfate affects the localization of FOXO1 protein]affects localization|decreases reaction 16973122
D019327 Copper Sulfate wortmannin inhibits the reaction [Copper Sulfate results in increased phosphorylation of FOXO1 protein]decreases reaction|increases phosphorylation 16973122
D003474 Curcumin Curcumin results in decreased phosphorylation of FOXO1 proteindecreases phosphorylation 18790744
D003474 Curcumin Curcumin results in increased expression of FOXO1 mRNAincreases expression 18403477
D016572 Cyclosporine Cyclosporine results in decreased expression of FOXO1 mRNAdecreases expression 20106945
C014347 decitabine [decitabine co-treated with vorinostat] affects the expression of FOXO1 mRNAaffects cotreatment|affects expression 17330099
C007262 deoxynivalenol deoxynivalenol results in increased phosphorylation of FOXO1 proteinincreases phosphorylation 15976193
D004041 Dietary Fats Dietary Fats results in decreased expression of FOXO1 mRNAdecreases expression 18042831
D002117 Calcitriol Calcitriol results in increased expression of FOXO1 mRNAincreases expression 16002434
D004317 Doxorubicin Doxorubicin results in increased phosphorylation of FOXO1 proteinincreases phosphorylation 17935137
D004317 Doxorubicin wortmannin inhibits the reaction [Doxorubicin results in increased phosphorylation of FOXO1 protein]decreases reaction|increases phosphorylation 17935137
D004642 Emodin Emodin results in increased expression of FOXO1 mRNAincreases expression 16045814
D004958 Estradiol Estradiol affects the expression of FOXO1 mRNAaffects expression 14699072
D005047 Etoposide Etoposide results in increased phosphorylation of FOXO1 proteinincreases phosphorylation 17935137
D005047 Etoposide wortmannin inhibits the reaction [Etoposide results in increased phosphorylation of FOXO1 protein]decreases reaction|increases phosphorylation 17935137
D005632 Fructose Fructose results in increased expression of FOXO1 mRNAincreases expression 19196556
D005632 Fructose rosiglitazone inhibits the reaction [Fructose results in increased expression of FOXO1 mRNA]decreases reaction|increases expression 19196556
D005947 Glucose FOXO1 protein mutant form results in increased abundance of Glucoseincreases abundance 15788402
D005947 Glucose FOXO1 protein results in increased abundance of Glucoseincreases abundance 15788402
D005947 Glucose INS1 protein inhibits the reaction [FOXO1 protein results in increased abundance of Glucose]decreases reaction|increases abundance 15788402
D005947 Glucose INS1 protein promotes the reaction [FOXO1 protein mutant form results in increased abundance of Glucose]increases abundance|increases reaction 15788402
D005947 Glucose resveratrol promotes the reaction [FOXO1 protein results in increased abundance of Glucose]increases abundance|increases reaction 15788402
D006861 Hydrogen Peroxide Hydrogen Peroxide results in increased localization of FOXO1 proteinincreases localization 15788402
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased phosphorylation of FOXO1 proteindecreases phosphorylation 19451193
D006861 Hydrogen Peroxide Hydrogen Peroxide promotes the reaction [FOXO1 protein binds to SIRT1 protein]affects binding|increases reaction 15788402
D006861 Hydrogen Peroxide Hydrogen Peroxide results in increased localization of [FOXO1 protein binds to SIRT1 protein]affects binding|increases localization 15788402
D006861 Hydrogen Peroxide INS protein inhibits the reaction [Hydrogen Peroxide results in increased localization of FOXO1 protein]decreases reaction|increases localization 15788402
D006861 Hydrogen Peroxide Niacinamide inhibits the reaction [Hydrogen Peroxide results in increased localization of FOXO1 protein]decreases reaction|increases localization 15788402
D006861 Hydrogen Peroxide [resveratrol co-treated with Hydrogen Peroxide] results in increased localization of FOXO1 proteinaffects cotreatment|increases localization 15788402
C038753 leptomycin B leptomycin B results in increased localization of FOXO1 proteinincreases localization 15788402
D019787 Linoleic Acid Linoleic Acid results in decreased expression of FOXO1 proteindecreases expression 17374693
C041786 palm oil palm oil results in decreased expression of FOXO1 mRNAdecreases expression 18042831
D010656 Phenylephrine Phenylephrine promotes the reaction [FOXO1 protein results in increased expression of TNF mRNA]increases expression|increases reaction 16020479
D010656 Phenylephrine Phenylephrine results in increased expression of and results in decreased phosphorylation of and affects the localization of FOXO1 proteinaffects localization|decreases phosphorylation|increases expression 16020479
D010833 Phytic Acid [resveratrol co-treated with Quercetin co-treated with Phytic Acid] results in increased expression of FOXO1 mRNAaffects cotreatment|increases expression 18657603
C006253 pirinixic acid pirinixic acid results in increased expression of FOXO1 mRNAincreases expression 18445702
C006253 pirinixic acid pirinixic acid results in increased phosphorylation of FOXO1 proteinincreases phosphorylation 19748123
C017674 procyanidin procyanidin results in decreased phosphorylation of FOXO1 proteindecreases phosphorylation 15827326
D011374 Progesterone Progesterone results in decreased expression of FOXO1decreases expression 17510236
D011794 Quercetin [resveratrol co-treated with Quercetin co-treated with Phytic Acid] results in increased expression of FOXO1 mRNAaffects cotreatment|increases expression 18657603
D020849 Raloxifene Raloxifene affects the expression of FOXO1 mRNAaffects expression 14699072
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in decreased expression of FOXO1 mRNAaffects cotreatment|decreases expression 19059307
C059514 resveratrol resveratrol inhibits the reaction [AKT1 protein results in increased phosphorylation of FOXO1 protein]decreases reaction|increases phosphorylation 16343977
C059514 resveratrol [resveratrol co-treated with Quercetin co-treated with Phytic Acid] results in increased expression of FOXO1 mRNAaffects cotreatment|increases expression 18657603
C059514 resveratrol resveratrol inhibits the reaction [stearic acid results in decreased expression of FOXO1 protein]decreases expression|decreases reaction 17374693
C059514 resveratrol resveratrol promotes the reaction [FOXO1 protein results in increased expression of G6PC mRNA]increases expression|increases reaction 16917544
C059514 resveratrol resveratrol promotes the reaction [FOXO1 protein results in increased expression of IGFBP1 mRNA]increases expression|increases reaction 16917544
C059514 resveratrol FOXO1 protein affects the reaction [resveratrol results in increased expression of G6PC mRNA]affects reaction|increases expression 15788402
C059514 resveratrol FOXO1 protein affects the reaction [resveratrol results in increased expression of IGFBP1 mRNA]affects reaction|increases expression 15788402
C059514 resveratrol resveratrol promotes the reaction [FOXO1 protein results in increased abundance of Glucose]increases abundance|increases reaction 15788402
C059514 resveratrol resveratrol results in decreased expression of FOXO1 mRNAdecreases expression 17851734
C059514 resveratrol Niacinamide inhibits the reaction [resveratrol results in increased localization of FOXO1 protein]decreases reaction|increases localization 15788402
C059514 resveratrol [resveratrol co-treated with Hydrogen Peroxide] results in increased localization of FOXO1 proteinaffects cotreatment|increases localization 15788402
C059514 resveratrol resveratrol results in increased localization of FOXO1 proteinincreases localization 15788402
C089730 rosiglitazone rosiglitazone inhibits the reaction [Fructose results in increased expression of FOXO1 mRNA]decreases reaction|increases expression 19196556
C017947 sodium arsenite sodium arsenite results in increased expression of FOXO1 mRNAincreases expression 19822182
C031183 stearic acid resveratrol inhibits the reaction [stearic acid results in decreased expression of FOXO1 protein]decreases expression|decreases reaction 17374693
C031183 stearic acid stearic acid results in decreased expression of FOXO1 proteindecreases expression 17374693
D013629 Tamoxifen ESR1 protein affects the reaction [Tamoxifen results in increased expression of FOXO1 mRNA]affects reaction|increases expression 14699072
D013629 Tamoxifen Tamoxifen affects the expression of FOXO1 mRNAaffects expression 14699072
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in decreased expression of FOXO1 mRNAaffects cotreatment|decreases expression 19059307
C496197 trans-10,cis-12-conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid affects the localization of FOXO1 proteinaffects localization 15992797
C012589 trichostatin A [Niacinamide co-treated with trichostatin A] inhibits the reaction [FOXO1 protein binds to SIRT1 protein]affects binding|affects cotreatment|decreases reaction 15788402
C012589 trichostatin A trichostatin A affects the localization of FOXO1 proteinaffects localization 15788402
D014635 Valproic Acid Valproic Acid results in increased expression of FOXO1 mRNAincreases expression 19101580
C025643 vinclozolin vinclozolin affects the expression of FOXO1 mRNAaffects expression 19015723
D009536 Niacinamide Niacinamide inhibits the reaction [FOXO1 protein results in increased expression of G6PC mRNA]decreases reaction|increases expression 16917544
D009536 Niacinamide Niacinamide inhibits the reaction [FOXO1 protein results in increased expression of IGFBP1 mRNA]decreases reaction|increases expression 16917544
D009536 Niacinamide Niacinamide results in increased expression of FOXO1 mRNAincreases expression 17851734
D009536 Niacinamide Niacinamide affects the localization of FOXO1 proteinaffects localization 15788402
D009536 Niacinamide [Niacinamide co-treated with trichostatin A] inhibits the reaction [FOXO1 protein binds to SIRT1 protein]affects binding|affects cotreatment|decreases reaction 15788402
D009536 Niacinamide Niacinamide inhibits the reaction [Hydrogen Peroxide results in increased localization of FOXO1 protein]decreases reaction|increases localization 15788402
D009536 Niacinamide Niacinamide inhibits the reaction [resveratrol results in increased localization of FOXO1 protein]decreases reaction|increases localization 15788402
D009536 Niacinamide Niacinamide results in increased acetylation of FOXO1 proteinincreases acetylation 15788402
D014810 Vitamin E Vitamin E results in decreased expression of FOXO1 mRNAdecreases expression 19244175
C111237 vorinostat [decitabine co-treated with vorinostat] affects the expression of FOXO1 mRNAaffects cotreatment|affects expression 17330099
C009687 wortmannin wortmannin inhibits the reaction [Copper affects the localization of FOXO1 protein]affects localization|decreases reaction 16973122
C009687 wortmannin wortmannin inhibits the reaction [Copper results in increased phosphorylation of FOXO1 protein]decreases reaction|increases phosphorylation 16973122
C009687 wortmannin wortmannin inhibits the reaction [Copper Sulfate affects the localization of FOXO1 protein]affects localization|decreases reaction 16973122
C009687 wortmannin wortmannin inhibits the reaction [Copper Sulfate results in increased phosphorylation of FOXO1 protein]decreases reaction|increases phosphorylation 16973122
C009687 wortmannin wortmannin inhibits the reaction [Doxorubicin results in increased phosphorylation of FOXO1 protein]decreases reaction|increases phosphorylation 17935137
C009687 wortmannin wortmannin inhibits the reaction [Etoposide results in increased phosphorylation of FOXO1 protein]decreases reaction|increases phosphorylation 17935137
C009687 wortmannin wortmannin inhibits the reaction [Zinc affects the localization of FOXO1 protein]affects localization|decreases reaction 16973122
C009687 wortmannin wortmannin inhibits the reaction [Zinc results in increased phosphorylation of FOXO1 protein]decreases reaction|increases phosphorylation 16973122
C009687 wortmannin wortmannin inhibits the reaction [Zinc Sulfate affects the localization of FOXO1 protein]affects localization|decreases reaction 16973122
C009687 wortmannin wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of FOXO1 protein]decreases reaction|increases phosphorylation 16973122
D015032 Zinc wortmannin inhibits the reaction [Zinc affects the localization of FOXO1 protein]affects localization|decreases reaction 16973122
D015032 Zinc wortmannin inhibits the reaction [Zinc results in increased phosphorylation of FOXO1 protein]decreases reaction|increases phosphorylation 16973122
D015032 Zinc Zinc affects the localization of FOXO1 proteinaffects localization 16973122
D015032 Zinc Zinc results in increased phosphorylation of FOXO1 proteinincreases phosphorylation 16973122
D019287 Zinc Sulfate wortmannin inhibits the reaction [Zinc Sulfate affects the localization of FOXO1 protein]affects localization|decreases reaction 16973122
D019287 Zinc Sulfate wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of FOXO1 protein]decreases reaction|increases phosphorylation 16973122
D019287 Zinc Sulfate Zinc Sulfate affects the localization of FOXO1 proteinaffects localization 16973122
D019287 Zinc Sulfate Zinc Sulfate results in increased phosphorylation of FOXO1 proteinincreases phosphorylation 16973122
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.0414745880
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.008875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.4819490988
MESH:D000138 Acidosis Ammonium Chloride 8.9718287403
MESH:D000138 Acidosis Zinc Sulfate 8.977265320
MESH:D000142 Acidosis, Respiratory Copper Sulfate 5.927265320
MESH:D000169 Acrodermatitis Zinc 4.9017190629 16889938 17202136
MESH:D058186 Acute Kidney Injury resveratrol 3.4116538975
MESH:D055371 Acute Lung Injury Acrolein 7.7721297076 20525806
MESH:D055371 Acute Lung Injury pirinixic acid 7.7718653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.2120127859 20464547
MESH:D000230 Adenocarcinoma Doxorubicin 6.2117418594
MESH:D000230 Adenocarcinoma Estradiol 6.2111473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 9.423712494
MESH:D000236 Adenoma Benzo(a)pyrene 9.426695378
MESH:D000236 Adenoma resveratrol 9.4215688382
MESH:D018248 Adenoma, Liver Cell pirinixic acid 2.9916434500
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.1915276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.3917306315 16712894
MESH:D000419 Albuminuria Doxorubicin 9.8921441931
MESH:D000419 Albuminuria Raloxifene 9.8917308373 17451421
MESH:D019973 Alcohol-Related Disorders Curcumin 4.5717887948
MESH:D000544 Alzheimer Disease Acrolein 17.2617570602 15207723 14715435
MESH:D000544 Alzheimer Disease Copper 17.2616325427 16886094 17119284 16866297 16410023 16962711
MESH:D000544 Alzheimer Disease Curcumin 17.2615590663
MESH:D000544 Alzheimer Disease Raloxifene 17.2615800139
MESH:D000544 Alzheimer Disease resveratrol 17.2616162502 16183991
MESH:D000544 Alzheimer Disease rosiglitazone 17.2619621015
MESH:D000544 Alzheimer Disease Zinc 17.2616325427 16580781 17119284 16410023
MESH:D000550 Amblyopia Valproic Acid 4.7217688650
MESH:D000690 Amyotrophic Lateral Sclerosis Copper 3.9810694572
MESH:D000743 Anemia, Hemolytic Quercetin 3.7917084956
MESH:D018798 Anemia, Iron-Deficiency Copper 4.4416614410
MESH:D000755 Anemia, Sickle Cell Zinc 4.4316916123
MESH:D000860 Anoxia Copper Sulfate 10.187265320
MESH:D000860 Anoxia Zinc Sulfate 10.187265320
MESH:D001008 Anxiety Disorders Valproic Acid 7.5417497229
MESH:D001008 Anxiety Disorders vinclozolin 7.5419015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.5919183758
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.6817460149
MESH:D001161 Arteriosclerosis 9,11-linoleic acid 14.6715778275
MESH:D001161 Arteriosclerosis Acrolein 14.6715014928
MESH:D001161 Arteriosclerosis Dietary Fats 14.6715238619
MESH:D001169 Arthritis, Experimental resveratrol 3.1817115116
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.6116807698
MESH:D001249 Asthma Zinc 2.7917085522
MESH:D001260 Ataxia Telangiectasia Quercetin 4.4815336622
MESH:D050197 Atherosclerosis Acrolein 9.4017363696 16037261 16126721
MESH:D050197 Atherosclerosis Curcumin 9.4018704882
MESH:D050197 Atherosclerosis resveratrol 9.4017967414 16873680
MESH:D001321 Autistic Disorder Linoleic Acid 2.6718582451
MESH:D001321 Autistic Disorder Valproic Acid 2.6717688650 18558336 16609825 18316065 18396377 17507914 18177632 18985861 18775368 15238991 17157402 20603192 19232924 19460635 18940202
MESH:D001327 Autoimmune Diseases Curcumin 9.2519761891
MESH:D001327 Autoimmune Diseases Quercetin 9.2519761891
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.5111289319 1440618
MESH:D001714 Bipolar Disorder Valproic Acid 2.8120046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 2.7019483382
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.078888407
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 10.4714601052
MESH:D019046 Bone Marrow Neoplasms Etoposide 10.4714601052
MESH:D001919 Bradycardia Phenylephrine 4.0515306635
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.8317868700
MESH:D001930 Brain Injuries Progesterone 15.6515665606 15380490 15845082
MESH:D001930 Brain Injuries Raloxifene 15.6516580743
MESH:D001930 Brain Injuries Zinc 15.6517109824
MESH:D002545 Brain Ischemia Curcumin 8.6716770732
MESH:D002545 Brain Ischemia resveratrol 8.6717600658
MESH:D001932 Brain Neoplasms Copper 12.3217079463
MESH:D001932 Brain Neoplasms Curcumin 12.3217596214
MESH:D001932 Brain Neoplasms Doxorubicin 12.3217150277
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 13.1720146248 17474063
MESH:D001943 Breast Neoplasms Calcitriol 13.1711237771
MESH:D001943 Breast Neoplasms Copper 13.1715986119 17079463
MESH:D001943 Breast Neoplasms Curcumin 13.1718462866 19250217 16243823 18593918
MESH:D001943 Breast Neoplasms decitabine 13.1719208741 18320071
MESH:D001943 Breast Neoplasms Dietary Fats 13.1720435547
MESH:D001943 Breast Neoplasms Doxorubicin 13.1715994142 19526202 17983394 16264153 11325840 18628466 18382427 16935488 16595493 18695136 15567936 15939500 16322301 15136595 16115903 15634643 15993339 18234424 16826403 16096432 17369602 15668708 15692762 17426702
MESH:D001943 Breast Neoplasms Estradiol 13.1714630087 19861407 17289903 18497071 12948864 17261762 16675129 17018787
MESH:D001943 Breast Neoplasms Etoposide 13.1716322251
MESH:D001943 Breast Neoplasms Progesterone 13.1715562024 16175315 17614352
MESH:D001943 Breast Neoplasms Quercetin 13.1718628248
MESH:D001943 Breast Neoplasms Raloxifene 13.1715775269 17893378 17440819 15572757 17242785 16837676 17049068 17595753 17952589 16912660 17261762 15758505
MESH:D001943 Breast Neoplasms resveratrol 13.1717534123 16393696 17651959
MESH:D001943 Breast Neoplasms Tamoxifen 13.1719155303 19487384 16202921 18997820 20135344 19103187 19011961 19244106 18351453 17440819 11161223 19410462 15668708 18984771 18855134 19066611 19084267 17049068 18629630 18821012 19115204 18425577 20544844 16273361 19221464 17261762 19288272 16818667 15565566 17242785 17893378 20005174 19189210 19289846 19189212 20065188 18815881 19142967 20859285 19059307 21138602 21152245 20390343 16873071 19200415
MESH:D001943 Breast Neoplasms vorinostat 13.1716144943
MESH:D002105 Cadmium Poisoning Quercetin 5.0416962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.9616111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.4516050911
MESH:D002276 Carcinoid Tumor Doxorubicin 4.3016051944
MESH:D002277 Carcinoma Curcumin 3.4418593918
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.0219066611
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 12.503581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 12.5017876044 18059187 16023760 16234567
MESH:D006528 Carcinoma, Hepatocellular Estradiol 12.5016924424
MESH:D006528 Carcinoma, Hepatocellular Quercetin 12.5019519916 12508355
MESH:D006528 Carcinoma, Hepatocellular resveratrol 12.5019321006 16227395
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 12.5016507464 17306315 15276417
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 12.5016924424
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.0916675471
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.7918414057
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.4717234771
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 5.707296757
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 5.7016201981 1485588
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 23.0420419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 23.0411237771
MESH:D002294 Carcinoma, Squamous Cell Curcumin 23.0418462866
MESH:D002294 Carcinoma, Squamous Cell decitabine 23.0419215824
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 23.046189445
MESH:D002294 Carcinoma, Squamous Cell resveratrol 23.0416227395
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 23.0418572023
MESH:D002294 Carcinoma, Squamous Cell Zinc 23.0416543248
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 8.0617572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 8.0617572228
MESH:D006332 Cardiomegaly Copper 10.0017327471
MESH:D006332 Cardiomegaly Phenylephrine 10.0015728586 11179087 17124262 11754973 16170337 17287366
MESH:D006332 Cardiomegaly Quercetin 10.0019794523
MESH:D009202 Cardiomyopathies Doxorubicin 3.1916455267 15792986 16278810 16651473 17007740 15811867 15476868 16952015 17382496 16731534 16242529 16269455 17924179 17351982 16612575 17519947 17928571 18627295 17308081 17131338 17974986 17329180 16109756 15505089 16364871
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.7616243910 17334414
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 14.4916936243
MESH:D002318 Cardiovascular Diseases Raloxifene 14.4915775269
MESH:D002318 Cardiovascular Diseases resveratrol 14.4915458977
MESH:D002318 Cardiovascular Diseases Zinc 14.4916936243
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 13.137505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 13.1312371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 13.1318566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 13.1319524636 20056578
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.5120734317
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 11.219022650 19486331
MESH:D002779 Cholestasis Cyclosporine 11.2119486331
MESH:D002779 Cholestasis pirinixic acid 11.2119176532
MESH:D003072 Cognition Disorders Raloxifene 4.1315800139
MESH:D003092 Colitis Curcumin 8.1916782535 18200517 16804969
MESH:D003092 Colitis resveratrol 8.1916474422
MESH:D003103 Coloboma Curcumin 4.1018809619
MESH:D003110 Colonic Neoplasms marker/mechanism 19050079
MESH:D003110 Colonic Neoplasms Curcumin 7.3719359593 16340194
MESH:D003110 Colonic Neoplasms decitabine 7.3717616700
MESH:D003110 Colonic Neoplasms Quercetin 7.3711134977 16640504 17148506 17191121 19440933 19056647 15741050
MESH:D003110 Colonic Neoplasms resveratrol 7.3716338953
MESH:D015179 Colorectal Neoplasms Acrolein 5.8317597105
MESH:D015179 Colorectal Neoplasms decitabine 5.8318981723
MESH:D015179 Colorectal Neoplasms Doxorubicin 5.8318802399 18259882
MESH:D015179 Colorectal Neoplasms Quercetin 5.8318095365 18852136
MESH:D015179 Colorectal Neoplasms resveratrol 5.8316550006
MESH:D016510 Corneal Neovascularization Curcumin 4.4118497527
MESH:D003327 Coronary Disease Fructose 7.6818504504
MESH:D003327 Coronary Disease resveratrol 7.6816507316
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.5517688650 16575769 8888407
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.5519769572
MESH:D019465 Craniofacial Abnormalities Zinc 3.5519302082
MESH:D003456 Cryptorchidism vinclozolin 3.8714966744
MESH:D003556 Cystitis Acrolein 4.8912161096
MESH:D003711 Demyelinating Diseases Tamoxifen 3.8819031437
MESH:D003865 Depressive Disorder, Major Raloxifene 3.7417474826
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.3518759878 2524372 8156756 12868966 14531868 8970840 11298694 11906362
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.1818249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.043621924 2952479
MESH:D003920 Diabetes Mellitus rosiglitazone 8.1917446233
MESH:D003920 Diabetes Mellitus Zinc 8.1916479319
MESH:D003921 Diabetes Mellitus, Experimental Fructose 11.7618603373
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 11.7619496084
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 11.7616873680
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 9.2118403477
MESH:D003924 Diabetes Mellitus, Type 2 Fructose 9.2118603373
MESH:D003924 Diabetes Mellitus, Type 2 Niacinamide 9.2119647726
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 9.2112642470
MESH:D003928 Diabetic Nephropathies Curcumin 23.6318204486
MESH:D003928 Diabetic Nephropathies Estradiol 23.6319279558
MESH:D003928 Diabetic Nephropathies Raloxifene 23.6317308373 17451421 15920148
MESH:D003928 Diabetic Nephropathies resveratrol 23.6316286809
MESH:D003928 Diabetic Nephropathies Tamoxifen 23.6319279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.0117187935
MESH:D003967 Diarrhea vorinostat 4.0420479100
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 5.3218692083 16192314 6482804 1440618 18289764 7440962 11289319 8291058 18648102 9653073 9328219 9022650 6679447
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 5.3217416283
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 5.321733752 19641884
MESH:D004362 Drug Toxicity Doxorubicin 3.3018602426
MESH:D004381 Duodenal Ulcer Curcumin 3.5817351913
MESH:D050171 Dyslipidemias Dietary Fats 3.0918367378
MESH:D004421 Dystonia Valproic Acid 3.591851702
MESH:C538011 Eales disease Vitamin E 4.209068938
MESH:D004487 Edema pirinixic acid 12.9012083418
MESH:D004487 Edema Raloxifene 12.9015860553
MESH:D004487 Edema resveratrol 12.908985016
MESH:D004487 Edema rosiglitazone 12.9012083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 23.7415138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 23.7417692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 23.7415845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 23.7417872969
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 23.7419031437
MESH:D004701 Endocrine Gland Neoplasms decitabine 12.3419294695
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 12.3419294695
MESH:D016889 Endometrial Neoplasms Doxorubicin 10.5217359293
MESH:D016889 Endometrial Neoplasms Estradiol 10.5211473722 19148513 18566989
MESH:D016889 Endometrial Neoplasms Tamoxifen 10.5216202921 19155303 17893378 20544844
MESH:D004715 Endometriosis Progesterone 3.3416134523
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.6518037988
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.3617923197
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.6717275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 3.413922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.6720417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.176426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 3.817750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.573659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 6.383581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 6.3816530937
MESH:D004938 Esophageal Neoplasms Zinc 6.3816543248
MESH:D005221 Fatigue vorinostat 5.1020479100
MESH:D005234 Fatty Liver Curcumin 41.0819297423
MESH:D005234 Fatty Liver Cyclosporine 41.0819224547
MESH:D005234 Fatty Liver Dietary Fats 41.0817967931 19551842 18296743 19004024
MESH:D005234 Fatty Liver Fructose 41.0818641190 19196556 18395287
MESH:D005234 Fatty Liver pirinixic acid 41.0820131406 19236843
MESH:D005234 Fatty Liver Raloxifene 41.0817473493
MESH:D005234 Fatty Liver rosiglitazone 41.0819196556
MESH:D005234 Fatty Liver Tamoxifen 41.0819224547 14986274
MESH:D005234 Fatty Liver Valproic Acid 41.0819224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 2.9216709447
MESH:D005315 Fetal Diseases Valproic Acid 4.3816575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.668888407 18558336
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.516705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.0314745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 9.7919069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 9.7919069698
MESH:D005355 Fibrosis Curcumin 28.2418705752
MESH:D005355 Fibrosis Cyclosporine 28.2412168785 12639820
MESH:D005355 Fibrosis Dietary Fats 28.2418296743
MESH:D005355 Fibrosis Emodin 28.2419474275
MESH:D005355 Fibrosis Fructose 28.2418504504
MESH:D005355 Fibrosis Quercetin 28.2419474275
MESH:D005756 Gastritis Zinc 4.2917241300
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.2118462866
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.4416973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.7916417039
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.1816452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.728708960
MESH:D005909 Glioblastoma Curcumin 14.2717596214
MESH:D005909 Glioblastoma Doxorubicin 14.2717150277
MESH:D005909 Glioblastoma Quercetin 14.2719804834
MESH:D005909 Glioblastoma trichostatin A 14.2718801729
MESH:D005910 Glioma Quercetin 2.8417643826
MESH:D005922 Glomerulonephritis, IGA deoxynivalenol 4.6216524712 15173396
MESH:D018149 Glucose Intolerance Fructose 4.8619165636
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.587505956
MESH:D006130 Growth Disorders Zinc 3.6317217573
MESH:D006258 Head and Neck Neoplasms Curcumin 11.0518462866 18829502
MESH:D006258 Head and Neck Neoplasms decitabine 11.0519215824
MESH:D006258 Head and Neck Neoplasms Doxorubicin 11.0515692506
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 5.7620471113
MESH:D006330 Heart Defects, Congenital Vitamin E 5.7616080930
MESH:D006331 Heart Diseases Doxorubicin 6.6716244372 18674790 18006777 16707910 17875725 16330681 16879835 17888722 14766674 16144979 16495754 12587719 16244371
MESH:D006331 Heart Diseases Raloxifene 6.6711110106
MESH:D006333 Heart Failure Doxorubicin 10.0217481944
MESH:D006333 Heart Failure pirinixic acid 10.0220558911
MESH:D006333 Heart Failure Zinc 10.0217162251
MESH:D006335 Heart Injuries Zinc 5.2617074742
MESH:D016481 Helicobacter Infections Zinc 4.0717241300
MESH:D006394 Hemangiosarcoma Doxorubicin 3.4615692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.9215720958
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.046705139
MESH:D006521 Hepatitis, Chronic Copper 4.7717338147
MESH:D006527 Hepatolenticular Degeneration Copper 15.8417109627 17276780 19888908 16607473 17182432
MESH:D006527 Hepatolenticular Degeneration Zinc 15.8417276780
MESH:D006527 Hepatolenticular Degeneration Zinc Sulfate 15.8417063115
MESH:D006529 Hepatomegaly pirinixic acid 2.5218467677 16221962 19772884 19176532
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.5517701891
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.5116863852 16490937
MESH:D006558 Herpes Genitalis Estradiol 4.5215709030
MESH:D006561 Herpes Simplex Etoposide 8.4510809021
MESH:D006561 Herpes Simplex resveratrol 8.4516876885
MESH:D006689 Hodgkin Disease Doxorubicin 9.9717606976 18501091 15147373
MESH:D006689 Hodgkin Disease Etoposide 9.9717606976 16135485 18180244 15147373 16200630
MESH:D006689 Hodgkin Disease sodium arsenite 9.9712676792
MESH:D019584 Hot Flashes Estradiol 8.3717088409
MESH:D019584 Hot Flashes Vitamin E 8.3714716179
MESH:D006849 Hydrocephalus Valproic Acid 4.3717688650
MESH:D006930 Hyperalgesia rosiglitazone 3.5312083418
MESH:D006937 Hypercholesterolemia Curcumin 12.8018704882
MESH:D006937 Hypercholesterolemia Dietary Fats 12.8021332399
MESH:D006937 Hypercholesterolemia resveratrol 12.8017188708
MESH:D006943 Hyperglycemia pirinixic acid 7.8120558911
MESH:D006943 Hyperglycemia Quercetin 7.8111834736 18262572
MESH:D006946 Hyperinsulinism Fructose 4.4819008412 14757778 18563319 15752949 18360027
MESH:D006949 Hyperlipidemias Dietary Fats 12.9421332399
MESH:D006949 Hyperlipidemias Fructose 12.9415752949
MESH:D006949 Hyperlipidemias resveratrol 12.9416873680
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.4515034207
MESH:D006973 Hypertension Cyclosporine 14.1510903974
MESH:D006973 Hypertension Fructose 14.1519008412 14568997 14573337 14633139 16843071
MESH:D006973 Hypertension Phenylephrine 14.1512717712 8949925
MESH:D006973 Hypertension Quercetin 14.1518356687
MESH:D006973 Hypertension Raloxifene 14.1515787275 17577099
MESH:D006976 Hypertension, Pulmonary Copper Sulfate 4.717265320
MESH:D015228 Hypertriglyceridemia Fructose 4.6419342510 19799862
MESH:D006984 Hypertrophy Phenylephrine 4.1118502941 12791704
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 3.8717488730
MESH:D007022 Hypotension Zinc Sulfate 4.027265320
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 9.8715869954
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 9.8717600658
MESH:D007248 Infertility, Male decitabine 9.3217581917
MESH:D007248 Infertility, Male sodium arsenite 9.3215346721 12646999
MESH:D007248 Infertility, Male vinclozolin 9.3216467254
MESH:D007249 Inflammation Curcumin 16.3618403477 16956363 17151092
MESH:D007249 Inflammation Dietary Fats 16.3620412841
MESH:D007249 Inflammation Progesterone 16.3615869954
MESH:D007249 Inflammation resveratrol 16.3616366677
MESH:D007249 Inflammation rosiglitazone 16.3612083418
MESH:D007249 Inflammation Tamoxifen 16.3619457130
MESH:D015212 Inflammatory Bowel Diseases Curcumin 2.9918596194 18200517
MESH:D007251 Influenza, Human Quercetin 15.7316624496
MESH:D007251 Influenza, Human resveratrol 15.7316624496
MESH:D007251 Influenza, Human Vitamin E 15.7316624496
MESH:D007333 Insulin Resistance Dietary Fats 19.6511836018 18457598
MESH:D007333 Insulin Resistance Estradiol 19.6516393666 16627594
MESH:D007333 Insulin Resistance Fructose 19.6517133782 19342510 18981581 14573337 18057795 14757778 19586609 19008412 18563319 19799862 14633139
MESH:D007333 Insulin Resistance pirinixic acid 19.6516306350
MESH:D007333 Insulin Resistance rosiglitazone 19.6516306350
MESH:D007414 Intestinal Neoplasms Curcumin 3.7910783313
MESH:D007511 Ischemia Zinc 4.1516584753
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.518074119 9022650
MESH:D007627 Keloid Quercetin 4.4717086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.9315604871
MESH:D007674 Kidney Diseases Acrolein 28.6512488133
MESH:D007674 Kidney Diseases Cyclosporine 28.6510903974 18776723 8314463
MESH:D007674 Kidney Diseases Doxorubicin 28.6515369732 16775033 15699352
MESH:D007674 Kidney Diseases Estradiol 28.6515618244
MESH:D007674 Kidney Diseases Quercetin 28.6516962696
MESH:D007674 Kidney Diseases sodium arsenite 28.6520008137
MESH:D007674 Kidney Diseases Vitamin E 28.6512488133
MESH:D007674 Kidney Diseases Zinc 28.6516960431
MESH:D007676 Kidney Failure, Chronic Copper 20.2416518626
MESH:D007676 Kidney Failure, Chronic Doxorubicin 20.2416707910
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 20.2416518626
MESH:D007676 Kidney Failure, Chronic Zinc 20.2416518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 14.426582329
MESH:D007680 Kidney Neoplasms Cyclosporine 14.4212371664
MESH:D007680 Kidney Neoplasms Estradiol 14.4215610895
MESH:D007680 Kidney Neoplasms Tamoxifen 14.4218625569
MESH:D007859 Learning Disorders Copper 4.3117134702
MESH:D007889 Leiomyoma Curcumin 9.6318555241
MESH:D007889 Leiomyoma Raloxifene 9.6316973256
MESH:D016773 Leishmaniasis, Cutaneous Zinc Sulfate 3.8615237267
MESH:D007938 Leukemia Curcumin 9.0518462866
MESH:D007938 Leukemia decitabine 9.0519235587 18980019
MESH:D007938 Leukemia Quercetin 9.0517468513
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.6516085563
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 8.7416106398
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Emodin 8.7417077332
MESH:D007951 Leukemia, Myeloid decitabine 3.5619117987 17236224 18454857
MESH:D015470 Leukemia, Myeloid, Acute marker/mechanism 17330099
MESH:D015470 Leukemia, Myeloid, Acute decitabine 5.5918704418 19010910 19387464 18460780 18206229 17679729
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 5.5918206229
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 5.5917596541 16294345
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 4.9518055864
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.2416087638
MESH:D015458 Leukemia, T-Cell Curcumin 4.2916106398
MESH:D007984 Leydig Cell Tumor vinclozolin 4.2316417039
MESH:D008064 Lipidoses Tamoxifen 2.8017567588 15342952
MESH:D008103 Liver Cirrhosis Dietary Fats 2.5918296743
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 2.8715034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 14.0818705752 18006644 17355460
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 14.0816595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Emodin 14.0815288473
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 14.0814716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 14.0815474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 14.0812741479
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 14.0817347453 15980055
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 14.0818564211
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 14.0816169303
MESH:D008107 Liver Diseases Curcumin 2.4816956363
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 18.6120195826 21137059
MESH:D008113 Liver Neoplasms Copper 18.6120302851
MESH:D008113 Liver Neoplasms pirinixic acid 18.6115890375 20007298 16377806
MESH:D008113 Liver Neoplasms Quercetin 18.6118980244
MESH:D008113 Liver Neoplasms resveratrol 18.6119073162 19812893 19321006 20405173
MESH:D008113 Liver Neoplasms sodium arsenite 18.6116712894 15276417
MESH:D008113 Liver Neoplasms Tamoxifen 18.6116684651
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 8.093712494 598648 6587162 1399818
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 8.0916842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Quercetin 8.0919519916
MESH:D008171 Lung Diseases Acrolein 10.4911504702
MESH:D008171 Lung Diseases sodium arsenite 10.4919095001
MESH:D008171 Lung Diseases Vitamin E 10.4916863852
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 3.7617228818
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 9.4820869020 20135361 18569708 6695378 18816296 18520028 20464547 17053015 20064080
MESH:D008175 Lung Neoplasms Curcumin 9.4818462866 19359593 16243823
MESH:D008175 Lung Neoplasms Doxorubicin 9.486189445 17418594
MESH:D008175 Lung Neoplasms Quercetin 9.4816280456
MESH:D008175 Lung Neoplasms sodium arsenite 9.4816712894 19931552 17306315 15276417 17077188
MESH:D008175 Lung Neoplasms Tamoxifen 9.4818625569
MESH:D008175 Lung Neoplasms Vitamin E 9.4811062179
MESH:D008223 Lymphoma Curcumin 14.9718462866
MESH:D008223 Lymphoma decitabine 14.9719470736
MESH:D008223 Lymphoma Doxorubicin 14.9716098063
MESH:D008223 Lymphoma Etoposide 14.9712556972 12854902
MESH:D016393 Lymphoma, B-Cell resveratrol 3.8417088997
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 7.5317654614
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 7.5314749477
MESH:D016399 Lymphoma, T-Cell Curcumin 9.9516173963
MESH:D016399 Lymphoma, T-Cell Doxorubicin 9.9515621674
MESH:D016410 Lymphoma, T-Cell, Cutaneous vorinostat 5.2020479100
MESH:D015674 Mammary Neoplasms, Animal resveratrol 8.3515688416
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 8.3519428831
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 23.4315458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 23.4311807958 11408345 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 23.4317203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 23.4311606380 8985016
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 23.4316827153
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 23.4314580682 19196722 11731420 19196723 16827153
MESH:D008325 Mammary Neoplasms, Experimental Zinc 23.4312773700
MESH:D020149 Manganese Poisoning Estradiol 10.9619453300
MESH:D020149 Manganese Poisoning Tamoxifen 10.9619453300
MESH:D008545 Melanoma Curcumin 16.4617885582 18462866
MESH:D008545 Melanoma decitabine 16.4617785578 16505122
MESH:D008545 Melanoma Doxorubicin 16.4616827129
MESH:D008545 Melanoma Glucose 16.4614993021
MESH:D008545 Melanoma resveratrol 16.4617992120
MESH:D008545 Melanoma sodium arsenite 16.4616487513 19082730
MESH:D008545 Melanoma Tamoxifen 16.4612393984 19393235
MESH:D008545 Melanoma trichostatin A 16.4616505122
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.6815990972
MESH:D008546 Melanoma, Experimental Acrolein 4.7210803710
MESH:D008569 Memory Disorders Curcumin 3.6817263510
MESH:D007706 Menkes Kinky Hair Syndrome Copper 5.3817268249 17109627
MESH:D008654 Mesothelioma Doxorubicin 2.8417638057
MESH:D008659 Metabolic Diseases resveratrol 3.9317112576
MESH:D024821 Metabolic Syndrome X Fructose 8.6817261469 19165636 18497449 17098227 16815490
MESH:D024821 Metabolic Syndrome X rosiglitazone 8.6817261469
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.2816801185
MESH:D008881 Migraine Disorders Valproic Acid 2.8318765137 18803445
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.0515792986
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.0515863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.8116381670
MESH:D052016 Mucositis Doxorubicin 4.2917415656
MESH:D009101 Multiple Myeloma Curcumin 18.8619372569
MESH:D009101 Multiple Myeloma decitabine 18.8618172295
MESH:D009101 Multiple Myeloma Raloxifene 18.8616497877
MESH:D009101 Multiple Myeloma resveratrol 18.8617935668 16490592 17164350 17049120 16267019 14749477
MESH:D009101 Multiple Myeloma trichostatin A 18.8618172295
MESH:D009134 Muscular Atrophy, Spinal Curcumin 10.7617962980
MESH:D009134 Muscular Atrophy, Spinal resveratrol 10.7617962980
MESH:D009135 Muscular Diseases pirinixic acid 3.0216239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.588888407
MESH:D009190 Myelodysplastic Syndromes decitabine 6.5118608210 19010910 16882708 19157545
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 6.5117596541
MESH:D009203 Myocardial Infarction Doxorubicin 11.6715857846 19429709
MESH:D009203 Myocardial Infarction pirinixic acid 11.6719151258
MESH:D009203 Myocardial Infarction Quercetin 11.6719595682
MESH:D009203 Myocardial Infarction resveratrol 11.6717125593 16525036 17015251 17188708 16456233 16317513
MESH:D017202 Myocardial Ischemia resveratrol 3.6117125593 17015251
MESH:D015428 Myocardial Reperfusion Injury Estradiol 11.9616810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 11.9616411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 11.9619207477
MESH:D009205 Myocarditis resveratrol 4.2617322642
MESH:D009232 Myxoma Raloxifene 5.0516343187
MESH:D009325 Nausea vorinostat 5.0220479100
MESH:D009361 Neoplasm Invasiveness Curcumin 3.9018495463
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 8.213581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 8.2118259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 8.2119393235
MESH:D009364 Neoplasm Recurrence, Local marker/mechanism 19050079
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.3419410462
MESH:D009369 Neoplasms Acrolein 16.3317329238
MESH:D009369 Neoplasms Benzo(a)pyrene 16.3311141357
MESH:D009369 Neoplasms decitabine 16.3317925555 19116145 19470736
MESH:D009369 Neoplasms pirinixic acid 16.3317405874
MESH:D009369 Neoplasms Quercetin 16.3315185748
MESH:D009369 Neoplasms sodium arsenite 16.3311559025
MESH:D009374 Neoplasms, Experimental resveratrol 7.628985016
MESH:D009374 Neoplasms, Experimental sodium arsenite 7.6220056578
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 9.1612497104
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 9.1619189210 19200415 19196722
MESH:D009389 Neovascularization, Pathologic Copper 8.7017308104
MESH:D009389 Neovascularization, Pathologic Estradiol 8.7017289903
MESH:D009393 Nephritis Acrolein 5.7812653641
MESH:D009401 Nephrosis Doxorubicin 4.2816899518 16636307
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.9317954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 7.9018481113 19348381
MESH:D009404 Nephrotic Syndrome Doxorubicin 7.9016889571 15640375
MESH:D009421 Nervous System Malformations Estradiol 3.1811399458 16427766
MESH:D009423 Nervous System Neoplasms Curcumin 5.1218462866
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 10.196679447
MESH:D009436 Neural Tube Defects sodium arsenite 10.1912854658
MESH:D009436 Neural Tube Defects Valproic Acid 10.198888407 16359493
MESH:D009447 Neuroblastoma Doxorubicin 2.9915555623
MESH:D019636 Neurodegenerative Diseases Acrolein 7.6111342003
MESH:D019636 Neurodegenerative Diseases resveratrol 7.6117652729
MESH:D020078 Neurogenic Inflammation Quercetin 9.1717929310
MESH:D020078 Neurogenic Inflammation resveratrol 9.1717929310
MESH:D009765 Obesity Curcumin 9.4519297423
MESH:D009765 Obesity Dietary Fats 9.4521332399 11836018 17217161 20518802 20132043 18674790 16723640 18457598 19632207
MESH:D009765 Obesity Fructose 9.4518585860 17707055
MESH:D009765 Obesity pirinixic acid 9.4520558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 2.996482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.513988306
MESH:D010024 Osteoporosis Curcumin 6.3518719352
MESH:D010024 Osteoporosis Raloxifene 6.3517882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 14.2719495926
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 14.2715579764 17823083 15758505 17893378
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 14.2717513867
MESH:D012516 Osteosarcoma Doxorubicin 3.7215930896
MESH:D010051 Ovarian Neoplasms Curcumin 20.1318462866 19020741
MESH:D010051 Ovarian Neoplasms decitabine 20.1319331143 19259094
MESH:D010051 Ovarian Neoplasms Estradiol 20.1319401270
MESH:D010051 Ovarian Neoplasms Progesterone 20.1316525653 17393432
MESH:D010051 Ovarian Neoplasms Quercetin 20.1319005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 20.1315276417 17306315
MESH:D010051 Ovarian Neoplasms trichostatin A 20.1319331143
MESH:D010190 Pancreatic Neoplasms Curcumin 14.1819401701 17440100 19196508
MESH:D010190 Pancreatic Neoplasms decitabine 14.1819294695
MESH:D010190 Pancreatic Neoplasms Etoposide 14.1819003803
MESH:D010190 Pancreatic Neoplasms Quercetin 14.1816965848
MESH:D010190 Pancreatic Neoplasms trichostatin A 14.1819294695
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 7.717296757
MESH:D010212 Papilloma Hydrogen Peroxide 7.7112065085
MESH:D010300 Parkinson Disease Acrolein 3.3917690948
MESH:D010391 Pemphigoid, Bullous Niacinamide 5.9411026799
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 11.396228378
MESH:D010787 Photosensitivity Disorders Acrolein 11.3911550810
MESH:D003557 Phyllodes Tumor Doxorubicin 4.6517983394
MESH:D010997 Pleural Neoplasms Doxorubicin 4.6517638057
MESH:D011230 Precancerous Conditions Cyclosporine 7.7112371664
MESH:D011230 Precancerous Conditions Quercetin 7.7119056647
MESH:D011225 Pre-Eclampsia Zinc 3.7917114810
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 13.5016679765
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 13.5020603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 13.5018220299 18042343 19015723
MESH:D055728 Primary Myelofibrosis decitabine 10.8117616702
MESH:D055728 Primary Myelofibrosis trichostatin A 10.8117616702
MESH:D011469 Prostatic Diseases vinclozolin 4.4418220299
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.2815572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.4420887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 8.3317292933
MESH:D011471 Prostatic Neoplasms Calcitriol 8.3316289102 12479363 18247401 15754350 16644109
MESH:D011471 Prostatic Neoplasms Copper 8.3317308104 17079463
MESH:D011471 Prostatic Neoplasms Curcumin 8.3311398177 18769126 18226269 15129424 18156803 12497104 10851300
MESH:D011471 Prostatic Neoplasms Doxorubicin 8.3318437689 16729912 15749863 15897917 16868541 16888761
MESH:D011471 Prostatic Neoplasms Estradiol 8.3316740699
MESH:D011471 Prostatic Neoplasms Etoposide 8.3317172428
MESH:D011471 Prostatic Neoplasms Quercetin 8.3317292933 14715546
MESH:D011471 Prostatic Neoplasms Raloxifene 8.3316536755 16220300 15731164
MESH:D011471 Prostatic Neoplasms resveratrol 8.3316731767 17804756 17718901 17636462 15767336 17675339
MESH:D011471 Prostatic Neoplasms sodium arsenite 8.3316039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 8.3315067354
MESH:D011471 Prostatic Neoplasms trichostatin A 8.3319789329 18798265
MESH:D011471 Prostatic Neoplasms Vitamin E 8.3315084515
MESH:D011471 Prostatic Neoplasms vorinostat 8.3317218635
MESH:D011471 Prostatic Neoplasms Zinc 8.3316517595 12429649 16606632 16700911
MESH:D011472 Prostatitis vinclozolin 4.4418629315
MESH:D019310 Pseudolymphoma Valproic Acid 4.0311422049 12752131
MESH:D011565 Psoriasis Cyclosporine 2.0416882103
MESH:D011656 Pulmonary Emphysema Curcumin 4.0919168576
MESH:D011693 Purpura Raloxifene 5.0515770314
MESH:D051437 Renal Insufficiency Acrolein 8.9912732208
MESH:D051437 Renal Insufficiency Doxorubicin 8.9917922066
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.0716325855
MESH:D015427 Reperfusion Injury pirinixic acid 5.6919058328
MESH:D015427 Reperfusion Injury resveratrol 5.6916317513 16314181 15827377 17520802 17058453
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.5710666014 18379247
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 7.763692021
MESH:D012162 Retinal Degeneration Zinc 7.7616584753
MESH:D012208 Rhabdomyosarcoma decitabine 9.4519155313
MESH:D012208 Rhabdomyosarcoma Valproic Acid 9.4519155313
MESH:D018232 Rhabdomyosarcoma, Alveolar marker/mechanism
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.6618045962
MESH:D012509 Sarcoma Curcumin 8.1318462866
MESH:D012509 Sarcoma Doxorubicin 8.1318313854 17710206 15675481 17203757 15625365 16767912
MESH:D012512 Sarcoma, Ewing's Doxorubicin 8.9816326096 14601052
MESH:D012512 Sarcoma, Ewing's Etoposide 8.9814601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.2917846226
MESH:D012554 Schistosomiasis japonica Quercetin 5.0416862918
MESH:D012559 Schizophrenia Copper 3.6416842975
MESH:D012559 Schizophrenia Valproic Acid 3.6415737665 19110320
MESH:D012640 Seizures Valproic Acid 2.4117978042 3137016 16876388 11044598 11738929 1511512 15475178 14763951
MESH:D018805 Sepsis Curcumin 3.6718389075
MESH:D012852 Sinusitis Phenylephrine 4.217327846
MESH:D012871 Skin Diseases Vitamin E 2.3018709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 19.1719755658 10029692
MESH:D012878 Skin Neoplasms Doxorubicin 19.1715692506
MESH:D012878 Skin Neoplasms Glucose 19.1714993021
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 19.1712065085
MESH:D012878 Skin Neoplasms resveratrol 19.1715837718 8985016
MESH:D012878 Skin Neoplasms sodium arsenite 19.1718572023 19524636
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.0817203757 15625365 16767912
MESH:D013088 Spermatocele Tamoxifen 3.7916709447
MESH:D013119 Spinal Cord Injuries Progesterone 9.2216503802 15862959
MESH:D013119 Spinal Cord Injuries Tamoxifen 9.2219457130
MESH:D016135 Spinal Dysraphism sodium arsenite 8.2612854658
MESH:D016135 Spinal Dysraphism Valproic Acid 8.2619490988
MESH:D013226 Status Epilepticus Valproic Acid 4.0312833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.3120155912 2093021
MESH:D013274 Stomach Neoplasms decitabine 2.3119037991
MESH:D013276 Stomach Ulcer Curcumin 3.0719188055 16631530
MESH:D020521 Stroke Acrolein 12.2616269634
MESH:D020521 Stroke Raloxifene 12.2616837676
MESH:D020521 Stroke Vitamin E 12.2616517955
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.0516321402
MESH:D013921 Thrombocytopenia vorinostat 4.5420479100
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 9.833712494 6582329 6587162 7505956 1399818
MESH:D013964 Thyroid Neoplasms decitabine 9.8317967635
MESH:D013964 Thyroid Neoplasms Doxorubicin 9.8316010429 17909728
MESH:D013978 Tibial Fractures Estradiol 12.0219048282
MESH:D013978 Tibial Fractures Raloxifene 12.0219048282
MESH:D014062 Tongue Neoplasms resveratrol 8.7016227395
MESH:D014062 Tongue Neoplasms Zinc 8.7016543248
MESH:D014178 Translocation, Genetic Valproic Acid 4.7217262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.023119515
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 28.718074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 28.7117053015
MESH:D001749 Urinary Bladder Neoplasms Curcumin 28.7118593936
MESH:D001749 Urinary Bladder Neoplasms decitabine 28.7117616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 28.7117653716
MESH:D001749 Urinary Bladder Neoplasms Quercetin 28.7116720314
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 28.7117572228
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 28.7117306315 11723127 16712894 16452187
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 28.7116712894 17572228 8653321
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.168888407
MESH:D014565 Urogenital Neoplasms Curcumin 4.7718462866
MESH:D002583 Uterine Cervical Neoplasms resveratrol 8.1317473185
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 8.1311813266
MESH:D014594 Uterine Neoplasms resveratrol 3.6717044934
MESH:D014604 Uveal Neoplasms decitabine 4.4117785578
MESH:D014605 Uveitis Cyclosporine 3.481336536
MESH:D014652 Vascular Diseases sodium arsenite 3.9317056641
MESH:D054556 Venous Thromboembolism Raloxifene 4.7016837676
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 8.7317678736 16364871 17334414 17638931
MESH:D018487 Ventricular Dysfunction, Left resveratrol 8.7317488730
MESH:D014846 Vulvar Neoplasms Raloxifene 5.0516343187
MESH:D015430 Weight Gain Dietary Fats 3.3216723640
MESH:D014985 Xerophthalmia Cyclosporine 3.9317120751
Pathway ID Pathway Name
KEGG:04910 Insulin signaling pathway
KEGG:05200 Pathways in cancer
KEGG:05215 Prostate cancer
REACT:13698 Regulation of beta-cell development
REACT:11061 Signalling by NGF
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28237
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    PA445062Neoplasms
    Releated drug ID Related drug Name
    PA448976choline
    PA448478l-arginine
    PA450635nitric oxide
    PA448976choline
    PA448478l-arginine
    PA450635nitric oxide
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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