AutismKB 2.0

Annotation Detail for TRIM35


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Basic Information Top
Gene Symbol:TRIM35 ( HLS5,KIAA1098,MAIR,MGC17233 )
Gene Full Name: tripartite motif-containing 35
Band: 8p21.2
Quick LinksEntrez ID:23087; OMIM: NA; Uniprot ID:TRI35_HUMAN; ENSEMBL ID: ENSG00000104228; HGNC ID: 16285
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of TRIM35 mRNAincreases expression 20106945
D016572 Cyclosporine Cyclosporine results in increased expression of TRIM35 mRNAincreases expression 20106945
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of TRIM35 mRNAincreases expression 19638242
D018038 Sodium Selenite Sodium Selenite results in increased expression of TRIM35 mRNAincreases expression 18175754
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TRIM35 mRNAincreases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3815322242 11752688 14514962
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0520127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 7.256695378
MESH:D000236 Adenoma Diethylnitrosamine 7.256695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 11.9217620307 19061943 17162532 16434500 18056438 19052882
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.9216835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2911748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.5619183758
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.4212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.4015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9715746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8017474063 20146248
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.8017474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8020435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0916835633
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 1.8716681979 18506893 20101231 20524982 10737359 19171122 16698587 3581430 20432363 19052882 20512989 17138121 18665156 20727157 19418558 19539802 19208518 16328049 16935385 17978847 17162532 18393292 18494052 20084675 20214788 16288022 18978308 17173139 16540662 21159647 19919837 3084413 19383236 19519916 18056438 20514400 16569478 20935162 18971187 20007298 16830150 16878318 18691550 19701751 19107877 19822196 18210153 19394651 17428255 18788625 10672840 16807293 11831363 17761372 19335982 16779866 16502159 17055752 18785209
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1320419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5418850075 18670907 16120746
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.4012371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 7.4021159647 7505956 17174075 2727394
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 10.4319052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 10.4316835633
MESH:D002779 Cholestasis Cyclosporine 3.1719486331
MESH:D019457 Chromosome Breakage Sodium Selenite 5.2415894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.228697196 12621046 16354765 15340226 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2710048152 20055451 15322242
MESH:D003920 Diabetes Mellitus Sodium Selenite 4.1016285004
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.4520387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.4517107852
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.7219107877
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 6.7215131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.7220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0211462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.5118230668 16714409 15322242
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.379294722 10568697
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.7316302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0716530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2711564622
MESH:D005234 Fatty Liver Cyclosporine 8.9819224547
MESH:D005234 Fatty Liver Diethylnitrosamine 8.9821071580 20387270
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.9411858732
MESH:D005355 Fibrosis Cyclosporine 10.1412168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 10.1420067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.768708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.2110696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.9920471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.9910048152 11294989
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.9615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.7111000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3715340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.6616959395 15340226 16354765 18606429 8697196
MESH:D006973 Hypertension Cyclosporine 5.3110903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.3118670907 18850075
MESH:D007249 Inflammation Diethylnitrosamine 5.4418785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.4412878042 12200463
MESH:D007333 Insulin Resistance Sodium Selenite 3.4914714311
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.7116580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.0515604871
MESH:D007674 Kidney Diseases Cyclosporine 2.5218776723 8314463 10903974
MESH:D007680 Kidney Neoplasms Cyclosporine 3.0412371664
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9920032147 19638242 18522880 18665156 18407596
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2512878042
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1617034775
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 8.0221137059 20195826
MESH:D008113 Liver Neoplasms Diethylnitrosamine 8.0219426721 20434301 12771043 20101389 19812893 20118626 19690152 15885732 20137499 19850985 19427195 19090486 12112319 18648771 18754104 19551842 20492335 21071580 18644402 21167192 21047994 18977376 9163691 18978307 19073162 20501860 19499222 19996281 20405173 19254457 10737359 15175105 19638242 19642983 20452335 2422723 19833225 2862719 19294768 19255062 19256749 20583210 16942905 21278145
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 8.0216984957
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.4517854601 18544905 16842330 18253720 18308698 18164116 2563599 18079962 18282651 18093689 19519916 16267830 9362446 18775883 17174075 19539802 19004024 17942915 21159647 19009564 3124819 19126423
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.4512151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.5218520028 18569708 20135361 20064080 20464547 18816296 17053015 6695378 20869020
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.5220970405 6695378 20512841 21163286
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5211884234 19555203
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.4614737004
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.4016801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4616381670
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3112213967
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.689029167 3581430
MESH:D009369 Neoplasms Benzo(a)pyrene 2.3111141357
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.0517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.6119348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.6514600291
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.6520387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.7320387270
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.5216540662
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.8612520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.0018163543
MESH:D011230 Precancerous Conditions Cyclosporine 10.0512371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 10.052563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.7311222880 11896295 11399792 11118676
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1517292933
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.1518760546
MESH:D011565 Psoriasis Cyclosporine 2.3216882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2818990726
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.9510029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.9516192470
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.4020155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.4018456281
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.5112697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.257505956
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2917053015
MESH:D014605 Uveitis Cyclosporine 4.591336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.2112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.8615886252
MESH:D014985 Xerophthalmia Cyclosporine 5.0517120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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