AutismKB 2.0

Annotation Detail for FOXO3


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Basic Information Top
Gene Symbol:FOXO3 ( AF6q21,DKFZp781A0677,FKHRL1,FKHRL1P2,FOXO2,FOXO3A,MGC12739,MGC31925 )
Gene Full Name: forkhead box O3
Band: 6q21
Quick LinksEntrez ID:2309; OMIM: 602681; Uniprot ID:FOXO3_HUMAN; ENSEMBL ID: ENSG00000118689; HGNC ID: 3821
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04722Neurotrophin signaling pathway
hsa05223Non-small cell lung cancer
hsa05213Endometrial cancer
hsa04062Chemokine signaling pathway
Pathway IDPathway Name
Signalling by NGF
Pathway IDPathway Name
200171Validated targets of C-MYC transcriptional repression
200183Trk receptor signaling mediated by PI3K and PLC-gamma
200156Signaling events mediated by Stem cell factor receptor (c-Kit)
200012Insulin Pathway
200020Signaling events mediated by HDAC Class III
200091FoxO family signaling
200099IL2 signaling events mediated by PI3K
200098Class I PI3K signaling events
200169Class I PI3K signaling events mediated by Akt
Pathway IDPathway Name
P00033Insulin/IGF pathway-protein kinase B signaling cascade
P00048PI3 kinase pathway
P00036Interleukin signaling pathway
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
IMMUNE
normalized brain volume, multiple sclerosis
Desease Name
Normalized brain volume
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the localization of and results in increased activity of FOXO3 proteinaffects localization|increases activity 19211844
C026137 3-hydroxyacetanilide 3-hydroxyacetanilide results in decreased expression of FOXO3 mRNAdecreases expression 18544908
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of FOXO3 mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen results in increased expression of FOXO3 mRNAincreases expression 18544908
D016572 Cyclosporine Cyclosporine results in decreased expression of FOXO3 mRNAdecreases expression 20106945
D004317 Doxorubicin BIRC5 protein inhibits the reaction [FOXO3 protein results in increased susceptibility to Doxorubicin]decreases reaction|increases response to substance 19211844
D004317 Doxorubicin Doxorubicin results in increased phosphorylation of FOXO3 proteinincreases phosphorylation 17935137
D004317 Doxorubicin [FOXO3 protein results in decreased expression of BIRC5 protein] which results in increased susceptibility to Doxorubicindecreases expression|increases response to substance 19211844
D004317 Doxorubicin FOXO3 protein results in increased susceptibility to Doxorubicinincreases response to substance 19211844
D004317 Doxorubicin wortmannin inhibits the reaction [Doxorubicin results in increased phosphorylation of FOXO3 protein]decreases reaction|increases phosphorylation 17935137
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of FOXO3 mRNAdecreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of FOXO3 mRNAaffects cotreatment|decreases expression 17942748
D005047 Etoposide BIRC5 protein inhibits the reaction [FOXO3 protein results in increased susceptibility to Etoposide]decreases reaction|increases response to substance 19211844
D005047 Etoposide Etoposide results in increased phosphorylation of FOXO3 proteinincreases phosphorylation 17935137
D005047 Etoposide [FOXO3 protein results in decreased expression of BIRC5 protein] which results in increased susceptibility to Etoposidedecreases expression|increases response to substance 19211844
D005047 Etoposide FOXO3 protein results in increased susceptibility to Etoposideincreases response to substance 19211844
D005047 Etoposide wortmannin inhibits the reaction [Etoposide results in increased phosphorylation of FOXO3 protein]decreases reaction|increases phosphorylation 17935137
D005472 Fluorouracil FOXO3 affects the susceptibility to Fluorouracilaffects response to substance 15067352
D019833 Genistein Genistein affects the expression of FOXO3 mRNAaffects expression 18431742
D019833 Genistein Genistein affects the expression of FOXO3 proteinaffects expression 18431742
D019833 Genistein Genistein affects the localization of FOXO3 proteinaffects localization 18431742
D019833 Genistein Genistein inhibits the reaction [HIST3H3 protein modified form binds to FOXO3 promoter]affects binding|decreases reaction 18431742
D019833 Genistein Genistein inhibits the reaction [SIRT1 protein binds to FOXO3 promoter]affects binding|decreases reaction 18431742
D019833 Genistein Genistein results in decreased phosphorylation of FOXO3 proteindecreases phosphorylation 18431742
D019833 Genistein [[Genistein results in increased expression of PTEN protein] which results in decreased activity of AKT1 protein] which results in increased activity of FOXO3 proteindecreases activity|increases activity|increases expression 18431742
D007529 Isoflavones Isoflavones results in increased expression of FOXO3 mRNAincreases expression 17374662
D007529 Isoflavones Isoflavones results in increased expression of FOXO3 proteinincreases expression 17374662
C533894 LG 100815 LG 100815 results in increased expression of FOXO3 mRNAincreases expression 16951191
C008493 methylselenic acid methylselenic acid results in decreased phosphorylation of and results in increased activity of FOXO3 proteindecreases phosphorylation|increases activity 17339365
C062198 octa-2,4,6-trienoic acid octa-2,4,6-trienoic acid results in increased expression of FOXO3 mRNAincreases expression 16951191
C059514 resveratrol resveratrol affects the localization of and results in increased activity of FOXO3 proteinaffects localization|increases activity 17513867
C059514 resveratrol resveratrol inhibits the reaction [IGF1 protein results in increased phosphorylation of FOXO3 protein]decreases reaction|increases phosphorylation 17513867
C059514 resveratrol resveratrol promotes the reaction [FOXO3 protein binds to CDKN1B promoter]affects binding|increases reaction 17513867
C059514 resveratrol resveratrol promotes the reaction [FOXO3 protein binds to FASLG promoter]affects binding|increases reaction 17513867
D012643 Selenium Selenium results in decreased phosphorylation of and results in increased activity of FOXO3 proteindecreases phosphorylation|increases activity 17339365
C017947 sodium arsenite sodium arsenite affects the expression of FOXO3 mRNAaffects expression 19590694
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of FOXO3 mRNAaffects cotreatment|decreases expression 17942748
D014635 Valproic Acid Valproic Acid results in decreased expression of FOXO3 mRNAdecreases expression 19101580
C009687 wortmannin wortmannin inhibits the reaction [Doxorubicin results in increased phosphorylation of FOXO3 protein]decreases reaction|increases phosphorylation 17935137
C009687 wortmannin wortmannin inhibits the reaction [Etoposide results in increased phosphorylation of FOXO3 protein]decreases reaction|increases phosphorylation 17935137
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.0311752688 14514962 15322242
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 8.038875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.8419490988
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.8617505938
MESH:D058186 Acute Kidney Injury resveratrol 3.7716538975
MESH:D000230 Adenocarcinoma Doxorubicin 10.0217418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 10.0214692618
MESH:D000230 Adenocarcinoma Fluorouracil 10.0217638652
MESH:D000230 Adenocarcinoma Genistein 10.0211473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.673712494
MESH:D000236 Adenoma resveratrol 6.6715688382
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.2916835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.6215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.8217306315 16712894
MESH:D000419 Albuminuria Doxorubicin 4.4621441931
MESH:D000505 Alopecia Isoflavones 4.6517569567
MESH:D000544 Alzheimer Disease resveratrol 2.5516183991 16162502
MESH:D000550 Amblyopia Valproic Acid 5.1517688650
MESH:D000740 Anemia Fluorouracil 8.4217963324 16511603 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.4211748828
MESH:D000799 Angioedema Acetaminophen 3.7610982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.5017497229
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.3811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.1815885639
MESH:D001169 Arthritis, Experimental resveratrol 7.1817115116
MESH:D050197 Atherosclerosis resveratrol 3.2217967414 16873680
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8517507914 19460635 18396377 18775368 20603192 16609825 18316065 18177632 18940202 17688650 18985861 19232924 15238991 17157402 18558336
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.941440618 11289319
MESH:D001714 Bipolar Disorder Valproic Acid 3.0320046352 17594078
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.9612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.8315746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.838888407
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 11.8914601052
MESH:D019046 Bone Marrow Neoplasms Etoposide 11.8914601052
MESH:D002545 Brain Ischemia resveratrol 4.2017600658
MESH:D001932 Brain Neoplasms Doxorubicin 3.7317150277
MESH:D001943 Breast Neoplasms Doxorubicin 2.9315939500 18234424 15136595 18382427 19526202 16115903 18628466 16595493 16264153 15634643 16096432 16322301 15993339 17983394 18695136 17426702 16826403 16935488 15692762 15994142 17369602 15668708 11325840 15567936
MESH:D001943 Breast Neoplasms Etoposide 2.9316322251
MESH:D001943 Breast Neoplasms Fluorouracil 2.9318608205 16595493 19217205 16110121 15136595 16557594 18357371
MESH:D001943 Breast Neoplasms Genistein 2.9316873071 17200150 16541309
MESH:D001943 Breast Neoplasms resveratrol 2.9317651959 16393696 17534123
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.9320435547
MESH:D002276 Carcinoid Tumor Doxorubicin 12.0816051944
MESH:D002276 Carcinoid Tumor Fluorouracil 12.0816051944
MESH:D002277 Carcinoma Fluorouracil 7.9517121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.9516835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 13.893581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.893084413
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 13.8918059187 16023760 16234567 17876044
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 13.8917971768 16799960 18930000 17045692 17088986 16332177
MESH:D006528 Carcinoma, Hepatocellular Genistein 13.8916924424
MESH:D006528 Carcinoma, Hepatocellular resveratrol 13.8916227395 19321006
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 13.8916507464 15276417 17306315
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.5116675471
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 10.557296757
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 10.551485588 16201981
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 10.5518695887
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 10.636189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 10.6316757204 16280240 17066447 18986760
MESH:D002294 Carcinoma, Squamous Cell resveratrol 10.6316227395
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 10.6318572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3218670907 18850075 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 3.4717924179 17351982 17928571 16651473 17382496 16269455 16455267 15505089 15792986 16731534 15811867 17308081 16952015 17519947 16242529 18627295 16278810 16364871 17007740 15476868 16612575 17974986 17131338 16109756 17329180
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9216243910 17334414
MESH:D002318 Cardiovascular Diseases Genistein 11.9916332659
MESH:D002318 Cardiovascular Diseases Isoflavones 11.9917689850
MESH:D002318 Cardiovascular Diseases resveratrol 11.9915458977
MESH:D002386 Cataract Acetaminophen 2.5310977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 10.817505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.8112371664
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 10.8119524636 20056578
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6820734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0816835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 13.009022650 19486331
MESH:D002779 Cholestasis Cyclosporine 13.0019486331
MESH:D002779 Cholestasis Ethinyl Estradiol 13.0016105132 11677210 17681005 15861022 16919318 17333356 17110522
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0715340226 12621046 8697196 15668235 16354765
MESH:D003092 Colitis resveratrol 9.3616474422
MESH:D003092 Colitis Selenium 9.3617936198
MESH:D003110 Colonic Neoplasms Fluorouracil 5.8118772588 16340194 17287894 16510598 17016597 15001691 17172411 17725105 17018589 17169374
MESH:D003110 Colonic Neoplasms Genistein 5.8117182828
MESH:D003110 Colonic Neoplasms resveratrol 5.8116338953
MESH:D015179 Colorectal Neoplasms Doxorubicin 4.8018259882 18802399
MESH:D015179 Colorectal Neoplasms Fluorouracil 4.8017094418 15148649 17594712 17454858 18288408 16524972 15289873 20501625 18949393 17695437 14970324 18383874 17016601 16282729 16391804 16303861 18448328 18509181 17255274 18802399 16331619 17401013
MESH:D015179 Colorectal Neoplasms Isoflavones 4.8017116718
MESH:D015179 Colorectal Neoplasms resveratrol 4.8016550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9817141729 14669216
MESH:D003327 Coronary Disease resveratrol 3.6916507316
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4520055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.4517688650 8888407 16575769
MESH:D007644 Darier Disease Fluorouracil 4.7116733453
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.7212868966 11298694 8156756 8970840 18759878 11906362 14531868 2524372
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.413621924 2952479
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.6916873680
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.2616647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2617107852
MESH:D003928 Diabetic Nephropathies resveratrol 3.8916286809
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 14.9318692083 6679447 8291058 18648102 18289764 9328219 9022650 9653073 16192314 7440962 1440618 11289319 6482804
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 14.932444490 16781746 12594235 17522070 19923254 14725611 19164858 19085960 16227642 19739265 16485898 16109766 11834606 11461765 14986274 12705907 14550746 10915739 17562736 15968718 10663392 11421492 19370779 12958197 15619225 16081117 16393943 19416960 11529661 18071297 12392966 17906064 11739529 11287661 10774834 16177239 12540782 12153990 11743745 18713872 19420014
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 14.9317416283
MESH:D056486 Drug-Induced Liver Injury Selenium 14.9315131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 14.9320420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 14.931733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0219426721
MESH:D004362 Drug Toxicity Doxorubicin 7.8918602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.8911462148
MESH:D004421 Dystonia Valproic Acid 3.961851702
MESH:D004487 Edema resveratrol 6.598985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.5912711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8215322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.8412538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 8.8417872969
MESH:D004714 Endometrial Hyperplasia Genistein 4.5016402032
MESH:D016889 Endometrial Neoplasms Doxorubicin 7.4917359293
MESH:D016889 Endometrial Neoplasms Genistein 7.4911473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.9410568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.0818037988
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.7617923197
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.0717275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 3.843922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.8920417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.517562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.217750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.983659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.453581430
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.4515173087 16337965 16785472 16481741 17638652
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9511564622
MESH:D005234 Fatty Liver Cyclosporine 12.6019224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 12.6015345470
MESH:D005234 Fatty Liver Valproic Acid 12.6014986274 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3711858732
MESH:D005315 Fetal Diseases Valproic Acid 4.8116575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.048888407 18558336
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.946705139
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.5019069698
MESH:D005355 Fibrosis Cyclosporine 8.1912168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.1920067830
MESH:D005756 Gastritis Acetaminophen 3.5916983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.5916452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.138708960
MESH:D005909 Glioblastoma Doxorubicin 7.1417150277
MESH:D005909 Glioblastoma Genistein 7.1416598420
MESH:D005910 Glioma Fluorouracil 2.8316145905
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.957505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5110696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 7.7215692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 7.7215102660 18337622 15162350
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2811294989 10048152
MESH:D006331 Heart Diseases Doxorubicin 3.4216244371 16244372 18674790 17875725 16144979 16495754 17888722 18006777 16879835 12587719 16707910 14766674 16330681
MESH:D006333 Heart Failure Doxorubicin 7.0717481944
MESH:D006333 Heart Failure Selenium 7.0717162251
MESH:D006394 Hemangiosarcoma Doxorubicin 3.8215692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2511000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.436705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.8115340226 12621046 16120746
MESH:D006561 Herpes Simplex Etoposide 9.8110809021
MESH:D006561 Herpes Simplex resveratrol 9.8116876885
MESH:D006689 Hodgkin Disease Doxorubicin 11.9315147373 17606976 18501091
MESH:D006689 Hodgkin Disease Etoposide 11.9318180244 17606976 16135485 15147373 16200630
MESH:D006689 Hodgkin Disease sodium arsenite 11.9312676792
MESH:D019584 Hot Flashes Isoflavones 4.9017290160 14716179
MESH:D006849 Hydrocephalus Valproic Acid 4.7817688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.968697196 18606429 15340226 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.6316870215
MESH:D006937 Hypercholesterolemia resveratrol 3.9217188708
MESH:D006949 Hyperlipidemias resveratrol 3.9416873680
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.8515034207
MESH:D006973 Hypertension Cyclosporine 4.8310903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.8318670907 18850075
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.2217488730
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7216945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.5617600658
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.4417937319
MESH:D007248 Infertility, Male sodium arsenite 6.4412646999 15346721
MESH:D007249 Inflammation resveratrol 4.9216366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.9212878042 12200463
MESH:D007251 Influenza, Human resveratrol 10.8116624496
MESH:D007251 Influenza, Human Selenium 10.8116624496
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.949022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2516580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3615604871
MESH:D007674 Kidney Diseases Acetaminophen 14.0212587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 14.0218776723 8314463 10903974
MESH:D007674 Kidney Diseases Doxorubicin 14.0215699352 16775033 15369732
MESH:D007674 Kidney Diseases sodium arsenite 14.0220008137
MESH:D007676 Kidney Failure, Chronic Doxorubicin 9.7116707910
MESH:D007676 Kidney Failure, Chronic Selenium 9.7116518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 11.986582329
MESH:D007680 Kidney Neoplasms Cyclosporine 11.9812371664
MESH:D007680 Kidney Neoplasms Fluorouracil 11.9816985049
MESH:D007938 Leukemia 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 6.6512970779
MESH:D007938 Leukemia Genistein 6.6518980019 17468513
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.0816085563
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1416294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.5216087638
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.1415034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 3.4816595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Genistein 3.4817823541
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4812878042
MESH:D008107 Liver Diseases Acetaminophen 1.6112587719 16610002 11587558 12969438 19460945 16611625 19784758 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.1616871587 17185352
MESH:D008113 Liver Neoplasms Fluorouracil 10.4617045692 16603448 15113037 18383874
MESH:D008113 Liver Neoplasms resveratrol 10.4619812893 19073162 20405173 19321006
MESH:D008113 Liver Neoplasms sodium arsenite 10.4616712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.4616984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 9.51598648 6587162 3712494 1399818
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 9.5117085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.5112151625
MESH:D008171 Lung Diseases sodium arsenite 3.1119095001
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.1817228818
MESH:D008175 Lung Neoplasms Doxorubicin 4.7817418594 6189445
MESH:D008175 Lung Neoplasms Fluorouracil 4.7815246190
MESH:D008175 Lung Neoplasms sodium arsenite 4.7817306315 15276417 16712894 17077188 19931552
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.7811884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.7115086387
MESH:D008223 Lymphoma Doxorubicin 7.7016098063
MESH:D008223 Lymphoma Etoposide 7.7012854902 12556972
MESH:D016393 Lymphoma, B-Cell resveratrol 4.2117088997
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 8.6317654614
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 8.6314749477
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.4815621674
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.1615688416
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 13.8515458769
MESH:D008325 Mammary Neoplasms, Experimental Genistein 13.8514578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 13.858985016 11606380
MESH:D008325 Mammary Neoplasms, Experimental Selenium 13.8515318939
MESH:D008545 Melanoma Doxorubicin 5.1216827129
MESH:D008545 Melanoma resveratrol 5.1217992120
MESH:D008545 Melanoma sodium arsenite 5.1216487513 19082730
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4819513568
MESH:D008654 Mesothelioma Doxorubicin 6.1717638057
MESH:D008654 Mesothelioma Selenium 6.1715107826
MESH:D008659 Metabolic Diseases resveratrol 4.2917112576
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7116801185
MESH:D008881 Migraine Disorders Valproic Acid 3.1318803445 18765137
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.4215792986
MESH:D009062 Mouth Neoplasms Fluorouracil 3.5616757204 18986760
MESH:D052016 Mucositis Doxorubicin 4.7017415656
MESH:D009101 Multiple Myeloma resveratrol 3.4017164350 17049120 17935668 16490592 14749477 16267019
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.7817962980
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.948888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.1017596541
MESH:D009203 Myocardial Infarction Doxorubicin 9.3915857846 19429709
MESH:D009203 Myocardial Infarction Genistein 9.3917141266
MESH:D009203 Myocardial Infarction resveratrol 9.3916456233 17188708 16317513 16525036 17125593 17015251
MESH:D017202 Myocardial Ischemia resveratrol 8.7717015251 17125593
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.7712213967
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.5917141266
MESH:D009205 Myocarditis resveratrol 4.6717322642
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.733581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 5.7318259882
MESH:D009369 Neoplasms Fluorouracil 5.0418239605 18600527 16928823
MESH:D009369 Neoplasms sodium arsenite 5.0411559025
MESH:D009374 Neoplasms, Experimental resveratrol 8.948985016
MESH:D009374 Neoplasms, Experimental sodium arsenite 8.9420056578
MESH:D009401 Nephrosis Doxorubicin 4.6816899518 16636307
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 9.0419348381 18481113
MESH:D009404 Nephrotic Syndrome Doxorubicin 9.0416889571 15640375
MESH:D009421 Nervous System Malformations Genistein 9.3216427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.3214600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 11.806679447
MESH:D009436 Neural Tube Defects sodium arsenite 11.8012854658
MESH:D009436 Neural Tube Defects Valproic Acid 11.8016359493 8888407
MESH:D009447 Neuroblastoma Doxorubicin 3.2215555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.1118514411
MESH:D019636 Neurodegenerative Diseases resveratrol 8.1117652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.3117929310
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.3816436463
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.346482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.943988306
MESH:D010024 Osteoporosis Genistein 7.4119401787
MESH:D010024 Osteoporosis Isoflavones 7.4116562857
MESH:D015663 Osteoporosis, Postmenopausal Genistein 9.8716169203
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 9.8717513867
MESH:D012516 Osteosarcoma Doxorubicin 4.0415930896
MESH:D010051 Ovarian Neoplasms 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 7.9016211241
MESH:D010051 Ovarian Neoplasms Genistein 7.9019005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 7.9017306315 15276417
MESH:D010146 Pain Acetaminophen 2.3216870215
MESH:D010190 Pancreatic Neoplasms Etoposide 5.5319003803
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.5315113037 16500647 19003803 16929163
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6011578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.407296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1712520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.396228378
MESH:D003557 Phyllodes Tumor Doxorubicin 5.0817983394
MESH:D010954 Plasmacytoma Selenium 4.8115087411
MESH:D010997 Pleural Neoplasms Doxorubicin 5.0817638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4718163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.1412371664
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 15.7816679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 15.7811222880 11399792 11896295 11118676
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 15.7820603192
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.4515897917 16888761 16729912 16868541 18437689 15749863
MESH:D011471 Prostatic Neoplasms Etoposide 2.4517172428
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.4518626508 19082440
MESH:D011471 Prostatic Neoplasms Genistein 2.4515256057 16925846 15378649
MESH:D011471 Prostatic Neoplasms Isoflavones 2.4517571952 16365062 17374662 17219775
MESH:D011471 Prostatic Neoplasms methylselenic acid 2.4516205645
MESH:D011471 Prostatic Neoplasms resveratrol 2.4517804756 15767336 17636462 17718901 17675339 16731767
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.4516039940
MESH:D011537 Pruritus Ethinyl Estradiol 3.2316919318 15861022
MESH:D019310 Pseudolymphoma Valproic Acid 4.4611422049 12752131
MESH:D011565 Psoriasis Cyclosporine 2.2016882103
MESH:D012004 Rectal Neoplasms Fluorouracil 3.9318286688 16160472 18722050 15538739
MESH:D051437 Renal Insufficiency Doxorubicin 4.1317922066
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.5016325855
MESH:D015427 Reperfusion Injury resveratrol 3.2316314181 17520802 17058453 16317513 15827377
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7518990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.313692021
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.0919155313
MESH:D012509 Sarcoma Doxorubicin 3.9118313854 15625365 17203757 17710206 16767912 15675481
MESH:D012512 Sarcoma, Ewing's Doxorubicin 10.2614601052 16326096
MESH:D012512 Sarcoma, Ewing's Etoposide 10.2614601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.7017846226
MESH:D012559 Schizophrenia Valproic Acid 2.0615737665 19110320
MESH:D012640 Seizures Valproic Acid 2.683137016 15475178 14763951 17978042 11044598 11738929 1511512 16876388
MESH:D012878 Skin Neoplasms Doxorubicin 13.2615692506
MESH:D012878 Skin Neoplasms resveratrol 13.268985016 15837718
MESH:D012878 Skin Neoplasms sodium arsenite 13.2618572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 13.2616192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.4816767912 15625365 17203757
MESH:D013088 Spermatocele Ethinyl Estradiol 3.8616709447
MESH:D016135 Spinal Dysraphism sodium arsenite 9.3112854658
MESH:D016135 Spinal Dysraphism Valproic Acid 9.3119490988
MESH:D013226 Status Epilepticus Valproic Acid 4.4612833885
MESH:D013274 Stomach Neoplasms Fluorouracil 2.0018396642 19084572 16424979 17172411 17522103 16951190 19015929 17498489 18567086 15786421
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.4016321402
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0715669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8212697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.036587162 6582329 3712494 1399818 7505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 7.0317909728 16010429
MESH:D014062 Tongue Neoplasms Fluorouracil 9.7216280240
MESH:D014062 Tongue Neoplasms resveratrol 9.7216227395
MESH:D014178 Translocation, Genetic Valproic Acid 5.1517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.443119515
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.178074119
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 8.1717653716
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 8.1716712894 11723127 17306315 16452187
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.568888407
MESH:D014581 Urticaria Acetaminophen 2.8910982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 15.4616803524
MESH:D002583 Uterine Cervical Neoplasms resveratrol 15.4617473185
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 15.4611813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 9.2114692618
MESH:D014594 Uterine Neoplasms resveratrol 9.2117044934
MESH:D014605 Uveitis Cyclosporine 3.901336536
MESH:D014652 Vascular Diseases sodium arsenite 4.3417056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4614671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 10.0516364871 17334414 17638931 17678736
MESH:D018487 Ventricular Dysfunction, Left resveratrol 10.0517488730
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1715886252
MESH:D014985 Xerophthalmia Cyclosporine 4.3617120751
Pathway ID Pathway Name
KEGG:04062 Chemokine signaling pathway
KEGG:05213 Endometrial cancer
KEGG:04722 Neurotrophin signaling pathway
KEGG:05223 Non-small cell lung cancer
REACT:11061 Signalling by NGF
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28239
    • No data
    No data
    Releated drug ID Related drug Name
    PA10804imatinib
    PA152241907lapatinib
    PA10804imatinib
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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