AutismKB 2.0

Annotation Detail for ARHGAP26


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Basic Information Top
Gene Symbol:ARHGAP26 ( FLJ42530,GRAF,KIAA0621,OPHN1L,OPHN1L1 )
Gene Full Name: Rho GTPase activating protein 26
Band: 5q31.3
Quick LinksEntrez ID:23092; OMIM: 605370; Uniprot ID:RHG26_HUMAN; ENSEMBL ID: ENSG00000145819; HGNC ID: 17073
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Signaling by Rho GTPases
Pathway IDPathway Name
200192Signaling events mediated by focal adhesion kinase
Pathway IDPathway Name
P00047PDGF signaling pathway
P00034Integrin signalling pathway
No data
Related Diseases/Disorders Top
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Desease Name
Leukemia, juvenile myelomonocytic
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ARHGAP26 mRNAdecreases expression 20106945
20064835
C006780 bisphenol A bisphenol A results in decreased expression of ARHGAP26 mRNAdecreases expression 18007998
D016572 Cyclosporine Cyclosporine results in increased expression of ARHGAP26 mRNAincreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of ARHGAP26 mRNAdecreases expression 18042831
C041786 palm oil palm oil results in decreased expression of ARHGAP26 mRNAdecreases expression 18042831
D014635 Valproic Acid Valproic Acid results in increased expression of ARHGAP26 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.958875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.2519490988
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0420127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.826695378
MESH:D000550 Amblyopia Valproic Acid 5.7517688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.8317497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4919183758
MESH:D001161 Arteriosclerosis Dietary Fats 4.3115238619
MESH:D001321 Autistic Disorder Valproic Acid 1.9917688650 15238991 18316065 20603192 18775368 17507914 16609825 19232924 17157402 19460635 18940202 18396377 18558336 18177632 18985861
MESH:D001714 Bipolar Disorder Valproic Acid 3.2120046352 17594078
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.598888407
MESH:D001862 Bone Resorption bisphenol A 4.1911985600
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9117474063 20146248
MESH:D001943 Breast Neoplasms bisphenol A 1.9117123778
MESH:D001943 Breast Neoplasms Dietary Fats 1.9120435547
MESH:D002278 Carcinoma in Situ bisphenol A 5.4517123778
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1220419170
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.7312371664
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.8020734317
MESH:D002779 Cholestasis Cyclosporine 3.1419486331
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.9016575769 17688650 8888407
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 2.2419641884 1733752
MESH:D050171 Dyslipidemias Dietary Fats 3.6718367378
MESH:D004421 Dystonia Valproic Acid 4.401851702
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.573659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.4416628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0718234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.877562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.717750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.533659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0716530937
MESH:D005234 Fatty Liver Cyclosporine 15.1019224547
MESH:D005234 Fatty Liver Dietary Fats 15.1018296743 19004024 19551842 17967931
MESH:D005234 Fatty Liver Valproic Acid 15.1014986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 5.4116575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.518888407 18558336
MESH:D005355 Fibrosis Cyclosporine 10.1212639820 12168785
MESH:D005355 Fibrosis Dietary Fats 10.1218296743
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.688708960
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8020471113
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8815720958
MESH:D006849 Hydrocephalus Valproic Acid 5.3317688650
MESH:D006937 Hypercholesterolemia Dietary Fats 3.9221332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.9721332399
MESH:D006973 Hypertension Cyclosporine 2.1910903974
MESH:D007249 Inflammation Dietary Fats 2.5720412841
MESH:D007333 Insulin Resistance bisphenol A 8.1416393666
MESH:D007333 Insulin Resistance Dietary Fats 8.1411836018 18457598
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.9615604871
MESH:D007674 Kidney Diseases Cyclosporine 2.508314463 18776723 10903974
MESH:D007680 Kidney Neoplasms Cyclosporine 3.0012371664
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1917596541 16294345
MESH:D054429 Leukemia, Myelomonocytic, Juvenile marker/mechanism
MESH:D008103 Liver Cirrhosis Dietary Fats 3.0318296743
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 2.1320195826 21137059
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.7817228818
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5718816296 17053015 6695378 20064080 20135361 20869020 18569708 18520028 20464547
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.3116801185
MESH:D008881 Migraine Disorders Valproic Acid 3.4118765137 18803445
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4316381670
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.358888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.3117596541
MESH:D009369 Neoplasms Benzo(a)pyrene 2.3011141357
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.9617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5719348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 4.3511399458 16427766
MESH:D009436 Neural Tube Defects Valproic Acid 3.328888407 16359493
MESH:D009765 Obesity Dietary Fats 2.3419632207 17217161 18674790 16723640 20132043 18457598 20518802 21332399 11836018
MESH:D010049 Ovarian Diseases bisphenol A 5.4511985600
MESH:D011230 Precancerous Conditions Cyclosporine 3.5112371664
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 11.3310548101
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 11.3320603192
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.5320887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1617292933
MESH:D011471 Prostatic Neoplasms bisphenol A 3.1616740699
MESH:D019310 Pseudolymphoma Valproic Acid 5.0611422049 12752131
MESH:D011565 Psoriasis Cyclosporine 2.3116882103
MESH:D011629 Puberty, Precocious bisphenol A 5.2510548101
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.5319155313
MESH:D012559 Schizophrenia Valproic Acid 2.1019110320 15737665
MESH:D012640 Seizures Valproic Acid 2.9416876388 14763951 17978042 1511512 15475178 3137016 11738929 11044598
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4919755658 10029692
MESH:D016135 Spinal Dysraphism Valproic Acid 4.0219490988
MESH:D013226 Status Epilepticus Valproic Acid 5.0612833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D019966 Substance-Related Disorders bisphenol A 4.4516045194 16684133
MESH:D014178 Translocation, Genetic Valproic Acid 5.7517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.983119515
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2817053015
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.068888407
MESH:D014591 Uterine Diseases bisphenol A 5.5314652134
MESH:D014605 Uveitis Cyclosporine 4.501336536
MESH:D015430 Weight Gain Dietary Fats 4.0216723640
MESH:D014985 Xerophthalmia Cyclosporine 4.9617120751
Pathway ID Pathway Name
REACT:11044 Signaling by Rho GTPases
Pharmacogenomics Knowledge Base Top
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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