AutismKB 2.0

Annotation Detail for SIPA1L3


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Basic Information Top
Gene Symbol:SIPA1L3 ( SPAL3 )
Gene Full Name: signal-induced proliferation-associated 1 like 3
Band: 19q13.13-q13.2
Quick LinksEntrez ID:23094; OMIM: NA; Uniprot ID:SI1L3_HUMAN; ENSEMBL ID: ENSG00000105738; HGNC ID: 23801
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000638 Amiodarone Amiodarone results in increased expression of SIPA1L3 mRNAincreases expression 19774075
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of SIPA1L3 mRNAdecreases expression 20064835
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of SIPA1L3 mRNAaffects binding|increases activity|increases expression 19710929
D012643 Selenium Selenium results in increased expression of SIPA1L3 mRNAincreases expression 19244175
C034028 vanadyl sulfate vanadyl sulfate results in increased expression of SIPA1L3 mRNAincreases expression 16330358
D014810 Vitamin E Vitamin E results in increased expression of SIPA1L3 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.4718653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0420127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.826695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.9416434500
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4919183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 4.1118218290 20041841 18057881
MESH:D001281 Atrial Fibrillation Amiodarone 4.1318651412 19698954
MESH:D001778 Blood Coagulation Disorders Amiodarone 10.1919483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 10.1919483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0017474063 20146248
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.3516050911
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1220419170
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9819225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.5518974383
MESH:D002779 Cholestasis pirinixic acid 3.0519176532
MESH:D003092 Colitis Selenium 4.2017936198
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5518249437
MESH:D003921 Diabetes Mellitus, Experimental vanadyl sulfate 4.6416684804
MESH:D056486 Drug-Induced Liver Injury Amiodarone 4.3415265979 18218290
MESH:D056486 Drug-Induced Liver Injury Selenium 4.3415131321
MESH:C538011 Eales disease Vitamin E 5.229068938
MESH:D004487 Edema pirinixic acid 2.8012083418
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0716530937
MESH:D005234 Fatty Liver Amiodarone 8.9114986274
MESH:D005234 Fatty Liver pirinixic acid 8.9119236843 20131406
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 7.1820471113
MESH:D006330 Heart Defects, Congenital Vitamin E 7.1816080930
MESH:D006333 Heart Failure pirinixic acid 7.5520558911
MESH:D006333 Heart Failure Selenium 7.5517162251
MESH:D006529 Hepatomegaly Amiodarone 10.0015265979
MESH:D006529 Hepatomegaly pirinixic acid 10.0019772884 16221962 18467677 19176532
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7916490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.4914716179
MESH:D006937 Hypercholesterolemia Amiodarone 4.208137927 9751232
MESH:D006943 Hyperglycemia pirinixic acid 3.4920558911
MESH:D007037 Hypothyroidism Amiodarone 4.9317991464 18020914
MESH:D007251 Influenza, Human Selenium 12.7616624496
MESH:D007251 Influenza, Human Vitamin E 12.7616624496
MESH:D007333 Insulin Resistance pirinixic acid 2.8216306350
MESH:D007674 Kidney Diseases Vitamin E 2.9612488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.2116518626
MESH:D008064 Lipidoses Amiodarone 3.7315342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4515474484
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.4516169303
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.7020195826 21137059
MESH:D008113 Liver Neoplasms pirinixic acid 4.7020007298 15890375 16377806
MESH:D008133 Long QT Syndrome Amiodarone 3.8217391786 15350150 11989578
MESH:D008171 Lung Diseases Amiodarone 8.1912587719
MESH:D008171 Lung Diseases Vitamin E 8.1916863852
MESH:D017563 Lung Diseases, Interstitial Amiodarone 5.0018516814
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.5017053015 18816296 20869020 20464547 18520028 6695378 20064080 18569708 20135361
MESH:D008175 Lung Neoplasms Vitamin E 2.5011062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9515318939
MESH:D008654 Mesothelioma Selenium 2.8915107826
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4316381670
MESH:D009135 Muscular Diseases pirinixic acid 3.9216239165
MESH:D009181 Mycoses Amiodarone 5.4217974566 12754197
MESH:D009203 Myocardial Infarction pirinixic acid 2.2519151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1916411023
MESH:D009369 Neoplasms Benzo(a)pyrene 5.2811141357
MESH:D009369 Neoplasms pirinixic acid 5.2817405874
MESH:D009765 Obesity pirinixic acid 1.8720558911
MESH:D010954 Plasmacytoma Selenium 5.4115087411
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1217292933
MESH:D011471 Prostatic Neoplasms Vitamin E 3.1215084515
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.9512832656 12490602 11597910
MESH:D015427 Reperfusion Injury pirinixic acid 2.5219058328
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.5518724381
MESH:D012871 Skin Diseases Vitamin E 2.5018709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4919755658 10029692
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D013276 Stomach Ulcer Amiodarone 3.6418087811
MESH:D020521 Stroke Vitamin E 3.7716517955
MESH:D013610 Tachycardia Amiodarone 4.6711238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.5719225199
MESH:D013959 Thyroid Diseases Amiodarone 5.2819731979
MESH:D013971 Thyrotoxicosis Amiodarone 5.2818020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 4.6511989578 17467628
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2817053015
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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