AutismKB 2.0

Annotation Detail for SARM1


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Basic Information Top
Gene Symbol:SARM1 ( FLJ36296,KIAA0524,SAMD2,SARM )
Gene Full Name: sterile alpha and TIR motif containing 1
Band: 17q11.2
Quick LinksEntrez ID:23098; OMIM: 607732; Uniprot ID:SARM1_HUMAN; ENSEMBL ID: ENSG00000004139; HGNC ID: 17074
Relate to Another Database: SFARIGene; denovo-db
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of SARM1 mRNAaffects expression 21346803
C006632 arsenic trioxide arsenic trioxide results in increased expression of SARM1 mRNAincreases expression 20458559
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3719825857 11798837
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 4.2216206674
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.9411589617
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 3.2016705839
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 3.2014691202 15073043 16217749 11135700 15553829
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.9419014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.6312490120
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 3.096135515
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8720501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.8612609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.9010525206
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.7818551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.7015213294
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 2.0721346803 18551238
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.4012903497
MESH:D005234 Fatty Liver arsenic trioxide 3.8415073043
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.9416904648
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.4116705839
MESH:D007938 Leukemia arsenic trioxide 3.0315070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.3517077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 5.1916972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.7914633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.3119077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1917050201 16968895 20471514 19850784 16467208
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.519834237 12712474 15213294 16331271 17649720 11161223 16823087 15336539 16891316 16112521 17712046 19035177 19075265 16966277 15622746 12018890 17217047 16330433 11468182 19225113 17107899 17869043 12679006 19642359 15748426
MESH:D015458 Leukemia, T-Cell arsenic trioxide 5.0316882451
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 5.097678174
MESH:D008113 Liver Neoplasms arsenic trioxide 5.0914682389
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.906135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.9020377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.7315213294
MESH:D008175 Lung Neoplasms arsenic trioxide 1.8711798837 19825857
MESH:D009101 Multiple Myeloma arsenic trioxide 3.4411468182 19417148 14977855 15949261 19549372
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.7418349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.3816105982 16882451
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.757678174 18551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.6316624393
MESH:D009436 Neural Tube Defects arsenic trioxide 3.4110525206
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.9416049721
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.5219769630 16624393 12452020
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.6615580305
MESH:D010235 Paraganglioma arsenic trioxide 4.7719927285
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2019131511
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.6316646077
MESH:D012640 Seizures 2,6-dinitrotoluene 2.8518551238
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.4719014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.8515213294
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.5916049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.5912973940 12845720 11780464 20435036
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 5.2010091137
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018