AutismKB 2.0

Annotation Detail for HIC2


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Basic Information Top
Gene Symbol:HIC2 ( HRG22,KIAA1020,ZBTB30,ZNF907 )
Gene Full Name: hypermethylated in cancer 2
Band: 22q11.21
Quick LinksEntrez ID:23119; OMIM: 607712; Uniprot ID:HIC2_HUMAN; ENSEMBL ID: ENSG00000169635; HGNC ID: 18595
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
systemic lupus erythematosus
IMMUNE
Desease Name
Hematological and biochemical traits
Systemic lupus erythematosus
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of HIC2 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of HIC2 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HIC2 mRNAaffects cotreatment|increases expression 17942748
D005472 Fluorouracil HIC2 protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of HIC2 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of HIC2 mRNAincreases expression 18301758
D013629 Tamoxifen Tamoxifen affects the expression of HIC2 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HIC2 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of HIC2 mRNAincreases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 5.1614745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3815322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.5517505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.5218653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.5814692618
MESH:D000230 Adenocarcinoma Fluorouracil 4.5817638652
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.7716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.7716835633
MESH:D000740 Anemia Fluorouracil 9.8617963324 16511603 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 9.8611748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.9511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8615885639
MESH:D001778 Blood Coagulation Disorders pirinixic acid 10.0419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 10.0412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.4015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9715746008
MESH:D001943 Breast Neoplasms Fluorouracil 1.8519217205 16595493 15136595 18608205 16557594 18357371 16110121
MESH:D001943 Breast Neoplasms Tamoxifen 1.8518821012 19103187 16873071 19115204 18997820 19221464 17261762 18855134 19289846 16202921 19410462 18629630 16273361 19155303 20005174 19084267 17242785 15668708 18984771 11161223 19059307 20544844 20390343 19189210 19487384 19142967 17049068 17893378 18425577 19189212 16818667 18815881 19244106 18351453 19066611 20135344 20065188 15565566 21138602 19011961 19288272 19200415 20859285 21152245 17440819
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8520435547
MESH:D002276 Carcinoid Tumor Fluorouracil 5.2816051944
MESH:D002277 Carcinoma Fluorouracil 9.1617121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 9.1616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.9919066611
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 3.2317045692 17971768 16332177 16799960 18930000 17088986
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 3.2316924424
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.1518695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.5717066447 16757204 16280240 18986760
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.9617572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5416120746 18670907 18850075
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4916835633
MESH:D002779 Cholestasis Ethinyl Estradiol 8.6217333356 17681005 15861022 16105132 17110522 16919318 11677210
MESH:D002779 Cholestasis pirinixic acid 8.6219176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2216354765 8697196 15668235 15340226 12621046
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2818772588 17172411 17725105 16340194 15001691 17287894 16510598 17169374 17018589 17016597
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0018509181 17695437 17016601 16524972 17255274 17454858 18288408 15148649 15289873 18383874 14970324 16282729 17594712 20501625 17094418 17401013 16303861 18802399 16391804 16331619 18448328 18949393
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3817141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2715322242 10048152 20055451
MESH:D007644 Darier Disease Fluorouracil 5.3316733453
MESH:D003711 Demyelinating Diseases Tamoxifen 4.8519031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5618249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7317107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.8019279558
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.6120420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0211462148
MESH:D004487 Edema pirinixic acid 7.7912083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.7911000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.5116714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.4512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.4519031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.2620544844 16202921 17893378 19155303
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.3710568697 9294722
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.5216785472 16337965 17638652 15173087 16481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2711564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 15.3115345470
MESH:D005234 Fatty Liver pirinixic acid 15.3119236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 15.3119224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.4316709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.9411858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 5.0714745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.7219069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.4320067830
MESH:D005910 Glioma Fluorouracil 2.9816145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.2110696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.6115102660 15162350 18337622
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4910048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.7320558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.7111000095
MESH:D006529 Hepatomegaly pirinixic acid 9.9216221962 18467677 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.9212621046 16120746 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.6618606429 8697196 16354765 15340226 16959395
MESH:D006943 Hyperglycemia pirinixic acid 3.5320558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0118670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2916945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.7117937319
MESH:D007249 Inflammation Tamoxifen 5.4319457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.4312878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.8516306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.7116580747
MESH:D007680 Kidney Neoplasms Fluorouracil 8.5416985049
MESH:D007680 Kidney Neoplasms Tamoxifen 8.5418625569
MESH:D008064 Lipidoses Tamoxifen 3.4015342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5615474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.5618564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5612878042
MESH:D008113 Liver Neoplasms Fluorouracil 11.6215113037 17045692 16603448 18383874
MESH:D008113 Liver Neoplasms pirinixic acid 11.6220007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 11.6216684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.6216984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.3112151625
MESH:D008175 Lung Neoplasms Fluorouracil 3.5715246190
MESH:D008175 Lung Neoplasms Tamoxifen 3.5718625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5711884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.3315086387
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.3019428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.8314580682 19196722 11731420 16827153 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 5.1619453300
MESH:D008545 Melanoma Tamoxifen 1.9219393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.7215990972
MESH:D009062 Mouth Neoplasms Fluorouracil 3.9016757204 18986760
MESH:D009135 Muscular Diseases pirinixic acid 3.9916239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2619151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2216411023
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6619393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.6019410462
MESH:D009369 Neoplasms Fluorouracil 5.4918600527 18239605 16928823
MESH:D009369 Neoplasms pirinixic acid 5.4917405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.6119189210 19196722 19200415
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.6514600291
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.6616436463
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7615113037 16929163 16500647 19003803
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0911578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.8612520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.0018163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.7311118676 11222880 11399792 11896295
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.2218626508 19082440
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.2215067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.8516919318 15861022
MESH:D012004 Rectal Neoplasms Fluorouracil 4.3415538739 18286688 18722050 16160472
MESH:D015427 Reperfusion Injury pirinixic acid 2.5319058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2818990726
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1816192470
MESH:D013088 Spermatocele Ethinyl Estradiol 13.6916709447
MESH:D013088 Spermatocele Tamoxifen 13.6916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.5819457130
MESH:D013274 Stomach Neoplasms Fluorouracil 2.0018396642 18567086 16424979 19015929 17522103 16951190 17498489 15786421 19084572 17172411
MESH:D019851 Thrombophilia Ethinyl Estradiol 4.0211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.5112697716
MESH:D014062 Tongue Neoplasms Fluorouracil 4.3416280240
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 2.4616712894 8653321 17572228
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.2316803524
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.7414692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.2112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.9115869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.8615886252
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA38357
    • No data
    Releated disease ID Related disease Name
    PA446714Neoplasm, Residual
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA450379mercaptopurine
    PA450428methotrexate
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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