AutismKB 2.0

Annotation Detail for FLG


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Basic Information Top
Gene Symbol:FLG ( ATOD2 )
Gene Full Name: filaggrin
Band: 1q21.3
Quick LinksEntrez ID:2312; OMIM: 135940; Uniprot ID:FILA_HUMAN; ENSEMBL ID: ENSG00000143631; HGNC ID: 3748
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
eczema
skin condition
dermatitis and eczema
asthma eczema
IMMUNE
No data
Desease Name
Ichthyosis vulgaris
Dermatitis, atopic, susceptibility to, 2
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C002202 4-oxoretinoic acid 4-oxoretinoic acid results in decreased expression of FLG mRNAdecreases expression 15982314
C103303 alitretinoin alitretinoin results in decreased expression of FLG mRNAdecreases expression 15982314
D000643 Ammonium Chloride Ammonium Chloride affects the expression of FLG mRNAaffects expression 16483693
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of FLG mRNAincreases expression 15171707
D010615 Phenacetin Phenacetin results in increased expression of FLG mRNAincreases expression 17082564
C030299 phenylhydrazine phenylhydrazine results in increased expression of FLG mRNAincreases expression 17082564
D015474 Isotretinoin Isotretinoin results in decreased expression of FLG mRNAdecreases expression 15982314
C009277 sodium arsenate sodium arsenate results in decreased expression of FLG mRNAdecreases expression 12727804
11485391
C017947 sodium arsenite sodium arsenite results in decreased expression of FLG mRNAdecreases expression 12727804
11485391
C017947 sodium arsenite sodium arsenite results in increased expression of FLG mRNAincreases expression 19524636
C017947 sodium arsenite sodium arsenite results in increased expression of FLG proteinincreases expression 19524636
D013749 Tetrachlorodibenzodioxin AHR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of FLG protein]affects reaction|increases expression 12151643
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of FLG proteinincreases expression 12151643
D014212 Tretinoin Tretinoin metabolite results in increased expression of FLG mRNAincreases expression 15982314
D014212 Tretinoin Tretinoin results in decreased expression of FLG mRNAdecreases expression 15982314
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Isotretinoin 9.3518769834
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.3511752688 15322242 14514962
MESH:D000015 Abnormalities, Multiple Isotretinoin 5.1218769834
MESH:D000138 Acidosis Ammonium Chloride 3.7518287403
MESH:D017486 Acneiform Eruptions Isotretinoin 6.5016232082
MESH:D000152 Acne Vulgaris Isotretinoin 5.7016185265 18769834
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5716835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.9215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.1217306315 16712894
MESH:D000505 Alopecia Tretinoin 3.7315955085
MESH:D000686 Amyloidosis Diethylstilbestrol 4.6415469931
MESH:D000740 Anemia Phenacetin 15.932444515
MESH:D000740 Anemia phenylhydrazine 15.932444515
MESH:D000740 Anemia Tetrachlorodibenzodioxin 15.9311748828
MESH:D000743 Anemia, Hemolytic Phenacetin 11.531949026 17698508 17082564
MESH:D000743 Anemia, Hemolytic phenylhydrazine 11.5317698508 17084956 17082564
MESH:D001169 Arthritis, Experimental Tretinoin 3.1616412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2916292516
MESH:D001249 Asthma Tretinoin 2.3816456186
MESH:D001471 Barrett Esophagus Tretinoin 4.5616935849
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.4112125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.4116206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001943 Breast Neoplasms alitretinoin 2.0116344269
MESH:D001943 Breast Neoplasms Diethylstilbestrol 2.0115324884 17129689
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0120435547
MESH:D001943 Breast Neoplasms Tretinoin 2.0116873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.7816813970
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.3816168501
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 4.7815948411 16924424
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 4.7817306315 15276417 16507464
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.781917145
MESH:D002294 Carcinoma, Squamous Cell Isotretinoin 7.9111237771
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 7.9118572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.9116051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4416120746 18670907 18850075
MESH:D002386 Cataract Tretinoin 3.1717460283
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 3.0819524636 20056578
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.7816129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002822 Choriocarcinoma Tretinoin 5.3816461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.9412621046 15340226 15668235 8697196 16354765
MESH:D002972 Cleft Palate Tretinoin 5.949407595
MESH:D003092 Colitis Tretinoin 3.8817035595
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1817141729 14669216
MESH:D019465 Craniofacial Abnormalities Isotretinoin 5.609879862 18769834
MESH:D019465 Craniofacial Abnormalities sodium arsenate 5.6010525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.6010048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 5.609664655 10589399 14991402 16925845 9125849 17551590 9211117 9142499 9224671 8800419
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.7216002989 12952375
MESH:D003876 Dermatitis, Atopic marker/mechanism 19349982
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D056486 Drug-Induced Liver Injury sodium arsenate 4.2018186108
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 4.2020420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D004485 Eczema marker/mechanism 17417636
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.6816714409 15322242 18230668
MESH:D004489 Edema, Cardiac Tretinoin 12.6818230668
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.8916402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 7.8916804899 15700306
MESH:D016889 Endometrial Neoplasms Tretinoin 7.8916569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1510568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.1811564622
MESH:D005124 Eye Abnormalities Tretinoin 9.189664655 16938888
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.7316002989 16611131 16534752 16513791 15751030
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.2120067830
MESH:D005355 Fibrosis Tretinoin 9.2117994277
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 13.4716452187
MESH:D005833 Genital Neoplasms, Female sodium arsenite 13.4716452187
MESH:D005909 Glioblastoma Tretinoin 3.0917312396
MESH:D018149 Glucose Intolerance sodium arsenate 5.2319446573
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2716096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.3816084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7610048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 6.769664655 14991402
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0715340226 16120746 12621046
MESH:D006689 Hodgkin Disease sodium arsenite 3.2712676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2618606429 8697196 16354765 15340226 16959395
MESH:D006930 Hyperalgesia Tretinoin 3.3216870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7416778211
MESH:D006965 Hyperplasia Diethylstilbestrol 4.6112960047 14722030
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9518850075 18670907
MESH:D007021 Hypospadias Diethylstilbestrol 4.7516002989
MESH:D016112 Ichthyosis Vulgaris marker/mechanism 17417636
MESH:D007246 Infertility Diethylstilbestrol 4.5215036965
MESH:D007248 Infertility, Male sodium arsenite 3.0812646999 15346721
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9212200463 12878042
MESH:D007410 Intestinal Diseases Tretinoin 3.9417994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.4016580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.4015992940 17551590
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.8316144296
MESH:D007674 Kidney Diseases sodium arsenite 2.8720008137
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 3.5815003126 14681315 16762066
MESH:D007859 Learning Disorders Diethylstilbestrol 4.2417184923
MESH:D007938 Leukemia Tretinoin 2.8317143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.8416482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1017596541 19850784 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2419075265 17217047 17339181 17368321 16788101 16766008 17361223 16140955 17107899 15748426 16891316 17506722 9834237 17712046 19642359 12679006 19035177 16331271 16823087 17301526 17649720 19225113 19029980 17294898 16935935
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.419224671
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3412878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.3418397230 16248980
MESH:D008113 Liver Neoplasms Diethylstilbestrol 7.7515890375 16712894
MESH:D008113 Liver Neoplasms sodium arsenite 7.7516712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.7516984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.1912151625
MESH:D008171 Lung Diseases sodium arsenite 3.2619095001
MESH:D008175 Lung Neoplasms alitretinoin 5.0616413115
MESH:D008175 Lung Neoplasms Isotretinoin 5.0615899809
MESH:D008175 Lung Neoplasms sodium arsenite 5.0616712894 17077188 19931552 17306315 15276417
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 5.0611884234 19555203
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.3415166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.5715700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.7316002989
MESH:D008527 Medulloblastoma Tretinoin 2.8317453147
MESH:D008545 Melanoma Isotretinoin 5.3817237267
MESH:D008545 Melanoma sodium arsenite 5.3816487513 19082730
MESH:D008545 Melanoma Tretinoin 5.3816752155
MESH:D008591 Meningomyelocele Tretinoin 4.6016940565
MESH:D008708 Methemoglobinemia Phenacetin 5.1016296465 4834387 3537620 1949026
MESH:D009139 Musculoskeletal Abnormalities sodium arsenate 5.0018186108
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1517596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D009369 Neoplasms alitretinoin 12.4816946489
MESH:D009369 Neoplasms Diethylstilbestrol 12.4815313581
MESH:D009369 Neoplasms sodium arsenite 12.4811559025
MESH:D009369 Neoplasms Tretinoin 12.4816594593 16946489
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.8420056578
MESH:D009421 Nervous System Malformations Diethylstilbestrol 17.3711399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 17.3714600291
MESH:D009421 Nervous System Malformations Tretinoin 17.379125849
MESH:D009436 Neural Tube Defects sodium arsenate 12.7911749123 19446573 10525206 18186108
MESH:D009436 Neural Tube Defects sodium arsenite 12.7912854658
MESH:D009436 Neural Tube Defects Tretinoin 12.799142499
MESH:D009447 Neuroblastoma Isotretinoin 4.1117368321
MESH:D010051 Ovarian Neoplasms sodium arsenite 5.0115276417 17306315
MESH:D010051 Ovarian Neoplasms Tretinoin 5.0116936753
MESH:D010146 Pain Tretinoin 3.0216870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5015976015
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.3914722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.8515687265 16977796
MESH:D017499 Porokeratosis alitretinoin 6.2216144296
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 17.5917184923
MESH:D011297 Prenatal Exposure Delayed Effects Isotretinoin 17.5918769834
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 17.5911118676 11896295 11222880 11399792
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 3.3715046698 15846301 17136230
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.3716039940
MESH:D011507 Proteinuria Tretinoin 3.7516636307
MESH:D011596 Psychomotor Disorders Isotretinoin 6.1118769834
MESH:D011625 Pterygium Tretinoin 4.9916723453
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.2516116481 16283617
MESH:D012878 Skin Neoplasms sodium arsenite 9.7919524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.7916192470
MESH:D012878 Skin Neoplasms Tretinoin 9.7916467112
MESH:D013088 Spermatocele Diethylstilbestrol 4.9316002989 16709447
MESH:D016135 Spinal Dysraphism sodium arsenite 3.9012854658
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013436 Sulfhemoglobinemia Phenacetin 6.77978859
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D013964 Thyroid Neoplasms Tretinoin 3.1316026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.9216051514
MESH:D014376 Tuberculosis Tretinoin 3.3116040207
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 8.8716712894 17306315 16452187
MESH:D001749 Urinary Bladder Neoplasms Phenacetin 8.8711144890
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 8.8716712894 17306315 11723127 16452187
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 16.6716175088
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 16.6711813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 16.6716129372
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.3914652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 4.2315809267 16690809
MESH:D014604 Uveal Neoplasms Tretinoin 4.8316752155
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.6116002989 16513791
MESH:D014652 Vascular Diseases sodium arsenite 4.6217056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D014820 Vitiligo Tretinoin 4.2216761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
MESH:D009396 Wilms Tumor Tretinoin 4.0916287080
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28169
    • No data
    Releated disease ID Related disease Name
    PA443879Dermatitis, Atopic
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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