AutismKB 2.0

Annotation Detail for CLASP2


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Basic Information Top
Gene Symbol:CLASP2 ( - )
Gene Full Name: cytoplasmic linker associated protein 2
Band: 3p22.3
Quick LinksEntrez ID:23122; OMIM: 605853; Uniprot ID:CLAP2_HUMAN; ENSEMBL ID: ENSG00000163539; HGNC ID: 17078
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Cell Cycle, Mitotic
DNA Replication
Axon guidance
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of CLASP2 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of CLASP2 mRNAaffects expression 21346803
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of CLASP2 mRNAdecreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CLASP2 mRNAdecreases expression 19150397
D004958 Estradiol Estradiol affects the expression of CLASP2 mRNAaffects expression 14699072
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of CLASP2 mRNAaffects cotreatment|increases expression 17183730
D007657 Ketone Bodies Ketone Bodies results in increased expression of CLASP2 mRNAincreases expression 16807920
D008628 Mercury Mercury results in increased expression of CLASP2 mRNAincreases expression 16823088
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of CLASP2 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.778875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1319490988
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.4320464547 20127859
MESH:D000230 Adenocarcinoma Estradiol 4.4311473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.766695378
MESH:D000550 Amblyopia Valproic Acid 5.5517688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.7417497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3319183758
MESH:D001321 Autistic Disorder Mercury 2.3617497416
MESH:D001321 Autistic Disorder Valproic Acid 2.3618985861 19232924 18316065 18396377 15238991 19460635 18558336 17688650 18775368 17507914 20603192 18940202 18177632 17157402 16609825
MESH:D001327 Autoimmune Diseases Mercury 5.1316634805
MESH:D001714 Bipolar Disorder Valproic Acid 3.1720046352 17594078
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.528888407
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0420146248 17474063
MESH:D001943 Breast Neoplasms Estradiol 2.0412948864 17261762 14630087 17018787 17289903 16675129 19861407 18497071
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.7516111702
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.7116705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.7116705839
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.7116924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1020419170
MESH:D002311 Cardiomyopathy, Dilated Mercury 3.5110334427
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.986135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.9820889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.9818566989
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7720734317
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.9017688650 16575769 8888407
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.7718551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.7718551238
MESH:D017449 Dermatitis, Allergic Contact Mercury 4.0516823706
MESH:D003928 Diabetic Nephropathies Estradiol 3.5919279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.5621346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.5618551238 21346803
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.561733752 19641884
MESH:D004421 Dystonia Valproic Acid 4.271851702
MESH:D016889 Endometrial Neoplasms Estradiol 3.1111473722 18566989 19148513
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.413659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.2316628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0318234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.777562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.567750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.353659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5020426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5016530937
MESH:D005234 Fatty Liver Valproic Acid 3.5019224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.2016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.378888407 18558336
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7520471113
MESH:D006558 Herpes Genitalis Estradiol 5.3515709030
MESH:D019584 Hot Flashes Estradiol 4.0717088409
MESH:D006849 Hydrocephalus Valproic Acid 5.1517688650
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.8816612254
MESH:D007333 Insulin Resistance Estradiol 3.0916393666 16627594
MESH:D007674 Kidney Diseases Estradiol 6.7515618244
MESH:D007674 Kidney Diseases Mercury 6.7517934191
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.4216705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.4216705839
MESH:D007680 Kidney Neoplasms Estradiol 13.4215610895
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1816294345 17596541
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 1.6814716833 14659978
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.717678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.7121137059 20195826
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.662876784 2876786 6135515
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.5817228818
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5620135361 20064080 17053015 18569708 18520028 20869020 6695378 20464547 18816296
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6816891317 17203775 11807958 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.8019453300
MESH:D008881 Migraine Disorders Valproic Acid 3.3318765137 18803445
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3516381670
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.238888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2617596541
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4416810080
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.3218551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.327678174 18551238
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2511141357
MESH:D009389 Neovascularization, Pathologic Estradiol 4.0217289903
MESH:D009421 Nervous System Malformations Estradiol 3.8911399458 16427766
MESH:D009436 Neural Tube Defects Valproic Acid 3.2516359493 8888407
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.5416049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.5416049721
MESH:D010051 Ovarian Neoplasms Estradiol 2.2719401270
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.1120603192
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0920887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.0617292933
MESH:D011471 Prostatic Neoplasms Estradiol 3.0616740699
MESH:D019310 Pseudolymphoma Valproic Acid 4.8612752131 11422049
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.4019155313
MESH:D012559 Schizophrenia Valproic Acid 2.0919110320 15737665
MESH:D012640 Seizures 2,4-dinitrotoluene 10.6218551238
MESH:D012640 Seizures 2,6-dinitrotoluene 10.6218551238
MESH:D012640 Seizures Valproic Acid 10.6211044598 17978042 1511512 11738929 3137016 15475178 16876388 14763951
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4510029692 19755658
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9419490988
MESH:D013226 Status Epilepticus Valproic Acid 4.8612833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D013978 Tibial Fractures Estradiol 5.0019048282
MESH:D014178 Translocation, Genetic Valproic Acid 5.5517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.813119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.6816049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.6816049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.6817053015
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.908888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.9610091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.9610091137
Pathway ID Pathway Name
REACT:18266 Axon guidance
REACT:152 Cell Cycle, Mitotic
REACT:383 DNA Replication
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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