AutismKB 2.0

Annotation Detail for PLXND1


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Basic Information Top
Gene Symbol:PLXND1 ( KIAA0620,MGC75353,PLEXD1 )
Gene Full Name: plexin D1
Band: 3q22.1
Quick LinksEntrez ID:23129; OMIM: 604282; Uniprot ID:PLXD1_HUMAN; ENSEMBL ID: ENSG00000004399; HGNC ID: 9107
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
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Pathway IDPathway Name
Axon guidance
No data
No data
Pathway IDPathway Name
500078Other semaphorin interactions
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of PLXND1 mRNAdecreases expression 19933214
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of PLXND1 mRNAaffects expression 17484886
D003907 Dexamethasone Dexamethasone results in increased expression of PLXND1 mRNAincreases expression 12782123
D020849 Raloxifene Raloxifene results in increased expression of PLXND1 mRNAincreases expression 19429434
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000419 Albuminuria Raloxifene 5.1017308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.6015800139
MESH:D001169 Arthritis, Experimental Dexamethasone 3.7617659584
MESH:D001930 Brain Injuries Raloxifene 5.0416580743
MESH:D001943 Breast Neoplasms Raloxifene 2.6317952589 17893378 17440819 15572757 17261762 17049068 16837676 15758505 17595753 17242785 16912660 15775269
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.3416011737 15721981 16050911 15673190 10355542 15700767 16192424 16227642 3786805 18705752 16124888 16097048
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 1.8618788625
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 4.4717572228
MESH:D002318 Cardiovascular Diseases Raloxifene 3.7115775269
MESH:D003072 Cognition Disorders Raloxifene 5.1815800139
MESH:D003110 Colonic Neoplasms Dexamethasone 2.5415824018
MESH:D019465 Craniofacial Abnormalities Dexamethasone 2.2917728286
MESH:D003865 Depressive Disorder, Major Raloxifene 4.5317474826
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.9612438553
MESH:D003928 Diabetic Nephropathies Raloxifene 4.3017308373 17451421 15920148
MESH:D003967 Diarrhea Dexamethasone 4.207237001
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 2.1210915739 11566570 9327722 3786805 15968718 16177239 4309450 3732212 21278145 19085960 17522070 15998439 15027814 7440962 7179309 6623471 6884620 7120509 10092053 19336974 16227642 2869522
MESH:D004485 Eczema Dexamethasone 4.9712438553
MESH:D004487 Edema Dexamethasone 8.6719703484
MESH:D004487 Edema Raloxifene 8.6715860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 4.5015845917
MESH:D005234 Fatty Liver Carbon Tetrachloride 9.4419224547 17595544 12795759 16045604 12631006 16239168 15959796 61145
MESH:D005234 Fatty Liver Raloxifene 9.4417473493
MESH:D005355 Fibrosis Carbon Tetrachloride 4.0118705752
MESH:D006331 Heart Diseases Raloxifene 3.8011110106
MESH:D006505 Hepatitis Carbon Tetrachloride 4.1019110552 19900420
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 3.187520565
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 5.1616899240
MESH:D006973 Hypertension Dexamethasone 6.0117042910
MESH:D006973 Hypertension Raloxifene 6.0117577099 15787275
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.6515338365
MESH:D007249 Inflammation Dexamethasone 3.0511099482 8960868
MESH:D007889 Leiomyoma Raloxifene 4.9616973256
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 3.0011408273 16239168 16943688 21278145 17334410 17174718 11903743 16221502 17157831
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.7518166357 15370692 14716833 12445418 16192424 18279442 12649538 18205269 12632512 12898905 17631135 18429990 18277467 15673190 17922224 16015684 16097048 18251166 17565644 14620537 18418968 17714472 16116963 12546737 18705752 10355542 15057751 18412020 15931870 14716496 12667390 16248980 16011737 12741479 17944888 15818738 18317297 18376398 17976157 17708605 15052691 16027843 17525996 14512876 16136751 18472332 18187930 15338365 18263696 18210741 18472094 17557913 17900296 17721639 16638106 18054572 18481824 15730626 15362042 12666154 17766677 12586293 18339082 15996030 18420326 15925388 17640975 17869086 18395095 17481882 12445421 12389079 15123356 12632514 18156304 17823541 16033810 17761835 20821823 17698563 11481614 17805973 14748882 18006644 15959796 18395914 13678700 12958196 12609069 15876570 14724832 15893842 15650968
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 2.7516718785
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1516246199 16964402 15830285 15720792 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 4.7315123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 4.0814706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 2.3419294768
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.8412014681 15583823
MESH:D008175 Lung Neoplasms Dexamethasone 2.2715824018 11195469
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 6.2815863610
MESH:D009101 Multiple Myeloma Dexamethasone 8.4915867202 15744524 16118317
MESH:D009101 Multiple Myeloma Raloxifene 8.4916497877
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.749809623
MESH:D009232 Myxoma Raloxifene 6.2816343187
MESH:D010024 Osteoporosis Raloxifene 3.6119059307 15775268 17882678
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.6917823083 17893378 15579764 15758505
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.7421297632
MESH:D011471 Prostatic Neoplasms Raloxifene 3.5416220300 16536755 15731164
MESH:D011693 Purpura Raloxifene 6.2815770314
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 4.4811700416 18379247
MESH:D013272 Stomach Diseases Dexamethasone 4.9515472012
MESH:D013276 Stomach Ulcer Dexamethasone 3.9115138204
MESH:D020521 Stroke Raloxifene 4.1516837676
MESH:D013978 Tibial Fractures Raloxifene 5.9319048282
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 2.9317572228
MESH:D014605 Uveitis Dexamethasone 5.541336536
MESH:D054556 Venous Thromboembolism Raloxifene 5.9316837676
MESH:D014846 Vulvar Neoplasms Raloxifene 6.2816343187
Pathway ID Pathway Name
REACT:18266 Axon guidance
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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