AutismKB 2.0

Annotation Detail for FLII


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Basic Information Top
Gene Symbol:FLII ( FLI,FLIL,Fli1,MGC39265 )
Gene Full Name: flightless I homolog (Drosophila)
Band: 17p11.2
Quick LinksEntrez ID:2314; OMIM: 600362; Uniprot ID:FLII_HUMAN; ENSEMBL ID: ENSG00000177731; HGNC ID: 3750
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of FLII mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of FLII mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of FLII mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of FLII mRNAaffects expression 17562736
C032036 bromobenzene bromobenzene results in increased expression of FLII mRNAincreases expression 12628495
C110904 capecitabine FLII protein results in decreased susceptibility to capecitabinedecreases response to substance 16734730
D016572 Cyclosporine Cyclosporine results in increased expression of FLII mRNAincreases expression 20106945
C025034 doxifluridine FLII protein results in decreased susceptibility to doxifluridinedecreases response to substance 16734730
C006253 pirinixic acid pirinixic acid results in decreased expression of FLII mRNAdecreases expression 18445702
D012643 Selenium Selenium results in increased expression of FLII mRNAincreases expression 19244175
D014810 Vitamin E Vitamin E results in increased expression of FLII mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.2718653653
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.833712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.6716434500
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.241440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2919483382
MESH:D001943 Breast Neoplasms capecitabine 3.7712972520 18473752
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1116050911
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.7116705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.7116705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.713581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.713084413
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.737296757
MESH:D002386 Cataract Acetaminophen 2.6610977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.706135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 11.707505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.7012371664
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 13.999022650 19486331
MESH:D002779 Cholestasis Cyclosporine 13.9919486331
MESH:D002779 Cholestasis pirinixic acid 13.9919176532
MESH:D003092 Colitis Selenium 3.9517936198
MESH:D015179 Colorectal Neoplasms capecitabine 3.3218473752 18448328
MESH:D003329 Coronary Vasospasm capecitabine 5.9717465463
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.4918551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.4918551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.978970840 18759878 11906362 12868966 11298694 8156756 14531868 2524372
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.642952479 3621924
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 15.7818551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 15.7818551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 15.7818692083 6679447 18289764 16192314 1440618 8291058 6482804 11289319 18648102 9022650 9653073 7440962 9328219
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 15.7819923254 19085960 2444490 15968718 14550746 16781746 12594235 12705907 10774834 19739265 12153990 11834606 12540782 11287661 11739529 16081117 16393943 18713872 11743745 16109766 19370779 19416960 11529661 17906064 17562736 11421492 16485898 17522070 19164858 18071297 10663392 14725611 12958197 16227642 15619225 14986274 19420014 16177239 12392966 10915739 11461765
MESH:D056486 Drug-Induced Liver Injury bromobenzene 15.7810092053 12628495
MESH:D056486 Drug-Induced Liver Injury Selenium 15.7815131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:C538011 Eales disease Vitamin E 4.929068938
MESH:D004487 Edema pirinixic acid 2.6212083418
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.143581430
MESH:D005234 Fatty Liver Cyclosporine 8.0319224547
MESH:D005234 Fatty Liver pirinixic acid 8.0319236843 20131406
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.246705139
MESH:D005355 Fibrosis Cyclosporine 3.3212168785 12639820
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.418708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.197505956
MESH:D006330 Heart Defects, Congenital Vitamin E 3.0516080930
MESH:D006333 Heart Failure pirinixic acid 7.2220558911
MESH:D006333 Heart Failure Selenium 7.2217162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6215720958
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.676705139
MESH:D006529 Hepatomegaly pirinixic acid 3.1716221962 19176532 18467677 19772884
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7416863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.1914716179
MESH:D006930 Hyperalgesia Acetaminophen 2.8116870215
MESH:D006943 Hyperglycemia pirinixic acid 3.3120558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.1115034207
MESH:D006973 Hypertension Cyclosporine 2.1410903974
MESH:D007251 Influenza, Human Selenium 11.7016624496
MESH:D007251 Influenza, Human Vitamin E 11.7016624496
MESH:D007333 Insulin Resistance pirinixic acid 2.7216306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.249022650 8074119
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6615604871
MESH:D007674 Kidney Diseases Acetaminophen 10.4512587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 10.458314463 10903974 18776723
MESH:D007674 Kidney Diseases Vitamin E 10.4512488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.0216518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 18.7516705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 18.7516705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 18.756582329
MESH:D007680 Kidney Neoplasms Cyclosporine 18.7512371664
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.289327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4115474484
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.4116169303
MESH:D008107 Liver Diseases Acetaminophen 1.6619014921 12587719 12969438 11587558 19460945 16611625 19784758 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3716871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.567678174
MESH:D008113 Liver Neoplasms pirinixic acid 4.5616377806 20007298 15890375
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.176135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.176587162 598648 1399818 3712494
MESH:D008171 Lung Diseases Vitamin E 3.2716863852
MESH:D008175 Lung Neoplasms Vitamin E 1.9011062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8515318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D008654 Mesothelioma Selenium 2.8415107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0116801185
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1919151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0516411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.0018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.0018551238 7678174
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 6.443581430
MESH:D009362 Neoplasm Metastasis capecitabine 6.4412972520
MESH:D009369 Neoplasms capecitabine 5.6816374040
MESH:D009369 Neoplasms pirinixic acid 5.6817405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4119348381 18481113
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.006679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9918514411
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 15.8516049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 15.8516049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 15.856482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.243988306
MESH:D010146 Pain Acetaminophen 2.5016870215
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.667296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.696228378
MESH:D010954 Plasmacytoma Selenium 5.1115087411
MESH:D011230 Precancerous Conditions Cyclosporine 3.3512371664
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2815084515
MESH:D011565 Psoriasis Cyclosporine 2.2716882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.483692021
MESH:D012640 Seizures 2,4-dinitrotoluene 6.1818551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.1818551238
MESH:D012871 Skin Diseases Vitamin E 2.4718709164
MESH:D020521 Stroke Vitamin E 3.6316517955
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.996582329 3712494 7505956 1399818 6587162
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.5716049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.5716049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.578074119
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.6510091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.6510091137
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D014605 Uveitis Cyclosporine 4.201336536
MESH:D014985 Xerophthalmia Cyclosporine 4.6617120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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