AutismKB 2.0

Annotation Detail for ZC3H3


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Basic Information Top
Gene Symbol:ZC3H3 ( KIAA0150,ZC3HDC3 )
Gene Full Name: zinc finger CCCH-type containing 3
Band: 8q24.3
Quick LinksEntrez ID:23144; OMIM: NA; Uniprot ID:ZC3H3_HUMAN; ENSEMBL ID: ENSG00000014164; HGNC ID: 28972
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of ZC3H3 mRNAincreases expression 19933214
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of ZC3H3 proteinaffects expression 20106945
D016572 Cyclosporine Cyclosporine results in decreased expression of ZC3H3 mRNAdecreases expression 20106945
C014347 decitabine decitabine results in decreased expression of ZC3H3 mRNAdecreases expression 19363521
C014347 decitabine TP53 protein affects the reaction [decitabine results in decreased expression of ZC3H3 mRNA]affects reaction|decreases expression 19363521
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of ZC3H3 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ZC3H3 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ZC3H3 mRNAaffects cotreatment|increases expression 17942748
D005472 Fluorouracil Fluorouracil affects the expression of ZC3H3 mRNAaffects expression 16584549
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of ZC3H3 mRNAaffects cotreatment|increases expression 17183730
D013629 Tamoxifen Tamoxifen affects the expression of ZC3H3 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ZC3H3 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ZC3H3 mRNAincreases expression 17942748
19933214
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of ZC3H3 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.8114745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.1115322242 11752688 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 9.118875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1019490988
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2117505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.4614692618
MESH:D000230 Adenocarcinoma Fluorouracil 4.4617638652
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6116835633
MESH:D000550 Amblyopia Valproic Acid 5.5017688650
MESH:D000740 Anemia Fluorouracil 9.2316511603 15504547 17963324
MESH:D000740 Anemia Tetrachlorodibenzodioxin 9.2311748828
MESH:D001008 Anxiety Disorders Valproic Acid 3.7117497229
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7615885639
MESH:D001321 Autistic Disorder Valproic Acid 1.9920603192 17507914 18940202 17157402 18396377 18558336 15238991 16609825 17688650 18985861 18316065 19232924 18775368 19460635 18177632
MESH:D001714 Bipolar Disorder Valproic Acid 3.1520046352 17594078
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.3715746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.378888407
MESH:D001943 Breast Neoplasms decitabine 1.9819208741 18320071
MESH:D001943 Breast Neoplasms Fluorouracil 1.9816595493 16110121 19217205 15136595 18608205 18357371 16557594
MESH:D001943 Breast Neoplasms Tamoxifen 1.9811161223 18425577 19155303 19115204 18629630 20544844 19244106 19410462 19142967 21138602 18855134 17893378 19103187 17261762 16202921 19288272 18351453 16873071 19189212 18815881 15565566 20390343 19189210 19084267 20859285 19221464 16818667 19487384 17049068 19289846 20005174 18821012 18997820 19066611 18984771 17242785 17440819 19200415 19011961 20065188 21152245 20135344 19059307 16273361 15668708
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9820435547
MESH:D002276 Carcinoid Tumor Fluorouracil 4.9316051944
MESH:D002277 Carcinoma Fluorouracil 8.6517121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.6516835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.7219066611
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.7721507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 4.7717045692 17971768 16799960 17088986 18930000 16332177
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.7716924424
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0918695887
MESH:D002294 Carcinoma, Squamous Cell decitabine 4.9919215824
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.9916757204 17066447 16280240 18986760
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.7817572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4516120746 18850075 18670907
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6412371664
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7620734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis Cyclosporine 8.2019486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.2017333356 17110522 15861022 17681005 16919318 16105132 11677210
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1615340226 8697196 16354765 15668235 12621046
MESH:D003110 Colonic Neoplasms decitabine 3.9617616700
MESH:D003110 Colonic Neoplasms Fluorouracil 3.9617169374 15001691 18772588 17725105 16340194 16510598 17018589 17172411 17016597 17287894
MESH:D015179 Colorectal Neoplasms decitabine 2.6718981723
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.6717594712 18383874 18949393 18509181 14970324 16524972 17016601 18448328 17255274 17454858 18288408 17695437 16331619 16391804 15289873 16282729 20501625 18802399 17401013 15148649 17094418 16303861
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5220055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.5216575769 8888407 17688650
MESH:D007644 Darier Disease Fluorouracil 5.0316733453
MESH:D003711 Demyelinating Diseases Tamoxifen 4.5819031437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.6319279558
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.9220420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 3.921733752 19641884
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D004421 Dystonia Valproic Acid 4.231851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1718230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.6212538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.6219031437
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.3819294695
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1517893378 16202921 19155303 20544844
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.189294722 10568697
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.373659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.1816628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0118234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.746426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.517750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.303659116
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.4815173087 16481741 16337965 17638652 16785472
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver Cyclosporine 20.2519224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 20.2515345470
MESH:D005234 Fatty Liver Tamoxifen 20.2514986274 19224547
MESH:D005234 Fatty Liver Valproic Acid 20.2514986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3316709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005315 Fetal Diseases Valproic Acid 5.1516575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.338888407 18558336
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.7614745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.4219069698
MESH:D005355 Fibrosis Cyclosporine 9.2112639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.2120067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D005910 Glioma Fluorouracil 2.9316145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006258 Head and Neck Neoplasms decitabine 8.2819215824
MESH:D006258 Head and Neck Neoplasms Fluorouracil 8.2815102660 15162350 18337622
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4111294989 10048152
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1115340226 16120746 12621046
MESH:D006849 Hydrocephalus Valproic Acid 5.1017688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3116959395 15340226 16354765 18606429 8697196
MESH:D006973 Hypertension Cyclosporine 5.1410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1418850075 18670907
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.8416612254
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6512013081
MESH:D007248 Infertility, Male decitabine 7.0917581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.0917937319
MESH:D007249 Inflammation Tamoxifen 5.1619457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.1612878042 12200463
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007674 Kidney Diseases Cyclosporine 2.438314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 13.2812371664
MESH:D007680 Kidney Neoplasms Fluorouracil 13.2816985049
MESH:D007680 Kidney Neoplasms Tamoxifen 13.2818625569
MESH:D007938 Leukemia decitabine 3.1519235587 18980019
MESH:D007951 Leukemia, Myeloid decitabine 4.1717236224 19117987 18454857
MESH:D015470 Leukemia, Myeloid, Acute decitabine 4.0918704418 18206229 17679729 19010910 18460780 19387464
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 4.0917596541 16294345
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.7318055864
MESH:D008064 Lipidoses Tamoxifen 3.2717567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.3318564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3312878042
MESH:D008113 Liver Neoplasms Aflatoxin B1 11.192125692 15890375 9163691 18177683
MESH:D008113 Liver Neoplasms Fluorouracil 11.1915113037 17045692 18383874 16603448
MESH:D008113 Liver Neoplasms Tamoxifen 11.1916684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.1916984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.158603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.1512151625
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.5317228818
MESH:D008175 Lung Neoplasms Aflatoxin B1 4.9914755239
MESH:D008175 Lung Neoplasms Fluorouracil 4.9915246190
MESH:D008175 Lung Neoplasms Tamoxifen 4.9918625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9911884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.0315086387
MESH:D008223 Lymphoma decitabine 3.5419470736
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.0019428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7319196723 11731420 19196722 16827153 14580682
MESH:D020149 Manganese Poisoning Tamoxifen 4.8119453300
MESH:D008545 Melanoma decitabine 3.4817785578 16505122
MESH:D008545 Melanoma Tamoxifen 3.4819393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.4215990972
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D008881 Migraine Disorders Valproic Acid 3.3118803445 18765137
MESH:D009062 Mouth Neoplasms Fluorouracil 3.7618986760 16757204
MESH:D009101 Multiple Myeloma decitabine 3.4618172295
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.208888407
MESH:D009190 Myelodysplastic Syndromes decitabine 7.8118608210 19157545 19010910 16882708
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.8117596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6019393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5619410462
MESH:D009369 Neoplasms decitabine 5.5219470736 19116145 17925555
MESH:D009369 Neoplasms Fluorouracil 5.5218239605 16928823 18600527
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.2619196722 19189210 19200415
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4419348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4114600291
MESH:D009436 Neural Tube Defects Valproic Acid 3.2316359493 8888407
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5516436463
MESH:D010051 Ovarian Neoplasms decitabine 2.6919259094 19331143
MESH:D010190 Pancreatic Neoplasms decitabine 5.6319294695
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.6316500647 16929163 15113037 19003803
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3712371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.2711896295 11399792 11222880 11118676
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 10.2720603192
MESH:D055728 Primary Myelofibrosis decitabine 4.9417616702
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.2518626508 19082440
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.2515067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.5516919318 15861022
MESH:D019310 Pseudolymphoma Valproic Acid 4.8111422049 12752131
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1616160472 18722050 15538739 18286688
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012208 Rhabdomyosarcoma decitabine 11.6019155313
MESH:D012208 Rhabdomyosarcoma Valproic Acid 11.6019155313
MESH:D012559 Schizophrenia Valproic Acid 2.0915737665 19110320
MESH:D012640 Seizures Valproic Acid 2.8516876388 1511512 14763951 3137016 11044598 17978042 15475178 11738929
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1116192470
MESH:D013088 Spermatocele Ethinyl Estradiol 12.4616709447
MESH:D013088 Spermatocele Tamoxifen 12.4616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.2819457130
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9119490988
MESH:D013226 Status Epilepticus Valproic Acid 4.8112833885
MESH:D013274 Stomach Neoplasms decitabine 2.6519037991
MESH:D013274 Stomach Neoplasms Fluorouracil 2.6517522103 15786421 18396642 19084572 16424979 17172411 17498489 16951190 18567086 19015929
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D013964 Thyroid Neoplasms decitabine 3.4617967635
MESH:D014062 Tongue Neoplasms Fluorouracil 4.1516280240
MESH:D014178 Translocation, Genetic Valproic Acid 5.5017262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.763119515
MESH:D001749 Urinary Bladder Neoplasms decitabine 5.3917616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.3916712894 8653321 17572228
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.868888407
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.0416803524
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5014692618
MESH:D014604 Uveal Neoplasms decitabine 5.1817785578
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7114671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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