AutismKB 2.0

Annotation Detail for MAPK8IP3


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Basic Information Top
Gene Symbol:MAPK8IP3 ( DKFZp762N1113,FLJ00027,JIP3,JSAP1,KIAA1066,SYD2,syd )
Gene Full Name: mitogen-activated protein kinase 8 interacting protein 3
Band: 16p13.3
Quick LinksEntrez ID:23162; OMIM: 605431; Uniprot ID:JIP3_HUMAN; ENSEMBL ID: ENSG00000138834; HGNC ID: 6884
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04010MAPK signaling pathway
No data
Pathway IDPathway Name
200046Arf6 trafficking events
200192Signaling events mediated by focal adhesion kinase
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of MAPK8IP3 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of MAPK8IP3 mRNAaffects expression 17562736
C044101 endotoxin, Escherichia coli endotoxin, Escherichia coli results in increased expression of MAPK8IP3 mRNAincreases expression 15919760
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of MAPK8IP3 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MAPK8IP3 mRNAaffects cotreatment|increases expression 17942748
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of MAPK8IP3 mRNAincreases expression 15919760
C009131 pyrimidin-2-one beta-ribofuranoside pyrimidin-2-one beta-ribofuranoside results in increased expression of MAPK8IP3 mRNAincreases expression 19194470
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MAPK8IP3 mRNAaffects cotreatment|increases expression 17942748
C025643 vinclozolin vinclozolin affects the expression of MAPK8IP3 mRNAaffects expression 19015723
C025643 vinclozolin vinclozolin results in decreased expression of MAPK8IP3 mRNAdecreases expression 18042343
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1815322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3217505938
MESH:D055371 Acute Lung Injury Lipopolysaccharides 4.2911850527 18653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8614692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001008 Anxiety Disorders vinclozolin 3.8319015723
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8015885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6820435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 2.9116705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.913084413
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4916120746 18670907 18850075
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0516919318 17110522 15861022 17681005 17333356 16105132 11677210
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1915340226 15668235 8697196 16354765 12621046
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2714669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 10048152 20055451
MESH:D003456 Cryptorchidism vinclozolin 4.6214966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.3218551238
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.4721346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.4712392966 10774834 10663392 15968718 16393943 14986274 12594235 16177239 19923254 16081117 19164858 16227642 10915739 16781746 12540782 14725611 15619225 18071297 11287661 11461765 18713872 11834606 17562736 19085960 16485898 19416960 11529661 11421492 2444490 17522070 14550746 19739265 19420014 12958197 19370779 16109766 11743745 12705907 11739529 17906064 12153990
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.4720420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2818230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.4712538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.259294722 10568697
MESH:D019446 Endotoxemia endotoxin, Escherichia coli 12.2018509659 17637181
MESH:D019446 Endotoxemia Lipopolysaccharides 12.2015821434 15328337 17637181
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 3.0515345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D005334 Fever endotoxin, Escherichia coli 10.5216997862
MESH:D005334 Fever Lipopolysaccharides 10.5211852909 9205823
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2520067830
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.2716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.6816417039
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4410048152 11294989
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.6116366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2015340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.428697196 18606429 16959395 16354765 15340226
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9818670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.1717937319
MESH:D007248 Infertility, Male vinclozolin 7.1716467254
MESH:D007249 Inflammation Lipopolysaccharides 5.459205823 17237260 17255318 12878042 17963957
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.4512200463 12878042
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.8917255318
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D007674 Kidney Diseases Acetaminophen 2.3212587719 15629191
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.1716705839
MESH:D007970 Leukopenia Lipopolysaccharides 5.0315821434
MESH:D007984 Leydig Cell Tumor vinclozolin 5.0716417039
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 2.5312878042
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.5312878042
MESH:D008107 Liver Diseases Acetaminophen 1.6712969438 19784758 19014921 16611625 19460945 16610002 12587719 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4617185352 16871587
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.7916984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2412151625
MESH:D055370 Lung Injury Lipopolysaccharides 4.3121114838
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2419555203 11884234
MESH:D008545 Melanoma pyrimidin-2-one beta-ribofuranoside 3.7716505122
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.2018551238
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4914600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.6612819281 16049721
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9511578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D011014 Pneumonia Lipopolysaccharides 4.8911605937 12224865
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.6411896295 11222880 11118676 11399792
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 10.6418220299 18042343 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.2718220299
MESH:D011472 Prostatitis vinclozolin 5.2718629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.6516919318 15861022
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.8810835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6818551238
MESH:D012772 Shock, Septic endotoxin, Escherichia coli 5.9718063050
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1416192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3216709447
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.3915821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3715669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.3616049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.6510091137
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5814692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7814671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
Pathway ID Pathway Name
KEGG:04010 MAPK signaling pathway
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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