AutismKB 2.0

Annotation Detail for RTF1


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Basic Information Top
Gene Symbol:RTF1 ( GTL7,KIAA0252 )
Gene Full Name: Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
Band: 15q15.1
Quick LinksEntrez ID:23168; OMIM: 611633; Uniprot ID:RTF1_HUMAN; ENSEMBL ID: ENSG00000137815; HGNC ID: 28996
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of RTF1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of RTF1 mRNAaffects expression 17562736
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RTF1 mRNAdecreases expression 19150397
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of RTF1 mRNAaffects cotreatment|affects expression 17602206
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of RTF1 mRNAaffects cotreatment|affects expression 17602206
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RTF1 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RTF1 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.2415322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3817505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8614692618
MESH:D000236 Adenoma Diethylnitrosamine 2.9910737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 11.4117620307 19052882 17162532 16434500 18056438 19061943
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.4116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2111748828
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8215885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9417474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9420435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.7216705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.723084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.7220084675 20514400 10737359 16878318 18665156 18788625 20512989 20007298 16830150 3084413 20935162 18506893 19394651 16288022 19418558 17978847 16502159 17761372 16569478 17173139 16698587 3581430 16935385 19335982 19208518 19701751 18785209 18393292 11831363 19919837 16779866 19539802 18971187 10672840 17055752 19052882 19519916 18210153 20214788 19171122 16328049 17138121 18494052 20432363 20727157 16681979 18691550 18056438 16807293 20524982 20101231 21159647 17162532 18978308 19822196 19383236 19107877 17428255 16540662
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5018670907 18850075 16120746
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 12.276135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 12.2720889678
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 12.272727394 7505956 21159647 17174075
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 10.1719052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 10.1716835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0717681005 17110522 11677210 15861022 16105132 17333356 16919318
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2012621046 8697196 15668235 15340226 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.3818551238
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.4120387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.4117107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.5321346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.5316485898 10663392 2444490 11529661 16177239 11461765 16081117 18071297 19370779 11834606 19085960 19416960 11743745 11287661 12392966 16227642 16393943 12540782 12594235 19739265 19923254 10915739 12958197 17906064 19420014 14986274 18713872 12705907 15619225 12153990 10774834 17522070 19164858 11421492 11739529 15968718 16109766 14725611 17562736 16781746 14550746
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 9.5319107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.5320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9611462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.3518230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.5212538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2910568697 9294722
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.5616302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1320426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2111564622
MESH:D005234 Fatty Liver Diethylnitrosamine 8.6520387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.6515345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3120067830
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4611294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2515340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4916354765 15340226 16959395 18606429 8697196
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9918670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1716945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6617937319
MESH:D007249 Inflammation Diethylnitrosamine 5.3318785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.3312878042 12200463
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6216580747
MESH:D007674 Kidney Diseases Acetaminophen 2.3412587719 15629191
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.2116705839
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9618665156 18407596 20032147 19638242 18522880
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008107 Liver Diseases Acetaminophen 4.1019784758 12587719 12969438 16610002 19460945 11587558 19014921 16611625
MESH:D008107 Liver Diseases Diethylnitrosamine 4.1017034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5016871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 11.467678174
MESH:D008113 Liver Neoplasms Clofibric Acid 11.4617602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 11.4620118626 18644402 18978307 21278145 19850985 20452335 19254457 19499222 20434301 12771043 19996281 18754104 18977376 19427195 19294768 20137499 15175105 19812893 19551842 19833225 18648771 12112319 19256749 19638242 2422723 19690152 19255062 19426721 21167192 21047994 2862719 16942905 19073162 19090486 19642983 20583210 20405173 15885732 10737359 20492335 20501860 21071580 20101389 9163691
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.4616984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.742876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.7418544905 9362446 18775883 17854601 18079962 2563599 19539802 19519916 16267830 16842330 19126423 17942915 3124819 18253720 18093689 18164116 19009564 19004024 18282651 18308698 17174075 21159647
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.7412151625
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.326695378 21163286 20512841 20970405
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3211884234 19555203
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2412213967
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.2618551238 7678174
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.669029167 3581430
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5414600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.9718514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.9720387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.5620387270
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.7016049721
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.5016540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9911578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.802563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5911118676 11399792 11896295 11222880
MESH:D011537 Pruritus Ethinyl Estradiol 3.7116919318 15861022
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012640 Seizures 2,6-dinitrotoluene 2.7118551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1516192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3816709447
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.197505956
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.3816049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.7110091137
MESH:D014581 Urticaria Acetaminophen 3.2810982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6314692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8214671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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