AutismKB 2.0

Annotation Detail for FLNB


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:FLNB ( ABP-278,ABP-280,AOI,DKFZp686A1668,DKFZp686O033,FH1,FLN1L,LRS1,SCT,TABP,TAP )
Gene Full Name: filamin B, beta
Band: 3p14.3
Quick LinksEntrez ID:2317; OMIM: 603381; Uniprot ID:FLNB_HUMAN; ENSEMBL ID: ENSG00000136068; HGNC ID: 3755
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04010MAPK signaling pathway
hsa04510Focal adhesion
No data
No data
Pathway IDPathway Name
P00034Integrin signalling pathway
No data
Related Diseases/Disorders Top
No data
No data
No data
No data
Desease Name
Atelostogenesis, type I
Boomerang dysplasia
Spondylocarpotarsal synostosis syndrome
Atelosteogenesis, type III
Larsen syndrome
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of FLNB mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of FLNB mRNAaffects expression 17562736
C015001 arsenite arsenite results in increased expression of FLNB mRNAincreases expression 18191166
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of FLNB mRNAincreases expression 15336504
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of FLNB mRNAincreases expression 17484886
D016572 Cyclosporine Cyclosporine results in increased expression of FLNB mRNAincreases expression 20106945
C017180 decamethrin decamethrin results in increased expression of FLNB mRNAincreases expression 19017407
D004041 Dietary Fats Dietary Fats results in increased expression of FLNB mRNAincreases expression 18042831
D004958 Estradiol Estradiol results in decreased expression of FLNB mRNAdecreases expression 20068009
C041786 palm oil palm oil results in increased expression of FLNB mRNAincreases expression 18042831
D020849 Raloxifene ESR2 protein affects the reaction [Raloxifene results in decreased expression of FLNB mRNA]affects reaction|decreases expression 14699072
D020849 Raloxifene Raloxifene affects the expression of FLNB mRNAaffects expression 14699072
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in decreased expression of FLNB mRNAaffects cotreatment|decreases expression 19059307
C116926 rofecoxib rofecoxib results in increased expression of FLNB mRNAincreases expression 17070997
D013629 Tamoxifen Tamoxifen affects the expression of FLNB mRNAaffects expression 14699072
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in decreased expression of FLNB mRNAaffects cotreatment|decreases expression 19059307
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of FLNB mRNAincreases expression 12377990
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of FLNB mRNAdecreases expression 20159946
D014212 Tretinoin Tretinoin results in increased expression of FLNB mRNAincreases expression 16012519
17431108
C025643 vinclozolin vinclozolin affects the expression of FLNB mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.5814745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8715322242 14514962 11752688
MESH:D000230 Adenocarcinoma Estradiol 2.1011473722
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4016835633
MESH:D000419 Albuminuria Raloxifene 4.6017308373 17451421
MESH:D000505 Alopecia Tretinoin 3.6215955085
MESH:D000544 Alzheimer Disease Raloxifene 2.5415800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9511748828
MESH:D000799 Angioedema Acetaminophen 3.8710982225
MESH:D001008 Anxiety Disorders vinclozolin 3.6419015723
MESH:D001161 Arteriosclerosis Dietary Fats 3.9015238619
MESH:D001169 Arthritis, Experimental rofecoxib 7.8316690336
MESH:D001169 Arthritis, Experimental Tretinoin 7.8316412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2616292516
MESH:D001249 Asthma Tretinoin 2.3416456186
MESH:C535396 Atelosteogenesis, type 1 marker/mechanism
OMIM:108721 ATELOSTEOGENESIS, TYPE III marker/mechanism
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001471 Barrett Esophagus Tretinoin 4.4116935849
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.9512125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.9516206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7615746008
MESH:C536573 Boomerang dysplasia marker/mechanism
MESH:D001930 Brain Injuries Raloxifene 4.4916580743
MESH:D001943 Breast Neoplasms Dietary Fats 2.9620435547
MESH:D001943 Breast Neoplasms Estradiol 2.9618497071 17289903 19861407 12948864 17261762 16675129 14630087 17018787
MESH:D001943 Breast Neoplasms Raloxifene 2.9616912660 17440819 17595753 15775269 17242785 17952589 16837676 17261762 17049068 15572757 15758505 17893378
MESH:D001943 Breast Neoplasms Tamoxifen 2.9611161223 21152245 18351453 17049068 19189210 19410462 17893378 21138602 18815881 17440819 18855134 19487384 20135344 20859285 19221464 18821012 19155303 18984771 19115204 20065188 20544844 19289846 19011961 16818667 19084267 19103187 19189212 17261762 16273361 19288272 19142967 18997820 16202921 16873071 19059307 15668708 18629630 19066611 17242785 18425577 20005174 15565566 19200415 20390343 19244106
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.9620435547
MESH:D001943 Breast Neoplasms Tretinoin 2.9616443354 16166294 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.6116813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4816111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.7916050911 15700767 16097048 15673190 16124888 16227642 3786805 15721981 16192424 18705752 16011737 10355542
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8016835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.5219066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.1916168501
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 11.4016705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.403084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 11.4018788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 11.4016924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 11.4016924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 11.401917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.2916096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 9.5117572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 9.5117572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3718670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Raloxifene 3.4515775269
MESH:D002386 Cataract Acetaminophen 7.2310977129
MESH:D002386 Cataract Tretinoin 7.2317460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.166135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.1612371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.1618566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.6116129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1616835633
MESH:D002779 Cholestasis Cyclosporine 2.9219486331
MESH:D002822 Choriocarcinoma Tretinoin 5.1916461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.7712621046 8697196 16354765 15340226 15668235
MESH:D002972 Cleft Palate Tretinoin 5.779407595
MESH:D003072 Cognition Disorders Raloxifene 4.6315800139
MESH:D003092 Colitis Tretinoin 3.7217035595
MESH:D003110 Colonic Neoplasms arsenite 4.3615037631
MESH:D003110 Colonic Neoplasms rofecoxib 4.3612902858
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0614669216 17141729
MESH:D019465 Craniofacial Abnormalities decamethrin 3.9319861644
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.9310048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.9314991402 16925845 9142499 10589399 9211117 9125849 9224671 9664655 8800419 17551590
MESH:D003456 Cryptorchidism vinclozolin 4.3514966744
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.0318551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.3819031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.1617474826
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6717107852
MESH:D003928 Diabetic Nephropathies Estradiol 15.0419279558
MESH:D003928 Diabetic Nephropathies Raloxifene 15.0417451421 15920148 17308373
MESH:D003928 Diabetic Nephropathies Tamoxifen 15.0419279558
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 8.9518551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.9511743745 11834606 12392966 12705907 12153990 14725611 10774834 17906064 19370779 16227642 10663392 15968718 18071297 19085960 17562736 14986274 12540782 16177239 11461765 16081117 12594235 10915739 16485898 12958197 14550746 11287661 19164858 16781746 18713872 19739265 11529661 16109766 19420014 19923254 19416960 17522070 15619225 2444490 16393943 11421492 11739529
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 8.952869522 3786805 6884620 7179309 10092053 15998439 21278145 6623471 10915739 19336974 4309450 7440962 17522070 7120509 19085960 11566570 16177239 15027814 16227642 3732212 15968718 9327722
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.9520420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7611462148
MESH:D050171 Dyslipidemias Dietary Fats 3.4518367378
MESH:D004487 Edema Raloxifene 6.8715860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.8712711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.0518230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 12.0518230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 9.2715845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.2719031437
MESH:D016889 Endometrial Neoplasms Estradiol 12.4411473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 12.4416202921 20544844 19155303 17893378
MESH:D016889 Endometrial Neoplasms Tretinoin 12.4416569247
MESH:D004715 Endometriosis rofecoxib 9.3415652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.3410568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.8411564622
MESH:D005124 Eye Abnormalities Tretinoin 8.8416938888 9664655
MESH:D005234 Fatty Liver arsenite 30.8518296743
MESH:D005234 Fatty Liver Carbon Tetrachloride 30.8515959796 16045604 12631006 17595544 61145 16239168 12795759 19224547
MESH:D005234 Fatty Liver Cyclosporine 30.8519224547
MESH:D005234 Fatty Liver Dietary Fats 30.8519551842 19004024 17967931 18296743
MESH:D005234 Fatty Liver Raloxifene 30.8517473493
MESH:D005234 Fatty Liver Tamoxifen 30.8519224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2416709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4711858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.5514745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.2019069698
MESH:D005355 Fibrosis arsenite 34.8118296743
MESH:D005355 Fibrosis Carbon Tetrachloride 34.8118705752
MESH:D005355 Fibrosis Cyclosporine 34.8112168785 12639820
MESH:D005355 Fibrosis Dietary Fats 34.8118296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 34.8120067830
MESH:D005355 Fibrosis Tretinoin 34.8117994277
MESH:D005756 Gastritis Acetaminophen 3.7116983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.9516973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.3316417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.248708960
MESH:D005909 Glioblastoma Tretinoin 3.0117312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6210696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.1916096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.1916084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.5410048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 6.549664655 14991402
MESH:D006331 Heart Diseases Raloxifene 3.5411110106
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3411000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.6019900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.9116120746 15340226 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.0615709030
MESH:D019584 Hot Flashes Estradiol 3.7817088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0815340226 18606429 8697196 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 7.6316870215
MESH:D006930 Hyperalgesia Tretinoin 7.6316870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.5516899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.6021332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.5816778211
MESH:D006949 Hyperlipidemias Dietary Fats 3.6221332399
MESH:D006973 Hypertension Cyclosporine 8.5910903974
MESH:D006973 Hypertension Raloxifene 8.5917577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.5918850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1015338365
MESH:D007248 Infertility, Male vinclozolin 3.0416467254
MESH:D007249 Inflammation Dietary Fats 8.2820412841
MESH:D007249 Inflammation Tamoxifen 8.2819457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.2812878042 12200463
MESH:D007299 Insect Bites and Stings decamethrin 5.8315189238
MESH:D007333 Insulin Resistance Dietary Fats 7.3818457598 11836018
MESH:D007333 Insulin Resistance Estradiol 7.3816393666 16627594
MESH:D007410 Intestinal Diseases rofecoxib 10.1915831440
MESH:D007410 Intestinal Diseases Tretinoin 10.1917994277
MESH:D007417 Intestinal Polyps rofecoxib 5.3711245490
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.9516580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.9515992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4715604871
MESH:D007674 Kidney Diseases Acetaminophen 9.9812587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 9.988314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 9.9815618244
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 17.7716705839
MESH:D007680 Kidney Neoplasms Cyclosporine 17.7712371664
MESH:D007680 Kidney Neoplasms Estradiol 17.7715610895
MESH:D007680 Kidney Neoplasms Tamoxifen 17.7718625569
OMIM:150250 LARSEN SYNDROME, AUTOSOMAL DOMINANT marker/mechanism
MESH:D007889 Leiomyoma Raloxifene 4.5016973256
MESH:D007938 Leukemia Tretinoin 2.7717143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.7016482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0817596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.1516935935 17339181 16766008 17368321 15748426 17712046 17217047 17107899 17506722 16788101 16331271 9834237 17361223 16823087 19225113 17294898 12679006 19035177 16140955 19642359 19029980 16891316 17301526 19075265 17649720
MESH:D007984 Leydig Cell Tumor vinclozolin 4.7516417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.319224671
MESH:D008064 Lipidoses Tamoxifen 3.1617567588 15342952
MESH:D008103 Liver Cirrhosis arsenite 11.1118296743
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 11.1116239168 11408273 17174718 16943688 17157831 16221502 11903743 21278145 17334410
MESH:D008103 Liver Cirrhosis Dietary Fats 11.1118296743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 8.7620821823 15673190 16097048 16027843 17766677 18251166 12609069 18277467 18395095 12445421 12741479 17714472 17721639 12546737 12586293 17761835 14724832 18210741 17900296 15818738 15996030 12667390 12958196 18376398 18205269 17708605 14716833 17823541 17944888 18412020 15650968 18054572 15893842 17922224 15057751 14716496 18705752 15925388 10355542 15730626 16033810 12649538 18429990 16248980 13678700 16015684 18481824 12898905 18156304 17869086 18279442 14620537 18166357 15338365 12632512 14512876 16192424 17525996 17631135 17640975 15362042 17557913 18339082 16638106 18187930 12389079 11481614 18006644 18420326 17481882 15123356 18472094 16116963 15876570 16011737 12666154 15052691 17805973 15959796 18395914 17976157 15370692 18263696 12632514 15931870 12445418 17565644 18472332 18317297 14748882 16136751 18418968 17698563
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.7614659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental rofecoxib 8.7617565644
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 8.7618564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.7612878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 8.7616248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 3.9016611625 11587558 19784758 16610002 19014921 12587719 12969438 19460945
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.9017285989 16964402 16246199 15830285 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 4.1815123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.4216871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.4214706259 16899240
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 10.707678174
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 10.7019294768
MESH:D008113 Liver Neoplasms Tamoxifen 10.7016684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.7016984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 9.792876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 9.7912014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.7912151625
MESH:D008175 Lung Neoplasms arsenite 3.4516809336
MESH:D008175 Lung Neoplasms Tamoxifen 3.4518625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4511884234 19555203
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.7819428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.9716891317 11807958 11408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 5.9719196723 11731420 16827153 14580682 19196722
MESH:D020149 Manganese Poisoning Estradiol 12.7519453300
MESH:D020149 Manganese Poisoning Tamoxifen 12.7519453300
MESH:D008527 Medulloblastoma Tretinoin 2.7817453147
MESH:D008545 Melanoma Tamoxifen 3.2912393984 19393235
MESH:D008545 Melanoma Tretinoin 3.2916752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.2015990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5819513568
MESH:D008591 Meningomyelocele Tretinoin 4.4416940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8216801185
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.5815863610
MESH:D009101 Multiple Myeloma Raloxifene 3.4416497877
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.0817596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0212213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.2816810080
MESH:D009232 Myxoma Raloxifene 5.5816343187
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.887678174 18551238
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5519393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5219410462
MESH:D009369 Neoplasms Tretinoin 2.4116946489 16594593
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.0319189210 19196722 19200415
MESH:D009389 Neovascularization, Pathologic arsenite 10.2215738583
MESH:D009389 Neovascularization, Pathologic Estradiol 10.2217289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2919348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 16.3916427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 16.3914600291
MESH:D009421 Nervous System Malformations Tretinoin 16.399125849
MESH:D009436 Neural Tube Defects Tretinoin 3.059142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8718514411
MESH:D009765 Obesity Dietary Fats 2.2918674790 16723640 20132043 21332399 19632207 11836018 20518802 18457598 17217161
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.4316049721
MESH:D010003 Osteoarthritis rofecoxib 4.3816690336
MESH:D010024 Osteoporosis Raloxifene 3.3919059307 17882678 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.2317893378 15579764 17823083 15758505
MESH:D010051 Ovarian Neoplasms Estradiol 4.8119401270
MESH:D010051 Ovarian Neoplasms Tretinoin 4.8116936753
MESH:D010146 Pain Acetaminophen 6.5916870215
MESH:D010146 Pain Tretinoin 6.5916870215
MESH:D010149 Pain, Postoperative rofecoxib 5.4216678543 18165598
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.4615976015
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2812520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5718163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2212371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.5611399792 11222880 11118676 11896295
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 9.5619015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 4.9518220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8920887781
MESH:D011471 Prostatic Neoplasms Estradiol 2.5916740699
MESH:D011471 Prostatic Neoplasms Raloxifene 2.5916536755 16220300 15731164
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.5915067354
MESH:D011472 Prostatitis vinclozolin 4.9518629315
MESH:D011507 Proteinuria Tretinoin 3.6116636307
MESH:D011565 Psoriasis Cyclosporine 2.2316882103
MESH:D011625 Pterygium Tretinoin 4.8116723453
MESH:D011693 Purpura Raloxifene 5.5815770314
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8518990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.1116283617 16116481
MESH:D012640 Seizures 2,6-dinitrotoluene 2.5418551238
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.448532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.4416192470
MESH:D012878 Skin Neoplasms Tretinoin 9.4416467112
MESH:D013088 Spermatocele Tamoxifen 4.3216709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.0619457130
OMIM:272460 SPONDYLOCARPOTARSAL SYNOSTOSIS SYNDROME marker/mechanism
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D020521 Stroke Raloxifene 3.8216837676
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9312697716
MESH:D013964 Thyroid Neoplasms Tretinoin 3.0316026305 17045167
MESH:D013978 Tibial Fractures Estradiol 13.8219048282
MESH:D013978 Tibial Fractures Raloxifene 13.8219048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.7916051514
MESH:D014376 Tuberculosis Tretinoin 3.2316040207
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.3716049721
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 8.3717572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.3716712894 17572228 8653321
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.3410091137
MESH:D014581 Urticaria Acetaminophen 2.9810982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.6816129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.6416752155
MESH:D014605 Uveitis Cyclosporine 4.011336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6212125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.2416837676
MESH:D014820 Vitiligo Tretinoin 4.0716761959
MESH:D014846 Vulvar Neoplasms Raloxifene 5.5816343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2815886252
MESH:D015430 Weight Gain Dietary Fats 3.7416723640
MESH:D009396 Wilms Tumor Tretinoin 3.9716287080
MESH:D014985 Xerophthalmia Cyclosporine 4.4717120751
Pathway ID Pathway Name
KEGG:04510 Focal adhesion
KEGG:04010 MAPK signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28173
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    PA443560Breast Neoplasms
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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