AutismKB 2.0

Annotation Detail for TTLL12


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Basic Information Top
Gene Symbol:TTLL12 ( FLJ41795,KIAA0153,dJ526I14.2 )
Gene Full Name: tubulin tyrosine ligase-like family, member 12
Band: 22q13.2
Quick LinksEntrez ID:23170; OMIM: NA; Uniprot ID:TTL12_HUMAN; ENSEMBL ID: ENSG00000100304; HGNC ID: 28974
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of TTLL12 mRNAaffects expression 21346803
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of TTLL12 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of TTLL12 mRNAaffects expression 17562736
D004041 Dietary Fats Dietary Fats results in decreased expression of TTLL12 mRNAdecreases expression 18042831
C041786 palm oil palm oil results in decreased expression of TTLL12 mRNAdecreases expression 18042831
D011374 Progesterone Progesterone results in decreased expression of TTLL12 mRNAdecreases expression 18037150
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 4.417525203
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D001161 Arteriosclerosis Dietary Fats 4.3115238619
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.8617868700
MESH:D001930 Brain Injuries Progesterone 4.6815665606 15380490 15845082
MESH:D001943 Breast Neoplasms Dietary Fats 2.2320435547
MESH:D001943 Breast Neoplasms Progesterone 2.2315562024 16175315 17614352
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 2.9316705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.933084413
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 7.9814694615
MESH:D002386 Cataract Acetaminophen 7.9810977129
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 4.4515095906
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.4318551238
MESH:D003929 Diabetic Neuropathies Progesterone 4.9117187935
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.7118551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 6.7121346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.7111421492 10663392 16177239 19416960 17522070 12153990 16109766 19739265 12392966 18713872 16781746 11739529 14725611 11461765 19420014 14550746 2444490 11529661 12594235 12540782 12958197 11743745 19085960 15619225 15968718 19923254 19370779 10915739 17562736 12705907 19164858 14986274 16081117 10774834 18071297 11287661 17906064 16227642 16393943 11834606 16485898
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D050171 Dyslipidemias Dietary Fats 3.6718367378
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 4.1617692515
MESH:D004715 Endometriosis Progesterone 4.0716134523
MESH:D005234 Fatty Liver Dietary Fats 3.5619551842 17967931 19004024 18296743
MESH:D005355 Fibrosis Dietary Fats 3.9418296743
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.9221332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.9721332399
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.8215869954
MESH:D007249 Inflammation Dietary Fats 5.6720412841
MESH:D007249 Inflammation Progesterone 5.6715869954
MESH:D007333 Insulin Resistance Dietary Fats 3.3011836018 18457598
MESH:D007674 Kidney Diseases Acetaminophen 2.3615629191 12587719
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.2416705839
MESH:D008103 Liver Cirrhosis Dietary Fats 3.0318296743
MESH:D008107 Liver Diseases Acetaminophen 1.6916611625 16610002 19460945 12587719 19784758 19014921 12969438 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5416871587 17185352
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 3.0517203775 11408345
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.3218551238
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D009765 Obesity Dietary Fats 2.3416723640 20132043 18457598 21332399 17217161 18674790 20518802 11836018 19632207
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 10.1616049721 12819281
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 10.1614694615
MESH:D010051 Ovarian Neoplasms Progesterone 2.6017393432 16525653
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9418045962
MESH:D012640 Seizures 2,4-dinitrotoluene 2.7318551238
MESH:D013119 Spinal Cord Injuries Progesterone 4.7416503802 15862959
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.3816049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.7810091137
MESH:D014581 Urticaria Acetaminophen 3.3310982225
MESH:D015430 Weight Gain Dietary Fats 4.0216723640
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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