AutismKB 2.0

Annotation Detail for METAP1


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Basic Information Top
Gene Symbol:METAP1 ( DKFZp781C0419,KIAA0094,MAP1A,MetAP1A )
Gene Full Name: methionyl aminopeptidase 1
Band: 4q23
Quick LinksEntrez ID:23173; OMIM: 610151; Uniprot ID:AMPM1_HUMAN; ENSEMBL ID: ENSG00000164024; HGNC ID: 15789
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of METAP1 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of METAP1 mRNAaffects expression 17562736
C020806 tetrabromobisphenol A tetrabromobisphenol A affects the expression of METAP1 mRNAaffects expression 18976794
C025643 vinclozolin vinclozolin affects the expression of METAP1 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.963712494
MESH:D000799 Angioedema Acetaminophen 4.5710982225
MESH:D001008 Anxiety Disorders vinclozolin 3.9719015723
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.7411289319 1440618
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 2.967296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.963084413
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.837296757
MESH:D002386 Cataract Acetaminophen 2.7910977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 3.027505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.4419486331 9022650
MESH:D003456 Cryptorchidism vinclozolin 4.8514966744
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.3514531868 18759878 8156756 12868966 2524372 8970840 11906362 11298694
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.952952479 3621924
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 4.0218289764 6482804 9653073 6679447 18692083 16192314 18648102 8291058 9022650 7440962 11289319 1440618 9328219
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.0219164858 19416960 17562736 10915739 10663392 16109766 12392966 11287661 12594235 12540782 16393943 11834606 19085960 11421492 16177239 19739265 11743745 16227642 19420014 12705907 10774834 11461765 19370779 14986274 12153990 17522070 18713872 18071297 11739529 14550746 16485898 14725611 2444490 17906064 19923254 16081117 15968718 11529661 15619225 16781746 12958197
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.8219426721
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.183581430
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.746705139
MESH:D005756 Gastritis Acetaminophen 4.4016983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.5716973722
MESH:D005832 Genital Diseases, Male vinclozolin 6.0216417039
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.507505956
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 4.026705139
MESH:D006930 Hyperalgesia Acetaminophen 3.0216870215
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.5015034207
MESH:D007248 Infertility, Male vinclozolin 3.2916467254
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.749022650 8074119
MESH:D007674 Kidney Diseases Acetaminophen 2.4015629191 12587719
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.316582329
MESH:D007984 Leydig Cell Tumor vinclozolin 5.3616417039
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.4215034207 9327722
MESH:D008107 Liver Diseases Acetaminophen 1.7019014921 12587719 19460945 16610002 12969438 11587558 19784758 16611625
MESH:D017114 Liver Failure, Acute Acetaminophen 3.6317185352 16871587
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.75598648 1399818 6587162 3712494
MESH:D008546 Melanoma, Experimental Acetaminophen 4.1319513568
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.593581430
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.156679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2118514411
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.816482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.743988306
MESH:D010146 Pain Acetaminophen 2.7316870215
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 4.047296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 5.196228378
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.5318042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.5718220299
MESH:D011472 Prostatitis vinclozolin 5.5718629315
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.673692021
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.197505956 6582329 3712494 6587162 1399818
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.408074119
MESH:D014581 Urticaria Acetaminophen 3.4410982225
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB01422 antagonist Nitroxoline Antifungal Agents;Anti-Infective Agents, Urinary
DB04324 - Ovalicin
DB07901 - 5-CHLORO-6-METHYL-N-(2-PHENYLETHYL)-2-PYRIDIN-2-YLPYRIMIDIN-4-AMINE
DB07902 - TERT-BUTYL {2-[(1,3-THIAZOL-2-YLAMINO)CARBONYL]PYRIDIN-3-YL}CARBAMATE
DB07903 - 3-[(2,2-DIMETHYLPROPANOYL)AMINO]-N-1,3-THIAZOL-2-YLPYRIDINE-2-CARBOXAMIDE
No data
No data
No data

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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