AutismKB 2.0

Annotation Detail for LPIN1


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Basic Information Top
Gene Symbol:LPIN1 ( DKFZp781P1796,KIAA0188,PAP1 )
Gene Full Name: lipin 1
Band: 2p25.1
Quick LinksEntrez ID:23175; OMIM: 605518; Uniprot ID:LPIN1_HUMAN; ENSEMBL ID: ENSG00000134324; HGNC ID: 13345
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Metabolism of lipids and lipoproteins
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Related Diseases/Disorders Top
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Desease Name
METABOLIC
Diabetes Mellitus, Type 2
No data
Desease Name
Myoglobinuria, acute recurrent, autosomal recessive
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of LPIN1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of LPIN1 mRNAaffects expression 21346803
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of LPIN1 mRNAincreases expression 16788091
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of LPIN1 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of LPIN1 mRNAaffects expression 17562736
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of LPIN1 mRNAaffects cotreatment|increases expression 18164116
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of LPIN1 mRNAdecreases expression 20064835
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of LPIN1 mRNAdecreases expression 14729362
D016572 Cyclosporine Cyclosporine results in decreased expression of LPIN1 mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of LPIN1 mRNAdecreases expression 18042831
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of LPIN1 mRNAaffects cotreatment|increases expression 18164116
D004958 Estradiol Estradiol results in decreased expression of LPIN1 mRNAdecreases expression 20068009
C106014 gedunin gedunin results in increased expression of LPIN1 mRNAincreases expression 17010675
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased expression of LPIN1 mRNAdecreases expression 18940942
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased expression of LPIN1 proteindecreases expression 18940942
C041786 palm oil palm oil results in decreased expression of LPIN1 mRNAdecreases expression 18042831
D010634 Phenobarbital Phenobarbital results in decreased expression of LPIN1 mRNAdecreases expression 19270015
D010634 Phenobarbital Phenobarbital results in increased expression of LPIN1 mRNAincreases expression 19270015
D010672 Phenytoin Phenytoin results in increased expression of LPIN1 mRNAincreases expression 14741686
D010840 Phytosterols APOE gene mutant form affects the reaction [Phytosterols results in increased expression of LPIN1 mRNA]affects reaction|increases expression 18155511
C006253 pirinixic acid pirinixic acid results in increased expression of LPIN1 mRNAincreases expression 18445702
D011374 Progesterone Progesterone results in increased expression of LPIN1 mRNAincreases expression 18070364
D012643 Selenium Selenium results in decreased expression of LPIN1 mRNAdecreases expression 19244175
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of LPIN1 mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of LPIN1 mRNAaffects expression 18691609
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of LPIN1 mRNAdecreases expression 17949056
C050414 tripterine tripterine results in increased expression of LPIN1 mRNAincreases expression 17010675
D014501 Uranium Uranium affects the expression of LPIN1 mRNAaffects expression 15672453
C005460 uranyl acetate uranyl acetate affects the expression of LPIN1 mRNAaffects expression 15672453
D014810 Vitamin E Vitamin E results in decreased expression of LPIN1 mRNAdecreases expression 19244175
D015054 Zymosan Zymosan results in decreased expression of LPIN1 mRNAdecreases expression 18940942
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 13.006195326
MESH:D000014 Abnormalities, Drug-Induced Phenytoin 13.006195326 10563481 9118846 8986270 9677735 3425630
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 13.0015322242 14514962 11752688
MESH:D055371 Acute Lung Injury Lipopolysaccharides 8.3411850527 18653653
MESH:D055371 Acute Lung Injury pirinixic acid 8.3418653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.0820127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 4.0811473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 14.903712494
MESH:D000236 Adenoma Benzo(a)pyrene 14.906695378
MESH:D000236 Adenoma beta-Naphthoflavone 14.9019389873
MESH:D000236 Adenoma Diethylnitrosamine 14.906695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 22.9718056438 19052882 16434500 19061943 17162532 17620307
MESH:D018248 Adenoma, Liver Cell Phenobarbital 22.9717620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 22.9716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 22.9716835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.3311748828
MESH:D000740 Anemia Zymosan 8.3318664788
MESH:D000799 Angioedema Acetaminophen 3.6110982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8519183758
MESH:D001161 Arteriosclerosis Dietary Fats 3.6615238619
MESH:D001169 Arthritis, Experimental Zymosan 3.9815944321 17659584 15188379 16872482 15142272
MESH:D050197 Atherosclerosis Phenytoin 3.7915136057
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.791440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.0919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.0912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6215746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.1117868700
MESH:D001930 Brain Injuries Progesterone 4.0315665606 15845082 15380490
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.8417474063 20146248
MESH:D001943 Breast Neoplasms Dietary Fats 2.8420435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.8417474063
MESH:D001943 Breast Neoplasms Estradiol 2.8417289903 18497071 17261762 19861407 17018787 16675129 12948864 14630087
MESH:D001943 Breast Neoplasms Progesterone 2.8417614352 15562024 16175315
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.8420435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2316111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.7116050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6216835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 13.4916705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 13.4916705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 13.497296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.493084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 13.4921159647 18506893 16779866 18056438 20101231 17978847 19822196 16328049 19383236 16502159 18785209 17138121 17428255 18393292 19394651 19208518 16540662 17761372 20524982 16288022 18494052 18691550 19539802 17173139 19335982 20432363 19418558 16681979 11831363 10672840 18971187 19171122 3581430 16878318 16807293 20214788 17162532 16935385 20084675 17055752 18665156 18788625 16830150 16569478 20512989 20514400 19107877 20727157 16698587 19919837 20007298 19052882 20935162 18210153 19519916 3084413 18978308 19701751 10737359
MESH:D006528 Carcinoma, Hepatocellular Estradiol 13.4916924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 13.4917173139 20935162 1701930 20007298 6705139
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.577296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 1.9920419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2416120746 18670907 18850075
MESH:D002386 Cataract Acetaminophen 2.4510977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 19.436135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 19.437505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 19.4312371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 19.4321159647 7505956 17174075 2727394
MESH:D002471 Cell Transformation, Neoplastic Estradiol 19.4318566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 10.924080065
MESH:D002493 Central Nervous System Diseases Phenytoin 10.924080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.6919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.6916835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 12.4119486331 9022650
MESH:D002779 Cholestasis Cyclosporine 12.4119486331
MESH:D002779 Cholestasis pirinixic acid 12.4119176532
OMIM:601042 CHOREOATHETOSIS/SPASTICITY, EPISODIC Phenytoin 5.6411748493
MESH:D002971 Cleft Lip Phenytoin 4.042227380
MESH:D002972 Cleft Palate Phenytoin 5.846856622 3877104 2227380 1687470 10789828 6862529
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.8415340226 16354765 8697196 15668235 12621046
MESH:D003092 Colitis Selenium 3.5617936198
MESH:D003103 Coloboma Phenytoin 4.959212184
MESH:D000013 Congenital Abnormalities Phenytoin 8.7510627286
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 8.7514669216 17141729
MESH:D019465 Craniofacial Abnormalities Phenytoin 3.769212184 19952982 8986270
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.7620055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.7619769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.1418551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.1418551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.5911906362 18759878 8970840 14531868 2524372 12868966 11298694 8156756
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3218249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.282952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.0320387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.0317107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.2219279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.2717187935
OMIM:607208 DRAVET SYNDROME Phenytoin 5.1611748493
MESH:D003875 Drug Eruptions Phenytoin 5.2715024534
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 17.6118551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 17.6121346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 17.6118692083 7440962 1440618 16192314 18289764 9328219 18648102 6482804 6679447 11289319 8291058 9653073 9022650
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 17.612444490 19416960 19923254 15968718 17562736 17906064 10663392 16177239 15619225 16227642 16485898 14725611 11739529 14986274 16393943 11287661 11529661 11421492 12153990 19085960 12705907 18071297 11743745 11461765 10774834 12958197 18713872 11834606 12540782 10915739 12392966 19164858 14550746 16781746 19420014 19739265 19370779 16081117 16109766 17522070 12594235
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 17.6119107877
MESH:D056486 Drug-Induced Liver Injury Selenium 17.6115131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 17.6120420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5911462148
MESH:D050171 Dyslipidemias Dietary Fats 3.2918367378
MESH:D004421 Dystonia Phenobarbital 3.791851702
MESH:C538011 Eales disease Vitamin E 4.479068938
MESH:D004487 Edema pirinixic acid 10.3412083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.3412711302 11000095
MESH:D004487 Edema Zymosan 10.347907874
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6715322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Phenytoin 8.8617654737
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 8.8617692515
MESH:D016889 Endometrial Neoplasms Estradiol 2.8311473722 18566989 19148513
MESH:D004715 Endometriosis Progesterone 8.2716134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.2710568697 9294722
MESH:D019446 Endotoxemia Lipopolysaccharides 4.1717637181 15328337 15821434
MESH:D004816 Epidermal Necrolysis, Toxic Phenytoin 4.9820235791
MESH:D004820 Epidermolysis Bullosa Phenytoin 6.001399206 6251365
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.883659116
MESH:D004828 Epilepsies, Partial Phenobarbital 9.5711558140 3922381
MESH:D004828 Epilepsies, Partial Phenytoin 9.5711558140 17116037
MESH:D004827 Epilepsy Phenobarbital 6.6520417680
MESH:D004827 Epilepsy Phenytoin 6.65821787 11434505 20417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.356401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 10.927750514
MESH:D017029 Epilepsy, Complex Partial Phenytoin 10.927750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 10.083659116
MESH:D004830 Epilepsy, Tonic-Clonic Phenytoin 10.083659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8916302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.163581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.1616530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8411564622
MESH:D005234 Fatty Liver Cyclosporine 17.0719224547
MESH:D005234 Fatty Liver Dietary Fats 17.0717967931 18296743 19004024 19551842
MESH:D005234 Fatty Liver Diethylnitrosamine 17.0720387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 17.0719236843 20131406
MESH:D005313 Fetal Death Phenytoin 9.9910627286
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 9.9911858732
MESH:D005334 Fever Lipopolysaccharides 3.829205823 11852909
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.796705139
MESH:D005355 Fibrosis Cyclosporine 13.4212639820 12168785
MESH:D005355 Fibrosis Dietary Fats 13.4218296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.4220067830
MESH:D005756 Gastritis Acetaminophen 3.4416983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 12.148708960
MESH:D005885 Gingival Hyperplasia Phenytoin 12.149029455
MESH:D019214 Gingival Overgrowth Phenytoin 6.0016390469 14659971
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.827505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3610696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.4120471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.4111294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 10.4116080930
MESH:D006333 Heart Failure pirinixic acid 6.4920558911
MESH:D006333 Heart Failure Selenium 6.4917162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1915720958
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.1916366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1311000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 8.906705139
MESH:D006505 Hepatitis Zymosan 8.9019110552
MESH:D006529 Hepatomegaly Phenobarbital 13.0816109766
MESH:D006529 Hepatomegaly pirinixic acid 13.0819772884 16221962 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.0815340226 16120746 12621046
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6216490937 16863852
MESH:D006558 Herpes Genitalis Estradiol 4.8015709030
MESH:D019584 Hot Flashes Estradiol 9.2817088409
MESH:D019584 Hot Flashes Vitamin E 9.2814716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8118606429 8697196 16959395 16354765 15340226
MESH:D006930 Hyperalgesia Acetaminophen 2.5216870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.3921332399
MESH:D006943 Hyperglycemia pirinixic acid 2.9920558911
MESH:D020138 Hyperhomocysteinemia Phenytoin 4.4810459572
MESH:D006949 Hyperlipidemias Dietary Fats 3.4021332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.7115034207
MESH:D006973 Hypertension Cyclosporine 4.6610903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.6618670907 18850075
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.1815869954
MESH:D007249 Inflammation Dietary Fats 18.4420412841
MESH:D007249 Inflammation Diethylnitrosamine 18.4418785209
MESH:D007249 Inflammation Lipopolysaccharides 18.4412878042 17255318 9205823 17237260 17963957
MESH:D007249 Inflammation Progesterone 18.4415869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 18.4412878042 12200463
MESH:D007249 Inflammation Zymosan 18.448014878 11289658
MESH:D007251 Influenza, Human Selenium 10.1916624496
MESH:D007251 Influenza, Human Vitamin E 10.1916624496
MESH:D007333 Insulin Resistance Dietary Fats 11.4411836018 18457598
MESH:D007333 Insulin Resistance Estradiol 11.4416393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 11.4416306350
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.4217255318
MESH:D043183 Irritable Bowel Syndrome Zymosan 5.6117553498
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.798074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1316580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2115604871
MESH:D007674 Kidney Diseases Acetaminophen 13.3412587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 13.348314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 13.3415618244
MESH:D007674 Kidney Diseases Vitamin E 13.3412488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.6816518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 21.3616705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 21.3616705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 21.366582329
MESH:D007680 Kidney Neoplasms Cyclosporine 21.3612371664
MESH:D007680 Kidney Neoplasms Estradiol 21.3615610895
MESH:D007970 Leukopenia Lipopolysaccharides 4.4715821434
MESH:D008103 Liver Cirrhosis Dietary Fats 10.3118296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 10.3118522880 19638242 20032147 18407596 18665156
MESH:D008103 Liver Cirrhosis Phenobarbital 10.3121047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.069327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.4114716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 6.4112878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.4115474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.4112878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 6.4116169303
MESH:D008107 Liver Diseases Acetaminophen 8.9111587558 19460945 16610002 19014921 12587719 12969438 16611625 19784758
MESH:D008107 Liver Diseases Diethylnitrosamine 8.9117034775
MESH:D008107 Liver Diseases Phenobarbital 8.9119363144
MESH:D008107 Liver Diseases Phenytoin 8.9114986274
MESH:D017114 Liver Failure, Acute Acetaminophen 3.0416871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 20.567678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 20.5620195826 21137059
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 20.5619389873 21295105
MESH:D008113 Liver Neoplasms Diethylnitrosamine 20.5620101389 19833225 21278145 18978307 20137499 20405173 20452335 19996281 12771043 19850985 18648771 21071580 15175105 19073162 15885732 21047994 19812893 20583210 19638242 9163691 19294768 19427195 19499222 20492335 19254457 2862719 12112319 21167192 18977376 19551842 18754104 16942905 19426721 19090486 18644402 19255062 19642983 20434301 10737359 20501860 2422723 19256749 20118626 19690152
MESH:D008113 Liver Neoplasms Phenobarbital 20.5619812893 15975961 8742319 19482888 21047994 19073162
MESH:D008113 Liver Neoplasms pirinixic acid 20.5620007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 20.5616984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 21.542876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 21.54598648 6587162 3712494 1399818
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 21.5418164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 21.5418079962 18253720 19004024 16842330 19009564 9362446 18544905 19519916 16267830 18164116 18775883 18093689 19539802 3124819 17942915 17174075 17854601 19126423 2563599 18308698 21159647 18282651
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 21.542563599 17172636 6150874 18308698 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 21.5412151625
MESH:D008171 Lung Diseases Vitamin E 3.0316863852
MESH:D055370 Lung Injury Lipopolysaccharides 3.7921114838
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.5920464547 6695378 17053015 20135361 18520028 20869020 18569708 20064080 18816296
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.5920512841 20970405 21163286 6695378
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.5911884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 4.5911062179
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.1516891317 17203775 11408345 11807958
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 9.1511408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Selenium 9.1515318939
MESH:D020149 Manganese Poisoning Estradiol 4.2519453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3419513568
MESH:D008607 Mental Retardation Phenytoin 3.599212184
MESH:D008654 Mesothelioma Selenium 2.7015107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5616801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0216381670
MESH:D009102 Multiple Organ Failure Zymosan 4.9917724436 15241586 10890648 18160304 10479408 12130978 15834315 15213630 12879239 15259001
MESH:D009135 Muscular Diseases pirinixic acid 3.2816239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.0519151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.6716810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.6716411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 11.7317484760
MESH:D020191 Myoclonic Epilepsies, Progressive Phenytoin 11.7317484760
OMIM:268200 MYOGLOBINURIA, ACUTE RECURRENT, AUTOSOMAL RECESSIVE marker/mechanism
MESH:D009224 Myotonia Congenita Phenytoin 5.181896199
MESH:D009336 Necrosis 2,4-dinitrotoluene 9.5818551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 9.587678174 18551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.403581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.403581430 9029167
MESH:D009369 Neoplasms Benzo(a)pyrene 4.4511141357
MESH:D009369 Neoplasms pirinixic acid 4.4517405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5017289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0918481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 8.7411399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.7414600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.136679447
MESH:D009436 Neural Tube Defects Phenytoin 7.139118846
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.5718514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.5720387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8920387270
MESH:D009765 Obesity Dietary Fats 4.2418457598 17217161 11836018 21332399 16723640 20132043 19632207 18674790 20518802
MESH:D009765 Obesity pirinixic acid 4.2420558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 13.9212819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 13.9216049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 13.924026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.793988306
MESH:D010018 Osteomalacia Phenobarbital 11.3117016548
MESH:D010018 Osteomalacia Phenytoin 11.3117016548
MESH:D010051 Ovarian Neoplasms Estradiol 4.6319401270
MESH:D010051 Ovarian Neoplasms Progesterone 4.6316525653 17393432
MESH:D010146 Pain Acetaminophen 6.3816870215
MESH:D010146 Pain Phenytoin 6.3815215642
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 4.9916540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 4.9916965848
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.267296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0212520081
MESH:D010538 Peritonitis Zymosan 4.6618977430 19088179 11985352 19641140 15979727 18557954 17371808 15259001 18760300 17826846 14761945
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.246228378
MESH:D010954 Plasmacytoma Selenium 4.6615087411
MESH:D011014 Pneumonia Lipopolysaccharides 4.3311605937 12224865
MESH:D017689 Polydactyly Phenytoin 4.859212184
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3418163543
MESH:D011230 Precancerous Conditions Cyclosporine 14.1612371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 14.162563599
MESH:D011230 Precancerous Conditions Phenobarbital 14.162563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.9611399792 11896295 11222880 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6820887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5917292933
MESH:D011471 Prostatic Neoplasms Estradiol 2.5916740699
MESH:D011471 Prostatic Neoplasms Vitamin E 2.5915084515
MESH:D019310 Pseudolymphoma Phenobarbital 11.7912752131
MESH:D019310 Pseudolymphoma Phenytoin 11.7912752131 1419762 8603615
MESH:D011565 Psoriasis Cyclosporine 2.1516882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.2819058328
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.5810835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6218990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.213692021
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7818045962
MESH:D012640 Seizures 2,4-dinitrotoluene 12.8618551238
MESH:D012640 Seizures 2,6-dinitrotoluene 12.8618551238
MESH:D012640 Seizures Phenobarbital 12.863137016 4039156 16876388 11442880
MESH:D012640 Seizures Phenytoin 12.863691417 16876388 19919933 10029267 9844417 11044598 3137016 15946322
MESH:D003294 Seizures, Febrile Phenobarbital 4.596407741
MESH:D018805 Sepsis Zymosan 4.4611441115
MESH:D012871 Skin Diseases Vitamin E 2.3818709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 8.7719755658 10029692
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 8.778532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.7716192470
MESH:D013119 Spinal Cord Injuries Progesterone 4.0516503802 15862959
MESH:D013262 Stevens-Johnson Syndrome Phenytoin 4.9320235791
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.2720155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.2718456281
MESH:D020521 Stroke Vitamin E 3.3416517955
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.9715821434
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6712697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 10.961399818 6582329 6587162 7505956 3712494
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 10.967505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 10.961399818
MESH:D013978 Tibial Fractures Estradiol 4.4519048282
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 11.1616049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 11.1616049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 11.168074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 11.1617053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 11.2210091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 11.2210091137
MESH:D014581 Urticaria Acetaminophen 2.7710982225
MESH:D014605 Uveitis Cyclosporine 11.211336536
MESH:D014605 Uveitis Zymosan 11.2111006244
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0215886252
MESH:D015430 Weight Gain Dietary Fats 3.5516723640
MESH:D014985 Xerophthalmia Cyclosporine 4.2117120751
Pathway ID Pathway Name
REACT:22258 Metabolism of lipids and lipoproteins
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30436
    • No data
    Releated disease ID Related disease Name
    PA445024Myoglobinuria
    PA443890Diabetes Mellitus, Type 2
    Releated drug ID Related drug Name
    PA451283rosiglitazone
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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