AutismKB 2.0

Annotation Detail for CEP68


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Basic Information Top
Gene Symbol:CEP68 ( FLJ25920,FLJ36750,KIAA0582 )
Gene Full Name: centrosomal protein 68kDa
Band: 2p14
Quick LinksEntrez ID:23177; OMIM: NA; Uniprot ID:CEP68_HUMAN; ENSEMBL ID: ENSG00000011523; HGNC ID: 29076
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of CEP68 mRNAaffects expression 21346803
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of CEP68 mRNAincreases expression 20064835
D016572 Cyclosporine Cyclosporine results in decreased expression of CEP68 mRNAdecreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of CEP68 mRNAaffects expression 17555576
D013629 Tamoxifen Tamoxifen affects the expression of CEP68 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with AHR gene mutant form] results in increased expression of CEP68 mRNAaffects cotreatment|increases expression 19465110
D014028 Tobacco Smoke Pollution Tobacco Smoke Pollution results in decreased expression of CEP68 mRNAdecreases expression 18087596
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.9914745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.2411752688 14514962 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3817505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.3720127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3714692618
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Tobacco Smoke Pollution 5.9715814487
MESH:D000236 Adenoma Benzo(a)pyrene 2.806695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7716835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2111748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4319183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8215885639
MESH:D001172 Arthritis, Rheumatoid Tobacco Smoke Pollution 3.2319898480
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.7917474063 20146248
MESH:D001943 Breast Neoplasms Tamoxifen 1.7920005174 18821012 15565566 16273361 17440819 11161223 20859285 17242785 20390343 16818667 21138602 19059307 19410462 20135344 15668708 20065188 19288272 18997820 19115204 19066611 19103187 19244106 17049068 19155303 19487384 19189212 17261762 19221464 19200415 18815881 18425577 17893378 19289846 18351453 18984771 19011961 20544844 16202921 16873071 19084267 21152245 19142967 18855134 19189210 18629630
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.7920435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.8719066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 3.0916705839
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 3.0916924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung Tobacco Smoke Pollution 3.5011212258
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 5.1320419170
MESH:D002294 Carcinoma, Squamous Cell Tobacco Smoke Pollution 5.1311212258
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8817572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5018670907 16120746 18850075
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.7112371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4116835633
MESH:D002779 Cholestasis Cyclosporine 8.4619486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.4616105132 11677210 16919318 17110522 15861022 17681005 17333356
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2015668235 12621046 15340226 16354765 8697196
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 20055451 10048152
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.3718551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.7219031437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.7219279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 3.9218551238 21346803
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.9220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9611462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.3516714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.0612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.0619031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.2120544844 17893378 19155303 16202921
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.299294722 10568697
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0616530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2111564622
MESH:D005234 Fatty Liver Cyclosporine 14.7519224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.7515345470
MESH:D005234 Fatty Liver Tamoxifen 14.7514986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3916709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.9214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.5819069698
MESH:D005355 Fibrosis Cyclosporine 9.7012168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.7020067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.628708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.8820471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.8810048152 11294989
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8215720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2516120746 15340226 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.498697196 16959395 15340226 18606429 16354765
MESH:D006973 Hypertension Cyclosporine 5.2410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2418670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1716945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6617937319
MESH:D007249 Inflammation Tamoxifen 9.1619457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 9.1612200463 12878042
MESH:D007249 Inflammation Tobacco Smoke Pollution 9.1618590791
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6216580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8815604871
MESH:D007674 Kidney Diseases Cyclosporine 2.488314463 18776723 10903974
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.7716705839
MESH:D007680 Kidney Neoplasms Cyclosporine 13.7712371664
MESH:D007680 Kidney Neoplasms Tamoxifen 13.7718625569
MESH:D008064 Lipidoses Tamoxifen 3.3517567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.3518564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3512878042
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.8920195826 21137059
MESH:D008113 Liver Neoplasms Tamoxifen 7.8916684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.8916984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2612151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 5.0820869020 20464547 20135361 17053015 6695378 18520028 18816296 20064080 18569708
MESH:D008175 Lung Neoplasms Tamoxifen 5.0818625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 5.0811884234 19555203
MESH:D008175 Lung Neoplasms Tobacco Smoke Pollution 5.0816288123 3440675 11091918 12111688
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.1519428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7911731420 19196722 14580682 19196723 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 4.9919453300
MESH:D008545 Melanoma Tamoxifen 1.9119393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.5815990972
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.2316801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 9.5116381670
MESH:D009062 Mouth Neoplasms Tobacco Smoke Pollution 9.5115006635
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2412213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.2518551238
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5919410462
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2811141357
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.4419200415 19196722 19189210
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5319348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5414600291
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.6916049721 12819281
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9911578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.4712371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5911399792 11118676 11222880 11896295
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.0717292933
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.0715067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.7116919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D012135 Respiratory Sounds Tobacco Smoke Pollution 4.9818410779
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012640 Seizures 2,4-dinitrotoluene 2.7118551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 10.1810029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 10.1816192470
MESH:D012878 Skin Neoplasms Tobacco Smoke Pollution 10.1818590791
MESH:D013088 Spermatocele Ethinyl Estradiol 13.0916709447
MESH:D013088 Spermatocele Tamoxifen 13.0916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.4319457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 12.7316049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 12.7317053015
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 12.7316712894 17572228 8653321
MESH:D001749 Urinary Bladder Neoplasms Tobacco Smoke Pollution 12.7312846360
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.7110091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6314692618
MESH:D014605 Uveitis Cyclosporine 4.431336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8214671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
MESH:D014985 Xerophthalmia Cyclosporine 4.8817120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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