AutismKB 2.0

Annotation Detail for PSME4


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:PSME4 ( FLJ21864,KIAA0077,MGC138374,MGC142228,PA200 )
Gene Full Name: proteasome (prosome, macropain) activator subunit 4
Band: 2p16.2
Quick LinksEntrez ID:23198; OMIM: 607705; Uniprot ID:PSME4_HUMAN; ENSEMBL ID: ENSG00000068878; HGNC ID: 20635
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PSME4 mRNAaffects expression 21346803
C016601 4-hydroxytamoxifen 4-hydroxytamoxifen results in decreased expression of PSME4 mRNAdecreases expression 16514628
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PSME4 mRNAaffects expression 16483693
D016572 Cyclosporine Cyclosporine results in increased expression of PSME4 mRNAincreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of PSME4 mRNAdecreases expression 18042831
D004958 Estradiol Estradiol results in increased expression of PSME4 mRNAincreases expression 16514628
C070081 fulvestrant fulvestrant results in decreased expression of PSME4 mRNAdecreases expression 16514628
C041786 palm oil palm oil results in decreased expression of PSME4 mRNAdecreases expression 18042831
D020849 Raloxifene Raloxifene results in decreased expression of PSME4 mRNAdecreases expression 16514628
C004648 testosterone enanthate testosterone enanthate affects the expression of PSME4 mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PSME4 mRNAincreases expression 19465110
D014747 Vinblastine PSME4 protein affects the susceptibility to Vinblastineaffects response to substance 16217747
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0014514962 11752688 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.7118287403
MESH:D000230 Adenocarcinoma Estradiol 2.1211473722
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5316835633
MESH:D000419 Albuminuria Raloxifene 4.7217308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.5615800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D001161 Arteriosclerosis Dietary Fats 4.0315238619
MESH:D001284 Atrophy fulvestrant 4.9711514358
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D001930 Brain Injuries Raloxifene 4.6116580743
MESH:D001943 Breast Neoplasms Dietary Fats 2.3820435547
MESH:D001943 Breast Neoplasms Estradiol 2.3818497071 17289903 16675129 17261762 12948864 19861407 14630087 17018787
MESH:D001943 Breast Neoplasms fulvestrant 2.3818984771
MESH:D001943 Breast Neoplasms Raloxifene 2.3817261762 16912660 17952589 15758505 15775269 17893378 17242785 15572757 16837676 17049068 17595753 17440819
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3820435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.6216111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 3.0116705839
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.0116924424
MESH:D002292 Carcinoma, Renal Cell Vinblastine 3.831485588
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 4.1717572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4218850075 16120746 18670907
MESH:D002318 Cardiovascular Diseases Raloxifene 3.5215775269
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.586135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.5812371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.5818566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2616835633
MESH:D002779 Cholestasis Cyclosporine 3.0019486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.148697196 12621046 15340226 15668235 16354765
MESH:D003072 Cognition Disorders Raloxifene 4.7615800139
MESH:D015179 Colorectal Neoplasms Vinblastine 2.7618802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1614669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 15322242 10048152
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.1618551238
MESH:D003865 Depressive Disorder, Major Raloxifene 4.2617474826
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D003928 Diabetic Nephropathies Estradiol 9.3419279558
MESH:D003928 Diabetic Nephropathies Raloxifene 9.3417451421 17308373 15920148
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 3.7918551238 21346803
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.7920420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:D050171 Dyslipidemias Dietary Fats 3.5318367378
MESH:D004487 Edema Raloxifene 7.2215860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.2212711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0815322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 4.1215845917
MESH:D016889 Endometrial Neoplasms 4-hydroxytamoxifen 8.0219148513
MESH:D016889 Endometrial Neoplasms Estradiol 8.0211473722 18566989 19148513
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1210568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0911564622
MESH:D005234 Fatty Liver Cyclosporine 13.8319224547
MESH:D005234 Fatty Liver Dietary Fats 13.8318296743 19004024 17967931 19551842
MESH:D005234 Fatty Liver Raloxifene 13.8317473493
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D005355 Fibrosis Cyclosporine 15.5612639820 12168785
MESH:D005355 Fibrosis Dietary Fats 15.5618296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 15.5620067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.378708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3811294989 10048152
MESH:D006331 Heart Diseases Raloxifene 3.6111110106
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5815720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0315340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.2115709030
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.9217440010
MESH:D006689 Hodgkin Disease Vinblastine 4.1218180244 18501091
MESH:D019584 Hot Flashes Estradiol 3.9317088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2216354765 18606429 15340226 16959395 8697196
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7021332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.7321332399
MESH:D006973 Hypertension Cyclosporine 8.8010903974
MESH:D006973 Hypertension Raloxifene 8.8017577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.8018670907 18850075
MESH:D007248 Infertility, Male fulvestrant 3.8211514358
MESH:D007249 Inflammation Dietary Fats 5.0920412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.0912200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 7.6018457598 11836018
MESH:D007333 Insulin Resistance Estradiol 7.6016393666 16627594
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6215604871
MESH:D007674 Kidney Diseases Cyclosporine 6.148314463 18776723 10903974
MESH:D007674 Kidney Diseases Estradiol 6.1415618244
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.9116705839
MESH:D007680 Kidney Neoplasms Cyclosporine 12.9112371664
MESH:D007680 Kidney Neoplasms Estradiol 12.9115610895
MESH:D007889 Leiomyoma Raloxifene 4.6116973256
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9318296743
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.2914659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.2912878042
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.497678174
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.4916984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 5.952876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.9512151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2419555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6211807958 16891317 17203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.6619453300
MESH:D008545 Melanoma Vinblastine 2.9215577320 18176117 16248763 18505091 17761969 16432458 15577323 16809738 18332650 12374674
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9616801185
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.7315863610
MESH:D009101 Multiple Myeloma Raloxifene 3.5116497877
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3616810080
MESH:D009232 Myxoma Raloxifene 5.7316343187
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.0118551238 7678174
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8917289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3819348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 9.8911399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.8914600291
MESH:D009503 Neutropenia Vinblastine 4.6917378895
MESH:D009765 Obesity Dietary Fats 2.3118674790 18457598 19632207 11836018 20518802 16723640 17217161 20132043 21332399
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.5316049721
MESH:D010024 Osteoporosis Raloxifene 3.4615775268 19059307 17882678
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.3415758505 15579764 17823083 17893378
MESH:D010051 Ovarian Neoplasms Estradiol 2.2519401270
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3212371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3411222880 11399792 11896295 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9920887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.3116740699
MESH:D011471 Prostatic Neoplasms Raloxifene 3.3116220300 15731164 16536755
MESH:D011565 Psoriasis Cyclosporine 2.2616882103
MESH:D011693 Purpura Raloxifene 5.7315770314
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6118551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0916192470
MESH:D020521 Stroke Raloxifene 3.9116837676
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D013978 Tibial Fractures Estradiol 14.3019048282
MESH:D013978 Tibial Fractures Raloxifene 14.3019048282
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.3416049721
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 5.3417572228
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.4710091137
MESH:D014605 Uveitis Cyclosporine 4.161336536
MESH:D014625 Vaginal Neoplasms Vinblastine 5.1815577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.3816837676
MESH:D014846 Vulvar Neoplasms Raloxifene 5.7316343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
MESH:D015430 Weight Gain Dietary Fats 3.8316723640
MESH:D014985 Xerophthalmia Cyclosporine 4.6217120751
Pathway ID Pathway Name
REACT:578 Apoptosis
REACT:6850 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
REACT:1538 Cell Cycle Checkpoints
REACT:152 Cell Cycle, Mitotic
REACT:383 DNA Replication
REACT:6185 HIV Infection
REACT:13 Metabolism of amino acids and derivatives
REACT:21257 Metabolism of RNA
KEGG:03050 Proteasome
REACT:13505 Proteasome mediated degradation of PAK-2p34
REACT:11045 Signaling by Wnt
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved