AutismKB 2.0

Annotation Detail for MLC1


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Basic Information Top
Gene Symbol:MLC1 ( KIAA0027,LVM,MLC,VL )
Gene Full Name: megalencephalic leukoencephalopathy with subcortical cysts 1
Band: 22q13.33
Quick LinksEntrez ID:23209; OMIM: 605908; Uniprot ID:MLC1_HUMAN; ENSEMBL ID: ENSG00000100427; HGNC ID: 17082
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
bipolar disorder
PSYCH
schizophrenia
bipolar disorder catatonia schizophrenia
No data
Desease Name
Megalencephalic leukoencephalopathy with subcortical cysts
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of MLC1 mRNAaffects expression 21346803
D001151 Arsenic Arsenic affects the expression of MLC1 mRNAaffects expression 18414638
D002995 Clofibric Acid Clofibric Acid affects the expression of MLC1 mRNAaffects expression 17602206
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of MLC1 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of MLC1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MLC1 mRNAaffects cotreatment|increases expression 17942748
D010269 Paraquat Paraquat results in decreased expression of MLC1 mRNAdecreases expression 15458575
D013629 Tamoxifen Tamoxifen affects the expression of MLC1 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MLC1 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.9914745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.2411752688 15322242 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3817505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8614692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7716835633
MESH:D018246 Adrenocortical Adenoma Arsenic 5.6617306315
MESH:D000382 Agricultural Workers' Diseases Paraquat 4.1611874814
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2111748828
MESH:D020261 Arsenic Poisoning Arsenic 2.9312569548 16251483 18414634 16835338
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8215885639
MESH:D050197 Atherosclerosis Arsenic 3.4019371607 12928151
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D001943 Breast Neoplasms Tamoxifen 1.9319155303 19189212 18425577 19221464 20390343 17893378 19200415 18815881 19066611 19487384 19103187 17440819 20859285 18351453 16273361 19115204 18821012 20544844 20005174 19011961 11161223 15565566 16818667 16202921 16873071 19084267 20065188 19142967 18997820 18855134 21152245 15668708 19410462 19189210 17261762 18629630 20135344 17049068 19244106 17242785 19059307 21138602 19288272 19289846 18984771
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9320435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D003528 Carcinoma, Adenoid Cystic marker/mechanism 16762588
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.7317687452 15504454
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.8719066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.8416705839
MESH:D006528 Carcinoma, Hepatocellular Arsenic 4.8417306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.8416924424
MESH:D002294 Carcinoma, Squamous Cell Arsenic 2.7517687452 18922899 15504454
MESH:D002295 Carcinoma, Transitional Cell Arsenic 10.4018640142
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 10.4017572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5018850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Arsenic 3.6315738583 17938729 19152805
MESH:D002340 Carotid Artery Diseases Arsenic 4.5616973168 18022660
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4116835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0715861022 16105132 17333356 16919318 11677210 17681005 17110522
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2015340226 16354765 8697196 12621046 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.3718551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.7219031437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.7219279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 3.9221346803 18551238
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.9220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9611462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.3516714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.0612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.0619031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.2117893378 19155303 16202921 20544844
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2910568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2111564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.6415345470
MESH:D005234 Fatty Liver Tamoxifen 8.6414986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3916709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.9214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.5819069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3120067830
MESH:D005534 Foot Diseases Arsenic 6.006392382
MESH:D005911 Gliosis Paraquat 5.6111124998
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4611294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2515340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.498697196 16959395 15340226 18606429 16354765
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.7217050553
MESH:D006973 Hypertension Arsenic 5.5216076760 9931084 11953799
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.5218850075 18670907
MESH:D006987 Hypesthesia Arsenic 6.0016093927
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1716569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.3317937319
MESH:D007248 Infertility, Male Paraquat 7.334850670
MESH:D007249 Inflammation Tamoxifen 5.3219457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.3212200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6216580747
MESH:D007642 Keratosis Arsenic 5.3916930632 12749816
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 8.1716705839
MESH:D007680 Kidney Neoplasms Tamoxifen 8.1718625569
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.7217339181
MESH:D008064 Lipidoses Tamoxifen 3.3517567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.3518564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3512878042
MESH:D008107 Liver Diseases Arsenic 2.5911134558
MESH:D008113 Liver Neoplasms Arsenic 11.4916368122
MESH:D008113 Liver Neoplasms Clofibric Acid 11.4917602206
MESH:D008113 Liver Neoplasms Tamoxifen 11.4916684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.4916984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2612151625
MESH:D008175 Lung Neoplasms Arsenic 3.5719168569 17306315 17976673
MESH:D008175 Lung Neoplasms Tamoxifen 3.5718625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5711884234 19555203
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.1519428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7911731420 16827153 14580682 19196723 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.9919453300
MESH:C536141 Megalencephalic leukoencephalopathy with subcortical cysts marker/mechanism 11254442
MESH:D008545 Melanoma Tamoxifen 1.9119393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.5815990972
MESH:D017202 Myocardial Ischemia Arsenic 9.7515371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.7512213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.2518551238
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5919410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.4419189210 19196722 19200415
MESH:D009410 Nerve Degeneration Paraquat 3.9316893418
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5414600291
MESH:D009436 Neural Tube Defects Arsenic 3.6216620997
MESH:D020078 Neurogenic Inflammation Arsenic 4.6817056641
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.6916049721 12819281
MESH:D010051 Ovarian Neoplasms Arsenic 2.8117306315
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9911578682
MESH:D010300 Parkinson Disease Paraquat 2.9012911755 16510128 11445065 16140633 11124998 11181820 15451049 15824117
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.7916190885
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.5116093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.3915371236 6392382 16905509
MESH:D011014 Pneumonia Paraquat 4.8512504350
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5911399792 11118676 11222880 11896295
MESH:D011471 Prostatic Neoplasms Arsenic 3.3116140617
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.3115067354
MESH:D011507 Proteinuria Arsenic 4.3121343184
MESH:D011537 Pruritus Ethinyl Estradiol 3.7115861022 16919318
MESH:D011658 Pulmonary Fibrosis Paraquat 3.0016324872 17997886
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 4.2111700416
MESH:D012135 Respiratory Sounds Paraquat 4.4111874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012162 Retinal Degeneration Paraquat 4.0716458197
MESH:D012468 Salivary Gland Neoplasms marker/mechanism 16762588
MESH:D012640 Seizures 2,4-dinitrotoluene 2.7118551238
MESH:D012871 Skin Diseases Arsenic 2.8015952646 16353154 19834688 17453740 16759981 16702368 6392382 18709164 17050553 17938729 17548696
MESH:D012878 Skin Neoplasms Arsenic 6.0917976673 17050553 17029826 16251483 15504454 19538983
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 6.0916192470
MESH:D013088 Spermatocele Ethinyl Estradiol 13.0916709447
MESH:D013088 Spermatocele Tamoxifen 13.0916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.4319457130
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.9016049721
MESH:D001749 Urinary Bladder Neoplasms Arsenic 8.9017976673 17306315 19322015 15987713 11144890 18640142 19429237
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.908653321 16712894 17572228
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.7110091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6314692618
MESH:D014652 Vascular Diseases Arsenic 5.1317056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8214671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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