AutismKB 2.0

Annotation Detail for SULF1


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Basic Information Top
Gene Symbol:SULF1 ( FLJ30905,FLJ38022,FLJ41750,HSULF-1,KIAA1077,SULF-1 )
Gene Full Name: sulfatase 1
Band: 8q13.2-q13.3
Quick LinksEntrez ID:23213; OMIM: 610012; Uniprot ID:SULF1_HUMAN; ENSEMBL ID: ENSG00000137573; HGNC ID: 20391
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SULF1 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in decreased expression of SULF1 mRNAdecreases expression 15725085
D016572 Cyclosporine Cyclosporine results in increased expression of SULF1 mRNAincreases expression 20106945
D002945 Cisplatin SULF1 protein results in increased susceptibility to Cisplatinincreases response to substance 17310998
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SULF1 mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of SULF1 mRNAincreases expression 19619570
D006493 Heparin SULF1 protein results in increased chemical synthesis of Heparinincreases chemical synthesis 15051888
D006497 Heparitin Sulfate SULF1 protein inhibits the reaction [Heparitin Sulfate results in increased activity of FGFR1 protein]decreases reaction|increases activity 15051888
D006497 Heparitin Sulfate SULF1 protein results in decreased sulfation of Heparitin Sulfatedecreases sulfation 15051888
C533894 LG 100815 LG 100815 results in increased expression of SULF1 mRNAincreases expression 16951191
C062198 octa-2,4,6-trienoic acid octa-2,4,6-trienoic acid results in increased expression of SULF1 mRNAincreases expression 16951191
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of SULF1 mRNAaffects binding|increases activity|increases expression 19710929
D012643 Selenium Selenium results in decreased expression of SULF1 mRNAdecreases expression 19244175
D018038 Sodium Selenite Sodium Selenite results in decreased expression of SULF1 mRNAdecreases expression 18175754
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SULF1 mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SULF1 mRNAincreases expression 19619570
D015032 Zinc Zinc results in increased expression of SULF1 mRNAincreases expression 17074742
D019287 Zinc Sulfate Zinc Sulfate results in increased expression of SULF1 mRNAincreases expression 17074742
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9014514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 10.7918287403
MESH:D000138 Acidosis Zinc Sulfate 10.797265320
MESH:D000169 Acrodermatitis Zinc 5.4517190629 16889938 17202136
MESH:D058186 Acute Kidney Injury Cisplatin 3.9915814532 17670903 12690470
MESH:D055371 Acute Lung Injury pirinixic acid 3.1518653653
MESH:D000230 Adenocarcinoma arsenic trioxide 7.2111798837 19825857
MESH:D000230 Adenocarcinoma Cisplatin 7.2117638652 11798837
MESH:D000230 Adenocarcinoma Estradiol 7.2111473722
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.0716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.0716835633
MESH:D000544 Alzheimer Disease Zinc 2.7616325427 17119284 16580781 16410023
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9711748828
MESH:D000755 Anemia, Sickle Cell Zinc 4.9416916123
MESH:D000860 Anoxia Zinc Sulfate 5.077265320
MESH:D001249 Asthma Zinc 2.9617085522
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 15.4616206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 15.4619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 15.4612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7815746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.9514601052
MESH:D001930 Brain Injuries Zinc 4.7317109824
MESH:D001943 Breast Neoplasms Cisplatin 1.8919526202 18382427
MESH:D001943 Breast Neoplasms Estradiol 1.8917018787 17261762 17289903 16675129 12948864 19861407 14630087 18497071
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8920435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.3611589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5116111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8216835633
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.7016217749 11135700 15073043 14691202 15553829
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 4.7017982673
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.7016924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.0412023789 16685392
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.9419014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.1412490120
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 5.1017066447 6189445 18337622
MESH:D002294 Carcinoma, Squamous Cell Zinc 5.1016543248
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3816120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Zinc 3.6816936243
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.6412371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.6418566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1916835633
MESH:D002779 Cholestasis Cyclosporine 7.8319486331
MESH:D002779 Cholestasis pirinixic acid 7.8319176532
MESH:D019457 Chromosome Breakage Sodium Selenite 4.7915894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1115668235 15340226 8697196 12621046 16354765
MESH:D003092 Colitis Selenium 3.8217936198
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.6720501625
MESH:D015179 Colorectal Neoplasms Cisplatin 2.6715273666
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0817141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.2212609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.8610525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8615322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Zinc 3.8619302082
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.1315213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4418249437
MESH:D003920 Diabetes Mellitus Sodium Selenite 9.4716285004
MESH:D003920 Diabetes Mellitus Zinc 9.4716479319
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6717107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.4419279558
MESH:D056486 Drug-Induced Liver Injury Selenium 6.2815131321
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 6.2815131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.2820420201
MESH:D004362 Drug Toxicity Cisplatin 8.2512649298 15033597 12231392 19839026
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.2511462148
MESH:D004487 Edema pirinixic acid 6.6312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.6311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9618230668 15322242 16714409
MESH:D016889 Endometrial Neoplasms Estradiol 3.0011473722 18566989 19148513
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.059294722 10568697
MESH:D004938 Esophageal Neoplasms arsenic trioxide 7.4612903497
MESH:D004938 Esophageal Neoplasms Cisplatin 7.4615464296 16785472 15173087 17638652 16481741
MESH:D004938 Esophageal Neoplasms Zinc 7.4616543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0311564622
MESH:D005234 Fatty Liver arsenic trioxide 13.2415073043
MESH:D005234 Fatty Liver Cyclosporine 13.2419224547
MESH:D005234 Fatty Liver pirinixic acid 13.2419236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5011858732
MESH:D005355 Fibrosis Cyclosporine 8.6212168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.6220067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.3016904648
MESH:D005756 Gastritis Zinc 4.8617241300
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.278708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6610696789
MESH:D006130 Growth Disorders Zinc 3.9817217573
MESH:D006258 Head and Neck Neoplasms Cisplatin 3.7315464296 15102660
MESH:D034381 Hearing Loss Cisplatin 4.3219898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.4415464296
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3411294989 10048152
MESH:D006333 Heart Failure pirinixic acid 11.9420558911
MESH:D006333 Heart Failure Selenium 11.9417162251
MESH:D006333 Heart Failure Zinc 11.9417162251
MESH:D006335 Heart Injuries Zinc 5.8317074742
MESH:D016481 Helicobacter Infections Zinc 4.5617241300
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4715720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3611000095
MESH:D006527 Hepatolenticular Degeneration Zinc 11.4617276780
MESH:D006527 Hepatolenticular Degeneration Zinc Sulfate 11.4617063115
MESH:D006529 Hepatomegaly pirinixic acid 8.4019176532 18467677 19772884 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.4012621046 16120746 15340226
MESH:D006558 Herpes Genitalis Estradiol 5.0915709030
MESH:D006689 Hodgkin Disease Cisplatin 3.6216200630 16170182
MESH:D019584 Hot Flashes Estradiol 3.8117088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.118697196 15340226 16959395 16354765 18606429
MESH:D006943 Hyperglycemia pirinixic acid 3.2120558911
MESH:D006973 Hypertension Cyclosporine 4.9810903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.9818670907 18850075
MESH:D007022 Hypotension Zinc Sulfate 4.507265320
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8712200463 12878042
MESH:D007251 Influenza, Human Selenium 4.2616624496
MESH:D007333 Insulin Resistance Estradiol 12.4216393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 12.4216306350
MESH:D007333 Insulin Resistance Sodium Selenite 12.4214714311
MESH:D007511 Ischemia Zinc 4.6716584753
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3616580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5015604871
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.2015464296
MESH:D007674 Kidney Diseases Cisplatin 14.6218289764 19839026 15190930 12231392 12649298
MESH:D007674 Kidney Diseases Cyclosporine 14.628314463 18776723 10903974
MESH:D007674 Kidney Diseases Estradiol 14.6215618244
MESH:D007674 Kidney Diseases Zinc 14.6216960431
MESH:D007676 Kidney Failure, Chronic Selenium 10.1816518626
MESH:D007676 Kidney Failure, Chronic Zinc 10.1816518626
MESH:D007680 Kidney Neoplasms Cyclosporine 7.3512371664
MESH:D007680 Kidney Neoplasms Estradiol 7.3515610895
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.8611231351
MESH:D016773 Leishmaniasis, Cutaneous Zinc Sulfate 4.2815237267
MESH:D007938 Leukemia arsenic trioxide 2.8415070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.8217077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.3616972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.4514633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.7919077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1417050201 16467208 20471514 16968895 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.239834237 11161223 17107899 15336539 19642359 15748426 16112521 12679006 16330433 16823087 19075265 16331271 11468182 12018890 12712474 16966277 19035177 15213294 17712046 17649720 15622746 17869043 16891316 19225113 17217047
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.3916882451
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 5.0314716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Heparin 5.0316904936
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 5.0315474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.0312878042
MESH:D008113 Liver Neoplasms arsenic trioxide 7.4114682389
MESH:D008113 Liver Neoplasms pirinixic acid 7.4115890375 16377806 20007298
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.4116984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 5.8620377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.8612151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.3715213294
MESH:D008175 Lung Neoplasms arsenic trioxide 3.4819825857 11798837
MESH:D008175 Lung Neoplasms Cisplatin 3.4817225452 11798837 6189445
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4811884234 19555203
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.0914737004
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 10.1511807958 17203775 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental Selenium 10.1515318939
MESH:D008325 Mammary Neoplasms, Experimental Zinc 10.1512773700
MESH:D020149 Manganese Poisoning Estradiol 4.5519453300
MESH:D008545 Melanoma Cisplatin 2.4817023156 16809738 11135225 18505091 16248763 16432458 15577323 18176117 12883367 12374674 17761969 12393984 18332650
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.8215990972
MESH:D008654 Mesothelioma Cisplatin 6.3917638057
MESH:D008654 Mesothelioma Selenium 6.3915107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8516801185
MESH:D009101 Multiple Myeloma arsenic trioxide 3.1215949261 19549372 11468182 19417148 14977855
MESH:D009135 Muscular Diseases pirinixic acid 3.5516239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.7318349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.1616882451 16105982
MESH:D009203 Myocardial Infarction pirinixic acid 2.1519151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.3216810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.3216411023
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.0016624393
MESH:D009369 Neoplasms Cisplatin 5.1516773208
MESH:D009369 Neoplasms pirinixic acid 5.1517405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7817289903
MESH:D009395 Nephritis, Interstitial Cisplatin 4.5515464296
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5017954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3119348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 9.5916427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.5914600291
MESH:D009436 Neural Tube Defects arsenic trioxide 3.1310525206
MESH:D009447 Neuroblastoma Cisplatin 3.468761367
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.758761367
MESH:D009765 Obesity pirinixic acid 1.8220558911
MESH:D010051 Ovarian Neoplasms marker/mechanism 17310998
MESH:D010051 Ovarian Neoplasms arsenic trioxide 7.9919769630 16624393 12452020
MESH:D010051 Ovarian Neoplasms Cisplatin 7.996897625 17225452 19769630 15464296
MESH:D010051 Ovarian Neoplasms Estradiol 7.9919401270
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.5115580305
MESH:D010190 Pancreatic Neoplasms Cisplatin 5.5119003803
MESH:D010235 Paraganglioma arsenic trioxide 4.1919927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3112520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.3415464296
MESH:D010954 Plasmacytoma Selenium 4.9515087411
MESH:D010997 Pleural Neoplasms Cisplatin 5.4117638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5918163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2512371664
MESH:D011225 Pre-Eclampsia Zinc 4.1917114810
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2411399792 11118676 11222880 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9120887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.1019131511
MESH:D011471 Prostatic Neoplasms Estradiol 2.1016740699
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.1018760546
MESH:D011471 Prostatic Neoplasms Zinc 2.1016700911 16517595 16606632 12429649
MESH:D011565 Psoriasis Cyclosporine 2.2416882103
MESH:D051437 Renal Insufficiency Cisplatin 4.4515464296
MESH:D015427 Reperfusion Injury pirinixic acid 2.4019058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8718990726
MESH:D012162 Retinal Degeneration Zinc 4.1516584753
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 10.4716646077
MESH:D012512 Sarcoma, Ewing's Cisplatin 10.4714601052
MESH:D012851 Sinus Thrombosis, Intracranial Heparin 6.1012269725
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0516192470
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.4115464296
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.6617007042
MESH:D013274 Stomach Neoplasms Cisplatin 2.6615958060 17522103 18396642
MESH:D013736 Testicular Neoplasms Cisplatin 4.6615464296 17225452
MESH:D013921 Thrombocytopenia Heparin 5.4816651880 16893407
MESH:D013927 Thrombosis Heparin 5.3316893407
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9612697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.1119014326
MESH:D013978 Tibial Fractures Estradiol 4.7519048282
MESH:D014062 Tongue Neoplasms Zinc 4.4216543248
MESH:D016171 Torsades de Pointes arsenic trioxide 4.0115213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.3612845720 20435036 11780464 12973940
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 5.3612973940 15464296 17225452
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 4.2316803524
MESH:D014605 Uveitis Cyclosporine 4.051336536
MESH:D014625 Vaginal Neoplasms Cisplatin 4.6515577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6612125929
MESH:D014657 Vasculitis Heparin 6.1020337814
MESH:D014839 Vomiting Cisplatin 4.7811897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3115886252
MESH:D014985 Xerophthalmia Cyclosporine 4.5017120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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